Anita Esfandiari
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali

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KIVFA-8 STUDI KASUS: PROFIL MINERAL MAKRO PADA SAPI PERAH YANG MENGALAMI RETENSI PLASENTA DI KUNAK KABUPATEN BOGOR Wulansari, Retno; Esfandiari, Anita; Widhyarti, Sus Derthi; Choliq, Chusnul; Mihardi, Arief Purwo; Maylina, Leni; Suryono, .
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

Susu merupakan salah satu bahan pangan yang sangat penting bagi masyarakat untuk memenuhi kebutuhan gizinya. Peningkatan kesadaran masyarakat akan pentingnya susu sebagai salah satu sumber gizi yang penting berefek terhadap kebutuhan susu nasional terus meningkat pula. Namun kebutuhan yang tinggi ini belum diimbangi dengan produksi susu nasional yang baru mencapai 3.29% per tahun, sehingga kekurangan akan kebutuhan susu ini masih harus diimport dari negara lain. Rata-rata produksi susu di Indonesia dari setiap sapi masih relatif rendah, sekitar 10-12 liter/ekor/hari (Deny 2014). Keterbatasan produksi susu dari dalam negeri ini disebabkan oleh masih belum maksimalnya produksi susu dari setiap sapi perah yang dimiliki oleh peternak di Indonesia.Manajemen pemeliharaan yang baik dalam usaha peternakan sapi perah sangat diperlukan untuk dapat meningkatkan produksi susu, salah satunya antara lain manajemen pakan. Pakan harus memenuhi unsur-unsur penting diantaranya mineral makro dan mikro dalam jumlah yang secukupnya.Masalah kesehatan yang sering ditemui pada sapi perah awal laktasi umumnya berupa gangguan metabolik, seperti milk fever dan ketosis (Divers & Peek 2008). Hipokalsemia adalah kelainan metabolik dimana mekanisme homeostasis gagal untuk mempertahankan konsentrasi Ca darah normal saat awal laktasi (Chamberlain et al. 2013). Kejadian ini sering didahului dengan kondisi hipokalsemia subklinis pada saat bunting dan kering kandang, tetapi tidak teramati oleh peternak (Goff 2008). Retensi Plasenta merupakan salah satu manifestasi dari gangguan metabolik akibat tidak cukupnya konsentrasi mineral pada hewan post partus. Sapi secara normal akan melepaskan plasenta dalam waktu 3 -6 jam post partus. Retensi atau tertahannya plasenta lebih dari 8 ? 12 jam pada induk post partus dapat dipertimbangkan sebagai suatu kondisi yang abnormal (Diver & Peek 2008. Salah satu predisposisi adalah tidak adanya program manajemen pakan atau pemberian suplemen mineral yang tidak tepat, sebagaimana disajikan pada studi kasus berikut.
KIVFA-2 EFEK IMUNOMODULATOR TERHADAP PROFIL LEUKOSIT INDUK SAPI FRIESIAN HOLSTEIN YANG DIBERI ANTIGEN AI H5N1 INAKTIF Murtini, Sri; Esfandiari, Anita; Widhyarti, Sus Derthi; Wulansari, Retno; Maylina, Leni; Mihardi, Arif Purwo
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Immunomodulator adalah zat yang memiliki kemampuan untuk meningkatkan  atau menekan respon imun. Cox (1988) melaporkan bahwa pengaruhnya  selain terhadap  respon imun, imunomodulator juga dapat memodulasi haematopoiesis, termasuk peningkatan jumlah RBC dan WBC (leukosit), peningkatan PCV dan aktivasi makrofag.  Sapi friesian holstein (FH) merupakan sapi perah yang dapat digunakan sebagai hewan donor penghasil immunoglobulin G anti AI H5N1 melalui produk kolostrumnya (Esfandiari et al, 2007).  Guna meningkatkan titer immunoglobulin pada hewan donor hiperimun sera umumnya hewan diberi imunomdulator.  Berbagai jenis bahan seperti glucan, lectin, dan berbagai jenis polisakarida dari tanaman maupun hewan (Alamgir dan Uddin 2010) serta polipeptide ribonukleotida dapat digunakan sebagai imunomodulator.(Hess dan Greenberg 2012)  Penggunaan  polipeptida ribonukleotida sebagai imunomodulator ada sapi saat ini belum banyak diteliti.  Pemberian imunomodulator memberikan dampak perubahan gambaran leukosit secara langsung maupun tidak langsung.  Dampak pemberian imunomodulator jenis polipeptide ribonukleotida pada sapi FH bunting trimester terakhir untuk tujuan produksi hiperimunsera melalui produksi kolostrum belum pernah dilaporkan.  Penelitian ini bertujuan untuk mengetahui efek pemberian imunomodulator peptide ribonukleotida pada sapi FH yang disuntik antigen AI H5N1 inaktif.
PF-4 IMMUNE RESPONSE OF DRY HOLSTEIN VACCINATED BY KILLED AVIAN INFLUENZA H5N1 VACCINE Esfandiari, Anita; Murtini, Sri; Widhyari, Sus Derthi; Wulansari, Retno; Febram, Bayu; Maylina, Leni; Mihardi, Arief Purwo
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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The establishment and spread of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in birds and coincident infections in humans since 2003 have raised concerns that we may be facing an influenza pandemic caused by an H5N1 influenza virus [4]. Globally, from January 2003 to 2 March 2017, there were 860 cases of human infection with avian influenza A(H5N1) virus reported from 16 countries worldwide. Of these 860 cases, 454 were fatal (CFR of 53%). The last case was reported from Indonesia on 26 September 2017 [7]. Although the human cases of H5N1 in Indonesia has decreased significantly since 2010, according to WHO until 2017 there have been reported 200 cases H5N1 in  human with 168 cases of deaths. The last case was reported from Indonesia on 26 September 2017. This is indicate Indonesia as the highest fatal case of H5N1 globally. With continued incidence of avian influenza due to existing AI H5N1 viruses in poultry, the avian influenza H5N1 has been believed remain to threaten Indonesia [6].Passive immunization using specific antibody against AI H5N1 from bovine colostrum is one of an alternative to control H5N1 virus infection due to lack of H5N1 vaccine production for human. Bovine colostrums consider an ideal alternative antibody source, as the antibody in the bovine?s blood is transported to mammary gland easily and accumulates in the colostrum in large quantities. As a ?biological factory?  and the source of natural antibody, bovine colostrum could be designed to produce the specific antibody against certain disease for animal and human by immunizing the dry cow (with the antigen of interest).Vaccine is an antigenic material used to produce active immunity against diseases. Vaccination is the administration of vaccine to the individual to generate immunity against a disease [2]. According to [1], the exposure of a dry cow against antigen (vaccine) will produce specific antibody in their blood circulation. Therefore, evaluation on the status of antibody against AI H5N1 following the vaccination of dry Holstein cows with killed AI H5N1 vaccine is needed. 
KINERJA KESEHATAN SAPI NEONATUS YANG DIBERI KOLOSTRUM DARI INDUK SAPI YANG DIVAKSIN ESCHERICHIA COLI Wulansari, Retno; Esfandiari, Anita; Wibawan, I Wayan Teguh; Murtini, Sri
Acta VETERINARIA Indonesiana Vol. 4 No. 1 (2016): Januari 2016
Publisher : Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.496 KB) | DOI: 10.29244/avi.4.1.19-26

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Penelitian ini dilakukan untuk mempelajari status kesehatan anak sapi baru lahir yang diberi kolostrum berasal dari induk yang telah divaksinasi dangan vaksin E. coli in-aktif. Sebelas ekor anak sapi baru lahir digunakan dalam penelitian ini dibagi menjadi dua kelompok yaitu kelompok kolostrum (diberi kolostrum sapi) dan non-kolostrum (diberi susu sapi). Kolostrum atau susu sapi diberikan sebanyak 10% berat badan secara langsung setelah dilahirkan dan selanjutnya tiap 12 jam selama 3 hari. Uji tantang dilakukan dengan pemberian E. Coli K99 hidup peroral saat anak sapi berumur 14 jam. Pemeriksaan status kesehatan termasuk suhu tubuh, frekuensi pulsus dan napas serta kualitas defikasi pada 0,12, 24, 48, 72 dan 168 jam setelah uji tantang. Hasil penelitian ini memperlihatkan bahwa diarrhea timbul pada 12 sampai 26 jam setelah uji tantang pada semua anak sapi kelompok non-kolostrun dan beberapa anak sapi kelompok kolostrum. Kelompok non-kolostrum memperlihatkan tanda klinis dengan diarrhe parah sebagai diarrhe profus yang berwarna pucat kekuningan. Bahkan 1 ekor mati pada 3 hari setelah uji tantang. Sebaliknya pada kelompok kolostrum hanya memperlihatkan diarrhe sedang pada 5 dari 8 ekor. Kesimpulan dalam penelitian ini adalah konsumsi kolostrum yang berasal dari induk yang telah divaksinasi dengan E. Coli memperlihatkan sifat protektif terhadap infeksi E. coli K99.Kata kunci: Escherichia coli, kolostrum, anak sapi baru lahir. (The Health Performance of Neonatal Calves Received Colostrum from Cows Vaccinated by Escherichia coli)This experiment was conducted to study the health status of neonatal calves received colostrum from cows vaccinated by in-active E. coli. Eleven healthy newborn calves were used in this experiment and divided into two groups, i.e colostrum (received bovine colostrum) and non-colostrum group (received bovine milk). Colostrum or milk were given to the calves at 10% of body weight directly after birth and followed every 12 h, for three days. Challenges were done orally to all newborn calves when they were 14 hours of ages, used live E. coli K-99. Examination of health status included body temperature, pulses and respiration rates, and defecations quality at 0, 12, 24, 48, 72 and 168 hours after challenges. Results of the experiment showed that diarrhea appeared at 12-26 hours after challenges in all calves of non-colostrum group and part of calves in colostrum group. The non-colostrum group showed a severe clinical signs of diarrhea as watery profuse diarrhea with pale yellowish color. One calf even death at three days after challenges. In contrast, the colostrum group showed only a mild diarrhea in 5 out of 8 calves. In conclusion, the consumption of colostrum originated from cows vaccinated by E. coli showed protective properties against E. coli K-99 infection.Keywords: Escherichia coli, colostrum, neonatal calves
PROFIL KREATININ DAN NITROGEN UREA DARAH PADA ANAK SAPI FRIESIAN HOLSTEIN YANG DISUPLEMENTASI ZN Widhyari, Sus Derthi; Esfandiari, Anita; Cahyono, Aditia Dwi
Acta VETERINARIA Indonesiana Vol. 3 No. 2 (2015): Juli 2015
Publisher : Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.41 KB) | DOI: 10.29244/avi.3.2.45-50

Abstract

Parameter kreatinin dan nitrogen urea darah atau blood urea nitrogen (BUN) dapat digunakan sebagai indikator untuk melihat adanya gangguan fungsi ginjal. Penelitian ini bertujuan untuk mengetahui kadar kreatinin dan BUN dalam serum anak sapi Friesian Holstein (FH) yang diberi suplementasi mineral Zn di dalam pakan. Penelitian ini menggunakan 9 ekor anak sapi FH yang sehat secara klinis dan umur berkisar antara 6-10 bulan. Hewan dibagi menjadi 3 kelompok, yaitu kelompok tanpa suplementasi Zn, kelompok yang diberi suplementasi Zn sebesar 60 ppm, dan kelompok yang diberi suplementasi Zn sebesar 120 ppm. Pengambilan sampel darah dilakukan melalui vena jugularis sebelum pemberian Zn dan setiap bulan setelah pemberian Zn selama 3 bulan. Sampel darah dalam bentuk serum dianalisis untuk kadar kreatinin dan BUN menggunakan alat spektrofotometer. Hasil pemeriksaan memperlihatkan bahwa kadar kreatinin darah berkisar antara 0,64 sampai 0,77 mg/dL, dan kadar BUN berkisar antara 8 sampai 19 mg/dL. Kadar kreatinin dan BUN darah pada anak sapi FH masih berada pada kisaran normal. Oleh karena itu suplementasi Zn 60 ppm maupun 120 ppm yang diberikan selama tiga bulan pada anak sapi FH relatif aman dan tidak menggangu fungsi ginjal.Kata kunci: mineral Zn, BUN, kreatinin, anak sapi Friesian Holstein. (Creatinin and Blood Urea Nitrogen Profiles on Friesian Holstein Calves Supplemented by Zn)Creatinine and blood urea nitrogen (BUN) can be used for indicator renal disfuction. The objective of this experiment was to study the concentration of creatinine and blood urea nitrogen in Friesian Holstein (FH) calves, received feed supplemented by Zn. Nine healthy Holstein calves, 6-10 months old were used in this experiment. The calves were devided into 3 groups, consisted of three calves, i.e. no supplementation (control), 60 ppm and 120 ppm of Zn supplementation. Blood sample were collected from jugular vein, before dan after supllementation Zn every month untill 3 months. Blood urea nitrogen and creatinine concentrations in serum were analysed using spectrophotometer. Results of the experiment had indicated that the creatinine and BUN concentration ranging between 0,64-0,77 mg/dL and 8-19 mg/dL, respectively. In conclusion, concentration of creatinine and Blood urea nitrogen were in a normal range. So the supplementation of Zn 60 and 120 ppm were given for three months in Friesian Holstein calves relatively safe for renal function.Keywords: zinc, blood urea nitrogen, creatinine, Friesian Holstein calves.
PERFORMANS PRODUKSI DAN PROFIL METABOLIK DARAH DOMBA GARUT DAN JONGGOL YANG DIBERI LIMBAH TAUGE DAN OMEGA-3 (PRODUCTION PERFORMANCE AND BLOOD METABOLIC PROFILES OF GARUT AND JONGGOL RAMS THAT WAS FED MUNG BEAN SPROUT WASTE AND OMEGA-3) Wijaya, Gagah Hendra; Yamin, Mohamad; Nuraini, Henny; Esfandiari, Anita
Jurnal Veteriner Vol 17 No 2 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The research objectives were to evaluate and compare of production performances and blood metabolicprofiles of garut and jonggol rams fed with mung bean sprout waste and omega-3. This research used 24rams aged of 1-2 years, consisted of 12 garut rams weighed of 36,43±1,45 kg (CV=13,87%) and 12 jonggolrams weighed of 23,09±0,57kg (CV=8,64%). Research used Completely Randomized factorial Design(CRD 2x3) with 2 main treatments x 3 factorials and four replications. The first factors as the maintreatments were different breeds of garut and jonggol. The second factors as the factorial treatments werethree different feed percentages which consisted of P0 (40% grass+60% concentrate I), P1 (40% mung beansprouts waste+60% concentrate II), and P2 (40% mung bean sprouts waste+60% concentrate II+omega-3).Data were analyzed by analysis of variance (ANOVA) and proceeded by Duncan Range Test. The resultsshowed that P1 had the highest performance on feed efficiency and average daily gain (ADG) parameters.Blood metabolic test showed that blood total protein, cholesterol, and glucose of all rams were normal. Inconclusion feeding rams with mung bean sprout waste as grass substitution have a positive effect on theperformance of the rams production performance.
KONSENTRASI PROTEIN TOTAL, ALBUMIN, DAN GLOBULIN ANAK KAMBING PERANAKAN ETAWAH SETELAH PEMBERIAN BERBAGAI SEDIAAN KOLOSTRUM* (TOTAL PROTEIN, ALBUMIN, AND GLOBULIN CONCENTRATIONS ON ETTAWAH CROSSBREED NEONATES FOLLOWING THE ADMINISTRATION OF VARIOUS FORM O Esfandiari, Anita; Widhyari, Sus Derthi; Widodo, Setyo; Wibawan, I Wayan Teguh; Sajuthi, Dondin; Sutama, I Ketut
Jurnal Veteriner Vol 15 No 3 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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This experiment was conducted to study the profile of total protein, albumin, and globulin concentrationson Ettawah crossbreed neonates after consuming various colostrums. Twenty four healthy neonatal kidswere used in this study. The neonates were divided into four groups. Each group received fresh maternal(goat) colostrum, frozen-thawed bovine colostrum, bovine spray dried colostrum, and bovine powdercommercial colostrum, respectively. Colostrums were given at 10% of body weight directly after birth andfollowed by the same amount every 12 hours, for three days. The blood was taken from jugular vein at 0, 12,24, 48, 72, and 168 hours after birth to determine total protein, albumin, and globulin concentrations.Results of this study indicated that the serum total protein and globulin concentration increased andreached the peak at 24 hours after birth. Compared to the concentration at birth, the increase of totalprotein concentration were 62.77%, 59.26%, 48.05%, and 66.67% in fresh maternal (goat), frozen-thawedbovine, bovine spray dried, and commercial bovine colostrum, respectively. Serum globulin concentrationincreased 4.9, 4.4, 4.8, and 14.6 times in fresh matermnal goat, frozen-thawed bovine, spray dried, andcommercial bovine colostrums respectively, compared to the concentration at birth. In conclusion, theconsumption of various colostrums i.e. fresh maternal goat colostrums, bovine colostrums (frozen-thawed,spray dried and commercial colostrums) would increase the concentration of blood total protein and globulin,which both reached the highest concentration at 24 h after birth.
PROFIL IMUNOGLOBULIN-G SERUM KAMBING PERANAKAN ETAWAH BUNTING YANG DIBERI IMBUHAN PAKAN MINERAL SENG (SERUM IMUNOGLOBULIN-G LEVEL ON PREGNANT ETTAWAH CROSSBRED WERE GIVEN ZINC MINERAL) Widhyari, Sus Derthi; Esfandiari, Anita; Sutama, I Ketut; Widodo, Setyo; Wibawan, I Wayan Teguh; Ramdhany, Rizal Rahadian
Jurnal Veteriner Vol 18 No 1 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2017.18.1.24

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The objective of this study was to find out the effect of zinc supplementation on the profile of immunoglobulin-G (IgG) in the pregnant etawah-cross ewes. Fifteen etawah-cross ewes (3-6 years old and 30-50 kg body weight) were used in this experiment and they were divided into three groups each of which consisted of 5 ewes. The first group (Zn40) received 40 ppm Zn as control, the second group (Zn60) received 60 ppm Zn, and the third group (Zn80) received 80 ppm Zn. Blood samples were collected from jugular vein every two weeks, started at twelve weeks of pregnancy up to eight weeks post partum for immunoglobulin-G analysis. IgG level were analyzed by competitive Enzyme Linked Immunosorbent Assay (ELISA) technique. Results showed that there were no significant difference of immunoglobulin-G level (P>0,05) among the three treatment groups ( Zn40, Zn60, and Zn80). However, IgG level of Zn40 and Zn80 groups tended to decrease during the last staget of pregnancy until two weeks post partum. In conclusion, supplementation of 60 ppm Zn showed higher IgG level than Zn 80 ppm. ABSTRAK Penelitian ini bertujuan untuk mengetahui efek suplementasi seng (Zn) terhadap imunoglobulin-G (IgG) pada kambing peranakan etawah (PE) bunting. Penelitian ini menggunakan 15 ekor kambing PE umur sekitar tiga sampai enam tahun, bobot badan sekitar 30-50 kg dibagi ke dalam tiga kelompok, masing-masing terdiri dari lima ekor. Kelompok Zn40 (kontrol) diberi pakan mengandung mineral Zn 40 ppm, kelompok Zn60 mengandung mineral Zn 60 ppm, dan kelompok Zn80 mengandung mineral Zn 80 ppm. Sampel darah diambil melalui vena jugularis untuk menganalisis konsentrasi IgG. Pengambilan sampel darah dilakukan setiap dua minggu mulai umur kebuntingan 12 minggu sampai delapan minggu setelah melahirkan. Hasil penelitian menunjukkan bahwa konsentrasi IgG serum tidak menunjukkan perbedaan secara nyata antar kelompok (P>0,05) antara kelompok Zn 0, Zn 40 dan Zn 80 ppm. Kelompok Zn 40 ppm dan 80 ppm cendrung memperlihatkan konsentrasi IgG mengalami penurunan pada akhir kebuntingan sampai dua minggu setelah melahirkan. Pada kelompok Zn 60 ppm memperlihatkan konsentrasi IgG lebih tinggi dibanding kelompok Zn 80 ppm.
PROFIL ELEKTROLIT SERUM PEDET SAPI YANG DIINFEKSI ESCHERICHIA COLI K-99 DAN DIBERI MIKROKAPSUL IMUNOGLOBULIN-G ANTI E. COLI Mihardi, Arief Purwo; Esfandiari, Anita; Widhyari, Sus Derthi; Murtini, Sri
Jurnal Veteriner Vol 20 No 2 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2019.20.2.158

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Escherichia coli (E. coli) K-99 infection cause acute diarrhea in calves which may reduce electrolyte, such as sodium and potassium.  The experiment was conducted to study the sodium and potassium profiles in calves infected by E. coli and received immunoglobulin G anti E. coli K99 microcapsules.  Sixteen calves, 4 ? 6 days years old, were grouped into four groups, consists of four calves, i.e. negative control/NC group (the calves were not infected by E. coli K-99 and no treatments); positive control/PC group (the calves were infected by E. coli K-99 and no treatments); treatment 1/P1 group (the calves were infected by E. coli K-99 and received colostrum suspension of IgG anti E. coli K-99); and treatment 2/P2 group (the calves were infected by E. coli K-99 and received microcapsules of IgG anti E. coli K-99).  Escherichia coli K-99 were infected to all calves except the NC group orally with the dosage of 5 × 1010 cfu/ml.  Suspension and microcapsules of IgG anti E. coli K-99 for each calf were given orally with dosage of 1.76 gram IgG anti E. coli K-99 per day.  Serum were collected from jugular vein at 0, 24, 48, 72, and 168 hours after E. coli K99 infection. The sodium and potassium concentrastion were analyzed using a spectrophotometer. Results of the experiment indicated that the concentration of sodium and potassium were not significantly different among groups.  Sodium concentration of P2 group was relatively higher than PC or P1 and showed increased concentration 168 hours after infection.  Potassium concentration of P2 were higher than the PC group, but lower than NC and P1 group.  In conclusion, the administration of IgG anti E. coli K-99 microcapsules was not significantly change the sodium and potassium concentration, but may maintain the stability of sodium level in calves infected by E. coli K-99.
KONDISI NEONATUS ANAK BABI YANG DILAHIRKAN OLEH INDUK YANG DISUNTIK GONADOTROPIN SEBELUM PENGAWINAN Montolalu, Friska Mery; Esfandiari, Anita; Ekastuti, Damiana Rita; Manalu, Wasmen
Jurnal Veteriner Vol 19 No 1 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2018.19.1.76

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Penyuntikan pregnant mare serum gonadotrophin (PMSG) dan human chorionic gonadotrophin (hCG) pada induk sebelum pengawinan telah terbukti memperbaiki sekresi endogen hormon kebuntingan yang selanjutnya memperbaiki lingkungan uterus selama periode kebuntingan sehingga anak babi yang dihasilkan tumbuh lebih sehat dan unggul. Penelitian ini dirancang untuk mempelajari pengaruh penyuntikan PMSG dan hCG induk babi sebelum pengawinan pada kondisi anak babi pada saat dilahirkan atau neonatus. Penelitian ini menggunakan 30 ekor babi dara keturunan Landrace yang dibagi ke dalam 2 kelompok, yaitu 15 ekor ekor disuntik PMSG dan hCG sebelum pengawinan, sedangkan 15 ekor disuntik NaCl fisiologis sebagai kontrol. Sebelum pengawinan, siklus estrus induk babi percobaan diseragamkan dengan menyuntikkan prostaglandin dua kali dengan selang 14 hari. Babi percobaan disuntik PMSG dan hCG atau NCl fisiologis pada waktu yang bersamaan dengan penyuntikan prostaglandin kedua. Babi percobaan selanjutnya dikawinkan secara alami dengan mencampurkan dengan pejantan. Induk babi percobaan dipelihara secara normal selama kebuntingan sampai melahirkan. Hasil penelitian menunjukkan bahwa induk yang disuntik PMSG dan hCG sebelum pengawinan melahirkan anak dengan proses kelahiran yang lebih cepat dengan daya hidup yang lebih tinggi. Anak babi yang dilahirkan oleh induk yang disuntik PMSG dan hCG sebelum pengawinan mempunyai bobot lahir yang lebih optimum yang disertai dengan panjang badan, tinggi tungkai depan, dan tinggi tungkai belakang yang lebih besar dan homogen dalam satu induk. Anak babi yang dilahirkan oleh induk yang disuntik PMSG dan hCG sebelum pengawinan menunjukkan keadaan yang lebih sehat dan unggul sehingga diharapkan pertumbuhan ke depan selama prasapih dan pascasapih akan lebih baik dan optimal. Kata kunci: Anak babi, bobot lahir, kondisi neonatus, ukuran morfometrik pada saat lahir, penyuntikan PMSG-hCG.