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Journal : Traditional Medicine Journal

AKTIVITAS ANTELMINTIK BIJI Veitchia merrillii TERHADAP Ascaridia galli SECARA IN VITRO Hamzah, Abdullah; Hambal, Muhammad; Balqis, Ummu; Darmawi, Darmawi; Maryam, Maryam; Rosmaidar, Rosmaidar; Athaillah, Farida; Muttaqien, Muttaqien; Azhar, Azhar; Ismail, Ismail; Rastina, Rastina; Eliawardani, Eliawardani
Majalah Obat Tradisional Vol 21, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.642 KB) | DOI: 10.22146/tradmedj.12818

Abstract

Tujuan penelitian ini adalah mengevaluasi aktivitas antelmintik ekstrak etanol biji Veitchia merrillii terhadap nematoda intestinal, Ascaridia galli. Metode fitokimia dilakukan untuk menguji keberadaan jenis kimiawi di dalam ekstrak. Efek dari ekstrak tersebut ditentukan melalui in vitro berdasarkan hambatan pergerakan dan kematian cacing. Sebanyak empat ekor cacing masing diperlakukan triplikat dalam phosphate buffered saline, 25 mg/mL, dan 75 mg/mL larutan ekstrak V. merrillii, dan 15 mg/mL albendazole. Pergerakan cacing diamati pada interval 9, 18, 27, dan 36 jam. Kematian cacing ditentukan berdasarkan ada tidaknya pergerakan badan, bagian kepala, dan ekor cacing. Kami menemukan bahwa larutan ekstrak V. merrillii mengandung tanin, alkaloid, flavonoid, triterpenoid, saponin, tetapi tidak mengandung steroid. Berdasarkan percobaan in vitro, penggunaan konsentrasi 25 dan 75 mg/mL ekstrak V. merrillii menunjukkan efek antelmintik. Ekstrak V. merrillii tersebut hanya efektif pada konsentrasi 75 mg/mL. Kajian tersebut mengindikasikan bahwa antelmintik berbasis herbal untuk mengendalikan A. galli berpontesi dikembangkan.
Histopathological Changes of Egg Cells in the Uterine of Ascaridia galli after Treatment with Extract of Veitchia merrillii Nuts Balqis, Ummu; Muslina, Muslina; Hambal, Muhammad; Athaillah, Farida; Muttaqien, Muttaqien; Azhar, Azhar; Ismail, Ismail; Rastina, Rastina; Eliawardani, Eliawardani; Harris, Abdul; Hamzah, Abdullah; Vanda, Henni; Darmawi, Darmawi
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (878.758 KB) | DOI: 10.22146/mot.31544

Abstract

The aim of the study was to observe the histopathological changes of the entire egg cells in the uterine of Ascaridia galli worms treated with crude ethanolic extract of Veitchia merrillii nuts. Histopathological changes of the entire egg cells were observed to describe that the activity of extract V. merrillii nuts interfered the reproduction process could decrease the quantity and quality of A. galli eggs. The experiments consisted of 16 head A. galli female adult worms divided into four groups, contained four worms of each, and maintained in 0.9% phosphate buffered saline (PBS). First group, a negative control experiment consisted of A. galli in 0.9% PBS. Second group, concentration of 15 mg/mL albendazole was used as a positive control. Third group and fourth group, in vitro exposure of the worms to the crude ethanolic extract V. merrillii nuts at a concentration of 25 mg/mL and 75 mg/mL, respectively. The histopathological changes of egg cells in the uterine region of stained worms was evaluated by light microscopic examination at 40x magnification. The results showed that shrinkage and disintegration of the entire egg cells in the breakage of uterus. The results indicate that the possible use of the plant as a potential anthelmintic against A. galli, the intestinal nematode parasite of domestic fowl.
Co-Authors Abdul Harris Abdullah Hamzah, Abdullah Abral, Mahdi Ademi, Gressha Vionalle Admi, Masda Afriyani, Afriyani Ahmad, Sagasias AK, M. Daud Al Azhar Amalia Sutriana Ananda Nasution, Annisah putri Annah, Nurjannah Arsih, Ulfi Widi Athaillah, Farida Ayuti, Siti Rani Azhar Azhar Azhari Azhari Basri Gani budianto panjaitan Cut Dahlia Iskandar Dani Rosdiana Darniati Darniati Daud AK, M. Dian Masyitha dwita, rina Eliawardani Eliawardani, Eliawardani Erdiansyah Rahmi Erina Erina Faisal Jamin Fakhrurrarzi, Fakhrurrazi Fakhrurrazi Fakhrurrazi Febrianty, Febrianty Fema Amzani Nasution, Feby Fifia Chandra Fitriani Fitriani Ginting, Septian Tri Mulyana Hamdani Budiman Hamny Hamny Harahap, Diannita Hasanuddin Hasanuddin Helmi, T. Zahrial Helmi, T. Zahrial HENDRA HADIWIJAYA, HENDRA Henni Vanda HENNIVANDA, HENNIVANDA Hidayati Hidayati Huriatul Masdar Husna Husna Ismail Ismail Jalaluddin, M M. Hasan M. Isa M. Nur Salim Mahdi Abrar Maryam Maryam Maryulia Dewi Matondang, Siti Wardianah Moliwati, Moliwati Muhammad Hambal Muhammad Jalaluddin, Muhammad Mulyadi Adam, Mulyadi Mulyadi Mulyadi Muslina Muslina, Muslina Muttaqien Bakri, Muttaqien Muttaqien Muttaqien, Muttaqien Muttaqin Muttaqin, Muttaqin Nasution, Borgo Mauly Nurdin, Hendri Nurhaspika, Nurhaspika NURLIANA NURLIANA Pratama Sekedang, M. Iqbal Prawana, Yogi Rahmi, Zikrina Ramadhani, Fitria Sari Rastina, Rastina Rastina, Rastina Rauzana, Anita Razali Daud Razali Razali Reimena, Resti Reynaldi, Fitrah Reynaldi, Fitrah Rinidar Rinidar, Rinidar Risa Tiuria Rosiana, Elva Rosmaidar Rosmaidar, Rosmaidar Safika, Safika Safika, Safika Safika, Safika Safrizal Safrizal Sahputra, Dedy Salim, Muhammad Nur Samadi Samadi Saputri, Pragita Ayu Siti Aisyah Siti Hajar Sugito Sugito Sulasmi Sulasmi Suyoto, Balqis Alrasyid Syafrina Sari Lubis, Syafrina Sari Syafruddin Syafruddin Syahputra, Yandi T. Fadrial Karmil T. Reza Ferasyi, T. Reza Taufiq Taufiq Teuku Reza Ferasyi Teuku Zahrial Helmi Teungku Nih Farisni, Teungku Nih Ummu Balqis Vara Tassa Sutari, Vara Tassa Veni Nella Syahputri, Veni Nella Waskito Waskito, Waskito Wenny Novita Sari Winaruddin Winaruddin Wiwit Ade Fidiawati xarolin, laras berlian Yarmaliza, Yarmaliza Yarmaliza, Yarmaliza Yuda, Sandy Cakra Yudha Fahrimal Yulina Rahmi, Yulina Yurliasni Yurliasni Zahra, Amalia Fatma Zakiah Heryawati Manaf, Zakiah Zakiyah Heryawati Manaf Zakiyuddin, Zakiyuddin Zulfan, Muhammad Zuraidawati Zuraidawati, Zuraidawati