Euis Filaila
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten

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Antibacterial and Antioxidant activities of Indonesian ginger (jahe emprit) essential oil extracted by hydrodistillation Azizah, Nurul; Filaila, Euis; Salahuddin, Salahuddin; Agustian, Egi; Sulaswatty, Anny; Artanti, Nina
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 20, No 2 (2018)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (689.817 KB) | DOI: 10.14203/jkti.v20i2.401

Abstract

The rhizome of ginger is commonly used as a spice, food, beverage as well as medicine. Plant essential oils including from ginger have been widely used for food preservation, pharmaceutical and alternative medicines.  Currently there are growing interest of consumer for natural sources such as essential oils for natural antibacterial and antioxidant.  Jahe emprit (Zingiber officinale var. Amarum) is one of Indonesian ginger variety used to obtain ginger essential oil. The objective of current study was to investigate the effect of solvent to feed (SF) ratio in hydrodistillation process on yield, chemicals content, antibacterial and antioxidant activities of ginger essential oils from jahe emprit.  SF ratio used in this study is 0.7: 1, 1.7: 1, 2.7: 1.  Chemicals content was conducted using GCMS analysis.  Antibacterial assay was conducted using disc diffusion method against Escherichia coli and Staphylococcus aureus.  Antioxidant assay was conducted using DPPH free radical scavenging assay.  The results show that the highest essential oil yield was obtained from SF ratio 1.7:1 which gave yield of 3.7%.  GCMS analysis shows that camphene was always the major compound present in those 3 SF ratio, although the amount present was differed.  Besides, 4 other major compounds present were varied.  Antibacterial assay using 1% concentration showed ginger oil obtained from SF 0.7:1 and 2.7:1 have the same activities for S. aureus, whereas SF ratio 1.7:1 has the lowest activities.  However for E. coli, all SF ratio gave same results.  For antioxidant activities at 1000 ppm concentration, the highest activity was obtained from SF ratio 2.7:1
ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis Lotulung, Puspa D.N.; Fajriah, Sofa; Sundowo, Andini; Filaila, Euis
Indonesian Journal of Chemistry Vol 9, No 3 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.149 KB) | DOI: 10.22146/ijc.21524

Abstract

The Flavanone compound with anti diabetic activity was isolated from ethyl acetate extract of Artocarpus communis leaves using column chromatography techniques. The structure of the flavanone compound was elucidated on the basic of spectroscopic evidence and comparison to published values. This compound, 8-geranyl-4,5,7-trihydroxyflavone, showed strong anti diabetic activity on α-glucosidase inhibition assay with IC50 18.120 µg mL-1.   Keywords: Artocarpus communis, 8-geranyl-4,5,7-trihydroxyflavone, anti diabetic activity
Aktivitas Antioksidan Senyawa Flavonoid Terprenilasi dari Ekstrak Diklorometana Daun Artocarpus communis LOTULUNG, PUSPA D.N.; FAJRIAH, SOFA; FILAILA, EUIS
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.423 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan senyawa flavonoid terprenilasi dari ekstrak diklorometana daun Artocarpus communis dengan menggunakan uji penangkapan radikal bebas1,1-difenil-2-pikril hidrazil. Ekstrak diklorometana daun Artocarpus communis difraksinasi dengan teknik kromatografi kolom pada silika gel, dan setiap fraksi diuji aktivitasnya. Senyawa aktif, 1-(2,4-dihidroksifenil)-3-[8-hidroksi-2-metil-2-(4-metil-3-pentenil)-2H-1-benzopiran-5-il]1-propanon, menunjukkan aktivitas antioksidan yang moderat dengan IC50 54.6 μg mL-1.
in vitro Antidiabetic, Antioxidant and Cytotoxic Activities of Syzygium cumini Fractions from Leaves Ethanol Extract Artanti, Nina; Maryani, Faiza; Dewi, Rizna Triana; Handayani, Sri; Dewijanti, Indah Dwiatmi; Meilawati, Lia; Filaila, Euis; Udin, Linar Zalinar
Indonesian Journal of Cancer Chemoprevention Vol 10, No 1 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss1pp24-29

Abstract

Ethanol extract of Syzygium cumini (jamblang) leaves reveal its significant α-glucosidase inhibitory activity which perform the potential activity of this plant extract as antidiabetic agent. However, other bioactivities of this plant extract have been reported. The aim of current study was to evaluate the comparison of in vitro antidiabetic, antioxidant and cytotoxic activity of S. cumini fractions. The S. cumini leaves ethanol extract was fractionated by using column chromatography with n-hexane, ethyl acetate and methanol as eluents. Seven fractions were obtained from column chromatography (F1-7). The results showed that the best antidiabetic activity was found in F5 (93% α-glucosidase inhibitory activity), the best antioxidant activity was found in F4 (83% inhibition of DPPH free radical) and the best cytotoxic activity was found in F2 (69% growth inhibition of T47D breast cancer cell line). Therefore besides in vitro antidiabetic activity, fractions of S. cumini leaves ethanol extract also showed antioxidant and cytotoxic activities. Since the results showed that the most active fractions for antidiabetic, antioxidant and cytotoxicity were differed, it could be possible to isolate the different potential active compounds for each activity.Keywords : Syzygium cumini, α-glucosidase inhibitor, DPPH, cytotoxicity