Christina Astutiningsih
Sekolah Tinggi Ilmu Farmasi ”Yayasan Pharmasi” Semarang

Published : 5 Documents
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Journal : Journal of Pharmaceutical Sciences and Community

DAYA HAMBAT MINYAK ATSIRI DAN EKSTRAK LIMBAH SISA DESTILASI RIMPANG KUNIR PUTIH (Kaempferia rotunda L.) TERHADAP PERTUMBUHAN Candida albicans ATCC 10231 Astutiningsih, Christina; Octaviani, Ratih; Suratiningsih, Sri
Journal of Pharmaceutical Sciences and Community Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.15 KB) | DOI: 10.24071/jpsc.11181

Abstract

Abstract: White turmeric rhizome contains alkaloid, saponin, flavonoid, polifenol, and essential oils. The purpose of this research is to determine the antifungal activity of essensial oil and residual destillation of white turmeric rhizome against Candida albicans. Essential oils of white turmeric rhizome isolated by steam distillation method, the extraction of waste with soxhletasimethod. Antifungal activities were investigated by the paper disc method method. The test results showed antifungal activity of essential oil of white turmeric rhizome in different concentrations (0.75, 1, 2, and 2.25%) were 0.0 ; 0.736 ; 0.894 ; 1.041 cm. The antifungal activities of the residual distillation of extract (2.25, 2.5, 3, and 4%) were 0.0, 0.674, 0.743 and 0.874 cm. Therewas a difference of the zone of inhibition of Candida albicans growth between essential oils and residual distillation of white turmeric rhizome.Keywords: White turmeric, Candida albicans, essential oils, extract of waste, inhibiton.
UJI DAYA ANTIBAKTERI DAN IDENTIFIKASI ISOLAT SENYAWA KATEKIN DARI DAUN TEH (Camellia sinensisL. var Assamica) Astutiningsih, Christina; Setyani, Wahyuning; Hindratna, Himawan
Journal of Pharmaceutical Sciences and Community Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.609 KB) | DOI: 10.24071/jpsc.112100

Abstract

Abstract: Antibacterial is a substance that can interfere with the growth and metabolism of bacteria, so that these substances can inhibit growth or even kill bacteria. This research aimed to utilize natural materials as a natural antibacterial. This study investigated the ability of isolates catechins of tea leaves to inhibit Staphylococcus aureus and spectral identification of these catechins. Catechin compounds was extracted by water, and then fractionated with CHCl3 and ethyl acetate. Ethyl acetate phase was concentrated fractionation results using a rotary evaporator for further separation using thin layer chromatography with various mobile. The results of the study showed that the concentration of isolates of demonstrated to be effective as antibacterial, with MIC 12.5%. UV spectrum measurement showed that the isolates had a maximum absorption at a wavelength of 279 nm while the FTIR spectrophotometer showed that isolates catechin-containing functional groups C = C aromatic absorption 1500-1600 nm^-1 and OH groups, a broad band between 2000 and 3600 nm^-1.Key words: isolates catechins, Staphylococcus aureus, tea leaves, antibacterial
ISOLASI DAN IDENTIFIKASI SENYAWA ALKALOID BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) SECARA SPEKTROFOTOMETRI UV-Vis DAN IR SERTA UJI TOKSISITAS AKUT TERHADAP LARVA Artemia salina Leach Astutiningsih, Christina; Nuzulia, Frida; Suprijono, Agus
Journal of Pharmaceutical Sciences and Community Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.836 KB) | DOI: 10.24071/jpsc.9272

Abstract

Abstract: Fruit Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) contains alkaloid, tannin, saponin, flavonoid, terpenoid dan lignin. The aim of this study was to elucidate compound from Mahkota Dewa based on the analyses on spectrophotometry UV-Vis, IR and to evaluate the compound in the Brine Shrimp Lethality Test. On IR spectra revealed the presence of alkaloid amin primer. The isolated alkaloid compound was found to be toxic to brine shrimp with LC50 33.8932 μg/ml.Keywords: alkaloid, Mahkota Dewa, toxicity, Artemia salina Leach