Sugianli, Adhi Kristianto
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PREVALENCE OF HEMATOTOXIC EFFECT OF INTRAVENOUS CHEMOTHERAPY AMONG RETINOBLASTOMA POPULATION IN TERTIARY HOSPITAL IN BANDUNG, INDONESIA Hadiman, Jennifer; Susanah, Susi; Sugianli, Adhi Kristianto
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1520

Abstract

Objective: To observe the prevalence of hematotoxic effect in retinoblastoma patients who were given intravenous chemotherapy with vincristine, etoposide, and carboplatin (VEC) regimen. Retinoblastoma is the second most common cancer in children in Indonesia. Standard chemotherapy agents used in retinoblastoma treatment is VEC given in 7 cycles intravenously. The most common side effect of VEC regimen is hematotoxic effect which might lead to chemotherapy failure.Methods: This study used descriptive method with cross sectional study design. Data were collected from medical records of retinoblastoma patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from 2014 until 2016 using total sampling technique.Results: Forty-six patients were included in this study. Of those subjects, 36 (78.3%) patients experienced hematotoxic effect. The most common hematotoxic effect occurred were anemia and neutropenia, that occurred in 32 (69.6%) and 18 (39.1%) patients, respectively. The most common hematotoxic effect severity occurred were grade 1 anemia, grade 1 leukopenia, grade 1 neutropenia, and grade 3 thrombocytopenia. Percentage of patients experienced anemia tended to increase until the 7th cycle. Seven (15.2%) patients had anemia prior to chemotherapy administration.Conclusion: The majority (78.3%) of the patients experienced hematotoxic effect on intravenous chemotherapy administration with VEC regimen. Anemia was the most common hematotoxic effect occurred.Keywords: Hematotoxic effect, intravenous chemotherapy, retinoblastoma 
MONOCYTE TO LYMPHOCYTE RATIO IN PERIPHERAL BLOOD OF TUBERCULOUS MENINGITIS WITH HIV PATIENTS IN TERTIARY HOSPITAL IN WEST JAVA Amalia, Ridha; Turbawaty, Dewi Kartika; Sugianli, Adhi Kristianto; Aminah, Siti
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v6n1.1140

Abstract

Objective: To describe peripheral blood monocyte to lymphocyte (ML) ratio in tuberculous meningitis (TBM) patients with human immunodeficiency virus (HIV) infection in Dr. Hasan Sadikin General Hospital Bandung as a tertiary hospital in West Java Province, Indonesia.Method: A cross-sectional study with retrospective data approach was done in Dr. Hasan Sadikin General Hospital, Bandung. Data were collected from TBM patients who were hospitalized in Dr. Hasan Sadikin General Hospital, Bandung in the period of 2014?2016. The sample size was determined using total sampling method. General data, clinical manifestation data, and laboratory finding data were collected. The ML ratio was collected and presented into three groups of percentile (25th, 25?75th and 75th) based on the pre-defined cut-off.Result: Six subjects (40%) had an ML ratio of ?0.47 and 3 subjects had an ML ratio of ?1.22 in TBM with HIV population. Among TBM with HIV-negative population, there were 16 subjects had ML ratio ?0.47, and 19 subjects had ML ratio ?1.22.Conclusion: The ML ratio in TBM with HIV infection has become additional tool for detecting the development of TBM with HIV-infected, as well as TBM with non-HIV-infected. Therefore, it could help directing the patients with clinical suspicious of TBM into the diagnosis algorithm and treatment of TBM, to have better outcome.Keywords: Human immunodeficiency virus infection,lymphocyte, monocyte, monocyte to lymphocyte ratio, tuberculous meningitis DOI: 10.15850/ijihs.v6n1.1140
PENGANGKAAN (KUANTIFIKASI) PERIKSAAN PULASAN GRAM DI BERBAGAI JENIS BAHAN PEMERIKSAAN Sugianli, Adhi Kristianto; Parwati, Ida
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1048

Abstract

In a clinical microbiology laboratory the Gram staining is used to classify bacteria on the basis of their forms, sizes, cellularmorphologies, and Gram reactions. Additionally it is a critical test for rapid presumptive diagnosis of infectious agents and serves toassess the quality of clinical specimens. Several methods of Gram staining quantification are already applied: Canadian Coalition forQuality in Laboratory Medicine (CCQLM), Clinical Microbiology Proficiency Testing (CMPT), and World Health Organization (WHO).Each method consists of several criteria for quantification and its interpretation, such as neutrophil cell (polymorphonuclear cells),squamous epithelial cell, and number of microorganisms. Those methods aren't limited in sputum specimen, but also could be used forother specimen such as urine, vaginal discharge, and other body fluids. These methods are also could be used as screening for specimenbefore it is continued into further testing. Even though there is several limitation for each method, quantification method of Gramstaining could be provide better diagnostic value in microbiology laboratory as an early detection in the examination to get betterdiagnosis as well as treatment.