Arta Farmawati
Department of Biochemistry Faculty of Medicine Universitas Gadjah Mada

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Journal : Jurnal Gizi Klinik Indonesia

KEPATUHAN KONSUMSI SUPLEMEN MIKRONUTRIEN TIDAK TERPENGARUH OLEH BENTUK SUPLEMEN Fauzia, Faurina Risca; Farmawati, Arta; Lestari, Lily Arsanti
Jurnal Gizi Klinik Indonesia Vol 16, No 2 (2019): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (27.526 KB) | DOI: 10.22146/ijcn.27617

Abstract

Compliance of micronutrients supplement consumption was not affected by supplements formBackground: Taburia is micronutrient sprinkle produced by Ministry of Health Indonesia to overcome malnutrition problem in Indonesia. Compliance of Taburia consumption is an important indicator for the success of the supplementation program. Taburia?s compliance in some regions is low (<80%). Gummy candies are children?s favorable food product.Objective: To evaluate the compliance of micronutrient consumption in the form of sprinkle and gummy candies in children. Methods: This study was a quasi-experimental study with randomizedcontrol group design.Respondents are mother and children aged 36-59 months in Yogyakarta District. The children received supplementation of Taburia sprinkle or fortified gummy candies for 30 days.Results: The compliance of Taburia sprinkle and fortified gummy candies were 85.39% and 80.32% respectively, however it was not significantly different (p>0.05). Several factors affected the compliance level such as mother?s employment status, gender of the children, and age of the children. Conclusions: The compliance level of Taburia sprinkle and fortified gummy candies was similar. Hence fortified gummy candies could be used as an alternative of micronutrient supplement to overcome nutrition problem in Indonesia.
Pemberian minuman kombinasi maltodekstrin dan vitamin C terhadap mood negatif dan VO2 maks atlet sepak bola Afriani, Yuni; Hadjam, Noor Rochman; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 13, No 4 (2017): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22838

Abstract

Background: Stress during the match can influence the change of mood and performance of athletes. Physical exercise can improve the ability of physiologically and psychologically, but lead to fatigue, dehydration and hypoglycemia. Maltodextrin has a lower osmolarity to improve emotional and performance. Vitamin C as a cofactor of neurotransmitters can support the performance of athletes.Objective: This study aimed to determine the effectiveness of a combination drinks of maltodextrin and vitamin C on mood and the correlation with VO2 max of football athletes.Method: This research is a quasi experimental with same subject design. The subjects were 14 University state of Yogyakarta football athlete. Subjects received a drink of 15% maltodextrin and 250 mg of vitamin C in 300 ml given 30 minutes before and 5 minutes after the performance test using yo-yo intermittent test continued by physical exercise. Measurement of mood would be done in 3 times; before cardiorespiratory test, 5 minutes after physical exercise, and 15 minutes after drink.Results: There are significant changes after consuming a combination of maltodextrin and vitamin C on the confusion (p<0.05), while components of anger, fatigue, depression, tension and vigor (p>0.05). There are significant changes after consuming plain water on fatigue and tension (p<0.05), while anger, confusion, depression, and vigor (p>0.05). There are no significant differences in every components of mood between two treatments. There is a correlation between anger and confusion with cardiorespiratory after consuming a combination of maltodextrin and vitamin C.Conclusion: Maltodextrin and vitamin C has the potential effect to improve the mood condition and have a correlation with VO2 Max improvement in football athletes.
Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil Istiqomah, Nor; Umarghanies, Sarah Safira; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18364

Abstract

Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.
Efek minuman kombinasi maltodekstrin dan vitamin C terhadap VO2maks atlet sepak bola Puspaningtyas, Desty Ervira; Sudargo, Toto; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 12, No 1 (2015): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22831

Abstract

Background: VO2max is one of win determiner in a game. Athletes receive training to improve technical skills, tactical skills, and physiology functions that can support the improvement of VO2max, so they can improve their achievement. Maltodextrin and vitamin C can be used as an ingredient for beverage products which can improve VO2max.Objective: To assess the effect of maltodextrin and vitamin C combination drink on VO2max in soccer athletes.Method: Type of this study was experimental design with the same subject design. The study was conducted from January 2014 until June 2014 at Culinary Laboratory Universitas Gadjah Mada (UGM) and Stadium of Universitas Negeri Yogyakarta (UNY). Subjects of this study were 14 soccer players coming from Universitas Negeri Yogyakarta (UNY). Every subject had to fulfill the inclusion and exclusion criteria, and the subjects were chosen by purposive sampling. In the first treatment, subjects received the combination drink―a drink with a composition 15% of maltodextrin and 250 mg of vitamin C in 300 mL. After 6 days washout period, subjects received 300 mL plain water. Drinks were given 30 minutes before VO2max test. VO2max test method used in this study was yo-yo intermittent recovery test level 2 (IR-2).Results: VO2max when subjects consumed maltodextrin and vitamin C combination drink was significantly lower than VO2max when athletes consumed plain water (p=0,0000).Conclusion: Maltodextrin and vitamin C combination drink was less effective than plain water to enhance VO2max.
Pengaruh pemberian kecambah kacang hijau (Phaseolus radiatus (L.)) terhadap kadar malondealdehid (MDA) plasma dan jaringan hati tikus Sprague Dawley yang diberi pakan lemak tinggi Novidiyanto, Novidiyanto; Farmawati, Arta; Lestari, Lily Arsanti
Jurnal Gizi Klinik Indonesia Vol 13, No 2 (2016): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22923

Abstract

Background: High-fat diet increases the levels of fat, especially cholesterol and triglycerides that cause hyperlipidemia. Polyunsaturated fatty acids are very easily oxidized by free radicals reactive oxygens species (ROS) called lipid peroxidation, to produce compounds that malondialdehyde (MDA), is toxic and can damage plasma membrane and liver tissue. Mung bean sprouts are known to contain antioxidants which act to inhibit lipid peroxidation process.Objective: Determine the effect of mung bean sprouts to the level of plasma MDA and liver tissue of rats with high-fat diets.Method: This research is an experimental study with an only post-test design with the control group. Thirty-five male Sprague-Dawley rats were divided into 5 groups. Group K1 received fed standard; K2 received high-fat diet without mung bean sprouts. Group P1 received high-fat diet and mung bean sprouts dose of  0.5 mL/gBW. Group P2 received high-fat diet and mung bean sprouts dose of 1 mL/gBW. Group P3 received high-fat diet and vitamin E doses of 23 IU. All group were treated for 28 days. Analysis of MDA plasma and liver tissue performed after treatment.Results: Group K1 has plasma MDA levels of 1.17 ± 0.14 nmol/mL Mean MDA plasma level in the group K1 Group of K1 Mean MDA plasma level in the group K2 (39.7±0.19 nmol/mL) was higher than the group of K1 (1,17±0,14 nmol/mL), group P1 (2.94±0.09 nmol/mL), group P2 (1.73±0.08 nmol/mL) and group P3 (1.53±0.07 nmol/mL). Group K1 has liver tissue MDA Levels of 1,64±0,11 nmol/g. Mean MDA liver tissue level in the group of K2 (4.90±0.29 nmol/g) was higher than the group of P1 (3.68±0.45 nmol/g), group P2 (2.27±0.10 nmol/g), and group P3 (2.01±0.11 nmol/g).Conclusion: Level of MDA plasma and liver tissue of rat in group P1 and P2 was lower than a level of MDA plasma and liver tissue of rat in group K1, but higher than the level of MDA plasma and liver tissue of rat in group P3. There was a very strong correlation between the level of MDA plasma and liver tissue of rat was given the mung bean sprouts and high-fat diet.
Pencegahan hipertensi dan penebalan dinding aorta dengan pemberian kecambah kacang hijau (Phaseolus radiatus (L)) pada tikus putih Sprague Dawley Hadi, Novian Swasono; Farmawati, Arta; Ghozali, Ahmad
Jurnal Gizi Klinik Indonesia Vol 12, No 3 (2016): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22454

Abstract

Background: Lifestyle changes with high-fat food consumption is one of the factors the risks of cardiovascular diseases like of coronary heart disease and atherosclerosis. A healthy diet and a balanced diet and consume foods that contain lots of antioxidants is one of the effective ways to prevent hyperlipidemia. Mung bean sprouts have properties that neutralize free radicals cause Hyperlipidemia and cardiovascular diseases because it is an antioxidant compound.Objective: The aim of this study was to determinate the effect of mung bean sprouts (Phaseolus radiatus (L)) to blood pressure and histopathology aorta of Sprague-Dawley male rats.Method: The type of study was experimental research using pre-post test controlled group design for blood pressure variable and post test only controlled group design histopathology aorta. The thirty-five of Sprague-Dawley male rats was eight weeks divided into 5 groups. The first group was given standard diet, group 2 was given a hight fat diet, the third group was given a high-fat diet and mung bean sprout 0,67 gram, group 4 was given a high-fat diet and mung bean 1,34 gram, and group 5 was given a high-fat diet and vitamin E doses of 23 IU.Results: Result of this study showed that after 4 weeks of treatment, increased in blood pressure systole in the given of  high fat diet higher than group who were given a high fat diet and mung bean sprout and also on group who were given high fat diet and vitamin E, but there is no difference effect a decrease in blood pressure between the provision of mung bean sprouts and vitamin E (p>0,05). Statistical analysis to thick the wall the aorta show the similarity meaningful in all the treatment group, it can be said that overall thick the wall the aorta in this research is not different.Conclusion: A dose of mung bean sprout 0,67 g is optimal doses in preventing a rise in blood pressure and prevent alterations histopathology Sprague-Dawley male rats.
Efektivitas minuman kombinasi maltodekstrin dan vitamin C terhadap hitung jenis leukosit pada atlet sepak bola Mahfida, Silvi Lailatul; Kandarina, Istiti; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 11, No 3 (2015): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.19295

Abstract

Backgrounds: The immune system changing affects the fitness. Exercise induces the immune responses, oxidative stress and tissue damage that alters leukocyte counts. Maltodextrin supplies higher energy reserves, that can improve the immune system profiles. Vitamin C as an antioxidant against tissue damage.Objective: This study aims to assess the effectiveness of a maltodextrin and vitamin C combination drink on leukocyte differential count after exercise.Method: This study was quasi-experimental with the within-subject design. Subjects were 14 collegiate football players of the State University of Yogyakarta and fulfilled the inclusion and exclusion criteria. Subjects were selected with a purposive sampling. Subjects received a combination of 15% maltodextrin and 250 mg of vitamin C beverage, 300 mL. Subjects did wash out for 6 days, then received placebo beverage (300 mL plain water). Subjects drank 30 minutes before and 5 minutes after physical exercise. Exercise loads were yoyo intermittent test and run gradually until 80 HRmaks. Blood samples were taken immediately and 30 minutes after exercise.Results: In the administration of intervention beverage, immediately to 30 minutes after exercise neutrophils increased (p=0,006); lymphocytes decreased (p=0.015); monocytes decreased (p=0.000); and eosinophils decreased (p=0.613). In the administration of placebo beverage, immediately to 30 minutes after exercise, neutrophils increased (p=0.359); lymphocytes decreased (p=0.257); monocytes decreased (p=0.146); and eosinophils increased (p=0.549). Neutrophils (p=0.003) and monocyte (p=0.003) had significant difference between both administration drink at 30 minutes after exercise. Lymphocyte and monocyte significantly decrease (p<0.05) at intervention than placebo.Conclusion: Maltodextrin and vitamin C combination drink effect on the decreasing of lymphocyte and monocyte 30 minutes after exercise.
Karakteristik sosial demografi dan konsumsi zat besi pada ibu hamil berdasarkan data Studi Diet Total (SDT) tahun 2014 di Indonesia Amir, Safrullah; Susetyowati, Susetyowati; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 15, No 2 (2018): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.668 KB) | DOI: 10.22146/ijcn.26779

Abstract

Background: Pregnant women are the group most vulnerable to iron deficiency anemia. This occurs as a consequence of a significantly increased demand for iron intake during pregnancy. The efforts of pregnant women to compensate for the increased need of iron depend on various sociodemographic characteristics.Objective: To analyze the relationship between sociodemographic characteristics and iron consumption of pregnant women in Indonesia.Method: This research is observational study design with cross-sectional approach using secondary data of the Total Dietary Study (SDT) year 2014. A total of 644 pregnant women inform the SDT study who met our inclusion and exclusion criteria were assessed for their level of consumption using 24-hour dietary recall method. Data were then processed using Nutrisurvey software and Indonesian Food Composition Table (TKPI) to estimate the consumption of iron. Analysis was conducted using Mann-Whitney and Kruskal-Wallis tests by including various social demographic characteristics in pregnant women.Results: The results of this study found that level of education, employment status, economic status, and residence of pregnant women are significantly related to iron consumption (p<0.05).Conclusion: Pregnant women with high education, working status, middle to upper economic status, and living in urban areas have better iron consumption.
Peran kecambah kacang hijau (Phaseolus radiatus (L.)) pada sel lemak retroperitoneal tikus Sprague Dawley yang diberi diet tinggi lemak Lestari, Dwi; Lestariana, Wiryatun; Lestari, Lily Arsanti; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 16, No 1 (2019): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1283.601 KB) | DOI: 10.22146/ijcn.41676

Abstract

The role of mung bean sprouts (Phaseolus radiatus (L.)) on retroperitoneal fat cells of Sprague Dawley rats fed a high-fat dietBackground: The tendency of current lifestyles with high consumption patterns of fat is one of the factors causing obesity which is a risk of cardiovascular disease. Prevention of cardiovascular disease can be done by adopting a dietary pattern that is rich in antioxidants including consumption of sources of vitamin E. Sprouts from mung beans contain vitamin E and phytochemicals rich in antioxidants, so they can be used as an alternative to prevent hyperlipidemia sourced from daily functional food.Objective: To assess the effects of mung bean sprouts on retroperitoneal fat weight, cell number and cell diameter in rats fed high-fat feed.Method: This research is an experimental study with a post-test design with the control group. Thirty-four male Sprague Dawley rats ± 2 months old were divided into five groups, group I (standard feed), group II (high-fat feed), group III (high-fat feed and intervention of feeding tube of mung bean sprout 0.67 g/ 200 g BW), group IV (high fat feed and intervention of feeding tube of mung bean sprout 1.34 g / 200 g BW), and group V (high-fat feed and 23 IU dose of vitamin E supplement with feeding tube). After adaptation for three days, the intervention was carried out for four weeks. Analysis of fat weight, fat cell number, and fat cell diameter were done after the treatments. Data analysis using the One-Way ANOVA test. Results: Mung bean sprout dose of 1.34 g given for 4 weeks did not significantly decrease fat weight and cell number, but it decreased the diameter of retroperitoneal fat cells.Conclusion: Mung bean sprouts dose 1.34 g was better than a dose of 0.67 g and vitamin E supplementation in reducing the diameter of retroperitoneal fat cells in rats fed a high-fat diet.