Nuzul Asmilia
Laboratorium Klinik Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh

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1. The Effect Of Moringa (Moringa olifera) Leaves Infusion On Hemoglobin Level Of Broiler Chicken (gallus-gallus domesticus) NA, Zuhrawati; Amiruddin, Amiruddin; Mardian, Yopi; Zuraidawati, Zuraidawati; Asmilia, Nuzul; Rusli, Rusli; Lubis, Triva Murtina
Jurnal Medika Veterinaria Vol 13, No 1 (2019): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.42 KB) | DOI: 10.21157/j.med.vet..v13i1.4085

Abstract

The research aimed to determine the effect of Moringa leaves infuse toward the haemoglobin levels of broiler chickens. This study used 21 broiler chickens which divided into three groups and each group consisting of 7 broiler chickens. The treatment group (P0) were given only mineral water (aquadest), the treatment group (P1) were given moringa leaves infuse with a concentration of 10 % and treatment group (P2) infusion were given moringa leaves with a concentration of 20 %. The given of Moringa leaves infuse was starting at seven days old of chickens and given for 28 days continously as a drinking water.  The chickens were feed by ad libitum during the research. After the treatment completion, a researcher carried out a blood sampling via the axillary vein.  Data were analyzed with ANOVA by Complete Random Design one way and Tukey test to determine a difference between the treatments of each group. The research results showed that ± SD haemoglobin (g / dl) in the group (P0) 7.71 ± 1.13, (P1) of 8.15 ± 1.95 and (P2) 10.8 ± 1.76. Statistical analysis showed the treatment effect (P > 0.05) of the haemoglobin levels of broiler chickens. The Tukey test results of the treatment group (P0) were significantly different (P < 0.05) with treatment group (P2), but not significantly different (P > 0.05) with treatment group (P1). The treatment group (P2) were significantly different (P < 0.05) with treatment group (P1). From the results of this research, it was concluded that infuse Moringa leaves can improve haemoglobin levels of broiler chicken.
PROFIL DARAH TIKUS PUTIH (RATTUS NORVEGICUS) YANG DIINFEKSIKAN TRYPANOSOMA EVANSI DAN DIBERIKAN EKSTRAK KULIT BATANG JALOH (SALIX TETRASPERMA ROXB) Fahrimal, Yudha; E, Eliawardani; Rafina, Afira; Azhar, Al; Asmilia, Nuzul
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2653

Abstract

Penelitian ini bertujuan mengetahui gambaran darah (hematokrit, eritrosit, leukosit, dan diferensial leukosit) tikus yang diinfeksi Trypanosoma evansi (T. evansi) dan diberi ekstrak kulit batang jaloh (Salix tetrasperma Roxb). Duapuluh lima ekor tikus jantan dibagi secara acak ke dalam 5 kelompok perlakuan yang masing-masing terdiri atas 5 ekor tikus. Kelompok 0 (K0) tanpa perlakuan, kelompok I (K1) hanya diinfeksikan dengan 103 T. evansi, kelompok II (K2) diinfeksikan dengan 103T. evansi dan diberikan ekstrak kulit batang jaloh 30 mg/kg bobot badan, kelompok III (K3) diinfeksikan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 45 mg/kg bobot badan, dan kelompok IV (K4) diinfeksi dengan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 60 mg/kg bobot badan. Infeksi T. evansi dilakukan secara intraperitoneal sedangkan ekstrak diberikan secara oral selama 3 hari berturut-turut. Hasil penelitian menunjukkan bahwa rata-rata ± SD nilai hematokrit dan eritrosit tikus dari K1, K2, K3 dan K4 lebih rendah dari K0. Sebaliknya, rata-rata ± SD jumlah leukosit (103/µl) lebih tinggi dari K0. Diferensial leukosit menunjukkan jumlah masing-masing sel leukosit semua tikus dalam kelompok perlakuan meningkat setelah pemberian ekstrak kulit batang jaloh kecuali eosinofil dan limfosit yang justru menurun. Dari penelitian dapat disimpulkan bahwa Infeksi T. evansi menurunkan kadar hematokrit dan eritrosit namun meningkatkan kadar leukosit tikus dan pemberian ekstrak kulit batang jaloh dosis rendah dalam waktu yang singkat mampu mengembalikan profil darah tikus mendekati nilai normal.
IN VITRO ANTIMALARIAL ACTIVITY OF JALOH LEAVES EXTRACT ON PLASMODIUM FALCIPARUM Asmilia, Nuzul; Sutriana, Amalia; Rahmi, Erdiansyah; Sugito, .
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Malaria still cause health problem in tropics including Indonesia, since its generate high mortality rate. Medication of Malaria has been performed long time ago without optimum result. One reason is the high rate of P.falciparum resistance on conventional antimalaria drug. This research aim to evaluate the activity of jaloh leaves extract (Willow leaves) on the inhibition of P.falciparum in vitro.This was a laboratory experimental research that using Indonesian isolates of cloroquin resistance P.falciparum obtained from NAMRU-2, Jakarta. P.falciparum isolate that has been synchronized were divided in to 3 groups of treatment : Jaloh leaves ethanolic extract, jaloh leaves ethyl acetate extract, and jaloh leaves n-hexane extract. Each group were then alloted into 5 dosage levels: 6,25ug/ml; 12,50ug/ml; 25,00ug/ml; 50,00ug/ml; and 100ug/ml. The observation of parasitemia degree were done 48 hours post-incubation in which the thick blood smear were colored with Giemsa and then examined using bioculer microscope. Data were analyzed using one way ANOVA and Newman-Keuls test. The result showed that the percentage of P.falciparum growth inhibition were sinificantly different (P 0.05) among treatments wherein ethanol extract and ethyl acetate extract more inhibit P.falciparum growth than the hexane extract. The administration of different dosage also resulted in significance different (P 0.05) of P.falciparum growth inhibition. This research concludes that jaloh leaves extract could inhibit P.falciparum growth.
PROFIL DARAH TIKUS PUTIH (RATTUS NORVEGICUS) YANG DIINFEKSIKAN TRYPANOSOMA EVANSI DAN DIBERIKAN EKSTRAK KULIT BATANG JALOH (SALIX TETRASPERMA ROXB) Fahrimal, Yudha; E, Eliawardani; Rafina, Afira; Azhar, Al; Asmilia, Nuzul
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2654

Abstract

Penelitian ini bertujuan mengetahui gambaran darah (hematokrit, eritrosit, leukosit, dan diferensial leukosit) tikus yang diinfeksi Trypanosoma evansi (T. evansi) dan diberi ekstrak kulit batang jaloh (Salix tetrasperma Roxb). Duapuluh lima ekor tikus jantan dibagi secara acak ke dalam 5 kelompok perlakuan yang masing-masing terdiri atas 5 ekor tikus. Kelompok 0 (K0) tanpa perlakuan, kelompok I (K1) hanya diinfeksikan dengan 103 T. evansi, kelompok II (K2) diinfeksikan dengan 103T. evansi dan diberikan ekstrak kulit batang jaloh 30 mg/kg bobot badan, kelompok III (K3) diinfeksikan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 45 mg/kg bobot badan, dan kelompok IV (K4) diinfeksi dengan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 60 mg/kg bobot badan. Infeksi T. evansi dilakukan secara intraperitoneal sedangkan ekstrak diberikan secara oral selama 3 hari berturut-turut. Hasil penelitian menunjukkan bahwa rata-rata ± SD nilai hematokrit dan eritrosit tikus dari K1, K2, K3 dan K4 lebih rendah dari K0. Sebaliknya, rata-rata ± SD jumlah leukosit (103/µl) lebih tinggi dari K0. Diferensial leukosit menunjukkan jumlah masing-masing sel leukosit semua tikus dalam kelompok perlakuan meningkat setelah pemberian ekstrak kulit batang jaloh kecuali eosinofil dan limfosit yang justru menurun. Dari penelitian dapat disimpulkan bahwa Infeksi T. evansi menurunkan kadar hematokrit dan eritrosit namun meningkatkan kadar leukosit tikus dan pemberian ekstrak kulit batang jaloh dosis rendah dalam waktu yang singkat mampu mengembalikan profil darah tikus mendekati nilai normal.
PENGARUH EKSTRAK ETANOL DAUN JALOH (SALIX TETRASPERMA ROXB) TERHADAP PERSENTASE PARASITEMIA PADA MENCIT (MUS MUSCULUS) YANG DIINFEKSI PLASMODIUM BERGHEI Asmilia, Nuzul; Sugito, Sugito; Rahmi, Erdiansyah; Febrianto, Niko
Jurnal Kedokteran Hewan Vol 4, No 1 (2010): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v4i1.9796

Abstract

This study aimed to verify the effect of ethanol extract of jaloh leaves at various doses on parasitemia percentage of in mice (Mus musculus), wich inoculated Plasmodium berghei. This study used 12 male mice (Mus musculus) strains Balb / C with average body weight of 30.2 grams of 2-month-old. This research using Completely Randomized Design (CRD) with four treatments and three replications. All the mice were infected with Plasmodium berghei prior to treatment on three days post infected the mice in group 2,3 and 4 were given with extract ethanol jaloh leaves at dose 50, 100, 150 mg/kgbw inspectively. The mice in group 1 (K0) were not given anything and consident as control.Observations parasitemia percentage using microscopy on preparations stained thin blood smear Giemsa. The parasitemia percentage data were analyzed using one way ANOVA. On the average (±SD) percentage of parasitemia during the three days in four treatments (K0, K1, K2, and K3) on the first day were 24.87±1.86; 24.33±1.53; 24.20±1.06; and 24.93±1.01. On the second day were 22.67±2.52; 23.00±1.00; 22.80±1.20; and 24.13±2.01; and on the third day were 24.77±1.66; 22.97±3.76; 21.13±1.90; and 24.27±1.42. Statistical analysis showed that ethanol extract of the jaloh leaves for KO, KI, KII, and KIV respectively treatment did not affect the percentage of parasitemia in mice (Mus musculus) inoculated Plasmodium berghei.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (PHYLLANTUS EMBLICA) TERHADAP MENCIT (MUS MUSCULUS). (ACUTE TOXICITY TEST OF ETHANOLIC EXTRACT OF MALAKA (PHYLLANTUS EMBLICA) LEAVES ON MICE (MUS MUSCULUS)) TR, T. Armansyah; Indriany, Sudi; Sutriana, Amalia; Rosmaidar, Rosmaidar; Asmilia, Nuzul; Panjaitan, Budianto; Aliza, Dwinna; Hamdan, Hamdan
Jurnal Kedokteran Hewan Vol 10, No 2 (2016): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i2.5137

Abstract

ABSTRACT The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each. All mice in group K1, K2, K3, and K4 were administered ethanolic extract of malaka leaves with the dose of 2, 4, 8, and 16 g/kg bw, respectively. Single dose of ethanolic extract of malaka leaves were given by oral gavage prior to clinical observation . The observation period was 14 days post administration, for sign of toxicity symptom, weight loss, and mortality. The result showed that no mortality was observed in the experimental animals during this study. Slight reduction of body weight was observed in group K2, K3, and K4, and no toxicity sign was found during fourteen days of observation. The LD50 of ethanolic extract of malaka leaves was higher than 16 g/kg body weight, thus, the substance was practically non toxic substance.
THE EFFECT OF MALACCA LEAVES (PHYLLANTUS EMBLICA) ETHANOLIC EXTRACT ON PLASMODIUM FALCIPARUM GROWTH IN VITRO Asmilia, Nuzul; TR, T Armansyah; Aliza, Dwinna; Melia, Juli; Rahmi, Erdiansyah; Daulay, Lingga Surya Maret
Jurnal Kedokteran Hewan Vol 12, No 4 (2018): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v12i4.10215

Abstract

The aim of this research was to find out in vitro antiplasmodium activity of Malacca leaves (Phyllantus emblica) ethanolic extract against Plasmodium falciparum growth. In this study, Plasmodium culture contained 5% parasitemia in ring stage was cultured using candle jar method and antiplasmodial activity test was carried out using microculture. The treatments were divided into 7 groups with four repetitions. K1 as negative control group was given Roswell Park Memorial Institute (RPMI), while K2 as positive control group was given artesdiaquine. Groups K3, K4, K5, K6, and K7 group was added with 100 µg/mL, 75 µg/mL, 50 µg/mL, 25 µg/mL, and 5 µg/mL of Malacca leaves ethanolic extract, respectively. Antiplasmodial activity was determined by inhibition concentration of 50% parasite growth (IC50). The data were analyzed using ANOVA and followed by Duncan test. The average of parasitemia level in group K1, K2, K3, K4, K5, K6, and K7 were 55.25±15.62, 8.50±2.52, 8.50±3.00, 9.25±0.95, 9.00±2.70, 9.79±2.06, and 10.75±2.22, respectively. The average of inhibition percentage in group K1, K2; K3; K4; K5; K6; and K7 were 0.00±0.00%, 84.62±4.55%; 84.62±5.43%; 83.26±1.73%; 83.71±4,90%; 82.35±3,73%; and 80.54±6.83%, respectively (P 0.01). The results showed that the administration of malacca leaves ethanolic extract significantly affect (P 0.01) the inhibition of Plasmodium growth as compared to group K1 (negative control). Probit analysis reveals the IC50 value was 3.889 µg/mL. In conclusion, all doses of malacca leaves ethanolic extract used in this study was able to inhibit Plasmodium falciparum growth with IC50 value was 3.889 µg/mL.
ANTI-TRYPANOSOMA ACTIVITY OF ETHANOLIC EXTRACT OF NEEM LEAF (AZADIRACHTA INDICA) ON TRYPANOSOMA EVANSI IN RATS (RATTUS NORVEGICUS) Fahrimal, Yudha; Maghfirah, Siti; Rinidar, Rinidar; Azhar, Al; Asmilia, Nuzul; Erina, Erina
Jurnal Kedokteran Hewan Vol 11, No 1 (2017): J. Ked. Hewan
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v11i1.5450

Abstract

The aim of this study was to determine the effect of neem leaf extract (Azadirachta indica) on parasitemia of rats infected with Trypanosoma evansi (T. evansi) Aceh local isolate. A total of 24 male rats aged three months were used in this study and randomly divided into six treatment groups equally. The negative control group (K0) without T. evansi infection and neem leaf extract, the positive control group (K1) was infected with T. evansi but no neem leaf extract given, group K2, K3, K4, and K5 were infected with 5x104 T. evansi and were given neem leaf extract after patent infection with dose of 50, 100, 400, and 800 mg/kg BW respectively. The extract was given orally for three consecutive days. On the fourth day, rat blood was drawn for parasitemia examination. The results showed that no T. evansi detected in rats in negative control group (K0), while parasitemia in group K1; K2; K3; K4; and K5 was 12,295 x106/mL; 10,495 x106/mL; 9,360 x106/mL; 5,080x106/mL; and 2,398x106/mL of blood, respectively. Percentage of inhibition of parasitemia in K2, K3, K4, and K5 reached 14.64, 23.78, 58.68, and 80.50%, respectively. Based on the result of the study, neem leaf extract of 800 mg/kg BW gave the highest reduction of parasitemia in rats infected with T. evansi.
UJI PREKLINIS FRAKSI ETIL ASETAT DAUN JALOH (SALIX TETRASPERMA ROXB) SEBAGAI ANTIPLASMADIUM SECARA IN VITRO Asmilia, Nuzul; Sugito, Sugito; Sutriana, Amalia
Jurnal Sain Veteriner Vol 29, No 2 (2011): DESEMBER
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1094.727 KB) | DOI: 10.22146/jsv.39532

Abstract

The aim of the present study was to find out the in vitro activity of ethyl acetate fraction of willow leaves (Salix tetrasperma Roxb) on Plasmodium folcifarum (P. falciparum) growth.
PENGARUH PENINGKATAN SUHU TERHADAP JUMLAH ERITROSIT IKAN NILA (Oreochromis niloticus) Bangsa, Puja Cikal; -, Sugito; -, Zuhrawati; Daud, Razali; Asmilia, Nuzul; -, Azhar
Jurnal Medika Veterinaria Vol 9, No 1 (2015): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.789 KB) | DOI: 10.21157/j.med.vet..v9i1.2985

Abstract

Penelitian ini bertujuan mengetahui pengaruh peningkatan suhu terhadap jumlah eritrosit ikan nila. Sampel yang digunakan adalah darah ikan nila yang berasal dari 18 ekor ikan nila dengan bobot badan berkisar 40-50 g. Rancangan penelitian yang digunakan adalah rancangan acaklengkap (RAL) pola searah dengan tiga perlakuan dan enam kali ulangan. Perlakuan P1 sebagai kontrol merupakan perlakuan dengan suhu akuarium 29±1°C, P2 merupakan perlakuan dengan suhu akuarium 32±1°C, dan P3 merupakan perlakuan dengan suhu akuarium 35±1°C. Ukuran akuarium pada masing-masing kelompok perlakuan adalah 80 x 60 x 40 cm dengan ketinggian air 30 cm. Perlakuan dilakukan selama 15hari dan pada hari ke-16 dilakukan pengambilan sampel darah. Darah diambil melalui vena caudalis. Data dianalisis dengan analisis varian(ANAVA) dan dilanjutkan dengan uji Duncan. Rata-rata (±SD) jumlah eritrosit ikan nila (106/mm3) pada P1, P2, dan P3 masing-masing adalah 3,01x106/mm3; 2,63x106/mm3; dan 2,08x106/mm3. Hasil penelitian menunjukkan bahwa peningkatan suhu berpengaruh (P<0,05) terhadap jumlaheritrosit ikan nila. Dapat disimpulkan bahwa peningkatan suhu air 32±1°C dan 35±1°C dalam akuarium dapat menurunkan jumlah eritrosit ikan nila.
Co-Authors . Sugito Abdul Harris Abdyad, Baradillah Adinata, Angga Putra Afira Rafina, Afira Agustina, Ayu Andella Al Azhar Amalia Sutriana Amiruddin A Amiruddin Amiruddin Arman Sayuti Armanyah TR, T. Athaillah, Farida Awaluddin Awaluddin AZHAR - budianto panjaitan Cut Dahlia Iskandar Darniati Darniati Dasrul Dasrul Daulay, Lingga Surya Maret Dwina Aliza Dwinna Aliza Ela Sesdapepi Hadi, Ela Sesdapepi Eliawardani E, Eliawardani Erdiansyah Rahmi Erina Erina Erwin - Erwin Erwin Faisal Jamin Fajri, Fauzan Fakhrurrazi Fakhrurrazi Febrianto, Niko Firdaus, Intan Fitriani Fitriani Ghani, Robbi Gholib G, Gholib Ginta Riady Girsang, Florentina Magdalena gumilar, arif Hamdan Hamdan Hamdani Budiman Hamny H, Hamny Hamny Hamny Herrialfian, Herrialfian Heryanita, Yola Indriany, Sudi Intan Fitri Aprila, Intan Fitri Ismail Ismail Jalaluddin, M Jalaluddin, M Joharsyah J, Joharsyah Juli Melia kamaruddin, mahmudi Karmil, T Fadrial Lubis, Nauval Gibran M. Hasan M. Isa M. Nur Salim Maghfirah, Siti Mahdi Abrar Mardian, Yopi Maryulia Dewi Muhammad Hambal Muhammad Hanafiah Muhammad Hasan Muhammad Jalaluddin, Muhammad Mulyadi Adam, Mulyadi Muslim Akmal Mustafa Sabri Mustika, Delvy Yuana Muttaqien Muttaqien, Muttaqien NA, Zuhrawaty Nazaruddin Nazaruddin Ochtavia, Zea Pratama, Emilaza Puja Cikal Bangsa, Puja Cikal Putri Dewi Razali Daud Rinidar R, Rinidar Rinidar Rinidar, Rinidar Rizky, Asri Roslizawaty -, Roslizawaty Roslizawaty r Roslizawaty Roslizawaty, Roslizawaty Rosmaidar Rosmaidar, Rosmaidar Rusli Rusli Safika, Safika Saputra, Fadli Sari, Cut Nurlaila Siregar, Doly Ihsan Sri Wahyuni Sugito - Sugito s Sugito Sugito Suriadi S, Suriadi Suryandari, Latifa Syafruddin s Syinta Ramadhani, Syinta T. Armansyah T. Armansyah TR, T. Armansyah T. Reza Ferasyi, T. Reza Tongku Nizwan Siregar TR, T Armansyah Triva Murtina Lubis Ummu Balqis Yudha Fahrimal YUNALDI, HEFRI Zainuddin Z Zainuddin Zainuddin Zuhrawati -, Zuhrawati Zuhrawati NA Zuhrawati Zuhrawati, Zuhrawati Zuraida -, Zuraida Zuraidawati Zuraidawati, Zuraidawati