Mark T Hamman
Department of Pharmacognosy, Faculty of Pharmacy, Mississippi University

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STRUCTURE ELUCIDATION OF BIOACTIVE ALKALOID COMPOUNDS ISOLATED FROM SPONGE Petrosia sp COLLECTED FROM BUNAKEN BAY MENADO Alam, Gemini; Astuti, Puji; Wahyuono, Subagus; Sari, Dinar; Hamman, Mark T
Indonesian Journal of Chemistry Vol 5, No 2 (2005)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1932.788 KB) | DOI: 10.22146/ijc.21828

Abstract

Two alkaloid compounds have been isolated from sponge Petrosia sp collected from Bunaken Bay Menado. These compounds have been found to inhibit several human cancer cell proliferation in vitro. Structure elucidation is needed to further characterize these bioactive compounds. The structure is determined by analyzing Ultra Violet (UV), Infra Red (IR), Mass Spectra (MS) and Nuclear Magnetic Resonance (NMR) spectra. Based on spectroscopic data, Thin Layer Chromatography (TLC) co-chromatograph with authentic samples and comparison with reported data the two compounds were identified as Manzamine A and 8-OH Manzamine A, respectively. Keywords: Manzamine A, 8-OH Manzamine A, Petrosia sp, stucture elucidation