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PENGARUH EKSTRAK METANOL DAUN KESUM (Polygonum minus Huds.) TERHADAP PENINGKATAN KADAR KREATININ DAN UREUM SERUM TIKUS PUTIH GALUR WISTAR TERINDUKSI SISPLATIN ., Michael
Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Vol 1, No 1 (2013): Jurnal S1 Prodi Farmasi FK UNTAN
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN

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Abstract

Cisplatin is a chemotherapy drug that had nephrotoxicity side effect which marked with the increase of urea and creatinine. Kesum (Polygonum minus Huds.) is one ofthe potential herbs that can be used to decrease urea and creatinine concentration. Thepurposes of this research is to find out the secondary metabolite contents of kesumleaves methanol extract and the activity of urea and creatinine concentrationreduction which rats were treated to have nephrotoxic with induction of cispatin.Kesum leaves extraction was done by maseration method using methanol solvent.Phytochemical screening test was perfomed with a tube to detect the compound inkesum leaves extract. The rats were divided into 5 groups which are non-treatedgroup (CMC1%), cisplatin control group, dose 1 group (8,664 mg/200 grBW), dose 2group (17,328 mg/200 grBW), and dose 3 group (34,656 mg/200 grBW). Theconcentration of urea and creatinine were checked at day 10 after the induction usespectrophotometer UV-Vis. Data were analyzed with Oney Way ANOVA and PostHoc Test Multiple Comparisons-Tukey HSD test. Phytocemistry screening showsthat kesum leaves methanol extract compound alkaloid, polyphenol, tannin,flavonoid, triterpenoid and saponin. The results show that dose 1, dose 2, and dose 3can decrease urea and creatinine concentration which indicate that it has potency toreduce the side effect of chemotherapy agent cisplatin.
RISIKO, PROFITABILITAS, PERTUMBUHAN ASET, DAN ASET TETAP TERHADAP KEBIJAKAN DIVIDEN DAN KEBIJAKAN UTANG ., Michael; Wijaya, Liliana Inggrit
Journal of Management and Business Vol 9, No 2 (2010): SEPTEMBER 2010
Publisher : Department of Management - Faculty of Business and Economics. Universitas Surabaya.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.78 KB) | DOI: 10.24123/jmb.v9i2.165

Abstract

The aim of this study is to analyze the factors that influence financing policy. Financing policy as the independent variable consist of dividend anddebt policies. The factors that influence the dividend policy are business risk, profitability, and growth. Debt policy influence by dividend, business risk,profitability, and fixed asset. Toestimate relation between these factors, this study used Seemingly Unrelated Regression (SUR) because the debt and dividend model have same error term. Research object are companies in manufacture industry that listing in Indonesian stock Exchange that paid dividend in minimum 4 periods in research periods. The result of the analysis indicates that profitability have a significant influence toward dividend policy. Result for debt policy are business risk, profitability, and fixed asset have a significant influence toward debt policy. The result also shows that profit has positive significant effect to dividend, which indicates the ability of the firm to pay higher dividend while their profit increased. Risk and profit also show positive effect to debt. Firms with higher profit will have higher debt, however their risk also increased in significant positive relationship.
Tata Laksana Terkini pada Hipertensi ., Michael; Natalia, Devita; Margarreta, Santa Lin; Putra, Wurry Devian; Gabrielia, Claudia Rosela
Jurnal Kedokteran Meditek Vol. 20 No. 52 Januari-April 2014
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v20i52.1012

Abstract

Abstrak Hipertensi merupakan penyakit degeneratif 80% ditemukan di dunia. Pada banyak pasien gejalanya asimtomatik. Dalam karya tulis ini akan dibahas tentang tata laksana pada hipertensi. Obat anti hipertensi dapat digunakan secara monoterapi maupun kombinasi. Terdapat bermacam-macam obat hipertensi yang dapat digunakan sebagai terapi inisial atau kombinasi dalam tata laksana hipertensi, antara lain : diuretic thiazid, calcium antagonist, ACE-inhibitor, angiotensin receptor antagonist dan beta blocker.Kata kunci: Hipertensi, Tata laksana Abstract Hypertension is a degenerative disease evidence in 80% of population. In many patients the symptoms are asymptomatic. In this paper will discuss about treatment in hypertension. Antihypertensive drugs can be used as monotherapy or in combination. There are various hypertension medications that can be used as initial therapy or in combination in the management of hypertension, such as : thiazide diuretics, calcium antagonists, ACE -inhibitors, angiotensin receptor antagonists and beta blockers.Keywords: Hypertension, Treatment