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Ekstrak Metanol Cengkeh (Syzygium Aromaticum (L.) Merry & Perry) Varietas Tuni Buru Selatan sebagai Antimalaria Taher, Dharmawaty M; Solihin, Dedi Duryadi; Cahyaningsih, Umi; Sugita, Purwantiningsih
Acta VETERINARIA Indonesiana Vol. 6 No. 2 (2018): Juli 2018
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (39.254 KB) | DOI: 10.29244/avi.6.2.38-47

Abstract

Malaria masih menjadi salah satu masalah kesehatan di dunia dan Indonesia. Cengkeh (Syzygium aromaticum (L.) Merry & Perry) adalah tanaman asli Indonesia yang berpotensi sebagai fitofarmaka. Tujuan penelitian ini adalah untuk menganalisis aktivitas antimalaria in vitro, uji toksisitas, dan uji penghambatan secara in vivo ekstrak metanol cengkeh varietas Tuni Buru Selatan. Konsentrasi uji in vitro bunga, tangkai bunga, dan daun cengkeh masing-masing adalah 0,01, 0,1, 1, 10, dan 100 μg/mL duplo. Dosis uji toksisitas bunga cengkeh dan tangkai bunga cengkeh masing-masing 625, 1250, 2500, 5000, dan 10000 mg/kg BB dan lima ulangan. Uji in vivo dengan menggunakan tiga dosis perlakuan bunga cengkeh dan tangkai bunga cengkeh masing-masing 25, 50, dan 100 mg/kg BB dan 5 ulangan. Hasil uji in vitro menunjukkan 50% Inhibition Concentration (IC50) bunga cengkeh 1,25 μg/mL; tangkai bunga cengkeh 7,89 μg/mL dan daun cengkeh 11,42 μg/mL; 50% Lethal doses (LD50) bunga cengkeh 19743,327 dan tangkai bunga cengkeh 47304,436 mg/kg BB; Persentase penghambatan rata-rata uji in vivo bunga cengkeh 94,19; 95,81; 78,28% dan tangkai bunga cengkeh 90,48; 80,43; 74,14%. Ekstrak metanol cengkeh varietas Tuni Buru Selatan berpotensi sebagai antimalaria dan tidak toksik.
PENGETAHUAN LOKAL MASYARAKAT KEPULAUAN TENTANG TUMBUHAN ANTI-NYAMUK Hasan, Said; Taher, Dharmawaty M; Tamalene, M. Nasir
TECHNO: JURNAL PENELITIAN Vol 9, No 1 (2020): Techno Jurnal Penelitian
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/tjp.v9i1.1544

Abstract

The Utilization of natural materials from local plants as mosquito repellent starts from the deepening of information about local knowledge of the community. Research about anti-mosquito is important to overcome problems of the use of synthetic anti-mosquitoes on the market; besides that, this is also to preserve the community's local wisdom. The purpose of this study is to describe the local knowledge of the island community about the use of anti-mosquito plants and analyze the potential of plants that are most widely used by people in the islands as anti-mosquito lotion products. The method used is the exploratory survey method. Data collection is done by interviewing techniques, in-depth observation of informants, and documentation. The most used anti-mosquito plant data were analyzed by phytochemical components. The results showed that there were 9 species of anti-mosquito plants used by the community, namely Tagetes erecta L, Lavandula L, Cymbopogon citratus, Citrus aurantifolia, Syzygium aromaticum, Evodia suaveolens, Catharanthus roseus (L) G. Don., Alphitonia incana BL., and Polygala paniculata. Alphitonia incana BL is the most widely used type of society and contains phytochemical compounds, alkaloids, terpenoids, flavonoids, phenolics, and tannins. The Alphitonia incana BL., has the potential to be developed as an anti-mosquito lotion product.