Articles

Found 4 Documents
Search
Journal : Medula

AKTIVITAS ANTIBAKTERI SABUN CUCI TANGAN YANG MENGANDUNG EKSTRAK METANOL RUMPUT LAUT EUCHEUMA SPINOSUM (ANTIBACTERIAL ACTIVITY TEST OF EUCHEUMA SPINOSUM METHANOL EXTRACT HAND WASH) Akib, Nur Illiyyin; Triwatami, Mariani; Putri, Andi Eka Purnama
MEDULA Vol 7, No 1 (2019)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.357 KB) | DOI: 10.33772/medula.v7i1.11494

Abstract

Background: Eucheuma spinosum seaweed contain flavonoid, triterpenoid, alkaloids and polyphenol which has been widely used in antibacterial activity. Purpose(s):The aim of the research are to determine antibacterial activities of metanol extracts of E. spinosum against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922; to formulate hand wash of seaweed of methanol extract E. spinosum that has antibacterial activity and has physical and chemical stability. Methods: Seaweed E.spinosum methanol extract was derived by maceration method. Antibacterial activities of the extract were tested by liquid dilution and solid dilution method. Hand wash was formulated by mechanical dissolved methods. Antibacterial activity of hand wash were tested by liquid dilution and solid dilution method. Physical and chemical stabilities were conducted by cycling test. Results:. These were showed through minimum inhibitory concentration (MIC) of ethanol extracts of E. spinosum against S. aureus ATCC 25923 at concentrations of 6% and E. coli ATCC 25922 at concentrations of 6%. The minimum bactericidal concentration (MBC) of ethanol extracts of E. spinosum against S. aureus ATCC 25923 at concentrations of 8% and E. coli ATCC 25922 at concentrations of 8%. Formulation of hand wash seaweed E. spinosum methanol extract at concentrations of 8% and 10%. The test of stabilities results of hand wash changes were organoleptic, viscosity, pH, and foaming ability were accordance to qualified standard. The antibacterial activity of hand wash contains seaweed E. spinosum methanol extract at concentration of  8% and 10% have bactericidal activity againts S. aureus ATCC 25923 and E. coli ATCC 25922. Conclusion: Overall, these results suggested that formula of hand wash contains E. spinosum metanol extracts have antibacterial properties against S. aureus ATCC 25923 and E. coli ATCC 25922.Keywords: antibacterial, Eucheuma spinosum, hand wash, physical and chemical stability Latar Belakang: Rumput laut Eucheuma spinosum mengandung flavonoid, triterpenoid, alkaloid, dan polifenol yang memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan mengetahui aktivitas antibakteri ekstrak metanol E. spinosum terhadap Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922; membuat sediaan sabun cuci tangan dari ekstrak metanol E. spinosum yang memiliki aktivitas antibakteri dan stabil secara fisika dan kimia. Metode: Ekstrak metanol E. spinosum diperoleh dengan metode maserasi. Uji aktivitas antibakteri ekstrak dilakukan dengan metode dilusi cair dan dilusi padat. Sabun cuci tangan diformulasi dengan metode pencampuran mekanik. Uji aktivitas antibakteri sabun cuci tangan dilakukan dengan metode dilusi cair dan dilusi padat. Uji stabilitas fisika kimia dilakukan dengan metodecycling test. Hasil: Konsentrsi Hambat Minimum (KHM) ekstrak metanol E. spinosum terhadap S. aureus ATCC 25923 adalah 6% dan terhadap E. coli ATCC 25922 adalah 8%. Ekstrak metanol E. spinosum dapat diformulasi menjadi sabun cuci tangan dengan konsentrasi 8% dan 10%. Uji stabilitas menunjukkan bahwa perubahan organoleptik, viskositas, pH, dan kemampuan membentuk busa masih berada dalam nilai yang dipersyaratkan. Uji aktivitas antibakteri sabun cuci tangan yang mengandung ekstrak metanol E. spinosum dengan konsentrasi 8% dan 10% memiliki aktivitas antibakteri terhadap ATCC 25923 and E. coli ATCC 25922. Simpulan: Formula sabu cuci tangan yang mengandung ekstrak metanol E. spinosum memiliki aktivitas antibakteri terhadap ATCC 25923 and E. coli ATCC 25922.Kata kunci: antibakteri, Eucheuma spinosum, sabun cuci tangan, stabilitas fisika kimia
EVALUASI MUTU PELAYANAN DAN HUBUNGAN ANTARA KEPUASAN KONSUMEN DAN PELAKSANAAN PELAYANAN KEFARMASIAN OLEH APOTEKER PENGELOLA APOTEK DI APOTEK-APOTEK KOTA KENDARI Ihsan, Sunandar; Rezkya, Putri; Akib, Nur Illiyyin
MEDULA Vol 2, No 1 (2014)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.71 KB) | DOI: 10.33772/medula.v2i1.244

Abstract

Pharmaceutical service  quality relate to consumer?s  satisfaction.  Twenty five percent   curage  of patient can be  found  from  good  pharmaceutical  sevice  and  75%  from  drug  usage.  This  study  aimed  to  determine pharmaceutical  service  quality  in  community  pharmacy  of  Kendari  City  and  to  determine  correlation  between  consumer?s  satisfaction  and  implementation  of  pharmaceutical  service  by  pharmacist  manager.  This  study  is  an observational analytic. Data collected from 519 respondents  through questionnaires in June-August 2014 spread across  ten  community  pharmacies  City  of  Kendari  with  sampling  method  used  simple  random  sampling,  and accidental  sampling  for  pharmacist  manager.  Correlation  test  used  to  determine  correlation  between  cons umer satisfaction and implementation of pharmaceutical care by pharmacist manager in pharmacy. The result showed that the percentage rate is 76.70% for consumer satisfaction with moderate category. Fixed percentage of any document procedures  and  dispensing  time  is  60%  with  moderate  category.  Pharmacist  manager  percentage  that  manages quality guarantee is 40% with less category.  Statistic correlation test showed that there is no cerrelation between consumer satisfaction and implementation of pharmaceutical care by pharmacist manager in pharmacy with p value 0,268 (> 0,05). Keywords: quality service, pharmaceutical service, consumer satisfaction
PREPARASI FENILBUTAZON DALAM PEMBAWA VESIKULAR ETOSOM DENGAN BERBAGAI VARIASI KONSENTRASI FOSFATIDILKOLIN DAN ETANOL Akib, Nur Illiyyin; Suryani, Suryani; Halimahtussaddiyah R, Halimahtussaddiyah R; Prawesti, Niken
MEDULA Vol 2, No 1 (2014)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.986 KB) | DOI: 10.33772/medula.v2i1.243

Abstract

Phenylbutazone is non steroidal anti-inflammatory drug (NSAID) used  in treatment of joint inflammation such  as  rheumathoid  arthritis.  In  order  to  minimize  irritation  effect  on  gastrointestinal  tract,  the  dose  of phenylbutazone is reduced or administered through transdermal pathways. Flux penetration of drugs across the membrane  can  be  improved  by  using  vesicular  type  of  delivery  system  such  as  ethosome.  This  study  aim  to prepare  phenylbutazone in  ethosome  vesicular  system.  Ethosome vesicular  systems  were prepared  with  various concentrations  of  phosphatidylcholine  (2%  and  3%)  and  ethanol  (30%,  35%,  and  40%).  Vesicles  that  are formed  further  characterized  by  shape,  size  and  entrapment  efficiency.  The  shaped  of  ethosome  produced  is large  unilamellar vesicle.  The size of vesicle  varies  between  0.57 to 0.81  µm  with  the smallest size  on Formula C.  The  highest  entrapment  efficiencies  was  also  on  the  Formula  C  by  59.88%  with  2%  concentration  of phosphatidylcholine and 40% of ethanol. Keywords: phenylbutazone, vesicle, ethosomes.
OPTIMASI KADAR FENILBUTAZON DALAM PEMBAWA VESIKULAR ETOSOM (OPTIMIZATION OF CONCENTRATION OF PHENYLBUTAZONE IN ETHOSOMES VESICULAR CARRIER) Akib, Nur Illiyyin; Sahumena, Muhammad Handoyo; Dawu, Yunita; Aspadiah, Vica; Hafizah, Indria; Ritonga, Halimahtussaddiyah
MEDULA Vol 7, No 2 (2020)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/medula.v7i2.11968

Abstract

Background: Phenylbutazone is a class of non-steroidal anti-inflammatory drugs (NSAIDs) used in the treatment of rheumatoid arthritis. Phenylbutazone is used by the transdermal route to reduce the irritating effect on the gastrointestinal tract. Purpose: This study aims to obtain phenylbutazone suspensions with optimal levels in the ethosome vesicular carrier. Methods: Preparation was carried out by the hot method (40oC) and cold method (30oC) as well as variations in the concentration of phosphatidylcholine (2% and 3%) and ethanol (30%, 35%, and 40%). Characterization of vesicles, namely the shape and size of vesicles using optical microscopy and entrapment efficiency using the spectrophotometer method with ? maks 266.6 nm. Optimization of phenylbutazone levels was carried out at a concentration of 0.1%; 0.15%; 0.2%; and 0.25%. The optimum formula was obtained at a concentration of phosphatidylcholine 3% and ethanol 35% prepared by the hot method. Results:. The form of a Small Unilamellar Vesicle (SUV), a size of 23.7 nm, and entrapment efficiency is 88.358%. Optimization of phenylbutazone levels was obtained at a concentration of 0.1% with entrapment efficiency of 88.358%. Conclusion: The optimum level of phenylbutazone in the vesicular carrier ethosome was 0.1%.Keywords: ethosome, optimation, phenylbutazone, transdermal ABSTRAKLatar Belakang: Fenilbutazon merupakan golongan obat antiinflamasi non stroid (AINS) yang digunakan pada pengobatan penyakit rheumatoid arthritis. Fenilbutazon digunakan melalui rute transdermal untuk mengurangi efek iritasi pada saluran cerna. Tujuan: Penelitian ini bertujuan memperoleh suspensi fenilbutazon dengan kadar yang optimal dalam pembawa vesikular etosom. Metode: Preparasi dilakukan dengan metode panas (40oC) dan metode dingin (30oC) serta variasi konsentrasi fosfatidilkolin (2% dan 3%) dan etanol (30%, 35%, dan 40%). Karakterisasi vesikel yaitu bentuk dan ukuran vesikel menggunakan mikroskop optik serta efisiensi penjerapan menggunakan metode spektrofotometer pada ?maks 266,6 nm. Optimasi kadar fenilbutazon dilakukan pada konsentrasi 0,1%; 0,15%; 0,2%; dan 0,25%. Diperoleh formula optimum pada konsentrasi fosfatidilkolin 3% dan etanol 35% yang dipreparasi dengan metode panas Hasil: Vesikel yang diperoleh berbentuk Small Unilamellar Vesicle (SUV), ukuran 23,7 nm, dan efisiensi penjerapan 88,358%. Optimasi kadar fenilbutazon diperoleh pada konsentrasi 0,1% dengan efisiensi penjerapan 88,358%. Kesimpulan: Disimpulkan bahwa kadar optimum fenilbutazon dalam pembawa vesikular etosom adalah 0,1%.Kata kunci: etosom, optimasi, fenilbutazon, transdermal