Budi Handono
Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

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Karakteristik Luaran Kehamilan Dengan Ketuban Pecah Dini Di Rsup Dr. Hasan Sadikin Periode Tahun 20132015 Abrar, Nazila Maghfiratul; Handono, Budi; Triyanti, Gita Indah
Jurnal Sistem Kesehatan Vol 2, No 4 (2017): Volume 2 Nomor 4 Juni 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.993 KB) | DOI: 10.24198/jsk.v2i4.12499

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Ketuban Pecah Dini merupakan salah satu permasalahan obstetrik dan merupakan faktor yang menyebabkan morbiditas dan mortalitas perinatal. 4,5%-7,6% dari seluruh kehamilan di Indonesia mengalami ketuban pecah dini. Penelitian ini bertujuan untuk mengetahui karakteristik luaran kehamilan dengan ketuban pecah dini. Penelitian deskriptif kuantitatif dengan teknik pengambilan data cross sectional yang telah dilakukan sejak bulan Oktober sampai November 2016. Data diambil dari rekam medis pasien ketuban pecah dini di RSUP Dr. Hasan Sadikin tahun 2013-2015. Pengambilan sampel menggunakan metode total sampling dan didapatkan sampel sebanyak 483. Ketuban pecah dini ≥37 minggu kehamilan terjadi 13,9% dari seluruh persalinan. Terjadi paling banyak pada wanita dengan rentang usia 20-35 (77,8%), dan multipara (54,4%). Luaran kehamilan pada ibu paling banyak terdapat hipertensi gestasional yaitu 3,9% pada ketuban pecah dini <6 jam dan 4,3% pada ketuban pecah dini ≥6 jam. Luaran bayi terdapat kejadian asfiksia sedang sebesar 2,6% pada ketuban pecah dini <6 jam dan 5,3% pada ketuban pecah dini ≥6 jam. Karakteristik luaran kehamilan pada ibu dengan ketuban pecah dini adalah tertinggi pada usia 20-35, multipara, dan terdapat kejadian hipertensi gestasional, sementara luaran bayi adalah terdapat asfiksia sedang, dan tidak ada infeksi.Kata Kunci: infeksi neonatus, ketuban pecah dini, luaran kehamilan, tanda vital
PERBANDINGAN KERAPATAN KOLAGEN LIGAMENTUM SAKROUTERINA PADA PASIEN DENGAN DAN TANPA PROLAPS UTERI Silitonga, Intan Renata; Sukarsa, M. Rizkar A.; Pohan, Lasma R.; Armawan, Edwin; Handono, Budi
Majalah Kedokteran Bandung Vol 47, No 4 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Kerapatan kolagen merupakan satu faktor penting dalam kejadian prolaps uteri. Beberapa penelitian menunjukkan pasien prolaps uteri mempunyai kerapatan kolagen ligamentum sakrouterina yang rendah. Penelitian ini bertujuan mengukur perbedaan kerapatan kolagen ligamentum sakrouterina pada pasien dengan dan tanpa prolaps uteri. Penelitian ini adalah penelitian analitik komparatif dengan case control study terhadap 16 pasien prolaps uteri dan 16 pasien tanpa prolaps uteri di Rumah Sakit Dr. Hasan Sadikin Bandung dan RS jejaring. Bahan penelitian diambil dari ligamentum sakrouterina saat operasi histerektomi lalu dibuat sediaan dengan pewarnaan hematoksilin-eosin dan Masson?s trichrome. Uji kemaknaan menggunakan uji Mann-Whitney. Hasil penelitian didapatkan hubungan bermakna antara kerapatan kolagen dan kejadian prolaps uteri, yaitu kerapatan kolagen pada pasien prolaps uteri lebih rendah (15,3%) dibanding dengan tanpa prolaps uteri (48,75%). Cut-off point kerapatan kolagen ligamentum sakrouterina untuk prediksi prolaps uteri adalah ? 30%; sensitivitas 93,8%; spesifisitas 87,5%; dan akurasi 90,6%. Simpulan penelitian ini adalah bahwa kerapatan kolagen ligamentum sakrouterina pada pasien prolaps uteri lebih rendah dibanding dengan pasien tanpa prolaps uteri. Cut-off point kerapatan kolagen ligamentum sakrouterina yang dapat memprediksi prolaps uteri adalah ? 30%. [MKB. 2015;47(4):212?7]Kata kunci: Kerapatan kolagen, ligamentum sakrouterina, prolaps uteriThe Comparison of Uterosacral Ligament Collagen Density in Patients with and without Uterine ProlapseAbstractCollagen density is one important factor in uterine prolapse. Several studies has shown that uterine prolapse patients have lower uterosacral ligament collagen density. The purpose of this study was to reveal the uterosacral ligament collagen density differences in patients with and without uterine prolapse. This case control study was an analitic comparative research of 16 uterine prolapse patients and 16 patients without uterine prolapse who underwent hysterectomy in Dr. Hasan Sadikin General Hospital Bandung and its networking hospitals during November?December 2008. Uterosacral ligament was sampled and then stained using HE and Masson?s trichrome staining. The significance of the result was analyzed using Mann-Whitney. The study found a significant correlation between collagen density and uterine prolapse, with the collagen density of uterine prolapse patients was lower (15.3%) than patients without uterine prolapse (48.75%). The uterosacral ligament collagen density cut-off point in predicting women having uterine prolapse was ?30%; with 93.8% sensitivity, 87.5% specificity, and 90.6% accuracy. The conclusion of this study is that uterosacral ligament collagen density in patients with uterine prolapse is lower (15.3%) than patients without uterine prolapse (48.75%). The uterosacral ligament collagen density cut-off point in predicting a women having uterine prolapse is ?30%. [MKB. 2015;47(4):212?7] DOI: 10.15395/mkb.v47n4.624
Rasio Low Density Lipoprotein dan High Density Lipoprotein pada Preeklamsi Berat dibandingkan dengan Kehamilan Normal di Rumah Sakit Dr. Hasan Sadikin Bandung Amrullah, Amran; Handono, Budi; Pramatirta, Akhmad Yogi
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstractObjective: This study aims to distinguish level of  (LDL/HDL)  and Low Density Lipoprotein/High Density Lipoprotein  ratio in severe preeclampsia patient compared to normal pregnancy.Method:  The study design was comparative cross-sectional study with consecutive sampling method that compared the laboratory results of LDL, HDL and ratio LDL/HDL that met the inclusion criteria. Subjects of this study were severe preeclampsia and normal pregnancy patient that fulfilled the inclusion criteria (n=60) in Dr. Hasan Sadikin General Hospital Bandung during August-September 2017.Result: It is revealed that the differences in level of LDL and LDL/HDL ratios in both groups were significant with p value ≤ 0,05. But there were no differences in HDL level. Increased level of LDL/HDL ratio in pregnancy was related to increased risk of preeclampsia with cut-off point> 2,632. If the increased level of LDL/HDL above cut-off point then the insident of severe preeclampsia increased 21,36 times.Conclusion: It was concluded that level of LDL and LDL/HDL ratios in severe preeclampsia were higher than in normal pregnancy. The increased LDL/HDL ratio of > 2.632 increased the risk of severe preeclampsia by 21.36 times.Key words: Preeclampsia, LDL, HDL, LDL/HDL ratioAbstrakTujuan: Penelitian ini adalah untuk mencari perbedaan rasio Low Density Lipoprotein/High Density Lipoprotein (LDL/HDL) pada preeklamsi berat dibandingkan dengan kehamilan normal sebagai faktor risiko timbulnya preeklamsi.Metode: Rancangan penelitian kasus kontrol membandingkan LDL, HDL, dan rasio LDL/HDL penderita preeklamsi berat dan kehamilan normal (n=60) bulan Agustus-September 2017 di Rumah Sakit Dr. Hasan Sadikin Bandung.Hasil: Hasil penelitian didapatkan perbedaan kadar LDL dan rasio LDL/HDL pada kedua kelompok secara bermakna dengan nilai p ≤0,05. Namun tidak didapatkan perbedaan yang bermakna pada kadar HDL. Peningkatan kadar LDL dan rasio LDL/HDL berhubungan dengan peningkatan risiko terjadinya preeklamsi dengan nilai cut-off > 2,632. Bila terjadi peningkatan rasio LDL/HDL diatas nilai cut-off maka risiko tejadinya preeklamsi berat sebesar 21,36 kali.Simpulan: Kadar LDL yang tinggi dan nilai cut-off rasio LDL/HDL >2,632 meningkatkan risiko terjadinya preeklamsi berat 21,36 kaliKata Kunci: Preeklamsi, LDL, HDL, Rasio LDL/HDL
PENGARUH PEMBERIAN VITAMIN D3 TERHADAP KADAR REACTIVE OXYGEN SPECIES (ROS) PADA SEL PHM1-41 YANG MENGALAMI HIPOKSIA Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Setiabudiawan, Budi; Handono, Budi
Majalah Kedokteran Bandung Vol 50, No 3 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n3.1408

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Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini menjadi permasalahan di seluruh dunia. Salah satu mekanisme patofisiologis yang menyebabkan kelahiran kurang bulan adalah aktivitas sumbu hipotalamus-pituitari-adrenal (HPA) pada ibu dan janin. Stres maternal biologis berupa hipoksia merupakan salah satu penyebab terjadi mekanisme kelahiran kurang bulan melalui jalur aktivasi sumbu HPA ibu dan sebagai respons terhadap reactive oxygen species (ROS).  Vitamin D3 sebagai salah satu sumber ion Ca2+ dibutuhkan untuk mekanisme kontraksi dan relaksasi otot halus miometrium. Selain itu, vitamin D diduga berpengaruh terhadap kerja sumbu HPA. Tujuan penelitian ini adalah mengetahui pengaruh penambahan vitamin D3 pada sel lini PHM1-41 yang menjadi model in vitro dari kontraksi miometrium pada ibu hamil yang mengalami stres hipoksia terhadap kadar ROS intraseluler sel PHM1-41. Penelitian dilakukan di Laboratorium penelitian Aretha Medika Utama, Biomolecular and Biomedical Research Centre dengan kurun waktu penelitian dari bulan Desember 2017 hingga Februari 2018. Sel PHM1-41 yang telah dikultur dengan keadaan hipoksia selama 24 jam diberi penambahan vitamin D3, kemudian diukur kadar ROS intraselulernya. Hasil menunjukkan bahwa kadar ROS menurun signifikan pada kelompok sel yang diberi penambahan vitamin D3 dengan konsentrasi 150 nM dibanding dengan kelompok sel kontrol hipoksia. Hal ini menunjukkan  bahwa penambahan vitamin D3 150 nM memiliki potensi mencegah kelahiran kurang  bulanEffects of Vitamin D3 Treatment on Reactive Oxygen Species (ROS) Level in PHM1-41 Cell Line Experiencing HypoxiaPreterm birth is one of the major global cause of perinatal mortality. One of the pathophysiologic mechanisms leading to preterm birth is the Hypothalamic-Pituitary-Adrenal (HPA) axis activity of mother and fetus.. Maternal biological stress, such as hypoxia condition, is one of the trigger  of preterm birth through the activation of HPA axis as a response to the reactive oxygen species (ROS). Vitamin D3 as a source of Ca2+ ion is needed for myometrium smooth muscle?s contraction and relaxation mechanism. Vitamin D is also thought to strongly influence the HPA axis?s work. The purpose of this study was to determine the effect of  vitamin D3 provisionon PHM1-41 cell line induced by hypoxia as an  of pregnant women?s myometrium contraction through assessment of intracellular ROS level in PHM1-41 cell lines. This study was conducted in Aretha Medika Utama Biomolecular and Biomedical Research Centre from December 2017 to February 2018. PHM1-41 cells were cultured for 24 hours in hypoxia condition,Vitamin D3 was then added and the level of intracellular ROS was measured. Results showed that the ROS level decreased in cell clusters receiving 150nM vitamin D3 when compared to control hypoxia cell cluster. This indicates that the provision of 150nM vitamin D3 potentially prevents preterm  labor incidents.  
MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy Suryawan, Aloysius; Mose, Johanes C; Handono, Budi
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.178

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BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion.METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%.SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy
Penggunaan Magnesium Sulfat untuk Menurunkan Angka Kejadian Cerebral Palsy pada Bayi Prematur Matondang, Herry Aktyar; Effendi, Jusuf Sulaeman; Handono, Budi; Kurniadi, Andi
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstrakLatar belakang: Magnesium Sulfat merupakan senyawa kimia yang sudah banyak terbukti manfaatnya pada kehamilan. Selain digunakan sebagai obat anti kejang, dan obat tokolitik pada kontraksi prematur, magnesium sulfat berperan banyak pada proses intraseluler, diantaranya sebagai agen vasodilator pembuluh darah otak, menurunkan reaksi inflamasi, seperti sitokin dan zat radikal bebas, serta mencegah masuknya ion kalsium kedalam sel.  Prematuritas merupakan masalah serius karena hampir sebagian besar dari neonatus yang berhasil hidup akan mengalami kecacatan neurologis kongenital termasuk cerebral palsy (CP).Metode: Analitik korelatif dengan desain cross sectional. Subjek penelitian adalah pasien dengan diagnosa cerebral palsy yang melakukan pemeriksaan ke Rumah Sakit Dr. Hasan Sadikin Bandung, dengan riwayat lahir prematur. Pengambilan sampel menggunakan teknik accidental sampling dengan jumlah total sampel 30 pasien. Analisis data secara statistik menggunakan uji Chi-square.  Hasil: Penelitian menunjukkan 7 (23,3%) pasien anak dengan diagnosa cerebral palsy memiliki riwayat ibu hamil dengan pemberian magnesium sulfat (MgSO4), dan 23 (76,6%) pasien dengan diagnosa cerebral palsy memiliki riwayat ibu hamil tanpa pemberian magnesium sulfat (MgSO4). Hasil analisa data dengan menggunakan uji Chi-square  didapatkan ρ-value 0,001< α = 0,05.Kesimpulan: Terdapat hubungan yang signifikan dari pemberian magnesium sulfat pada ibu hamil terhadap angka kejadian cerebral palsy pada bayi prematur di Rumah Sakit Hasan Sadikin Bandung.Kata kunci: magnesium sulfat, persalinan prematur, bayi prematur, cerebral palsyThe Used of Sulfate Magnesium  to Reduce Incidence of Cerebral Palsy on Preterm BirthAbstractObjective: Magnesium Sulfate is a chemical compound that has been widely used in pregnant women and has proven benefits to the condition of pregnancy.  Prematurity is a serious problem because most of the successful neonates will experience congenital neurological disability including cerebral palsy (CP).Methods: This research is a kind of analytic correlative research with cross sectional design. The research subjects were pediatric patients with a diagnosis of cerebral palsy who performed the examination at Hasan Sadikin Hospital Bandung, with a history of premature birth. Samples were taken by purposive sampling technique with a total number of samples 30 patients. Statistical analysis using Chi-square statistical test.Result: The result of this research showed 7(23,3%) pediatric patients with a diagnosis of cerebral palsy had a history of pregnant women with administration of magnesium sulfate (MgSO4), and 23(76,6%) patients with a diagnosis of cerebral palsy has a history of pregnant women without administration of magnesium sulphate (MgSO4). The data were analyzed using Chi-square test and obtained ρ-value 0,001 <α = 0,05.Conclusion: There is a significant relationship between administration of magnesium sulfate in pregnant women and the incidence of cerebral palsy in premature infants at Hasan Sadikin Hospital Bandung.Keywords: magnesium sulfate, preterm birth, premature infants, cerebral palsy
CORRELATION BETWEEN FMS-LIKE TYROSINE KINASE-1 (SFLT-1) CELL-FREE MESSENGER RNA EXPRESSION AND FMS-LIKE TYROSINE KINASE-1 (SFLT-1) PROTEIN LEVEL IN SEVERE PREECLAMPSIA AND NORMAL PREGNANCY Gurnadi, Jeffry Iman; Mose, Johanes Cornelius; Handono, Budi; Fauziah, Prima Nanda; Pramatirta, Akhmad Yogi
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : International Journal of Integrated Health Sciences

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Objective: Preeclampsia is still a problem in Indonesia due to the high maternal and neonatal morbidity and mortality. Placental soluble fms-like tyrosine kinase-1 (sFlt-1), an antagonist of vascular endothelial growth factor (VEGF), and placental growth factor (PIGF), is considered as one of the etiology factors that cause endothelial damage in preeclampsia due to increased sFlt-1 level modulating vascular endothelial integrity. This study aims to analyze sFlt-1 and sFlt-1 mRNA levels in severe preeclampsia and normal pregnancy, and the correlation between both in occurrence of severe preeclampsia.Methods: This is a cross-sectional analytic observational study involving 18 subjects with severe preeclampsia and 19 subjects with normal pregnancy as controls who met inclusion and exclusion criteria. Levels of sFlt-1 and sFlt-1 mRNA were measured with ELISA and RT PCR. Statistical analysis was performed with Chi square test, Fisher?s exact test, T-test, Mann-Whitney test, and Spearman?s rank correlation test.Results: This study showed no significant difference (p>0.05) in characteristics of maternal age, gestational age, and parity in both study groups. Mean level of sFlt-1 mRNA in severe preeclampsia was higher (6.3404 pg/mL) compared to its level in normal pregnancy (5.9701 pg/mL). There is a not significant (p>0.05) positive correlation between sFlt-1 mRNA with sFlt-1 level in normal pregnancy, and a not significant (p>0.05) negative correlation between both level in severe preeclampsia.Conclusions: sFlt-1 mRNA levels in severe preeclampsia are higher than its level in normal pregnancy. There is no correlation between sFlt-1 mRNA level and sFLt-1 protein level in severe preeclampsia. There is a not significant positive correlation between sFlt-1 mRNA with sFlt-1 level in normal pregnancy, and a not significant negative correlation between both in severe preeclampsia.Keywords: Normal pregnancy, severe preeclampsia, sFlt-1 mRNA DOI: 10.15850/ijihs.v3n2.586
LAPORAN KASUS: Eksensefali sebagai Salah Satu Komplikasi Amniotic Band Syndrome Sri Prajanta Putri, Dewi Maharsita; Susiarno, Hadi; Handono, Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstrakAmniotic band syndrome(ABS) merupakan kelainan non genetik dengan spektrum luas dari  konstriksi dan amputasi sederhana pada jari ekstremitas hingga kelainan kraniofasial mayor hingga defek visera bahkan kematian. Beberapa laporan kasus menyebut anensefali merupakan contoh defek kraniofasial yang dihubungkan dengan ABS. Sonografi membantu diagnosis eksensefali sebagai kondisi peralihan menuju kondisi terminal anensefali sebagai kondisi yang lebih sering ditemukan yaitu kondisi otak janin sudah habis teresorbsi oleh cairan serebrospinal. Fetus dengan eksensefali tidak dapat bertahan hidup, sebagian besar berakhir dengan abortus, intrauterine fetal death dan stillbirth sehingga jika terdeteksi perlu dipertimbangkan untuk dilakukan terminasi kehamilan. Berdasar laporan kasus persalinan spontan Bracht di kamar bersalin RS Hasan Sadikin pada 1 Desember 2016, Ny RA 33 tahun, G3P1A1 gravida 30-31 minggu, letak sungsang, eksensefali, anemia. Pada laporan kasus ini ditemukan membran amniotik berfusi dengan kranium bayi dan absennya tulang tengkorak pada tempat perlekatan membran amnion.  Eksensefali pada kasus ini diperkirakan diawali oleh residu selaput korion berupa jaringan fibrosa yang membentang cavum korionik dan menekan kranium sehingga migrasi membran neurokranium tergganggu dan berakhir dengan akalvaria. Ekstremitas yang berkembang sempurna namun cacat pada beberapa segmen terutama tempat perlekatan membran amnion dan kranium  sesuai letak kejadian cincin konstriksi mendukung teori Torpin. Kata kunci: amniotic band syndrome; acrania Exencephaly as One of Amniotic Band Syndrome ComplicationAbstractAmniotic Band Syndrome includes a spectrum of non-genetic anomalies, varying from simple digital band constriction to major craniofacial and visceral defects, and even fetal death. Anencephaly represents the most common neural tube defect. Sonographic as well as pathologic evidence points to a close link between exencephaly (also frequently referred to as “acrania”) and anencephaly. It has been proposed that the brain tissue of exencephalics may gradually degenerate due to the exposure to amniotic fluid in combination with mechanical trauma. ABS is an aetiological factor in exencephaly. Appropriate counselling for affected families needs to be given after prenatal diagnosis. Based on medical report Mrs RA 33 years old , G3P1A1 30-31 weeks of pregnancy, breech presentation, exencephaly, anemia that delivered her baby on Delivery Room Hasan Sadikin General Hospital at December 1,2016.Amniotic membrane found  fused with fetal cranium and on its attachment found that the cranium was absent (acrania) In the case reported here, the amniotic membrane was well fused to the scalp, and skull bones were absent on the site of attachment of the amniotic membrane. This case supports Torpin’s hypothesis of early amnion rupture, with failure of the cranial bones to develop at the site of attachment of the amniotic band as “early amnion disruption sequence.”. The fibrous strands would entangle and entrapped the fetal head, resulting in faulty migration of the membranous neurocranium which leads to exencephaly on this case. Keywords: Amniotic band syndrome; exencephaly
Perbandingan Faktor Determinan, Morbiditas dan Mortalitas Ibu dan Bayi Preeklamsi di Rumah Sakit Hasan Sadikin Bandung Periode Sebelum dan Saat Program Jaminan Kesehatan Nasional Dilaksanakan Leha, Irene; Mose, Johanes C; Handono, Budi; Anwar, Anita Deborah; Zulvayanti, Zulvayanti; Syam, Hanom Husni
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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AbstrakTujuan: Mencari perbedaan faktor determinan (karakteristik dan faktor risiko), morbiditas dan mortalitas ibu dan bayi dalam kasus preeklamsi pada periode sebelum dan saat program Jaminan Kesehatan Nasional dilaksanakan.Metode: Rancangan penelitian ini adalah studi cross-sectional terhadap data sekunder untuk menganalisis karakteristik faktor risiko, morbiditas dan mortalitas pada kejadian preeklamsi di RSUP Dr. Hasan Sadikin antara periode Maret−September 2012−1 Januari 2016−31 Desember 2017. Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Februari−Mei 2018.Hasil: Didapatkan perbedaan yang bermakna (p<0,05) pada(usia, pasien, indikator, antenatal care, dan penyakit-penyakit)  subjek penelitian. Didapatkan peningkatan angka seksio sesarea pada kasus preeklamsi (p<0,001). Tidak ditemukan perbedaan yang bermakna pada angka kematian ibu dengan kasus preeklamsi (p=0,366). Tidak terdapat perbedaan yang bermakna pada hasil luaran perinatal pada subjek penelitian dari segi skor APGAR, kejadian stillbirth dan kematian neonatal dini.Simpulan: Pada periode saat program JKN dilaksanakan terdapat perbedaan karakteristik dan faktor risiko ibu preeklamsi, serta terdapat peningkatan angka seksio sesarea. Tidak didapatkan perbedaan angka mortalitas ibu dan luaran (morbiditas dan mortalitas) bayi.Kata kunci: preeklamsi, Jaminan Kesehatan Nasional, luaran ibu dan bayiAbstractObjective: To distinguish determinant factors (characteristics and risk factors), maternal and neonatal morbidity and mortality in preeclampsia cases in periods before and when the National Health Insurance program was implemented. Method: The study design is cross sectional analyticstudy  by taking the data from medical record to analyze the determinant factor (characteristics and risk factors), morbidity and mortality of preeclampsia at Dr. Hasan Sadikin General Hospital Bandung on March−September 2012 and January 2016−December 2017. This study was conducted in Dr. Hasan Sadikin General Hospital Bandung during February-May 2018.Results: There is a significant difference (P<0.05) in characteristics and risk factor subject of research in terms of age, gestational age, parity, educational degree,  ANC, a history of hypertension and cardiovascular disorder. There is an incrising of cesarean section rate on preeclampsia cases (p<0.001).There is no  significant difference in maternal mortality and perinatal outcomes (APGAR score, stillbirth and early neonatal death). Conclusion: There are differences in determinant factor (characteristics and risk factors) preeclampsia when the National Health Insurance program was implemented. There was no difference in maternal mortality and perinatal outcomes.Key words: preeclampsia, National Health Insurance, maternal and perinatal outcome
Faktor-faktor yang Mempengaruhi Perempuan Usia Reproduksi dalam Mencari Bantuan Penanganan Inkontinensia Urin di Rumah Sakit Hasan Sadikin Bandung Gazali, Indra; Purwara, Benny Hasan; Armawan, Edwin; Effendi, Jusuf Sulaeman; Handono, Budi; Susiarno, Hadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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Abstract

AbstrakTujuan: Inkontinensia urin merupakan kondisi yang sering dialami wanita. Meskipun demikian, hanya kurang dari setengah wanita dengan gejala tersebut yang berkonsultasi ke dokter mengenai inkontinensia, dan faktor penentu dalam pengobatan tidak dipahami dengan baik. Penelitian ini bertujuan untuk mengetahui dan menganalisis apakah faktor pengetahuan, budaya, pendidikan, dan penghasilan memengaruhi pasien inkontinensia urin tidak berobat ke rumah sakit, serta mengetahui faktor yang paling dominan dan alasan-alasan pasien inkontinensia urin tidak berobat ke rumah sakit.  Metode: Jenis penelitian ini adalah metode kombinasi (mixed methods) dengan desain penelitian cross sectional atau potong lintang. Sampel pada penelitian ini berjumlah sebanyak 70 pasien menderita inkontinensia urin. Adapun pasien yang diwawancarai adalah sebanyak 10 orang pasien atau informan. Hasil: Penelitian kuantitatif pada variabel faktor pendidikan dan faktor penghasilan, hasil analisis Kolmogorov test terlihat nilai P>0.05. Pada variabel faktor pengetahuan dan faktor budaya, hasil analisis Kolmogorov test terlihat nilai P<0.05 Kesimpulan: Penelitian kuantitatif dari empat faktor yang berpengaruh adalah variabel faktor pengetahuan dan budaya, sedangkan yang paling berpengaruh adalah variabel faktor budaya, Pada hasil penelitian kualitatif diketahui bahwa faktor pengetahuan dan budaya paling banyak berpengaruh, hal ini dikarenakan pengetahuan responden tentang inkontinensia urin sangat kurang serta rasa malu pada diri responden apabila ada orang lain yang mengetahui mengenai inkontinensia urin yang dideritanya. Kata kunci : Inkontinensia urin, faktor pengetahuan, faktor budaya, faktor pendidikan, faktor penghasilan. AbstractObjective: Urinary incontinence is a highly prevalent and burdensome condition among women. However, fewer than half of women with symptoms talk to a physician about incontinence. The factors, including knowledge, culture, education, and income, the most dominant factor influence anf the reason  patient of urinary incontinence not to go to hospital.Method: The method used in this research is mixed methods with cross sectional research design. The sample amounted to 70 patients suffering from urinary incontinence. The patients interviewed were 10 patients / informants.Result: The quantitative research with Kolmogorov test  is known that on variable of educational and income factors, with P >0,05. The knowledge and cultural factors result with P <0,05. Conclusion: There is correlation between knowledge and eastern culture with urinary incontinence patient not treatment at polyclinic RS Hasan Sadikin Bandung, the most dominant factor influencing is the culture factor, as well as the reasons patients with urinary incontinence do not go to the hospital is due to not knowing that urinary incontinence is a disease and a shame.Key words: Urinary incontinence, knowledge factor, cultural factor, educational factor, income factor