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Perbedaan efek ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak buah naga putih (Hylocereus undatus) terhadap kadar kolesterol total tikus putih (Rattus norvegicus) Prakoso, Luthfi Octafyan; Yusmaini, Hany; Thadeus, Maria Selvester; Wiyono, Sugeng
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.377 KB) | DOI: 10.25182/jgp.2017.12.3.195-202

Abstract

This study aimed to compare the effect of red dragon fruit extract (Hylocereus polyrhizus) and white dragon fruit extract (Hylocereus undatus) to total cholesterol levels in white rats (Rattus norvegicus). Total of 30 males white wistar strains were divided into five treatments i.e: (1) standard feed and Na-CMC 1% (K1), (2) standard feed and quail egg 10ml/kgBW (K2), (3) standard feed, quail egg 10ml/kgBW and simvastatin dose 0,72mg/day (P1), (4) standard feed, quail egg 10ml/kgBW and red dragon fruit extract dose 60mg/200gBW/day (P2), (3) standard feed, quail egg 10 ml/kgBW and white dragon fruit extract dose 120mg/200gBW/day (P3). The intervention was carried out for 14 days after 7 days acclimatization period. Data was analyzed by One Way ANOVA test and continued with Post Hoc Bonferroni test (p=0.05). In P2 group, there was a difference of total blood cholesterol level by 25.83 mg/dl compared with the positive control group and statistically significant (p<0.05). In P1 and P3 group there were difference in cholesterol levels of 9.5 mg/dl and 11.5 mg/dl compared with the positive control group, but not statistically significant (p>0.05). The comparison between red dragon extract group and white dragon extract showed a non-significant difference (p>0.05). Red dragon fruit extract and white dragon extract have a potential effect to improve hypercholesterolemia conditions.
Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats Pujangga, Ibnu Wadud; Nainggolan, Dorlina; Thadeus, Maria Selvester
Jurnal Gizi dan Pangan Vol. 14 No. 3 (2019)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.711 KB) | DOI: 10.25182/jgp.2019.14.3.157-164

Abstract

This research aimed to add evidence on the effect of white leadtree seed extract (Leucaena leucocephala) on postprandial blood glucose level on white male alloxan induced diabetic rats. This research was an experiment with pretest-posttest control group design. The subjects of this research were 25 white male rats, Wistar strain was divided into 5 groups. Group I was the positive control, which was treated with Acarbose, group II was the negative control, and group III, group IV, and group V were treatment groups and were given white leadtree seed extract of 1.5 g/kg of BW, 3.5 g/kg of BW, and 7.8 g/kg of BW respectively. Blood glucose level was checked before and two hours after treatment. The statistical analysis used one-way ANOVA and Bonferroni post hoc test. The result showed that there were no significant differences between group III, group IV, and group V and the positive control group (p<0.05). The best result of inhibition of the increase in blood glucose level was found in 7.8 g/kg of BW (group V) dosage group with average difference of 186.4 mg/dl. In conclusion, white leadtree seed extract could decrease two hour postprandial blood glucose level in white male alloxan-induced diabetic rats and a dosage of 7.8 g/kg of BW was shown to be the most effective.
HUBUNGAN GAGAL GINJAL KRONIK TINGKAT 4 DAN 5 DENGAN KEJADIAN DISLIPIDEMIA PADA PASIEN GAGAL GINJAL KRONIK DI RUMAH SAKIT UMUM PUSAT FATMAWATI PERIODE TAHUN 2016 Wibawanto, Dimas Farhan; Paris, Salman; Thadeus, Maria Selvester
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v12i2.296

Abstract

Dyslipidemia is a common complication of chronic kidney disease. Dyslipidemia itself is a common risk for a cardiovascular disease, which is the leading cause of death in chronic kidney disease. This study aims to identify the relationship of chronic kidney disease stage 4 and 5 with the incidence of dyslipidemia at Fatmawati General Hospital in the period of 2016. Design cross-sectional with simple random sampling technique. Data were collected by looking at the patient's medical records. Respondents are 80 people. The study population were all patients diagnosed with chronic kidney disease at Fatmawati Central General Hospital in 2016. The results showed that most chronic kidney disease stage 4 has normal level of low density lipoprotein as many 22 people (73.33%) while at stage 5 most have high level of low density lipoprotein high as many 36 people (72%). High density lipoprotein obtained in patients with chronic kidney disease stage 4 mostly had normal level as many 20 people (66.67%) for stage 5 mostly had low level as many 33 people (66%). Mean lipid values of triglyceride X? = 152,36, high density lipoprotein X? = 39,36 and low density lipoprotein X? = 145,01. Result of bivariate analysis with chi square test showed significant relationship of chronic kidney disease stage 4 and 5 with incidence of dyslipidemia (p = 0,002).
ANALISIS FAKTOR TINGKAT KEPATUHAN MINUM OBAT PASIEN DIABETES MELITUS DI PUSKESMAS PANCORAN MAS PERIODE MARET – APRIL 2019 Jasmine, Nadira Safa; Wahyuningsih, Sri; Thadeus, Maria Selvester
Jurnal Manajemen Kesehatan Indonesia Vol 8, No 1 (2020): April 2020
Publisher : Prodi Magister Ilmu Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat Undip

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmki.8.1.2020.61-66

Abstract

The prevalence of diabetes mellitus (DM) will continue to increase throughout the years. A way to achieve normal blood sugar levels is through adherence to medications. Nonadherence to medications in DM patients can result in high blood sugar levels and increase the risk of complications. This study was conducted to determine factors affecting medication adherence among DM patients in Puskesmas Pancoran Mas Depok in March ? April 2019. This was an observational analytic study using a cross-sectional method. MMAS-8, DKQ-24 and family support questionnaires were used to collect the data along with the demographic data. Chi-square was used to analyze the data. The factors affecting medical adherence included patients? education level (OR=2.325; 95%CI=1.034-5.224), gender (OR=4.200 95%CI=1.699-10.380), diabetes duration (OR = 2.426 95%CI=1.019-5.775), number of drugs taken (OR=3.680 95%CI=1.604-8.445), dosing frequency (OR=3.350 95%CI=1.283-8.749), and patient?s knowledge (OR=2.668 95%CI=1.135-6.276). Logistic regression analyzes showed that gender is the most powerful factors in affecting medication adherence.