Articles

UJI SINERGISME AKTIVITAS ANTIBAKTERI KOMBINASI MINYAK ATSIRI SYZYGIUM AROMATICUM L. DAN MYRISTICA FRAGRANS HOUTT. TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS ATCC 25923 SERTA PROFIL KIMIANYA Fauziah, Dewi Winni; Darmawan, Endang
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Infection can be caused by bacteria, one of them is Staphylococcus aureus which is a gram-positive bacteria. The treatment of bacterial infection was done using antibiotics or essential oils. Both essential oil from Syzygium aromaticum L. and Myristica fragrans Houtt had antibacterial activities against gram-positive bacteria. The research study aims were to investigate the synergism antibacterial effect of the essential oil from Sys combination with Myr against S. aureus ATCC 25923. The synergism test was performed using microdilution checkerboard method by adding MTT as an indicator for the presence of bacterial growth. The effect of combination can be seen from the FIC Index and isobologram, while the essential oil components of each plant were analyzed by GC-MS. The results showed that additive effect caused by the ratio of Myr vs Syz was 2/5 and 8/5 (FIC index was 0.75), and on 2/5 showed the indifferent result (FIC index was 1.5). The best concentration ratio between Myr and Syz was 1.0: 2.5 (mg/mL). The GC-MS analysis results showed that the major essential oil components of Syz was caryophyllene and eugenol, and Myr was ?-pinene, ?-pinene, sabinene, p-cymene, terpinene-4-ol, safrol, and myristate. In conclusion, we can assume that the combination of the essential oil from Syz and Myr have an additive effect to inhibit S. aureus and potent as antimicrobial.
EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA baroroh, farida; darmawan, endang
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents
Efek Serbuk Bunga Rosella Merah (Hibiscus sabdariffa L.) terhadap Ekspresi IL-10 pada Sukarelawan Sehat Syahrana, Nur Azizah; Akrom, Akrom; Darmawan, Endang
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol 4, No 1 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Fakultas Farmasi Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.913 KB) | DOI: 10.20473/jfiki.v4i12017.1-5

Abstract

Pendahuluan: Bunga rosella merah (Hibiscus sabdariffa L.) mengandung fenol dan flavonoid antosianin yang memiliki aktivitas sebagai antioksidan dan dapat meningkatkan sistem imun. Tujuan: Tujuan penelitian ini untuk mengetahui pengaruh kapsul serbuk bunga rosella terhadap ekspresi IL-10 menggunakan metode pre and post test pada 21 sukarelawan sehat yang memenuhi kriteria inklusi dan bersedia mengisi informed consent. Metode: Relawan diberikan serbuk rosella dalam bentuk kapsul dengan dosis 500 mg selama 30 hari dan dilakukan pemeriksaan IL-10 menggunakan metode flowsitometri pada hari ke-0, 30 dan 45. Hasil dianalisis menggunakan SPSS dengan uji wilcoxon. Hasil: Nilai ekspresi IL-10 pada sukarelawan hari ke 0, ke-30 dan ke-45 adalah 0,42 ± 0,24; 0,83 ± 0,47 dan 1,06 ± 0,67. Hasil ini menunjukkan ekspresi IL-10 bepengaruh pada hari ke-0 ke-30 (p < 0,05) dan ekspresi IL-10 tidak berpengaruh hari ke-30 ke-45 (p > 0,05). Kesimpulan: pemberian kapsul serbuk rosella (Hibiscus sabdariffa L.) dosis 500 mg/hari selama 30 hari meningkatkan ekspresi IL-10, tetapi dalam batas nilai normal pada sukarelawan sehat.
PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR – AWAR (FICUS SEPTICA BURM. F) DAN EKSTRAK ETANOL DAUN KELOR (MORINGA OLEIFERA) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN Anovia, Rizka Angerti; Sari, Dewi Indah; Yazin, Annisa Hardikasari; Ismayani, Ulfa; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2663.276 KB) | DOI: 10.12928/pharmaciana.v5i2.2145

Abstract

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p&gt; 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.
EVALUASI PENGARUH PEMBERIAN INFORMASI OBAT OLEH APOTEKER TERHADAP KEPATUHAN PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN DI RSUD DR. MOEWARDI SURAKARTA Asmini, Puji; Supadmi, Woro; Darmawan, Endang
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v0i0.1203

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ABSTRAK Diabetes Melitus merupakan penyakit kronis gangguan metabolisme yang ditandai dengan kadar gula darah melebihi nilai normal (hiperglikemia) sebagai akibat dari kelainan pada sekresi insulin, kerja insulin, atau keduanya. Prevalensi diabetes diabetes diperkirakan mencapai 2,8% pada tahun 2000, dan diperkirakan terus meningkat. Kepatuhan pasien dan modifikasi gaya hidup memegang peranan penting dalam manajemen diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian informasi obat oleh apoteker terhadap terhadap peningkatan kepatuhanpasien diabetes mellitus rawat jalan di RSUD Dr Muwardi Kota Surakarta. Penelitian ini dilakukan dengan menggunakan rancangan studi deskriptif observasional dengan pengambilan data secara prospektif, selama  3 bulan dari Juni-Agustus 2014. Responden sebanyak 90 pasien dengan intervensi pemberian informasi obat untuk kelompok 1 dengan leaflet dan oral sebanyak 2kali ulangan, kelompok 2 dengan leaflet sebanyak 2kali ulangan, dan kontrol dengan pemberian informasi di awal kunjungan.Data pasien diperoleh dari rekam medis dan pemberian kuesioner Morisky Medication Adherence Scale (MMAS). Penelitian ini dilakukan di Poliklinik Penyakit Dalam rawat jalan di RSUD Dr Moewardi Surakarta. Mengenai pemberian informasi obat oleh apoteker terhadap kepatuhan pasien diabetes melitus tipe 2 dianalisis menggunakan uji wilcoxon. Hasil penelitian diperoleh nilai uji kelompok kontrol hasil pre test dan posttest (p = 0.001), nilai uji kelompok perlakuan pertama hasil pre test dan post test (p = 0.001), dan nilai uji kelompok perlakuan kedua hasil pre test dan post test (p = 0.000). Analisis data menunjukkan ada perbedaan tingkat kepatuhan yang signifikan (p = < 0,05) setelah pemberian informasi obat dengan leaflet. Kata kunci: Diabetes, Pemberian Informasi Obat, Kepatuhan
COST OF ILLNESS DIABETES MELITUS TIPE 2 DAN KOMPLIKASINYA PADA PESERTA JAMINAN KESEHATAN NASIONAL (JKN) DI RAWAT JALAN RUMAH SAKIT CONDONG CATUR YOGYAKARTA Putri, Rr. Erni Kusuma; Darmawan, Endang; Perwitasari, Dyah Aryani
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.8915

Abstract

Type 2 diabetes mellitus is a chronic disease that requires lifelong therapy and high service costs so that the use of antidiabetic drugs affects the patient's therapeutic costs. The purpose of this study was to determine the cost of outpatient type 2 diabetes mellitus therapy for National Health Insurance (JKN) participants in Condong Catur Hospital Yogyakarta. The research method used is observational. The parameters measured are calculating the average direct medical costs (drug costs, doctor's examination and consultation fees, laboratory costs, medical treatment costs), and comparison between the costs of oral drugs, insulin, oral and insulin. The results of normality tests with Shapiro-Wilk (microvascular, microvascular and macrovascular), Kolmogorrov-Smirnov (macrovascular) p<0.05 indicate that data are not normally distributed, the results of the Kruskal Wallis test of the three groups (microvascular, macrovascular, microvascular and microvascular) show that differences are not normally distributed significant (p = 0.001).The results showed that the microvascular group therapy costs Rp 3,164,733.58 per month, the macrovascular group Rp 9,984,566.85 per month, the microvascular and macrovascular groups Rp 11,260,372.39 per month. The cost of therapy is based on the microvascular group drug Rp. 408,567.78 per month, the macrovascular group Rp. 1,245,987.48 per month, the microvascular and macrovascular groups Rp. 1,786,270.68 per month so that statistically from the three complications groups show significant differences p = 0,001 (p <0,005). The difference in the difference between the total real costs and the total INA-CBG's rates, the microvascular group Rp -38,741.14 per patient, the macrovascular group Rp -10,914.03 per patient, while in the microvascular and macrovascular group Rp 3,272.90 per patient shows that from to three groups of complications were not significantly different p = 0.207 (p> 0.005). Statistically it can be concluded that the cost of therapy based on antidiabetic drugs in the three groups of complications shows a significant difference. There is no significant difference in the difference between the real costs in the three groups of complications
PENGGUNAAN POTENTIALLY INAPPROPRIATE MEDICATIONS (PIMs) PADA PASIEN GERIATRI RAWAT INAP OSTEOARTHRITIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Namirah Muh. Syuaib AS, Andi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.48 KB) | DOI: 10.12928/pharmaciana.v5i1.2289

Abstract

Potentially inappropriate medications (PIMs) use among elderly is a serious public health problem because it is intrinsically linked to increased morbidity, mortality, and healthcare costs. This study  aims to determine the association between number of drug prescribed, duration of hospital stay and PIMs use among elderly hospitalized patients at PKU Muhammadiyah Yogyakarta General Hospital. This study was analytic observational with cross-sectional study. Beers criteria 2012 were used to identify PIMs use among elderly hospitalized patients with osteoarthritis. Logistic regression analysis were used to determine association between number drugs of prescribed, duration of hospital stay and PIMs use. The results showed that 7 (38.9%) out of 18 hospitalized elderly patients were identified PIMs use and all of patients received atleast one PIM. The most common agents involved in PIMs were estazolam (11.1%), and metoclopramide (11.1%). Polypharmacy is a major predictor factor of PIMs use in this study.
EVALUASI PENGARUH PEMBERIAN KONSELING DAN SHORT MESSAGES SERVICE (SMS) TERHADAP KEPATUHAN TERAPI HIPERTENSI PASIEN HEMODIALISIS DI RSUD BANJAR Kurniasih, Nia; Supadmi, Woro; Darmawan, Endang
e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Ter
Publisher : e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang

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Abstract

ABSTRAK Kepatuhan terapi hipertensi pasien hemodilisis dapat ditingkatkan dengan pemberian edukasi. Edukasi dapat diberikan dalam bentuk konseling langsung atau pengiriman Short Messages Service (SMS). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian konseling dan Short Messages Service (SMS) Apoteker terhadap kepatuhan terapi hipertensi pasien hemodialisa. Penelitian ini menggunakan pre test dan post test dengan desain kelompok kontrol. Data pasien hemodialisa dikumpulkan selama 4 minggu periode Maret hingga April 2014. Data pasien diperoleh dari rekam medis dan pemberian kuesioner Morisky Medication Adherence Scale Morisky (MMAS). Penelitian ini dilakukan di Poli Hemodialisa RSUD Banjar, Jawa Barat. Analisis statistik untuk mengetahui pengaruh konseling dan Short Messages Service (SMS) terhadap kepatuhan menggunakan uji wilcoxon. Hasil penelitian diperoleh nilai uji kelompok kontrol hasil pre test dan post test (p = 0.206) dan nilai uji kelompok perlakuan hasil pre test dan post test (p = 0.008). Analisis data menunjukkan ada perbedaan tingkat kepatuhan yang signifikan (p = &lt; 0,05) setelah pemberian konseling dengan Short Messages Service (SMS). Kata kunci: Terapi Hipertensi, Hemodialisis, Kepatuhan
EVALUASI PENGARUH PEMBERIAN INFORMASI OBAT OLEH APOTEKER TERHADAP KEPATUHAN PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN DI RSUD DR. MOEWARDI SURAKARTA Asmini, Puji; Supadmi, Woro; Darmawan, Endang
e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Ter
Publisher : e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang

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Abstract

ABSTRAK Diabetes Melitus merupakan penyakit kronis gangguan metabolisme yang ditandai dengan kadar gula darah melebihi nilai normal (hiperglikemia) sebagai akibat dari kelainan pada sekresi insulin, kerja insulin, atau keduanya. Prevalensi diabetes diabetes diperkirakan mencapai 2,8% pada tahun 2000, dan diperkirakan terus meningkat. Kepatuhan pasien dan modifikasi gaya hidup memegang peranan penting dalam manajemen diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian informasi obat oleh apoteker terhadap terhadap peningkatan kepatuhanpasien diabetes mellitus rawat jalan di RSUD Dr Muwardi Kota Surakarta. Penelitian ini dilakukan dengan menggunakan rancangan studi deskriptif observasional dengan pengambilan data secara prospektif, selama  3 bulan dari Juni-Agustus 2014. Responden sebanyak 90 pasien dengan intervensi pemberian informasi obat untuk kelompok 1 dengan leaflet dan oral sebanyak 2kali ulangan, kelompok 2 dengan leaflet sebanyak 2kali ulangan, dan kontrol dengan pemberian informasi di awal kunjungan.Data pasien diperoleh dari rekam medis dan pemberian kuesioner Morisky Medication Adherence Scale (MMAS). Penelitian ini dilakukan di Poliklinik Penyakit Dalam rawat jalan di RSUD Dr Moewardi Surakarta. Mengenai pemberian informasi obat oleh apoteker terhadap kepatuhan pasien diabetes melitus tipe 2 dianalisis menggunakan uji wilcoxon. Hasil penelitian diperoleh nilai uji kelompok kontrol hasil pre test dan posttest (p = 0.001), nilai uji kelompok perlakuan pertama hasil pre test dan post test (p = 0.001), dan nilai uji kelompok perlakuan kedua hasil pre test dan post test (p = 0.000). Analisis data menunjukkan ada perbedaan tingkat kepatuhan yang signifikan (p = &lt; 0,05) setelah pemberian informasi obat dengan leaflet. Kata kunci: Diabetes, Pemberian Informasi Obat, Kepatuhan
PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Sah Putra, Suyandra; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.888 KB) | DOI: 10.12928/pharmaciana.v5i2.2655

Abstract

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used  was divided into groups (n=6) including normal groups, positive control, negatif control, and  groups were treated by  khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freund?s Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p&lt;0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p&lt;0,05), hemoglobin 7,77% (p&lt;0,05) and PLCR 35,29% (p&lt;0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p&gt;0,05) and PLCR 35,66% (p&lt;0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.