Linda Armelia
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Non-psychogenic polydipsia in 45-year-old man with primary hyperparathyroidism and recurrent bilateral nephrolithiasis Cahyanur, Rahmat; Sarwono, Johannes; Armelia, Linda; Marbun, Maruhum B.H.; Soewondo, Pradana
Medical Journal of Indonesia Vol 21, No 4 (2012): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.727 KB) | DOI: 10.13181/mji.v21i4.506

Abstract

Non-psychogenic polydipsia with hyponatremia is a rare clinical presentation. Primary hyperparathyroidism is a disorder of calcium, phosphate, and bone metabolism caused by increased level of parathyroid hormone (PTH). It is estimated the incidence of primary hyperparathyroidism are 21.6 per 100,000 person a year. This case report describe a 45-year-old man presented with non-psychogenic polydipsia. This patient drank a lot of water out of the fear of recurrent kidney stones. He had history of recurrent nephrolithiasis with hypercalcemia. We investigate further the cause of hypercalcemia and we diagnosed primary hyperparathryoidism as the cause. (Med J Indones. 2012;21:230-4)Keywords: Hyponatremia, non-psychogenic polydipsia, primary hyperparathyroidism
Hubungan Peningkatan Kadar Eritropoietin dan Jumlah Endothelial Progenitor Cell dengan Perbaikan Fungsi Endotel pada PasienGagal Ginjal 3 Bulan Setelah Transplantasi Ginjal Armelia, Linda; Susalit, Endang; HM, Maruhum Bonar; Irawan, Cosphiadi
Jurnal Penyakit Dalam Indonesia Vol 4, No 2 (2017)
Publisher : Jurnal Penyakit Dalam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan. Endothelial progenitor cell (EPC) dinilai dapat menurunkan kadar asymmetric dimethylarginine (ADMA) yang merupakan penanda membaiknya fungsi endotel. Namun, secara klinis peran EPC masih menjadi perdebatan. Penelitian ini dilakukan untuk mengetahui hubungan peningkatan kadar eritropoietin (Epo) dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel pada penderita gagal ginjal 3 bulan setelah transplantasi ginjal.Metode. Dilakukan studi potong lintang sebelum dengan 3 bulan setelah transplantasi ginjal pada penderita gagal ginjal yang menjalani transplantasi ginjal di RSCM. Jumlah subjek 21 orang yang dikumpulkan dalam kurun waktu Juli 2013– Februari 2014. Pengambilan sampel darah untuk memeriksa kadar Epo, jumlah EPC CD34+ dan CD133+ dan kadar asimetrik dimetilarginin (ADMA) dilakukan sebelum dan 3 bulan setelah transplantasi ginjal. Analisis statistik dengan uji korelasi Pearson atau Spearman.Hasil. Penelitian ini menunjukkan adanya peningkatan kadar Epo tetapi tidak bermakna secara statistik (p>0.05), sedangkan jumlah EPC CD34+ dan CD133+ meningkat (p<0.05), serta kadar ADMA menurun yang bermakna secara statistik (p<0.05). Tiga bulan setelah transplantasi ada korelasi bermakna antara peningkatan kadar Epo dengan jumlah EPC CD34+ (r = 0.466 ; p < 0.05). Tidak ada hubungan peningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel 3 bulan setelah transplantasi ginjal.Simpulan. Tiga bulan setelah transplantasi ginjal didapatkan adanya peningkatan kadar Epo, jumlah EPC CD34+ dan CD133+ serta penurunan kadar ADMA. Tetapi tidak ada korelasi peningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel dalam rentang 3 bulan setelah transplantasi ginjal. Kata Kunci: asimetrik dimetilarginin, endothelial progenitor cell, eritropoietin, transplantasi ginjal  The Association between Elevated Levels of Erythropoietin and Endothelial Progenitor Cell with Improvement of Endothelial Function in Renal Failure Patients 3 Months after Kidney TransplantationIntroduction. Endothelial progenitor cell (EPC) is considered possible to reduce asymmetric dimethylarginine (ADMA) levels, which is a marker of improved endothelial function. However, clinically, there is still a debate about the role of EPC. This study was conducted to determine the correlation of elevated levels of erythropoietin (Epo) and the number of EPC CD34 + and CD133 + with improvement of endothelial function in renal failure patients 3 months after kidney transplantation.Methods. A cross-sectional study was conducted in prior and 3 months after kidney transplantation of renal failure patients who underwent a kidney transplant in Cipto Mangunkusumo hospital. The study included 21 subjects who enrolled from July 2013 to February 2014. Blood samples prior and 3 months after kidney transplantation were collected to evaluate the level of Epo, numbers of EPC CD34+ and CD133+ and level of assymetric dimethylarginine (ADMA). Statistical analysis was performed using Pearson or Spearman correlation test. Results. Results of this study showed that prior to kidney transplantation, level of Epo was increased but not statistically significant (p>0.05). The EPC numbers of CD34+ and CD133+ were significantly increased (p<0.05), whereas the ADMA level was significantly decreased (p<0.05). Three months after transplantation showed a significant association between elevated level of Epo and the numbers of EPC CD34+ (r=0.466, p>0.05). There was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function three months after kidney transplantation. Conclusions. In three months after kidney transplantation, there is an elevated level of Epo, the numbers of EPC CD34+ and CD133+ and decrease level of ADMA. However, there was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function in patients 3 months after kidney transplantation. 
Hubungan Peningkatan Kadar Eritropoietin dan Jumlah Endothelial Progenitor Cell dengan Perbaikan Fungsi Endotel pada PasienGagal Ginjal 3 Bulan Setelah Transplantasi Ginjal Armelia, Linda; Susalit, Endang; Marbun, Maruhum Bonar H; Irawan, Cosphiadi
Jurnal Penyakit Dalam Indonesia Vol 4, No 2 (2017)
Publisher : Internal Medicine Department, Faculty of Medicine Universitas Indonesia-RSCM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1452.587 KB) | DOI: 10.7454/jpdi.v4i2.126

Abstract

Pendahuluan. Endothelial progenitor cell (EPC) dinilai dapat menurunkan kadar asymmetric dimethylarginine (ADMA) yang merupakan penanda membaiknya fungsi endotel. Namun, secara klinis peran EPC masih menjadi perdebatan. Penelitian ini dilakukan untuk mengetahui hubungan peningkatan kadar eritropoietin (Epo) dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel pada penderita gagal ginjal 3 bulan setelah transplantasi ginjal.Metode. Dilakukan studi potong lintang sebelum dengan 3 bulan setelah transplantasi ginjal pada penderita gagal ginjal yang menjalani transplantasi ginjal di RSCM. Jumlah subjek 21 orang yang dikumpulkan dalam kurun waktu Juli 2013– Februari 2014. Pengambilan sampel darah untuk memeriksa kadar Epo, jumlah EPC CD34+ dan CD133+ dan kadar asimetrik dimetilarginin (ADMA) dilakukan sebelum dan 3 bulan setelah transplantasi ginjal. Analisis statistik dengan uji korelasi Pearson atau Spearman.Hasil. Penelitian ini menunjukkan adanya peningkatan kadar Epo tetapi tidak bermakna secara statistik (p>0.05), sedangkan jumlah EPC CD34+ dan CD133+ meningkat (p<0.05), serta kadar ADMA menurun yang bermakna secara statistik (p<0.05). Tiga bulan setelah transplantasi ada korelasi bermakna antara peningkatan kadar Epo dengan jumlah EPC CD34+ (r = 0.466 ; p < 0.05). Tidak ada hubungan peningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel 3 bulan setelah transplantasi ginjal.Simpulan. Tiga bulan setelah transplantasi ginjal didapatkan adanya peningkatan kadar Epo, jumlah EPC CD34+ dan CD133+ serta penurunan kadar ADMA. Tetapi tidak ada korelasi peningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+ dengan perbaikan fungsi endotel dalam rentang 3 bulan setelah transplantasi ginjal. Kata Kunci: asimetrik dimetilarginin, endothelial progenitor cell, eritropoietin, transplantasi ginjal  The Association between Elevated Levels of Erythropoietin and Endothelial Progenitor Cell with Improvement of Endothelial Function in Renal Failure Patients 3 Months after Kidney TransplantationIntroduction. Endothelial progenitor cell (EPC) is considered possible to reduce asymmetric dimethylarginine (ADMA) levels, which is a marker of improved endothelial function. However, clinically, there is still a debate about the role of EPC. This study was conducted to determine the correlation of elevated levels of erythropoietin (Epo) and the number of EPC CD34 + and CD133 + with improvement of endothelial function in renal failure patients 3 months after kidney transplantation.Methods. A cross-sectional study was conducted in prior and 3 months after kidney transplantation of renal failure patients who underwent a kidney transplant in Cipto Mangunkusumo hospital. The study included 21 subjects who enrolled from July 2013 to February 2014. Blood samples prior and 3 months after kidney transplantation were collected to evaluate the level of Epo, numbers of EPC CD34+ and CD133+ and level of assymetric dimethylarginine (ADMA). Statistical analysis was performed using Pearson or Spearman correlation test. Results. Results of this study showed that prior to kidney transplantation, level of Epo was increased but not statistically significant (p>0.05). The EPC numbers of CD34+ and CD133+ were significantly increased (p<0.05), whereas the ADMA level was significantly decreased (p<0.05). Three months after transplantation showed a significant association between elevated level of Epo and the numbers of EPC CD34+ (r=0.466, p>0.05). There was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function three months after kidney transplantation. Conclusions. In three months after kidney transplantation, there is an elevated level of Epo, the numbers of EPC CD34+ and CD133+ and decrease level of ADMA. However, there was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function in patients 3 months after kidney transplantation. 
Efektifitas pemakaian ulang ginjal buatan Armelia, Linda
Jurnal Kedokteran YARSI Vol 16, No 2 (2008): MEI - AGUSTUS 2008
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.604 KB) | DOI: 10.33476/jky.v16i2.238

Abstract

Hemodialysis is a therapy for patient with end state renal diseases, but it is very expensive specially dialyzer. Now we could use a reuse of dialyzer to reduce the cost. The aim of this study was to examine the effectiveness of dialyzer reuse and its frequent possible reuse. A prospective study with the comparative experimental approach was carried out. The population was all patient with end state renal diseases underwent twice hemodialysis in a week at fifth hours in each period at least within three months using acetate dialysate and reuse dialyzer in the Dialysis Unit. Sample size was 20 subjects determined based on time continuum It was concluded that the reuse dialyzer could be used 6,06+2,01 times without negative influence on dialysis adecuacy.
Gambaran Rerata Kadar Kalsium Dan Fosfor Pada Pasien Yang Menjalani Hemodialisis Di Rumah Sakit Anna Medika Bekasi Annisya, Nur; Armelia, Linda
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.191 KB) | DOI: 10.33533/jpm.v12i1.276

Abstract

Background: Chronic Kidney Disease (CKD) is a pathophysiological process with a diverse etiology, resulting in slow progressive kidney function. Hemodialysis is used as a therapy to replace deteriorating renal function. PGK has high mortality and morbidity, because it can cause various complications, one of the complications of PGK is the regulation of mineral settings, especially calcium and phosphate. Methods: The type of research in this study is descriptive quantitative with cross sectional study design. The population in this study were PGK patients undergoing hemodialysis at Anna Medika Bekasi Hospital. Sample selection using simple random sampling technique with condition to fulfill inclusion criteria. Secondary data retrieval (medical record). Results: From 55 samples were 32 patients (58.2%) with hypocalcemia category, 14 patients (25.4%) with normal calcium level, 9 patients (16.4%) with hypercalcemia category, 10 patients (18.2%) with hypophosphatemia category, 4 patients (7.3% ) with normal phosphorus levels and 41 patients (74.5%) by category. Of 32 patients (58.2%) hypocalcemia and 41 (74.5%) hyperphosphatemia which decreased calcium along with a rise in phosphorus by 22 patients (40%). Conclusion: In this study it was found that patients were more likely to have hypocalcemia and hyperphosphatemia. Less than half the patients had decreased levels of calcium along with elevated levels of phosphorus.
GAMBARAN RERATA KADAR KALSIUM DAN FOSFOR PADA PASIEN YANG MENJALANI HEMODIALISIS DI RUMAH SAKIT ANNA MEDIKA BEKASI Annisya, Nur; Armelia, Linda
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v12i1.276

Abstract

Background: Chronic Kidney Disease (CKD) is a pathophysiological process with a diverse etiology, resulting in slow progressive kidney function. Hemodialysis is used as a therapy to replace deteriorating renal function. PGK has high mortality and morbidity, because it can cause various complications, one of the complications of PGK is the regulation of mineral settings, especially calcium and phosphate. Methods: The type of research in this study is descriptive quantitative with cross sectional study design. The population in this study were PGK patients undergoing hemodialysis at Anna Medika Bekasi Hospital. Sample selection using simple random sampling technique with condition to fulfill inclusion criteria. Secondary data retrieval (medical record). Results: From 55 samples were 32 patients (58.2%) with hypocalcemia category, 14 patients (25.4%) with normal calcium level, 9 patients (16.4%) with hypercalcemia category, 10 patients (18.2%) with hypophosphatemia category, 4 patients (7.3% ) with normal phosphorus levels and 41 patients (74.5%) by category. Of 32 patients (58.2%) hypocalcemia and 41 (74.5%) hyperphosphatemia which decreased calcium along with a rise in phosphorus by 22 patients (40%). Conclusion: In this study it was found that patients were more likely to have hypocalcemia and hyperphosphatemia. Less than half the patients had decreased levels of calcium along with elevated levels of phosphorus.