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Faktor Risiko Kejadian Stroke Iskemik pada Penderita Diabetes Mellitus Tipe 2 (Studi Kasus di RSUP Dr Kariadi Semarang) Muliawati, Ratna; Pemayun, Tjokorda Gde Dalem; Hadisaputro, Suharyo; Samekto, Widiastuti; Juliati, Hari Peni
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 1: Februari 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.618 KB) | DOI: 10.14710/j.e.k.k.v1i1.3938

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Background : Stroke is the second leading cause of death and a major cause of long term disability. The prevalence of stroke in type 2 diabetes mellitus patients were increased. Diabetic patients have 3-4 times greater risk for ischemic stroke than non-diabetic. Information regarding risk factors for ischemic stroke in patients with type 2 diabetes mellitus is still limited. This study propose to determine risk factors of ischemic stroke in type 2 diabetes patients.Methods : Observational-analytic with case-control design study and qualitative data. Two groups of patients were include in this study, 48 ischemic stroke patient s with type 2 diabetes mellitus and 48 ischemic stroke without diabetes mellitus in Kariadi hospital, used by consecutive sampling. Data were collected by medical records and indepth interview. Data were analyzed by multiple logistic regression and content analysis.Results : Risk factors of ischemic stroke in patients with type 2 diabetes mellitus are hypertension (OR 5.42; 95% CI 1.40 to 20.93), fasting blood glucose levels ≥ 100 mg/dL(OR=2.72; 95%CI=1.13 to 6.56), and microalbuminuria (OR=10.92; 95%CI= 1.46 to 81.66). Age,sex, working status, cholesterol levels, triglycerid levels, HDL levels, LDL levels, total cholesterol/HDL ratio, triglyceride/HDL ratio, LDL/HDL ratio, and hyperuricemia are not statistically significant as a risk factors of ischemic stroke in type 2 diabetes mellitus patients. Conclusion: Hipertension, fasting blood glucose levels ≥ 100 mg/dL and microalbuminuria are significantly risk factors of ischemic stroke in type 2 diabetes mellitus patients. Microalbuminuria is the most dominant risk factor in stroke patients with type 2 diabetes mellitus.
Faktor Risiko Kejadian Infeksi Cacing Tambang pada Petani Pembibitan Albasia di Kecamatan Kemiri Kabupaten Purworejo Wijaya, Norra Hendarni; Anies, Anies; Suhartono, Suhartono; Hadisaputro, Suharyo; Setyawan, Henry
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 1: Februari 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

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Background : The prevalence of hookworm infection in Indonesia in 2002 - 2006 amounted to 2,4% ; 0,6% ; 5,1% ; 1,6% and 1,0%. No data reports on de-worming of DHO Purworejo. The results of a preliminary study of the month January 2014 shows the proportion of de - worming of 94,1% of the population of farmers plant nursery albasia 51 people, with the proportion of 41,2% hookworm.Methods : This study is observational analytic study with cross-sectional design. The study sample as many as 101 people, with purposive sampling. Samples taken from population studies that met the inclusion criteria (job as Albasia nursery growers, willing as respondent, place of residence in the territory of the district health center Kemiri, aged 18-64 years) and criteria exclusion (habit of consumption of raw vegetables, travel/resettled in a long time, not willing to be made respondents).Results : The proportion of patients with hookworm infection (64,3 %) or 65 people. The risk factors are shown to affect the incidence of hookworm infection among others ; wash feet after work (OR = 4,41), available toilet at work (OR = 3,77), wash hands after work (OR =3,74) and wear footwear when working (OR = 3,56).Conclusion : Several risk factors that influence the incidence of hookworm infection in nursery growers in the district albasia hazelnut is to wash the feet after work, lack of latrines in the workplace, wash hands after work and do not use footwear when working with a probability of 99,03%.
ANALISIS FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEJADIAN KERACUNAN PESTISIDA ORGANOFOSFAT PADA PETANI PENYEMPROT HAMA TANAMAN DI KECAMATAN BULU, KABUPATEN TEMANGGUNG, 2002. Mualim, Khabib; Setiani, Onny; Hadisaputro, Suharyo
Jurnal Kesehatan Lingkungan Indonesia Vol 1, No 2 (2002): OKTOBER 2002
Publisher : Master of Environmental Health Study Program, Faculry of Public Health, Faculty of Public

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ABSTRACT Background : Pesticides spraying which does not follow the regulation, will give many effect to human health. For example, the farmers will be Poisoning Pesticides Poisoning can be found by the examination of the blood cholinesterase activities. The factor that influence to the occurrence of pesticides poisoning are factors from the inside of the human body (internal) and the outside of the human body (external). Based on the result of examination of the farmer?s blood cholinesterase activities  that had been carried on  for four  times, it showed that in year 1994, 58.4% from 65 person were Poisoned; in year 1997, 36.3% from 85 person were Poisoning in year 1999, 30.7% from 80 person were Poisoning, in year 2000, 65.3% from 80 persons were Poisoned. Methods : Research design used case-control study with 104 cases and 104 controls. Risk factors were the  research area,  age, nutritional status, anemia, pesticides processing, using of personal protective equipment, pesticides dose, the number of pesticides used, work duration, spraying duration, spraying frequency, spraying action in the same wind direction, and spraying time. The research was carried on in the  sub district of Bulu, district of Temanggung, Central Java. Results : the number of Poisoning occurences in Pakurejo village are 30.3%, age group of 30 ? 39 years are 30.8%  and  SD Graduation 59.1%. Risk factors that influence to the occurrence of pesticides Poisoning are  nutritional status < 18.5 (OR = 6.78; 95% CI = 2.08 ? 22.62); not properly  pesticides dose (OR = 6.46; 95% Cl = 2.52-16.57); the number of pesticides types ³ 3 types (OR = 5.37; 95% Cl = 2.23-12.92); anemia (OR = 5.03; 95% Cl = 1.54-16.46); spraying frequency ³ 3 times (OR = 4.95; 95% Cl = 2.03-12.7); bad sprying times (OR = 3.94; 95% Cl = 1.70-9.17); age ³ 40 year (OR = 3.83; 95% Cl = 1.64-8.94); sprying action opposites the wind direction (OR = 3.43; 95% Cl = 1.37-8.62); and using of un complete personal protective equipment (OR = 2.83; 95% Cl = 1.19-19.68). Conclusion, nutritional status risk factor < 18.5 is the most influenced risk factor to the occurrence of organophosphate pseticides Poisoning at the sprayer farmers of plant pest. Key Word: Rick factors, Cholinesterease activities, Organophosphate Pesticides poisoning
HUBUNGAN PRODUKSI IFN- DAN IL-4 DENGAN PENGOBATAN STRATEGI DOTS FASE INTENSIF PADA PENDERITA TUBERKULOSIS PARU Indreswari, Sri Andarini; Hadisaputro, Suharyo; Soesatyo, Marsetyawan HNE; Dharmawan, Yudhy
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2008: CONTINUING MEDICAL AND HEALTH EDUCATION (CMHE) | Peran Biomolekuler dalam Penegakan Diagnosis
Publisher : Universitas Muhammadiyah Semarang

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Latar Belakang: Tuberkulosis paru masih menjadi masalah utama di seluruh dunia, terutama di Negara sedang berkembang. Di Indonesia hasil pengobatan dan konversi belum optimal. Banyak penyebab kekurang berhasilan pengobatan ini belum diketahui, khususnya yang berkaitan dengan faktor imunologi. Penelitian ini bertujuan menjelaskan hubungan produksi IFN- dan IL-4 dengan kesembuhan klinis, dalam hal ini terjadinya konversi BTA pasca 2 bulan pengobatan dengan strategi DOTS.Metoda: Rancangan penelitian adalah nested case control, pada penderita baru tuberkulosis paru dengan pemeriksaan sputum BTA positip yang mendapat pengobatan strategi DOTS selama 2 bulan. Kasus adalah penderita yang tidak mengalami konversi pasca 2 bulan pengobatan (BTA tetap positip), sedangkan kontrol adalah penderita yang mengalami konversi pasca 2 bulan pengobatan (BTA menjadi negatip). BTA sebagai hasil pemeriksaan Ziehl Neelsen yang diteruskan dengan tes Niasin. Produksi IFN-dan IL-4 di dalam serum diperiksa dengan metode ELISA. Untuk uji beda rata-rata produksi sitokin antara kasus dan kontrol dilakukan analisis dengan T- test.Hasil: Jumlah sampel 73, diperoleh dari 158 penderita baru berobat jalan yang diikuti selama 2 bulan, terdiri dari 34 kasus (14 diperiksa sitokin) dan 39 kontrol (21 diperiksa sitokin). Penelitian dilakukan di BP4, 12 Puskesmas dan RSUD Kota Semarang. Produksi rata-rata IFN- di dalam serum pasca 2 bulan pengobatan berbeda secara signifikan antara kasus dan kontrol dengan stimulasi PPD 0,5 ug/mL dan PPD 5 ug/mL. Tidak terdapat perbedaan antara kasus dan kontrol pada produksi rata-rata IL-4 dengan semua stimulasi dan tanpa stimulasi.Simpulan: Perbedaan secara signifikan antara kasus dan kontrol pasca 2 bulan pengobatan dalam produksi sitokin (IFN-) bersifat spesifik (hanya dengan stimulasi antigen). Produksi IL-4 tidak terdeteksi kecuali dengan stimulasi PHA, tidak terdapat perbedaan secara signifikan antara kasus dan kontrol.Kata kunci: Tuberkulosis, Interferon-, Interleukin-4, DOTS
PENGARUH KEDALAMAN MENYELAM, LAMA MENYELAM, ANEMIA TERHADAP KEJADIAN PENYAKIT DEKOMPRESI PADA PENYELAM TRADISIONAL Duke, Halena Isrumanti; Widyastuti, Sri Rahayu; Hadisaputro, Suharyo; Chasani, Shofa
Jurnal Kesehatan Masyarakat Indonesia Volume 12. No. 2. Tahun 2017
Publisher : Universitas Muhammadiyah Semarang

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Latar Belakang:Penyakit dekompresi adalah suatu penyakit yang disebabkan oleh pelepasan dan pengembangan gelembung-gelembung gas dari fase larut dalam darah atau jaringan akibat penurunan tekanan dengan cepat di sekitarnya. Faktor-faktor yang diduga meningkatkan dekompresi adalah kedalaman menyelam, lama menyelam, dan anemia.Tujuan :Untuk menjelaskan besarnya pengaruh kedalaman menyelam, lama menyelam, anemia terhadap kejadian penyakit dekompresi pada penyelam tradisional. Metode :Penelitian mix methode desain studi kasus kontrol yang diperkuat dengan  indepth interview ini dilakukan terhadap 46 responden, meliputi 23 kasus (penyelam tradisional penderita penyakit dekompresi) dan 23 kontrol (penyelam tradisional bukan penderita penyakit dekompresi) yang diambil secara purposive sampling. Instrument penelitian adalah  kuesioner wawancara. Analisis data secara univariat, bivariat (chi-square), dan multivariat (logistic regression).Hasil :Kedalaman  menyelam  ? 30 meter (OR = 6,62; 95% CI = 1,059 ? 41,390, p<0.043), lama menyelam ? 2 jam (OR = 61,680; 95% CI = 3,687 ? 1031,93, p<0.004) dan anemia (OR = 14,453, 95% CI = 2,146-97,346, p<0.006) berpengaruh terhadap kejadian penyakit dekompresi.Kesimpulan :Kedalaman  menyelam ? 30 meter, lama menyelam  ? 2 jam, dan anemia berpengaruh terhadap kejadian penyakit dekompresi dengan probabilitas 94,45%.
BEBERAPA FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEJADIAN STROKE NON HEMORAGIK (STUDI KASUS DI STROKE CENTER RUMAH SAKIT KHUSUS DAERAH PROPINSI SULAWESI SELATAN) ., Nildawati; Hadisaputro, Suharyo; Samekto, Widiastuti
Jurnal Kesehatan Vol 7, No 2 (2014): Jurnal Kesehatan
Publisher : Kesehatan Masyarakat UIN Alauddin Makassar

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Stroke non hemoragik masih menjadi masalah kesehatan masyarakat, berkaitan dengan tingginya angka morbiditas, mortalitas dan disability. Data tahun 2009 menunjukkan bahwa jumlah kunjungan Stroke non hemoragik di RS khusus daerah Propinsi Sulawesi Se-latan mencapai 890. Tujuan Penelitian ini adalah untuk mengetahui beberapa faktor risiko yang berpengaruh terhadap kejadian stroke non hemoragik.Metode Case Control Study dimana kasus adalah pasien stroke non hemoragik yang berkunjung di Stroke Center Rumah Sakit Khusus Daerah Propinsi Sulawesi Selatan antara kurun waktu Januari 2011 hingga April 2012, sedangkan kontrol adalah pasien yang pernah dan sedang dirawat inap dari bangsal penyakit dalam, dalam kurun waktu yang sama dengan kelompok kasus. Data diperoleh dari buku register, catatan medis, serta dilakukan indepth interview.Hasil analisis multivariat menunjukkan bahwa faktor risiko yang terbukti berpengaruh terhadap kejadian stroke non hemoragik adalah riwayat penyakit dalam keluarga (p = 0,004, OR = 3,6, 95%CI = 1,5-8,9), kebiasaan mengkonsumsi alkohol/ballo (p = 0,004, OR = 4,9, 95%CI = 1,8-13,3), stressor psikososial (p = 0,050, OR = 2,9, 95%CI = 1,0-7,9), pola perilaku (p = 0,004, OR = 5,1, 95%CI = 1,7-15,7), diabetes mellitus (p = 0,000, OR = 5,6, 95%CI = 2,5-12,9%), penyakit jantung (p = 0,011, OR = 3,7, 95%CI = 1,3-9,9), dan kebia-saan mengkonsumsi daging (p = 0,008, OR = 6,0, 95%CI = 1,5-22,7).Faktor risiko yang terbukti secara signifikan adalah riwayat penyakit dalam keluarga, kebiasaan mengkonsumsi alkohol, stressor psikososial, pola perilaku tipe A, diabates melli-tus, kelainan jantung, serta kebiasaan mengkonsumsi daging. Perilaku hidup sehat dengan tidak mengkonsumsi alkohol, olah raga secara teratur, makan makanan yang sehat dan kon-sumsi kolesterol yang berimbang serta tidak stress merupakan faktor penting untuk mencegah terjadinya stroke non hemoragik.Kata kunci : Stroke Non Hemoragik, Faktor-Faktor Risiko, Kasus Kontrol.
FAKTOR RISIKO LINGKUNGAN KEJADIAN LEPTOSPIROSIS DI JAWA TENGAH (STUDI KASUS DI KOTA SEMARANG, KABUPATEN DEMAK DAN PATI) Riyaningsih, Riyaningsih; Hadisaputro, Suharyo; suhartono, suhartono
Jurnal Kesehatan Lingkungan Indonesia Vol 11, No 1 (2012): April 2012
Publisher : Master of Environmental Health Study Program, Faculry of Public Health, Faculty of Public

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.765 KB) | DOI: 10.14710/jkli.11.1.87-94

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Background : Leptospirosis is zoonotic disease caused by Leptospira bacteria and transmitted to human through contact with animal urine and contaminated environment.The number of cases increased since 2005, particulary Semarang, Demak, and Pati regency. The purpose of this study is to analyze environmental risk factors related to leptospirosis incidence in Central Java. Method : This research was an explanatory research with  observational method using  case control design. The subjects were 60 cases and 60 controls recruted with  inclusion criteria. Diagnosis  of control was based on  clinical diagnosis and examination of blood sample with  Leptotek Lateral Flow. The data was analyzed in univariate, bivariate and multivariate tests using logistic regression. Result : The results of this research found that  physical environmental factors that influenced the incidence of leptospirosis were stagnant water of the ditch (OR = 3.5; 95% CI: 1,282-9,301; p = 0.014) and habit of taking bath  or washing in the river (OR = 7.5; 95% CI: 1.534- 36.185; p = 0.014). Recomendation: It was sugested for Health Departement to control the risk factors of physical environment by cooperating with relevant agencies, especially PROKASIH (Clean River Program). People need to keep cleaning the house and the neighborhood, especially the existence of  pools of water around the house and do not get a shower and take out the trash / dead mouse in a river. Keywords : Leptospirosis, Environment, Risk Factors
Prevention and control of Typhoid fever Hadisaputro, Suharyo
Medical Journal of Indonesia Vol 7 (1998): Supplement 1
Publisher : Faculty of Medicine Universitas Indonesia

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[no abstract available]
FAKTOR HLA-DRB PADA PENDERITA TUBERKULOSIS PARU DENGAN PENGOBATAN STRATEGI DOTS Indreswari, Sri Andarini; Hadisaputro, Suharyo; Soesatyo, Marsetyawan HNE; Handono, Kusworini
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTHLA-DRB factor in pulmonal tuberculosis with DOTS strategic treatmentBackground: Tuberculosis remains one of the world?s greatest public health problems, especially in developing countries. In Indonesia the results of DOTS strategic treatment and conversion have not been fruitful results. Many factors play important roles in the success of DOTS strategic treatment, but a little attention was given to the immuno genetics aspects. This study was aimed at theassociation between HLA-DRB factors and clinical output on DOTS strategic treatment (after first 2 months of treatment):conversion of sputum smear positive.Method: A nested case control study was carried out. The exposure variables were alleles of HLA-DRB (result of PCR examination), while the independent variables were sputum smear positive and negative (result of laboratories examination with Ziehl Neelsen staining, Niacin test). Body mass index (BMI) and sex were confounding variables. Odds ratio (OR) was calculated using bivariate and logistic regression for multivariate analysis.Result: A total sample of 73 new patients with active tuberculosis (sputum smear positive) in developing treatment with DOTS strategic treatment, consist of 34 cases and 39 controls. The odds ratio (OR) of HLA-DRB1*1502 and HLA-DRB5*01 were 3.2 (95%CI: 1.103-9.287). The OR of HLA-DRB1*1201 was 0.305 (95% CI: 0.117-0.798), OR of HLA-DRB3*01 was 0.214 (95% CI: 0.077- 0.592). The PAR (population attributable rate) of HLA-DRB1*1502 and HLA-DRB%*01 were 42.64%. While confounding variables were analyzed, only allele HLA-DRB1*1502 was significant, OR 4.9 (95% CI: 1.234-15.617), the probability was 70.57%.Conclusion: HLA-DRB1*1502 is an allele is a risk factor for the conversion of sputum smear positive after 2 months of treatment.Keywords: Tuberculosis, human leukocyte antigen (HLA)ABSTRAKLatar belakang: Di Indonesia hasil pengobatan  tuberkulosis paru belum optimal. Penyebab kekurangberhasilan pengobatan ini belum diketahui, khususnya yang berkaitan dengan faktor imunogenetika. Penelitian bertujuan menjelaskan hubungan faktor HLADRBdengan kesembuhan klinis, dalam hal ini terjadinya konversi BTA pasca 2 bulan pengobatan dengan strategi DOTS.Metoda: Rancangan penelitian adalah nested case control, pada penderita baru tuberkulosis paru dengan pemeriksaan sputum BTA positif yang mendapat pengobatan strategi DOTS selama 2 bulan. Jenis alel (HLA-DRB) yang ditemukan dengan pemeriksaan PCR dinyatakan sebagai variabel paparan, variabel efek adalah hasil pemeriksaan sputum (BTA) dengan pengecatan Ziehl Neelsen yangditeruskan dengan tes Niacin pasca 2 bulan pengobatan. Sebagai variabel perancu ditetapkan BMI dan jenis kelamin. Analisis dilakukan dengan menghitung rasio odds dengan chi-square dan regresi logistik.Hasil: Jumlah sampel 73, diperoleh dari 158 penderita baru berobat jalan yang diikuti selama 2 bulan, terdiri dari 34 kasus (BTA tetap positif pasca 2 bulan pengobatan) dan 39 kontrol (BTA menjadi negatif). Penelitian dilakukan di BP4, 12 puskesmas dan RSUD di Kota Semarang. Hasil penelitian adalah besar risiko (OR) HLA-DRB1*1502 dan HLA-DRB5*01 untuk tidak terjadinya konversi BTA 3,2 (95% CI: 1,103-9,287). Alel HLA-DRB1*1201 dan alel HLA-DRB3*01 merupakan alel yang bersifat protektifdengan OR 0,305 (95% CI: 0,117-0,798), sedangkan HLADRB3*01 dengan OR 0,214 (95% CI: 0,077-0,592). PAR untuk alel HLADRB1* 1502 dan HLA-DRB5*01 sebesar 42,64%. Apabila variabel perancu dimasukkan dalam analisis, maka hanya alel HLA-DRB1*1502 yang secara signifikan merupakan faktor risiko untuk tidak terjadinya konversi BTA pasca 2 bulan awal pengobatan dengan strategi DOTS. OR 4,9 (95% CI:1,234-15,617). Probabilitas untuk HLA-DRB1*1502 adalah sebesar 70,57%.Simpulan: Alel HLA-DRB1*1502 merupakan faktor risikountuk tidak terjadinya konversi BTA pasca 2 bulanpengobatan, dengan probabilitas cukup besar.
HIPOTIROIDISME PADA WANITA USIA SUBUR (WUS) DI DAERAH PERTANIAN: PENELITIAN DI KECAMATAN KERSANA KABUPATEN BREBES Suhartono, Suhartono; Djokomoeljanto, Sri; Hadisaputro, Suharyo; Subagio, Hertanto Wahyu; Kartini, Apoina
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Background: Hypothyroidism can cause infertility, spontaneous abortion, fetal growth-development disorders, placental abruption and prematurity. Exposure to pesticides, both of organochlorines and organophosphate, can cause hypothyroidism. The aim of the study was to examine the prevalence of hypothyroidism in WCA in agricultural areas.Methods: A cross-sectional study was conducted in two hundred and eight women of WCA who were randomly selected from four villages and TSH levels were examined. The TSH cut-off point for the diagnosis of hypothyroidism was ?4.5 ?IU/mL. In a sub-sample, fT4 levels, UEI and thiocyanate in urine, were also examined. Result: The mean level of TSH was 3.66 (±5.330) ?IU/mL, the lowest value was 0.05, and the highest was 60 µIU/mL; the median was 2.38 ?IU/mL; the mean FT 4 (n=89) was 16.207±3.0438 pmol/L; UEI median value (n=41) was 288.0 mcg/L; while the mean of urinary thiocyanate levels (n=41) was 1.468±1.25 mcg/mL. There were 47 WCA (22,6%) with hypothyroidism, 46 of which (97.9%) are sub-clinical hypothyroidism.Conclusion: The prevalence of hypothyroidism in WCA was 22.6% and almost all women had sub-clinical hypothyroidism. Pesticide exposure is suspected as a risk factor for hypothyroidism in this population.ABSTRAKLatar belakang: Hipotiroidisme merupakan keadaan, di mana kelenjar tiroid tidak dapat memproduksi hormon cukup untuk memenuhi kebutuhan tubuh. Pada WUS, hipotiroidisme dapat menyebabkan infertilitas, abortus spontan, gangguan tumbuh-kembang janin, placental abruption dan bayi lahir sebelum waktunya. Pajanan pestisida, baik dari golongan organoklorin maupun organofosfat, dapat menyebabkan hipotiroidisme. Penelitian ini bertujuan mengkaji berapa besar prevalensi hipotiroidisme pada WUS yang bertempat tinggal di daerah pertanian.Metode: Penelitian ini menggunakan desain cross-sectional. 208 WUS dipilih secara acak dari empat desa dan dilakukan pemeriksaan kadar TSH. Diagnosis hipotiroidisme ditegakkan berdasarkan kadar TSH ?4,5 µIU/mL. Pada sebagian WUS (sub-sampel) dilakukan pemeriksaan kadar fT4, UEI dan kandungan tiosianat dalam urin. Hasil: Rerata kadar TSH adalah 3,66 (±5,330) µIU/mL, nilai terendah 0,05, nilai tertinggi 60 µIU/mL sedangkan median TSH 2,38 µIU/mL; rerata fT 4 (n=89) adalah 16,207±3,0438 pmol/L; nilai median UEI (n=41) adalah 288,0 µg/L; rerata kadar tiosianat urin (n=41) adalah 1,25±1,468 µg/mL. Didapatkan 47 WUS (22,6%) dengan hipotiroidisme, 46 di antaranya (97,9%) adalah hipotiroidisme sub-klinik.Simpulan: Prevalensi hipotiroidisme pada WUS sebesar 22,6%, hampir semuanya hipotiroidisme sub-klinik. Pajanan pestisida patut dicurigai sebagai faktor risiko pada WUS di daerah pertanian yang diteliti ini.
Co-Authors Ag Soemantri Agus Suwandono Agustie, Panglukies Ratna Agustinus Soemantri Alamsyah, Dedi Amelia, Maria Ani Margawati Anies Anies Anwar, M.Choirul Apoina Kartini Ardiani, Hanifah Ari Budi Himawan Ari Suwondo Arianto, Mostang Ariyanto Ariyanto Asmawariza, Lalu Hersika Asril Aminullah Astuti, Ismi Puji Awan Hariyanto, Awan Bagoes Widjanarko Banundari Rachmawati Budi Laksono Budi Palarto Chasani, Sofa Diana Diana Diki Retno Yuliani, Diki Retno Diyah Fatmasari Djamaluddin Ramlan, Djamaluddin Djokomoeljanto Djokomoeljanto Djokomoeljanto, Sri Duke, Halena Isrumanti Duke, Halena Isrumanti Dwi Pudjonarko Estiyani, Arum Fajri, Umi Nur Fara, Yetty Dwi Fatmasari, Dyah Gautama, Mada Hadi Hadi Hamdan, Yusuf Lensa Hamdan, Yusuf Lensa Harfaina, Harfaina Hasriyani Hasriyani, Hasriyani Henry Setyawan, Henry Heri Nugroho Herry Poernomo Hertanto Wahyu Subagio Ikawati, Kartika Imam Djamaluddin Mashoedi Iskandar, Arif Iswari Setianingsih Juliati, Hari Peni Kabulrachman Kabulrachman Kamilah Budhi Kamilah Budhi Rahardjani, Kamilah Budhi Khabib Mualim, Khabib Kristiyanto, Stanislaus Kumala, Ferry Kun Aristiati Susiloretni, Kun Aristiati Kurniati Puji Lestari Kurniawati, Erna Yovi Kusworini Handono Lestaringsih, Lestariningsih Lestariningsih Lestariningsih Lintang Dian Saraswati Lukmono, Djoko Trihadi Lukmono, Djoko Trihadi M. Sholeh Kosim Maharani, Yennita Mardiyono Mardiyono Maria Mexitalia Marsetyawan HNE Soesatyo Martini Martini Martinus, Ishak Mashoedi, Imam D Mashudi, Imam Djamaludin Mateus Sakundarno Adi, Mateus Sakundarno Mateus Sakundarno, Mateus Meilantika, Ayu Diana Meilantika, Ayu Diana Meiwarnis, Resna Melyana Nurul Widyawati Mexitalia Setiawati Moedrik Tamam Muchlis Achsan Udji Sofro Muliawati, Ratna Muliawati, Ratna Munasik Munasik N. P. Noerpramana, N. P. Nildawati . Nugroho, Rakhamanto Wahyu Nur Djanah, Nur Oktaviarini, Eka Oktaviarini, Eka Olys, Olys Onny Setiani Pariaribo, Konstantina Parwati, Desak Made Wenten Pramukarso, Dodik Tugasworo Prasetya, Dias Irawan Prihananto, Dhian Ika Projosudjadi, Wiguno Pujiastuti, Rr. Sri Endang Pujiastuti, Rr. Sri Endang Resmi, Dewi Candra Resty Ryadinency Rina Rina Rini Astuti Rini, Sulistio Riyaningsih Riyaningsih Roesipin, Sri Wahyuningsih RRJ. Sri Djokomoeljanto Runjati Runjati, Runjati Sakundarno Adi, Sakundarno Samekto, Marek Sandra, Tuti Sari, Gracilaria Puspa Selamat Budijitno Seno, Heri Nugroho Hario Shofa Chasani Siti Musyarofah, Siti Siti Patimah Soejoenoes, Ariawan Sofro, Muchlis AU Sofro, Muchlis AU Sri Achadi Nugraheni Sri Andarini Indreswari Sri Rahayu Sri Wahyuningsih Sugianto Sugianto Sugiri, Sugiri Suhartono Suhartono Sumini Sumini, Sumini Supriharti, Supriharti Suprihati Suprihati Supriyadi - Supriyana Supriyana, Supriyana Suratman Suratman Suryani Suryani Suryosaputro, Antono Sutaryo Sutaryo Sya’bani, Mochamad Thaariq, Nurul Aziza Ath Titi Suherni Tjokorda Gde Dalem Pemayun Triana Sri Hardjanti, Triana Sri Ulkhasanah, Muzaroah Ermawati Widiastuti Samekto Widyastuti, Sri Rahayu Widyastuti, Sri Rahayu Wijaya, Norra Hendarni Wiwoho, Fadjar Harry Yudhy Dharmawan Yulaeka, Yulaeka Yusuf, Nuuva Zain, Sidartani Zuhdan, Elhamangto