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PHYTOPREVENTIVE EFFECT OF BUAH MERAH (Pandanus conoideus Lam.) OIL IN COLITIS-ASSOCIATED CARCINOGENESIS Adhika, Oeij Anindita
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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Abstract

Colorectal cancer has provided a paradigm for the connection between inflammation and cancer. Modulation of intracellular signaling involved in chronic inflammatory response by anti-inflammatory agents represents an important strategy in molecular target-based chemoprevention. The aim of this research is to study the effect of buah merah oil on  IL-6  serum level and histopathology of colon in colitis-associated cancer (CAC) mice model. BALB/c mice were randomly divided into four groups. The negative control and buah merah control were given aquabidest and buah merah, respectively, without CAC induction. The AOM/DSS control and buah merah treatment were given azoxymethane (AOM) followed by dextran sulfate sodium (DSS) to induce CAC. The AOM/DSS control was given aquabidest while the buah merah treatment was given buah merah. Data were analyzed by One-Way ANOVA continued with Tukey-HSD. The result showed that IL-6 level in mice administrated with buah merah was significantly lower than the AOM/DSS control (p=0.000). Histopathological analysis scores  of colon were analyzed by Kruskal-Wallis continued with Mann-Whitney. The result showed that histopathological analysis score in buah merah treatment was significantly lower than in the AOM/DSS control (p=0.002). Taken together, buah merah oil lowered IL-6 level and histopathological analysis score of colon in CAC mice model. Keywords: CAC, buah merah oil,  IL-6 level, histopathological  analysis scores of  colon
The Role of Signal Transducer and Activator of Transcription 3 (STAT3) in Tumor Immunity Adhika, Oeij Anindita; Shahib, M Nurhalim
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.174

Abstract

BACKGROUND: Inflammation is a key component of the tumor microenvironment. Cancer-associated inflammation is marked by the presence of specific inflammatory cells and inflammatory mediators. Moreover, immune cells in the tumor microenvironment not only fail to mount an effective antitumor immune response, but also interact intimately with the tumor cells to actively promote oncogenesis.CONTENT: Their roles in regulating cytokine-dependent inflammation and immunity make the signal transducer and activator of transcription (STAT) proteins critical players in determining whether immune responses in tumor microenvironment promote or inhibit cancer. Recent evidence suggests a crucial role for STAT family proteins, especially STAT3 (signal transducer and activator of transcription 3), which is a point of convergence for numerous oncogenic signaling pathways, in selectively inducing and maintaining a procarcinogenic inflammatory microenvironment, both at the initiation of malignant transformation and during cancer progression. The persistent activation of STAT3 increases tumor cell proliferation, survival, and invasion while supressing antitumor immunity. SUMMARY: STAT3 signaling pathway constitutes a potential preventive and therapeutic target for cancer immunotherapy.  KEYWORDS: STAT3, inflammation, tumor microenvironment, cancer immunotherapy
PHYTOPREVENTIVE EFFECT OF BUAH MERAH (Pandanus conoideus Lam.) OIL IN COLITIS-ASSOCIATED CARCINOGENESIS Adhika, Oeij Anindita
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.66 KB) | DOI: 10.28932/jmh.v1i2.508

Abstract

Colorectal cancer has provided a paradigm for the connection between inflammation and cancer. Modulation of intracellular signaling involved in chronic inflammatory response by anti-inflammatory agents represents an important strategy in molecular target-based chemoprevention. The aim of this research is to study the effect of buah merah oil on  IL-6  serum level and histopathology of colon in colitis-associated cancer (CAC) mice model. BALB/c mice were randomly divided into four groups. The negative control and buah merah control were given aquabidest and buah merah, respectively, without CAC induction. The AOM/DSS control and buah merah treatment were given azoxymethane (AOM) followed by dextran sulfate sodium (DSS) to induce CAC. The AOM/DSS control was given aquabidest while the buah merah treatment was given buah merah. Data were analyzed by One-Way ANOVA continued with Tukey-HSD. The result showed that IL-6 level in mice administrated with buah merah was significantly lower than the AOM/DSS control (p=0.000). Histopathological analysis scores  of colon were analyzed by Kruskal-Wallis continued with Mann-Whitney. The result showed that histopathological analysis score in buah merah treatment was significantly lower than in the AOM/DSS control (p=0.002). Taken together, buah merah oil lowered IL-6 level and histopathological analysis score of colon in CAC mice model. Keywords: CAC, buah merah oil,  IL-6 level, histopathological  analysis scores of  colon