Basuki Budiman
Kelompok Program Penelitian Sistem Kewaspadaan Gizi, Puslitbang Gizi, Bogor

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PENGARUH PEMBERIAN GARAM BERIODIUM TERHADAP KADAR TIROKSIN PADA IBU USIA SUBUR DI DAERAH ENDEMIK DEFISIENSI IODIUM Budiman, Basuki; -, Komari; -, Saidin
GIZI INDONESIA Vol 28, No 1 (2005): Maret 2005
Publisher : PERSATUAN AHLI GIZI INDONESIA

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THE EFFECT OF IODIZED SALT INTERVENTION ON THYROXINE OF CHILDBEARING AGE MOTHERS IN ENDEMIC IODINE DEFICIENCY AREAThe national evaluation on implementation of Iodized salt indicate an excess dietary intakes of iodine. It is a consequence of the correction of iodine deficiency. However there is no confirmation of the adverse effect to the excess in Indonesia. Our aim is to elaborate whether the excess of iodine consumption affect serum thyroxine. We supplied 50-ppm iodized salt to 82 mothers at childbearing age’s family every two weeks for three months. We suggest the mothers used the supplied iodized salt for family consumption only and not used the salt for any other purposes such as cattle feeding. Mother’s blood drawn before and after intervention. Urine iodine exretion (UIE) were collected from school age children of participant family. The study revealed that three month-iodized salt intervention increased median UIE by 18.4 % and serum thyroxine level by 36.5 %. The number of children being at risk for hyperthyroidism were constributed from normal and deficit range level at initial study by 62,5 % and 41.7 % respectively. The number of mothers being thyroxine excess were 22.2 and 22.7 % respectively. We conclude that the level of iodine consentration in salt at 50 ppm is high and suggest that consentration should be lowered.Keywords: EIU, at risk for hyperthyroidism, thyroid hormone excess.mother at child bearing age.
PERANAN PROTEKTIF DAN NON-PROTECTIF NITRIC OXIDEs(NOs) PADA RESPON IMUN Budiman, Basuki
GIZI INDONESIA Vol 31, No 2 (2008): September 2008
Publisher : PERSATUAN AHLI GIZI INDONESIA

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THE ROLE OF PROTECTIVE AND NON-PROTECTIVE NITRIC OXIDES (NOs) IN IMMUNE RESPONSNitric oxides (NO), included in this term are radical NO., (ionic) NO-, NO, NO2, NO2-, NO3-, N2O3,N2O4, S-nitrosothiols, peroxynitrite (ONOO-), and nitrisyl-metal complex. NOs are radical substances which have characteristic both protective and non-protective immunity due to unable to distinguish pathogen DNA or host DNA. NO is by_product of arginine metabolism. NO plays roles in muscle relaxation to prevent platelets aggregation, as intra cell neurotransmitter, mediated macrophage of tumor cell and bacteria. The activity is under controlled by NO-synthetase (NOS) which has three isomers, namely NOS1 or neural NOS (nNOS), NOS2 or inducible NOS (iNOS) and NOS3 or endothelial NOS (eNOS). The role of iNOS/NO in immune system could be as a protective and non-protective which work simultaneously and depend on the immune system equilibrium. The function of iNOS/NO is as regulator and effector. As regulator the function includes change of lymphocyte from proliferation and modulated cytokine response. As effector the function includes necrosis and immnunoprotective activities. The main target of NO 2 toxicity is lungs but depends on the concentration of toxicity and duration of exposure to the targetKeywords: arginine, immonology, NOS, nitric oxide, protective
Hubungan antara konsumsi iodium dan gondok pada siswi berusia 15-17 tahun Budiman, Basuki; Sumarno, Iman
Universa Medicina Vol 26, No 2 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.80-89

Abstract

LATAR BELAKANGKonsekuensi gangguan akibat kekurangan iodium (GAKI) yang paling utama adalah kelainan neuropsikologi dalam masa pertumbuhan janin. Remaja merupakan kelompok usia yang segera akan menghasilkan keturunan. Penelitian ini bertujuan untuk menilai adanya hubungan antara konsumsi iodium dan prevalensi gondok pada remaja. METODEPenelitian ini dirancang menggunakan desain potong-lintang. Sebanyak 300 siswa putri SMU usia 15-18 tahun di Kabupaten Minahasa (Mn, Sulawesi), Bukittinggi (Bt, Sumatera) dan Gunungkidul (Gk, Jawa), berpartisipasi dalam penelitian ini. Pembesaran tiroid (gondok) dipalpasi dengan mengikuti kriteria WHO/ICCIDD. Data yang dikumpulkan termasuk sampel urin sesaat (casual urine), perihal kesukaan remaja mengudap, contoh garam dapur rumahtangga, dan penggunaan garam beriodium. HASILPrevalensi gondok pada siswi sangat tinggi di tiga kabupaten, sebesar 51,0% (Mn), 41,6% (Bt) dan 31,1% (Gk) searah dengan gradasi proporsi defisit iodium menurut konsentrasi iodium dalam urin (KIU) (<100 mg/L bertutur-turut: 38,1%; 24,3% dan 11,6%) yang berada dalam kisaran normal. Kualitas garam beriodium di Mn paling bagus (>20 ppm iodium = 56%) begitu pula jenis garam yang dikonsumsi (92,0% garam halus) dibandingkan dengan dua kabupaten lainnya (Gk 90% garam bata; Bt 61,5 % garam curai/krosok). KESIMPULANKonsumsi iodium berhubungan dengan prevalensi gondok pada siswi berusia 15-17 tahun.
GANGGUAN PERTUMBUHAN DAN PERKEMBANGAN PADA ANAK USIA 0,5-1,9 TAHUN TERKAIT DENGAN ASUPAN MAKANAN DAN PENGASUHAN YANG KURANG Harahap, Heryudarini; Budiman, Basuki; Widodo, Yekti
GIZI INDONESIA Vol 41, No 1 (2018): Maret 2018
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Growth and development of children affected by various risk factors include malnutrition, poverty, and a less stimulated home environment. The objective of this analysis was to calculate the proportion of growth and development disorder and to determine the association of food intake and care for children with children’s growth and development. Samples were 247 children aged of 0.5-1.9 years who participated in the South East Asian Nutrition Survey (SEANUTS) in 2011. Growth was assesed by height for age in Z-score of WHO standard. Development was measured using Denver II test. Children were divided into four groups: 1).normal height with normal development (NH-ND); 2).stunting with normal development (S-ND), 3).normal height with suspected underdevelopment (NH-SD), and 4).stunting with suspected underdevelopment (S-SD). Protein intake was divided into adequate (≥80% RDA) and inadequate (<80% RDA). Care for children was measured by the length of carrying them, categorized into ≤2 hours or >2 hours. Socio-economic status was categorized into low and high based on quintile. Age was categorized into 0.5–0.9 years and 1.0–1.9 years. Data analysis employed multi-nomial logistic regression. Proportions of NH-SD, S-ND, NH-SD and S-SD were 53.6%, 17.9%, 19.4%, and 9.1%, respectively. S-ND was associated with protein intake (OR=2.2;95%CI:1.1-4.6), aged 1.0–1.9 years (OR=6.9: 95%CI:2.2-22.1). NH-SD was associated with aged 1–1.9 years (OR=0.3; 95%CI:0.1-0.6). S-SD was associated with inadequate protein intake (OR=3.1; 95%CI:1.2-8.2), low SES and duration of carrying them more than 2 hours (OR=6.9; 95%CI:2.5-19.0). Protein intake, SES and care for children were risk factors for growth and development of children.ABSTRAKPertumbuhan dan perkembangan anak dipengaruhi oleh berbagai faktor risiko diantaranya kekurangan gizi, kemiskinan, dan lingkungan rumah yang kurang stimulasi. Tujuan analisis adalah mengetahui proporsi gangguan pertumbuhan dan perkembangan dan mempelajari asosiasi asupan makanan dan pengasuhan dengan pertumbuhan dan perkembangan anak. Sampel adalah 247 anak, berusia 0,5–1,9 tahun dari penelitian South East Asian Nutrition Study tahun 2011. Pertumbuhan dinilai melalui Z-skor tinggi badan (TB) menurut umur standar WHO. Perkembangan diukur menggunakan test Denver II. Anak dikelompokkan menjadi: 1).TB dan perkembangan normal (NH-ND), 2).stunting tetapi perkembangan normal (S-ND), 3).TB normal tetapi perkembangan terganggu (NH-SD), dan 4). stunting dan perkembangan terganggu (S-SD). Asupan protein dikelompokkan atas cukup (≥80% RDA) dan kurang (<80% RDA). Pengasuhan diukur dari lama anak digendong, dikelompokkan menjadi ≤2 jam atau >2 jam. Status sosial ekonomi dikategorikan menjadi rendah dan tinggi. Analisis yang digunakan adalah multi-nomial logistic regression. Proporsi NH-ND, S-ND, NH-SD dan S-SD berturut-turut adalah 53,6%, 17,9%, 19,4%, dan 9,1%. S-ND berhubungan dengan kurang asupan protein (OR=2,2;95%CI:1,1-4,6), umur 1–1,9 tahun (OR=6,9: 95%CI:2,2-22,1). NH-SD berhubungan dengan umur 1,0–1,9 tahun (OR=0,3; 95%CI:0,1-0,6). S-SD berhubungan dengan kurang asupan protein (OR=3,1; 95%CI:1,2-8,2), SES rendah dan anak digendong > 2 jam (OR=6,9; 95%CI:2,5-19,0). Asupan protein, sosial ekonomi status dan pengasuhan anak merupakan faktor risiko untuk terjadinya pertumbuhan dan hambatan perkembangan pada anak.Kata kunci: konsumsi makanan, pengasuhan anak, perkembangan anak, status gizi 
PENGARUH PEMBERIAN GARAM BERIODIUM TERHADAP KADAR TIROKSIN PADA IBU USIA SUBUR DI DAERAH ENDEMIK DEFISIENSI IODIUM Budiman, Basuki; -, Komari; -, Saidin
GIZI INDONESIA Vol 28, No 1 (2005): Maret 2005
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Abstract

THE EFFECT OF IODIZED SALT INTERVENTION ON THYROXINE OF CHILDBEARING AGE MOTHERS IN ENDEMIC IODINE DEFICIENCY AREAThe national evaluation on implementation of Iodized salt indicate an excess dietary intakes of iodine. It is a consequence of the correction of iodine deficiency. However there is no confirmation of the adverse effect to the excess in Indonesia. Our aim is to elaborate whether the excess of iodine consumption affect serum thyroxine. We supplied 50-ppm iodized salt to 82 mothers at childbearing age’s family every two weeks for three months. We suggest the mothers used the supplied iodized salt for family consumption only and not used the salt for any other purposes such as cattle feeding. Mother’s blood drawn before and after intervention. Urine iodine exretion (UIE) were collected from school age children of participant family. The study revealed that three month-iodized salt intervention increased median UIE by 18.4 % and serum thyroxine level by 36.5 %. The number of children being at risk for hyperthyroidism were constributed from normal and deficit range level at initial study by 62,5 % and 41.7 % respectively. The number of mothers being thyroxine excess were 22.2 and 22.7 % respectively. We conclude that the level of iodine consentration in salt at 50 ppm is high and suggest that consentration should be lowered.Keywords: EIU, at risk for hyperthyroidism, thyroid hormone excess.mother at child bearing age.
ANEMIA PADA IBU USIA 17-35 TAHUN DI DAERAH ‘REPLETE’ ENDEMIK DEFISIENSI IODIUM Budiman, Basuki; Dewi, Rosmala; Muljati, Sri
GIZI INDONESIA Vol 30, No 1 (2007): Maret 2007
Publisher : PERSATUAN AHLI GIZI INDONESIA

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ANEMIA OF CHILD BEARING AGE MOTHERS 17-35 YEARS OF AGE IN ENDEMIC IODINE ‘REPLETE’ AREAIron Deficiency Anemia (IDA) as well as Iodine Deficiency Disorder (IDD) both have adverseeffects on cognitive and neuropsychomotor, and adverse pregnant outcomes. Both iron andiodine have role on nuero development. Iron interact with iodine through the activity of thyroidperoxidase (TPO), an iron-dependent enzyme. IDA in iodine replete area (IRA) have not beenreported. Assesments IDA (Hb), free thyroxine (fT4), Thyrotropin hormone (TSH) of reproductivemothers 17-35 years of age were conducted in IRA and non-endemic deficiency iodine area(NEDIA). Casual iodine urin concentration (UIC) of school age children was also assesed toconfirm iodine endemicity of study area. Analysis of risk for anemia according to iodine status andcorrelation hemoglobin and thyrotropin were performed. The study area was confirmed to be nonendemic iodine deficiency (UIC criteria). Median EIU were 242 (24-880) µg/L in IRA and 211 (44-387) µg/L in NEDIA respectively. Proportion of EIU less than 100 µg/L in IRA were 5.0 % and inNEDIA 1.2 %. Proporsion of EIU greater than 300 µg/L were 29.6 dan 24.7 persen respectively.The results indicated that study areas were no longer endemic iodine deficiency and the peoplewhere they live consumed iodine tend to excess. These situation may effect on thyroid function asindicated by suppressed TSH and fT4 in normal range. Those two thyroid function parameterssignificantly different in the IRA and NEDIA. The everages serum concentration of TSH in thestudy area were 1,96(1,56-2,36) in IRA compared to 1,38 (1,09-1,67) mUI/L in NEDIA(p=0,23);while fT4 were 1,29 (1,14-1,44) and 0,98 (0,90-1,05) µg/dL respectively. Hemoglobin serumconcentration of mothers in those two area was not signicantly different; 12,45 (12,19-12,71) inIRA compared to 12,21 (11,96-12,46) mg/dL di NEDIA. Iron deficiency anemia was found 23,3 %in IRA and 35,7 % in NEDIA; however mothers in IRA have risk for anemia as big as mothers inNEDIA OR: 0,54(0,24-1,24). Analysis correlation (Spearman’s) between TSH and Hb providedcoefisient correlation Rho as much as 0.072 indicated very weak correlation between the twoparameters. There were no difference in proportion of hypothyroidism in the two study areas (OR:0,68 (0,207-2,25). Although the proportion of iron deficiensi anemia (IDA) in IRA much less thanthe proportion in NEDIA; there were no relationship between IDA and Iodine deficiency.Absorption of Fe in IRA may be more efficient than did in NEDIA. More studies are needed toconfirm this finding.Keywords: IDA, TSH, fT4, Hb, EIU, NEDIA, IRA
PERKEMBANGAN MENTAL BAYI DAN ANAK INDONESIA: HASIL SEANUTS INDONESIA Budiman, Basuki; Syarief, Nurmeida S; Soekatri, Moesijanti
GIZI INDONESIA Vol 36, No 2 (2013): September 2013
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Status gizi ibu hamil mempunyai dampak perkembangan neuropsikologik pada bayi yang dilahirkan. Penyimpangan perkembangan (fisik dan mental) dapat diidentifikasi pada awal kehidupan. South East Asian Nutrition Survey (SEANUTS) adalah penelitian gizi klinik multi-center di empat negara pada bayi dan anak (0,5-12,9 tahun). Negara yang berpartisipasi adalah Indonesia, Malaysia, Thailand dan Vietnam. Data psikologi untuk mengetahui perkembangan mental anak,  termasuk aspek yang dikumpulkan. Pengukuran perkembangan anak menggunakan metode Denver Development Screening Test (DDST). Desain penelitian telah dijelaskan oleh Sandjaja, dkk. dalam artikel yang dimuat pada jurnal ini. Hasil penelitian menunjukkan bahwa anak Indonesia berusia balita yang dideteksi mengalami penyimpangan perkembangan (all four) sebesar 21,6 persen. Secara rinci penyimpangan perkembangan motorik kasar sebesar 11,5 persen; kemandirian (personal-social), adaptif-motor halus dan bahasa masing-masing 14,5; 11,8; dan 15,8 persen. Proporsi penyimpangan perkembangan pada bayi (0,5-0,9 tahun) terdeteksi paling besar (45,8%) dan secara keseluruhan penyimpangan yang terjadi pada keterampilan berbahasa (bicara) dan perkembangan kemandirian. Secara agregat (pool), hubungan antara penyimpangan neuropsikologik (all four) dan postur tubuh tidak ditemukan. Namun demikian, pada kelompok umur 1,0-2,9 tahun, hubungan tersebut ditemukan, sebaliknya hubungan ini tidak ditemukan pada kelompok umur lain. Pola asuh yang tidak optimal (bahasa, kemandirian) merupakan faktor risiko penyimpangan negatif perkembangan anak.ABSTRACTMENTAL DEVELOPMENT OF INDONESIAN INFANTS AND CHILDREN: RESULTS OF SEANUTS INDONESIAMaternal nutrition during gestation has consequences on mental development of the offspring. The physical and mental disorders can be identified in early life. South East Asian Nutrition Survey (SEANUTS) is a multicenter nutrition study on children aged 0.5 to 12.9 years in which measurement of mental development is also included. The aim of this paper was to describe mental development of Indonesian children 0.5-5.9 years old. Denver Development Screening Test (DDST) was used to identify the deviation of development. Child’s height was measured to reflect posture. Detailed study design was described by Sandjaja, et al earlier in this issue. The results revealed that total suspected of late all four development was 21.6 percent, including 11.5, 14.5, 11.8, and 15.8 percent for gross-motor development, personal social, adaptation-fine motor, and language skill, respectively. Infants were the most often detected as severe suspected of late developments (45.8%), especially for language and personal social skill. Unadjusted data revealed that there were no associations found between neuropsychological deviation (all four) and posture. When it was adjusted, a significant difference was found only in 1.0-2.9 years old group. We concluded that parenting stimulation as be shown in language skill and personal-social were important risk factors. Keyword: mental development, DDST, posture, multi-center study
TINGKAT KOGNISI ANAK INDONESIA BERUSIA 5,5-12,0 TAHUN: HASIL SEANUTS DI INDONESIA Syarief, Nurmeida S; Budiman, Basuki; Sandjaja, nFN
GIZI INDONESIA Vol 36, No 2 (2013): September 2013
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Perkembangan kognisi atau karakteristik mental dicirikan dengan perkembangan persepsi, memori, imajinasi, daya pikir, kecerdasan. Artikel ini menyajikan hasil SEANUTS tentang tingkat kognisi anak berusia 5,5-12,0 tahun secara deskriptif. Partisipan sebanyak 1368 menggambarkan populasi nasional yang diambil secara acak jamak bertingkat (two stage randomized cluster sampling). Raven’s Coloured Progressive Matrices (CPM) digunakan untuk mengukur tingkat kognisi anak. Kelompok anak terdiri 5,5-7,9 tahun dan 8,0-12,0 tahun. Tingkat kognisi disajikan menurut postur tubuh. Postur dinilai dari skor Z pada indeks TB/U. Tingkat kognisi di bawah rerata pada anak kelompok berusia 5,5-7,9 tahun antara 16,0- 50,0 persen; dan kelompok berusia 8,0-12,0 tahun antara 25,7-69,6 persen. Secara keseluruhan, asosiasi antara kognisi dan postur tubuh tidak nyata pada anak berusia 5,5-7,9 tahun. Pada kelompok usia yang lebih tua tampak perbedaan yang signifikan baik di perkotaan maupun di perdesaan (p<0,05). Namun demikian, hubungan itu diduga dipengaruhi oleh lingkungan tempat anak tumbuh termasuk stimulasi neuropsikologis dan status gizi baik mikro maupun makroABSTRACT COGNITIVE LEVEL OF CHILDREN 5.5-12.0 YEARS OLD: RESULT OF SEANUTS IN INDONESIA Cognitive or mental characteristic development includes development of perception, memory, imagination, intellectual skill and IQ. This article provides SEANUTS’ result especially on mental development of school children (5.5-12.0 years old). A nationally representative number of 1368 children involved in this study. Two-stage randomized cluster sampling was implied for deriving required participants. Raven’s Coloured Progressive Matrices (CPM) was administered to measure cognition. Posture was represented by HAZ score. Results showed that proportion of level cognition was below average in the 5.5-7.9 year age group and in the 8.0-12.0 year age group between 16.0- 50.0 percent and 25.7-69.6 percent respectively. The association between cognition and posture at younger group was unclear while at older group, it seemed significantly different (p<0.05) both in rural and urban. However, the significant association at lower cognition level were influenced by environment where chlidren grow including neuropsychological stimulation and nutritional status both micro- and macronutrient level. Keywords: cognition, posture, CPM, Indonesian children
PERANAN PROTEKTIF DAN NON-PROTECTIF NITRIC OXIDEs(NOs) PADA RESPON IMUN Budiman, Basuki
GIZI INDONESIA Vol 31, No 2 (2008): September 2008
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Abstract

THE ROLE OF PROTECTIVE AND NON-PROTECTIVE NITRIC OXIDES (NOs) IN IMMUNE RESPONSNitric oxides (NO), included in this term are radical NO., (ionic) NO-, NO, NO2, NO2-, NO3-, N2O3,N2O4, S-nitrosothiols, peroxynitrite (ONOO-), and nitrisyl-metal complex. NOs are radical substances which have characteristic both protective and non-protective immunity due to unable to distinguish pathogen DNA or host DNA. NO is by_product of arginine metabolism. NO plays roles in muscle relaxation to prevent platelets aggregation, as intra cell neurotransmitter, mediated macrophage of tumor cell and bacteria. The activity is under controlled by NO-synthetase (NOS) which has three isomers, namely NOS1 or neural NOS (nNOS), NOS2 or inducible NOS (iNOS) and NOS3 or endothelial NOS (eNOS). The role of iNOS/NO in immune system could be as a protective and non-protective which work simultaneously and depend on the immune system equilibrium. The function of iNOS/NO is as regulator and effector. As regulator the function includes change of lymphocyte from proliferation and modulated cytokine response. As effector the function includes necrosis and immnunoprotective activities. The main target of NO 2 toxicity is lungs but depends on the concentration of toxicity and duration of exposure to the targetKeywords: arginine, immonology, NOS, nitric oxide, protective
GANGGUAN PERTUMBUHAN DAN DEFISIT BERAT BADAN PADA BALITA DI PERKOTAAN DAN PEDESAAN Muljati, Sri; Hapsari, Dwi; Budiman, Basuki
GIZI INDONESIA Vol 28, No 2 (2005): September 2005
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GROWTH FAILURE AND BODY WEIGHT DEFICIT OF UNDERFIVE CHILDREN IN URBAN AND RURAL AREASThe prevalence of malnutrition in Indonesia in 2003 is 19 percents; three percents of them are severe malnutrition. Study on the age beginning deviation of growth failure and the extent of the deficit in body weight of underfive children in Indonesia is scarce. We analysed 1694 records of children underfive year old from National Household Survey (SKRT) having complete data in weight, height and age. The study revealed that 42.9% children underfives suffered from growth failure, in which the magnitude was greater in rural than urban e.i. 53.8% and 46.2% respectively growth failure started. In the age 4 months, infant begins deficit his her body weight and the peak of the deficit is infant in six months e.i 21.05%. This analysis supports international finding that deviation in growth failure begin at 4 month for Indonesian children should be consideredKeywords: under five year children, growth