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THE ROLE OF INTELLECTUAL AND SPIRITUAL CAPITAL IN DEVELOPING HALAL TOURISM Ariyanto, Agus; Chalil, Rifyal Dahlawy
Proceedings of AICS - Social Sciences Vol 7 (2017): 7th AIC in conjuction ICMR 2017 Universitas Syiah Kuala October 2017
Publisher : Proceedings of AICS - Social Sciences

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The trend of Islamic tourism shows an immense improvement not only in Indonesia but also worldwide. In Indonesia alone, development of Islamic tourism relies on the human factor (intellectual capital) which works in tourism departments as the source of organization. The aim of the research is to test and analyses the role of intellectual capital and spiritual capital in improving the organization performance of tourism department of Aceh. The design of the research is a survey which uses multiple regressions as the data analysis method. The research object is The Tourism Department of Banda Aceh in Aceh Province. Research subjects (respondents) are 75 employees who work at the Department of Tourism City Banda Aceh. The questionnaire (Likert scale) is used as the instrument of data collection with a convenience sampling. The results show that intellectual capital and spiritual capital have a positive and significant impact on the performance of organization. Moreover, spiritual capital plays as the most pivotal in increasing the performance of tourism department of Banda Aceh
KAJIAN TEKNOEKONOMI PERANGKAT PENCACAH RADIOIMMUNOASSAY (RIA) IP.8 Waluyo, Joko; Nurcahyadi, Hari; Ariyanto, Agus
TEKNOEKONOMI - Jurnal Pendayagunaan Hasil Litbang Iptek Nuklir Vol 7, No 2 (2012): Nopember 2012
Publisher : BATAN

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Kajian ini mempunyai tujuan untuk menentukan nilai ekonomis dari suatu perangkat pencacah RIA IP.8. Hal ini diperlukan sebagai bahan pertimbangan kelayakan investasi bagi para investor yang ingin mengembangkan usaha untuk memproduksi perangkat ini. Pada kajian ini dilakukan beberapa tahapan kegiatan. Tahap awal yaitu penyiapan larutan standar Aflatoksin B1 yang bersifat karsinogenik sebagai bahan kit RIA yang akan dilakukan ujicoba pencacahan. Tahap selanjutnya adalah ujicoba mesin pencacah kit RIA IP.8 dengan menggunakan sampel kit RIA Aflatoksin B1. Tahap akhir adalah melakukan perhitungan teknoekonomi berdasarkan seluruh biaya yang digunakan dalam pembuatan, penyiapan dan pengujian perangkat pencacah RIA IP.8 serta asumsi-asumsi yang diperlukan. Kajian teknoekonomi dengan asumsi modal yang digunakan 70% berasal dari pinjaman bank, diperoleh hasil sebagai berikut: Net Present Value (NPV) 1.873.632.901, Internal Rate of Return (IRR) 45,5%, Payback Period (PP) 3 tahun, Benefit/Cost Ratio (B/C) 3,8 sehingga peluang investasi ini layak dipertimbangkan untuk dilakukan.  This study has the objective to determine the economic value of an enumerator device IP.8 RIA. It is necessary for consideration the feasibility of investment for investors who want to develop the business to manufacture these devices. In this study conducted a few stages. The early stages of the preparation of standard solutions which are carcinogenic aflatoxin B1 as a RIA kit will do tests enumeration. The next step is testing thrasher IP.8 RIA kit using RIA kit Aflatoxins B1 samples. The final stage is to perform calculations based on the total cost teknoekonomi used in the manufacture, preparation and testing of the enumerators RIA IP.8 and assumptions required. Studies teknoekonomi assuming capital employed 70% from bank loans, obtained the following results: Net Present Value (NPV) 1873632901, Internal Rate of Return (IRR) of 45.5%, Payback Period (PP) 3 years, Benefit / Cost Ratio (B / C) 3.8 so this investment opportunity worth considering to do.  
PENGARUH BUDAYA ORGANISASI ISLAMI DAN KEPEMIMPINAN SPIRITUAL TERHADAP KEPUASAN KERJA KARYAWAN MQ CORPORATION BANDUNG Ariyanto, Agus
Jurnal Ilmiah Manajemen Muhammadiyah Vol 2, No 1 (2012)
Publisher : Universitas Muhammadiyah Aceh

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The purpose of this research is to know the description of organizational culture, spiritual leadership and job satisfaction as well as the influence of organizational culture and spiritual leadership both partialy and simultaneously to job satisfaction.This research conducted at MQ Corporation. The desain of this research is descriptive and verificative with an explanatory survey method. Where the respondents of this research are company?s employee. The collection of data is carried out by interview and disseminates the questionnaires to 85 respondents. The analysis of data and hypothesis-test uses path analysis.The result of research and hypothesis-test indicate that: (1) there is close correlation between organizational culture and spiritual leadership by positive connection direction; (2) organizational culture and spiritual leadership to job satisfaction partialy have a significant effect, with a larger influence on spiritual leadership; (3) organizational culture and spiritual leadership simultaneously have a significant on the increased job satisfaction. Key words: organizational culture, spiritual leadership and job satisfaction
PERANCANGAN LOGO DAN MEDIA PROMOSI ALASKA MOBIL SEBAGAI UPAYA MENINGKATKAN BRAND AWARENESS Ariyanto, Agus
Jurnal Art Nouveau Vol 3, No 1 (2014): Pemberdayaan Nilai Lokal dalam Industri Kreatif
Publisher : Jurnal Art Nouveau

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Abstract

Abstract: CV.ALASKA JAYA known as Car Alaska, is a company engaged in trading second car in the city of Surabaya. Not all companies second car providers with innovative and creative concepts, especially in the promotion to the wider community. So, not many people recognize excellence services Car Alaska. The purpose of this design is to know how to design a logo and media campaign as an effort to increase brand awareness. The design uses qualitative methods with the method, observation, in-depth interviews, and existing studies to find a formulation of the concept design. From the analysis of the data found superiority and uniqueness of Alaska Cars that are not conveyed to the public. Promotional activities that have not been done and corporate identity is not known to be a reason why excellence Car Alaska unknown audience. After processing the data analysis found the design concept key words "Smart Choice", which means someone who has the decision, intelligence, selective, and easy to adjust. Which "Smart Choice" explains what to expect and it takes a smart and selective customers, paced lifestyle effective, efficient, and reliable. Audiences are given a fantastic visual display, imaginative thinking, and wonderful things using active and aggressive communication. So the result is expected to increase customer awareness of the brand and company Car Alaska.  Keywords: Design, Logo, Promotion, Brand Awareness, Second Car, Smart Choice
PRODUKSI KIT IMMUNORADIOMETRICASSA Y (IRMA) CA-125 UNTUK DETEKSI DINI KANKER OV ARIUM Widayati, Puji; Ariyanto, Agus; Lestari, Wening
Jurnal Radioisotop dan Radiofarmaka Vol 14, No 1 (2011): Jurnal PRR 2011
Publisher : Jurnal Radioisotop dan Radiofarmaka

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Abstract

ABSTRAKPRODUKSI KIT IMMUNORADIOMETRICASSAY (IRMA) CA-125 UNTUK DETEKSI DINIKANKER OV ARIUM.Kanker ovarium merupakan kanker terbanyak sesudah kanker leher rahim, namuntingkat kematiannya lebih besar dari pada kanker leher rahim. Penderita yang datang ke dokter (75%) pada umumnya telah mengidap kanker pada stadium lanjut (III-IV) sehingga pasien tidak dapat lagi tertolong. Kanker akan lebih mudah disembuhkan bila diketahui pada tahap awal pertumbuhan (terdeteksi dini). Carbohydrate Antigen-125 (CA-125) adalah glikoprotein antigenik yang dilepaskan ke darah penderita kanker ovarium, dengan kadar sangat rendah pada awalnya dan meningkat sesuai dengan keganasan kanker, sehingga deteksi kanker ovarium dapat dilakukan dengan mengukur kadar rendah senyawa CA-125 di dalam darah. Metode yang sesuai adalah immunoradiometricassay (IRMA). Pusat Radioisotop dan Radiofarmaka(PRR) telah mengembangkan metode ini sejak 2003, diawali dengan pembuatan komponen kit IRMA CA125, meliputi perunut CA-125 bertanda 1251,larutan standar CA-125, dan tabung bersalut antibodi monoklonal (coated tube), kemudianoptimasi assay kit IRMA CA-125 yang menghasilkan nilai Bff = 19,05% dan NSB = 0,53%, dengan daerah kerja 0-200 mIU/mL. Selanjutnya validasi metode menggunakansampel kadar tinggi (QCH) dan kadar rendah (QCL), menunjukkan nilai %CV intra assay (n=15) sebesar 9.9 % (QCL) dan 2.97 % (QCH) serta %CV inter assay (n=7) berturut-turut 13.1% (QCL) dan 4.9% (QCH), yang memenuhi syarat, memenuhi syarat Protocol IAEA Kata kunci: Kanker ovarium, Immunoradiometricassay(IRMA), CA-125, optimasi, validasiABSTRACTPRODUCTION OF IMMUNORADIOMETRICASSAY (IRMA) CA-125 FOR EARLYDETECTION OF OVARIAN CANCER. Ovarian cancer is the second highest incidence after cervix cancer, but has higher fatality level than cervix cancer. Generally, patient is known suffering ovarian cancer in very late stadium, III or IV, which almost incurable. Cancer would be easier cured if detected early. Carbohydrate Antigen-125 (CA-125) is an antigenic glycoprotein presence in blood of ovarian cancer patient, in a very low concentration initially and will increase proportionally with the level of malignancy,therefore, early detection of ovarian cancer can be carried out by measurement of low level CA-125 in the blood. The most suitable method is immunoradiometricassay (IRMA). Our laboratory has developed CA-125 IRMA kit since 2003, started from preparation of CA-125 IRMA kit components, consists of 125I_CA_125 tracer, CA-125 standard, and monoclonal antibody-coated tubes, followed by assay optimization of IRMA CA-125 kit, which produced BIT value of 19,05%, NSB value of 0,53% and working area of 0 to 200 mIU/mL. Furthermore, method validation of IRMA CA-125 kit using high and low concentration quality control (QCH and QCd, showed an intra assay (n= 15) CV value of 9.9% for QCL and 2.97% for QCH, while inter assay (n=7) CV value of 13.1% and 4.9% for QCL and QCH respectively. The results comply with theIAEA protocol requirement.Keyword :
PRODUCTION OF IMMUNORADIOMETRICASSA Y (IRMA) CA 15.3 KIT COMPONENT FOR DETECTION OF BREAST CANCER Widayati, Puji; Ariyanto, Agus; Sutari, Sutari; Mondrida, Gina; Darwati, Siti
Jurnal Radioisotop dan Radiofarmaka Vol 11 (2008): Jurnal PRR 2008
Publisher : Jurnal Radioisotop dan Radiofarmaka

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PRODUCTION OF IMMUNORADIOMETRICASSA Y (IRMA) CA 15.3 KITCOMPONENT FOR DETECTION OF BREAST CANCER. YKI has ranked that breast cancer as a second deseas in causing death of Indonesian women (, 2007). This phenomenon has been caused by the low level of public awareness in early detection of cancers. As a consequences this kind of cancer has generally been diagnosed in advanced stadium which is difficult to be treated  In spite of this, the disease actually can be detected early by measuring level of CA 15.3, a tumor marker for breast cancer. One of such in vitro method is immunoradiometricassay (IRMA) for CA 15.3. The CA 15.3 itself is a glycoprotein of heterogen compound capable of reacting with monoclonal antibody CA 15.3. Production of the IRMA CA 15.3 kit has been performed in the Center for Radioisotope and Radiopharmac.eutical, National Nuclear Energy Agency of Indonesia. Optimization of the kit component has been carried out using several parameter including type ofmonoclonal antibody for tracer and buffer coating type. The results showed that monoclonal anti CA M37901M type is better than M37552M type for tracer production. The M3790lM gave yield about 79.51%, with specific activity 29.12 ~Ci/~g, radiochemical purity 94.21% and %B/T about11.94%. Several buffers have been evaluated and 0.05 M pH 9.6 carbonate bicarbonate buffer showed the highest specific binding when it was used as coating buffer. Preparation of IRMA CA 15.3 standard solution gave a linier relation between CA 15.3 concentration and the maximumbinding (%B/T) Y=0.227X+0.5177 and correlation coefficient R 0.9840Keywords: Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-15.3
OPTIMASI RANCANGAN ASSAY KIT IRMA CA-125 Widayati, Puji; Ariyanto, Agus; Abidin, Zaenal; Yunita, F.; Sutari, Sutari
Jurnal Radioisotop dan Radiofarmaka Vol 9 (2006): jurnal PRR 2006
Publisher : Jurnal Radioisotop dan Radiofarmaka

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OPTIMASI RANCANGAN ASSAY KIT IRMA CA-125. Carbohydrate Antigen-125 (CA-125) adalah antibodi yang bereaksi spesifik dengan monoklonal CA-125. Antigen CA-125 dapat digunakan sebagai tumor marker dan penentuan kadarnya dapat dilakukan dengan teknik Immunoradiometricassay (IRMA). Pusat Pengembangan Radiosotop dan Radiofarmaka (P2RR-BATAN) telah membuat kit IRMA CA-125 untuk memenuhi kebutuhan dalam negeri. Telah dillakukan optimasi rancangan assay kit IRMA CA-125 buatan PRR tersebut, meliputi penetapan jumlah cacahan perunut, volume perunut, volume standar, waktu inkubasi dan suhu inkubasi yang terbaik sehingga diperoleh nilai %B/T dan % NSB yang optimum dan dapat digunakan sebagai acuan setiap kali assay. Hasil penelitian menunjukkan bahwa jumlah cacahan perunut terbaik adalah ± 100000 cpm, volume perunut terbaik adalah 50µL, volume standar terbaik adalah 50µL, waktu inkubasi terbaik adalah 16 jam dan suhu inkubasi terbaik adalah 25°C (suhu kamar). Penelitian optimasi assay kit IRMA CA-125 menyimpulkan bahwa dengan menggunakan komposisi pereaksi dan kondisi reaksi optimum dihasilkan nilai %B/T = 19,05% dan NSB = 0,53%. Kata kunci: Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-125 ASSAY DESIGN OPTIMIZATION OF CA-125 IRMA KIT. Monoclonal Antibody CA-125 is an antibody against the Carbohydrate Antigen (CA-125). The CA-125 antigen can be used as a tumour marker, and its concentration can be determined by the Immunoradiometricassay (IRMA) method. The center for Radioisotopes and Radiopharmaceuticals (BATAN) has prepared the CA-125 IRMA kit for domestic use. This reportdiscuse the assay design optimization of the a bove mentioned CA-125 IRMA kit, covering determenation of total count oftracer, tracer volume, standart volume, optimum incubation time and temperature, that will be used in daily assay. Investigation showed that the optimum total countof tracer was approx ±100.000 cpm, optimation tracer volume was 50 µL, optimum standard volume was 50 µL, and the optimum incubation time and temperature were 16 hours and 25 °C respectively. It can be concluded that the optimum reagents compositation and reaction conditions can produce %B/T value of 19.05% and NSB value of 0.53%. Key words:Radioimmunoassay, Immunoradiometricassay, tumor marker, CA-125
Optimasi dan Validasi KIT Immunoradiometric Assay Carbohydrate Antigen -125 untuk Pemantauan Kanker Ovarium Widayati, Puji; Darwati, Siti; Ariyanto, Agus
Indonesian Journal of Cancer Vol 3, No 2 (2009): Apr - Jun 2009
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Carbohydrate Antigen-125 (CA-125) adalah glikoprotein antigenik yang dilepaskan ke darah penderita kanker ovarium, dengan kadar yang sangat rendah pada awalnya dan meningkat sesuai dengan keganasan kanker. Dengan demikian, pemantauan kanker ovarium dapat dilakukan dengan mengukur kadar rendahnya senyawa CA-125 di dalam darah. Metode yang sesuai adalah immunoradiometricassay (IRMA). PRR telah mengembangkan metode ini sejak beberapa tahun lalu, diawali dengan tahap pembuatan komponen kit IRMA CA-125, meliputi perunut CA-125 bertanda 125I dengan rendemen penandaan sebesar 96,5%. Hasil uji imunologi menunjukkan aktivitas imunologi sebesar 21,39% (%B/T) untuk standar 500 mIU/mL dan ikatan tidak spesifiknya 0,21 (%NSB) untuk standar 0 mIU/mL. Hasil uji kemurnian radiokimia 94,2%. Larutan standar CA-125 menunjukkan bahwa sensitivitas larutan standar yang digunakan adalah baik dengan daerah kerja assay yang luas, yaitu dari 0 mIU/mL sampai 200 mIU/mL. Persamaan garis regresi Y = 0,0705X + 0,7103 dan koefisien korelasi R = 0,9930. Tabung bersalut antibodi monoklonal (coated tube) dengan monoklonal jenis M86924M sebagai penyalut menunjukkan aktivitas imunologi untuk standar 0 mIU/mL sebesar 0,1% dan untuk larutan standar 500 mIU/mL sebesar 21,39%. Optimasi assay kit IRMA CA-125 meliputi radioaktivitas optimum perunut 100000 cpm, volume perunut optimum 50 ?L, volume standar optimum 50 ?L, waktu inkubasi optimum 16 jam, dan suhu inkubasi optimum sebesar 25oC sehingga menghasilkan nilai B/T = 19,05% dan NSB = 0,53%, dengan daerah kerja 0-200 mIU/mL. Validasi metode menggunakan sampel kadar tinggi (QCH) dan kadar rendah (QCL) menunjukkan nilai %CV intra assay (n=15) sebesar 9,9% (QCL) dan 2,97% (QCH) serta %CV inter assay (n=7) berturut-turut 13,1% (QCL) dan 4,9% (QCH) memenuhi syarat Protocol IAEA. Kit IRMA CA-125 ini juga menunjukkan karakter yang baik, yaitu dengan nilai %NSB dan nilai %B/T sebesar 0,1% dan 12,6%; daerah kerja kit yang luas, yaitu 0 mIU/mL sampai 200 mIU/mL); serta kestabilan kit selama 8 (delapan) minggu.Kata kunci: kanker ovarium, immunoradiometricassay(IRMA), CA-125, optimasi, validasi
Optimization of Thyroglobulin Coated Tube for Thyroglobulin IRMA Kit Sutari, Sutari; Triningsih, Triningsih; Setiyowati, Sri; Susilo, V.Y.; Ariyanto, Agus; Widayati, Puji; Lestari, Wening
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 3, No 2 (2018): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

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Immunoradiometric assay (IRMA) is a method of analysis based on immunological reactions of antigens-antibodies binding. This highly specific and sensitive method was used for in vitro diagnosis in small quantity of sample. Center for Radioisotope and Radiopharmaceutical Technology, BATAN has developed Thyroglobulin IRMA Kit using coated tube method that can determine thyroglobulin levels in microgram quantities. Coated tube was made with immobilisation of anti thyroglobulin into polistyrene tube. Development of IRMA kit performed through several steps including: optimization component of kit, optimization assay and kit validation. Optimization of coated tube involved selection and volume of solvent, using blocking and non-blocking agent, and volume of blocking agent. The optimum condition for coated tubes was found to be using 0.1M phosphate buffer pH 7.4 with coating volume of 500 μL, 3% BSA in 500 μL blocking agent 0.1M phosphate buffer pH 7.4, with maximum binding and non-specific binding (NSB) of 60.58 and 1.40%, respectively. The optimized coated tube was found to be stable up to 4 weeks.
Validation of the TSH IRMA Kit for Determination of the TSH Levels in Human Blood Serum Mondrida, Gina; Sutari, Sutari; Triningsih, Triningsih; Setyowati, Sri; Yulianti S, V.; Lestari, Wening; Ariyanto, Agus; Widayati, Puji
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 3, No 3 (2018): JKPK( Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (626.612 KB) | DOI: 10.20961/jkpk.v3i3.22334

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TSH IRMA kit is a kit used for the determination of TSH (Thyroid Stimulating Hormone) levels in human blood serum. Thyroid hormone is a hormone that our bodies need for growth of the brain, bone and other tissues and regulate the metabolism in the body. TSH normal range for adult is in the range of 0.4-4.5 mIU/L, whereas for baby is about 3.0-18.0 mIU/L. Thyroid would affect the quality of optimal growth of children if disturbed. Therefore, TSH assay in the blood needs to be determined to know whether the function of the thyroid gland works normally or not. Detection of TSH in blood can be performed by Immunoradiometricassay (IRMA) method. IRMA method is one of the immunoassay techniques based on immunological reactions (antigen-antibody binding) using radionuclide 125I as a tracer, that sample in small quantity can be detected.  IRMA method was developed locally by replacing TSH IRMA kit which is costly since imported from commercial companies. Center for Radioisotope and Radiopharmaceutical Technology (PTRR) BATAN has successfully developed the TSH IRMA kit that can be used to determine the levels of TSH in human blood. TSH IRMA kit must be validated to know the limit of detection, sensitivity, accuracy, precision and the assay parameters, such as Non-Specific Binding (NSB) and Maximum Binding (MB). Validation of TSH IRMA kit had been carried out resulting in the limit of detection of 0.115 ng/mL, accuracy with a recovery of 93.6-108.0 %, intra-assay precision (% CV) QC L = 1.9848, QC M = 3.6360 % and QC H = 2.2085 % while the inter-assay precision (% CV) QC L = 11.0055, QC M = 5.6768 %  and  QC H = 5.4181 %.  It was concluded that this TSH IRMA kit showed good performance based on the % NSB and % B/T of 0.68 and 34.64 %, respectively.