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Recent Therapeutics Policies of Arthritis Rheumatoid (part I) Andisari, Hendrata Erry
Oceana Biomedicina Journal Vol 1, No 1 (2018): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i1.2

Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
Current Therapy of Rheumatoid Arthritis (Recent Therapeutics Policies of Rheumatoid Arthritis part 2) Andisari, Hendrata Erry
Oceana Biomedicina Journal Vol 1, No 2 (2018): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i2.14

Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA. Keywords : conventional DMARDs, biological agents
Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA Terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Tamara, Thalia; Andisari, Hendrata Erry; Mudjiono, Totot
Oceana Biomedicina Journal Vol 2, No 2 (2019): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.33

Abstract

Latar Belakang: Artritis Rheumatoid/ Rheumatoid Arthritis (RA) adalah suatu penyakit autoimun dengan prevalensi yang terus meningkat dari tahun ke tahun. Angka kematian RA terus meningkat dalam 1 dekade terakhir akibat belum ditemukannya pencegahan dan terapi yang efektif. Terapi oksigen hiperbarik bisa menjadi terapi adjuvant untuk penderita Rheumathoid Arhtritis.Tujuan: Penelitian ini menggunakan Terapi Oksigen Hiperbarik untuk mengurangi reaksi inflamasi pada penderita Rheumatoid Arthritis.Metode: Sampel yang digunakan adalah Mice BALB/C jantan sebanyak 16 ekor yang dibagi menjadi 2 kelompok, yaitu 1) kelompok mencit yang diinduksi menjadi model Rheumatoid Arthritis, 2) kelompok hewan coba yang diinduksi menjadi model Rheumatoid Arthritis dan diberikan terapi HBO 2,4 ATA 3x30 menit selama 10 hari berturut-turut. Pada hari ke-59 dilakukan pemeriksaan C-Reactive Protein menggunakan metode ELISA.Hasil: Hasil rerata kadar C-Reactive Protein antara 2 kelompok yaitu, kelompok mencit model RA yang tidak diterapi HBO memiliki rerata kadar CRP 0.204 Pg/ml, sedangkan kelompok mencit model RA yang diterapi HBO memiliki rerata kadar CRP 0.113 Pg/ml.Kesimpulan: Terdapat pengaruh terapi oksigen hiperbarik terhadap kadar C-Reactive Protein darah mencit model rheumatoid arthritis.Kata kunci: Rheumatoid Arthritis, Terapi Oksigen Hiperbarik, C-Reactive Protein