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OPTIMASI TABLET FLOATING TEOFILIN MENGGUNAKAN METODE DESAIN FAKTORIAL siswanto, agus; Hapsari, Indri; zulaikha, yusni ulfiani; rosmawati, eva
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

ABSTRACTTheophylline is a drug used in the management of asthma. It has relatively short half-life and narrow therapeutic index with 5-20 ?g/mL serum concentration. Thus, Floating tablet formulations that can increase the bioavailability of the drug. The aims of this study were to determine the effect of the excipient (HPMC K4M CR and NaHCO3) to the quality of tablets and determine the optimum formula of theophylline floating tablet. A 22 randomized factorial design was used in development of theophylline floating tablet with HPMC K4M CR (A) and NaHCO3 (B) as independent variables.The flowability of mass tablet, floating character, and dissolution profile were chosen as dependent variables.The results showed that NaHCO3 was the most important factor on increasing flowability of mass tablet. HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978.
PASAR KOTA REMBANG Hapsari, Indri
IMAJI Vol 3, No 3 (2014): jurnal IMAJI - Juli 2014
Publisher : IMAJI

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Pasar tradisional merupakan pusat perbelanjaan yang masih diminati banyak orang dari berbagai kalangan ekonomi. Rembang merupakan sebuah Kota kecil dengan rata-rata ekonomi menengah kebawah. Keberadaan pasar tradisional ini sangatlah dibutuhkan bagi masyarakat. Namun sayangnya kondisi pasar tradisional yang ada sudah tidak layak untuk dijadikan tempat transaksi jual beli. Kajian diawali dengan mempelajari pengertian tentang Pasar, pengertian dan standar-standar mengenai perancangan sebuah pasar, fasilitas penunjang pasar, serta studi banding beberapa pasar yang telah ada. Dilakukan juga tinjauan mengenai eksisting Pasar Kota Rembang dan pendekatan mengenai aspek-aspek fungsional, kinerja, teknis, dan konstekstual. Pemilihan tapak menggunakan tapak eksisting Pasar Kota Rembang. Sebagai kesimpulan, luaran program ruang yang diperlukan, serta gambar-gambar 2 dimensi dan 3 dimensi sebagai ilustrasi desain.
STUDI ALTERNATIF SUBSTRAT KERTAS UNTUK PENGUJIAN VIABILITAS BENIH DENGAN METODE UJI UKDDP i Suwarno, Faiza Chairan; Hapsari, Indri
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 36 No. 1 (2008): Jurnal Agronomi Indonesia
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (60.511 KB) | DOI: 10.24831/jai.v36i1.1360

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A study to determine the best alternative substrate paper for testing seed viability in rolled paper method was conducted with 2 experiments. The first experiment studied the physical characteristic of six substrate papers, straw, filter, stencil, CD, HVS and Samson related to seed germination. The second experiment was conducted to identify the best alternative substrate for testing germination of different seeds. High and low viability of rice, maize, peanut, yardlong bean, chick pea and leafy vegetable seeds were tested with the substrate papers arranged in a Randomized  Block Design with three replications. The first experiment showed that CD and Stencil papers had good physical characters for germination substrate. Water absorption of CD and stencil papers were 28.1g and 24.4g per medium unit, lower than Straw paper (46.51 g/medium unit) but significantly higher than the international standard of filter paper  (20.7g/medium unit). In rolled paper test, no significant difference of water holding ability among the papers. Water lost during the 7 day testing were less than 2 g/medium unit for all of the papers. All of the papers including stencil and CD papers were homogenous with low coefficient of variation, less than 5%. The second experiment showed that different data of germination percentages and dry weight of normal seedlings were obtained from the diferrent subtrate papers. As compared to the common substrate straw paper, the stencil paper produced the most similar data, 100% and 91.7% similarities of germination percentage and  dry weight of normal seedlings, respectively, whereas the other papers performed 37.5 - 91.6% and 29.1 - 66.7%.   Key words:  Substrate paper, physical characteristic, seed viability testing.
The pattern of acute respiratory infections treatment in children of 0 – 59 month’s old in Puskesmas I Purwareja, Banjarnegara year of 2004 Wahyono, Djoko; Hapsari, Indri; Budi Astuti, Ika Wahyu
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.403 KB) | DOI: 10.14499/indonesianjpharm0iss0pp20-24

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The purpose of this research was to describe the pattern of acute of respiratory tract infections in children of 0-59 month’s old in Puskesmas I Purwareja Klampok, Banjarnegara. The data was taken by retrospective method from medical record. The data collected was analysed by nonanalytic descriptive statistic method, and then compared them to standard of therapy provided by Indonesian Health Departement. The result showed that all of 120 patients were pneumonia acute respiratory tract infections, which were 55.8% boys and 44.2% girls. The antimicrobials used were Cotrimoxazol (86.7%) and amoxicillin (13.3%). The major product used in that puskesmas was syrup (91.7%), and tablet that delivered in the form of powder was 8.3%. The treatment using these antimicrobial at Puskesmas I Purwareja, Klampok, Banjarnegara was in accordance to standard of therapy provided by Indonesian Health Departement. Key words: pneumonia acute respiratory tract infection, 0-59 months old children, antimicrobial, puskesmas I Purwareja Klampok Banjarnegara
Hubungan Hipertirotropinemia Terhadap Tingkat dan Aspek Kecerdasan Anak TK di Desa Seloharjo Kecamatan Pundong, Bantul, Yogyakarta Hapsari, Indri; Patria, S.Yudha; Gamayanti, IL.
Sari Pediatri Vol 15, No 6 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.965 KB) | DOI: 10.14238/sp15.6.2014.420-6

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Latar belakang. Hipertirotropinemia (peningkatan TSH) menunjukkan adanya insufisiensi saturasi reseptor T3 di otak dan potensial berisiko defisiensi dalam perkembangan kecerdasan. Semakin muda anak mengalami defisiensi hormon tiroid maka semakin berat terhadap gangguan kecerdasan. Hormon tiroid dirangsang sekresinya oleh TSH (Thyroid stimulating hormone). Hipertirotropinemia digunakan sebagai penapis pertama dalam deteksi gangguan tiroid.Tujuan. Mengetahui adanya hubungan hipertirotropinemia dengan tingkat dan aspek kecerdasan anak taman kanak-kanak (TK) di Desa Seloharjo, Kecamatan Pundong, Bantul, Yogyakarta.Metode. Rancangan penelitian potong lintang dengan jumlah subjek 51 anak dari dua TK di Desa Seloharjo selama bulan Desember 2010. Desa Seloharjo dipilih karena termasuk daerah endemik GAKI, sumber data lengkap, dan bisa dijangkau. Penilaian dilakukan terhadap kadar tetes darah TSH (dengan ELISA) dan tingkat kecerdasan serta aspek (dengan Stanford-Binet). Analisis dengan uji kai-kuadrat dan uji regresi logistik.Hasil. Terdapat 39,2% responden termasuk hipertirotropinemia dengan rerata TSH 5,59 μUI/mL. Intelligency Quotient poin di bawah rata-rata 25,5% dengan rerata 96,8 poin. Anak hipertirotropinemia dengan IQ di bawah rata-rata 6 orang (30%) dengan rerata TSH 7,63 μUI/ml (kenaikan 1,38 kali) dan rerata IQ 81 poin. Tidak didapatkan hubungan bermakna antara kadar TSH dengan tingkat kecerdasan (p=0,553, RP=1,469, 95%IK 0,4-5,254) dan enam aspek kecerdasan (p>0,05). Hasil uji regresi logistik menunjukkan variabel lain tidak memengaruhi tingkat kecerdasan, sedangkan untuk aspek penalaran aritmatika terbukti dipengaruhi oleh adanya anggota keluarga yang gondok (p=0,045, RP 8,448, IK95% 1,050-67,977).Kesimpulan. Hipertirotropinemia tidak terbukti memengaruhi tingkat dan aspek kecerdasan anak TK.
DAYA REPELAN GEL MINYAK ATSIRI BUNGA KENANGA (Cananga odorata (Lmk) Hook.f & Thoms) DALAM BASIS CARBOPOL, TERHADAP NYAMUK Aedes aegypti Kurniawati, Linda; Hapsari, Indri; Hartanti, Dwi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 07 No. 03 Desember 2010
Publisher : Fakultas Farmasi, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v7i3.574

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ABSTRAK Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi carbopol terhadap sifat fisik gel dan daya repelan gel minyak atsiri bunga kenanga. Minyak atsiri bunga kenanga diperoleh dengan cara penyulingan uap air. Dibuat tiga formula gel minyak atsiri bunga kenanga dengan konsentrasi carbopol yang berbeda (0,5 g, 1,0 g dan 1,5 g). Gel yang dihasilkan dievaluasi sifat fisiknya meliputi uji pH, viskositas, homogenitas, daya sebar, daya lekat dan identifikasi minyak atsiri bunga kenanga. Uji daya repelan dilakukan dengan memasukkan tangan naracoba ke dalam sangkar dengan interval waktu diluar sangkar nyamuk selama 5 menit. Ada lima kelompok yang diujikan, meliputi tangan tanpa intervensi, kontrol negatif berupa tiga formula gel tanpa minyak atsiri bunga kenanga, minyak atsiri bunga kenanga, tiga formula gel minyak atsiri bunga kenanga dan kontrol positif berupa lotion merk “X”. Hasil penelitian menunjukkan bahwa konsentrasi carbopol berbanding terbalik dengan nilai pH dan daya sebar tetapi berbanding lurus dengan daya lekat dan viskositas gel minyak atsiri bunga kenanga. Daya repelan gel minyak atsiri bunga kenanga berbanding lurus dengan konsentrasi carbopol. Kata kunci: daya repelan gel, minyak atsiri bunga kenanga (Cananga odorata (Lmk) Hook.f & Thoms), carbopol, Aedes aegypti ABSTRACT The aim of this research is to know the influence of carbopol concentration to physical characteristic and repellency of cananga flowers volatile oil in carbopol gel base. Cananga flowers volatile oil was extracted by steam water destilation. Three formulas of gel were made by various carbopol concentration (0,5 g, 1,0 g and 1,5 g). The gels produced were tested physical characteristic (organoleptic, pH, viscosity, homogeneity, spread ability, adhesive ability and identification of cananga flowers volatile oil). Repellency was done by entering hand of person into the cage contain mosquitoes with interval five minute. This research used five groups. They were untreated hand, negative control with three formulas of gel did not used cananga flowers volatile oil, cananga flowers volatile oil, three formulas of gel contain cananga flowers volatile oil and lotion merk “X” as positive control. The result showed that the greater carbopol consentration, the smaller in pH and spread ability but the greater in adhesive ability, viscosity and repellency of gel from cananga flowers volatile oil. Key words: repellency of gel, cananga (Cananga odorata (Lmk) Hook.f & Thoms) flowers volatile oil, carbopol, Aedes aegypti
OPTIMASI TABLET FLOATING TEOFILIN MENGGUNAKAN METODE DESAIN FAKTORIAL siswanto, agus; Hapsari, Indri; zulaikha, yusni ulfiani; rosmawati, eva
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTTheophylline is a drug used in the management of asthma. It has relatively short half-life and narrow therapeutic index with 5-20 μg/mL serum concentration. Thus, Floating tablet formulations that can increase the bioavailability of the drug. The aims of this study were to determine the effect of the excipient (HPMC K4M CR and NaHCO3) to the quality of tablets and determine the optimum formula of theophylline floating tablet. A 22 randomized factorial design was used in development of theophylline floating tablet with HPMC K4M CR (A) and NaHCO3 (B) as independent variables.The flowability of mass tablet, floating character, and dissolution profile were chosen as dependent variables.The results showed that NaHCO3 was the most important factor on increasing flowability of mass tablet. HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978.
PENGARUH KONSENTRASI MALAM PUTIH ( Cera Alba ) PADA SUPPOSITORIA BASIS LEMAK COKLAT ( Oleum Cacao ) TERHADAP LAJU DISOLUSI PARASETAMOL Amin, Faesol; Astuti, Ika Yuni; Hapsari, Indri
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 06 No. 01 April 2009
Publisher : Fakultas Farmasi, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v6i01.397

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ABSTRAK Telah dilakukan penelitian tentang pengaruh konsentrasi malam putih (Cera Alba) terhadap disolusi suppositoria parasetamol dalam bahan dasar lemak coklat (Oleum Cacao). Tujuan penelitian ini untuk mengetahui pengaruh konsentrasi malam putih (Cera Alba ) terhadap kecepatan disolusi suppositoria parasetamol dalam basis lemak coklat (Oleum Cacao). Pada penelitian ini dibuat suppositoria parasetamol dengan basis lemak coklat yang ditambah malam putih (Cera Alba) dengan konsentrasi 0%, 3%, 5% dan 7%. Setiap suppositoriia mengandung 250mg parasetamol yang dibuat dengan metode sistem peleburan dan dicetak langsung. Kemudian diuji sifat fisik suppositoria meliputi titik leleh, waktu hancur, kekerasan dan dilakukan uji disolusi. Hasil penelitian menunjukkan bahwa semakin besar konsentrasi malam putih (Cera Alba) yang ditambahkan maka semakin kecil kecepatan disolusinya. Kata kunci : Suppositoria, Malam putih, Parasetamol, Disolusi. ABSTRACT The research about the influence of white wax concentration toward dissolution of parasetamol suppositories in cacao butter base of white wax concentration toward the dissolutions rate of parasetamol suppositories in cacao butter base. In this research by parasetamol suppositories in cacao butter base adding with white wax in parasetamol which was made by melted method and was poured into molds. Then the suppositories were tested physically including melting point, solidification time, hardness, and dissolution test. The results of this research showed that the greater concentration of white wax the smaller of dissolution rate. Keywords : Suppository, white wax, parasetamol, dissolution
PERENCANAAN PRODUKSI PROSES PEMBUATAN ALAT MUSIK FLUTE Hapsari, Indri; Al Habshe, Azizah; Santoso, Amelia
Rekayasa Vol 12, No 1: April 2019
Publisher : Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.865 KB) | DOI: 10.21107/rekayasa.v12i1.4565

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PT. X di Pasuruan merupakan perusahaan industri manufaktur yang memproduksi alat-alat musik seperti, piano, keyboard, gitar dan bass, drum, alat tiup seperti flute, pianika, dan lain-lain. Tingginya jam lembur membuat penelitian ini terfokus pada parts process department section body process khusus alat musik flute. Produk jadi flute terdiri dari 3 part yang berupa flute head, flute body, dan flute foot yang diproduksi di parts process department section body process khusus memproduksi flute head, flute body, dan flute foot. Fluktuatifnya permintaan konsumen membuat pihak manajemen kesulitan untuk meramalkan berapa jumlah flute head, flute body, dan flute foot yang harus diproduksi secara tepat. Apabila hasil peramalan yang kurang tepat tersebut mengakibatkan adanya ketidaksesuaian antara jumlah permintaan dengan kapasitas produksi flute head, flute body, dan flute foot di PT. X. Oleh karena itu perlu adanya perencanaan produksi usulan agar dapat memenuhi permintaan sesuai dengan kapasitas yang dimiliki PT. X dan meminimumkan total biaya yang dikeluarkan. Perencanaan produksi usulan yang dilakukan menggunakan metode mix integer linear programming dengan bantuan software Lingo 11.0. Total biaya yang dikeluarkan untuk perencanaan produksi metode perusahaan sebesar Rp35.766.639.589 sedangkan, metode usulan sebesar Rp35.687.132.806. Metode usulan dapat melakukan penghematan total biaya produksi sebesar 0,22% yaitu Rp79.506.783.  Kata kunci:  Perencanaan produksi, Forecasting, Safety stock, Mix integer linear programming Production Planning of  Flute Musical Instrument Production ProcessAbstract? PT. X in Pasuruan is an industrial manufacturing company that produces musical instruments such as, piano, keyboard, guitar and bass, drums, flutes, pianica, etc. Highly overtimes is the reason why this research focuses on parts process department section body process specific to a flute. The flute consist of 3 parts which are flute head, flute body, and flute foot that produces on parts process department section body process. Fluctuatively consumer request had caused confusion for the management to accurately estimate the number of flute head, flute body, and flute foot to be produced. If the result of forecasting is not matching, therefore there is a difference in a number of orders and production capacity of flute head, flute body, and flute foot at PT. X Hence, there should be a production estimate plan to overcome the problem relating to the capacity at PT. YMPI at the same time minimizing costs. Mix integer linear programming method was used as a suggestion with the help of software Lingo 11.0. The total cost spent on the company method is Rp35.766.639.589, while the proposed method is Rp35.687.132.806. The proposal method of production and planning managed to cut the cost by 0,22% which is Rp79.506.783.Keywords:  Production and planning control, Forecasting, Safety stock, Mix integer linear programming.
EVALUASI PENGGUNAAN OBAT PADA PASIEN SKIZOPRENIA DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM DAERAH BANYUMAS PERIODE JANUARI –APRIL 2009 Kurniawan, Gayuh; Hapsari, Indri; Utaminingrum, Wahyu
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 08 No. 03 Desember 2011
Publisher : Fakultas Farmasi, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1136

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ABSTRAK Skizofrenia merupakan gangguan psikiatrik yang sangat kompleks yang dapat menimbulkan paling banyak masalah baik medik, psikologik maupun social. Penelitian ini dilakukan dengan menggunakan rancangan deskriptif non analitik yang bersifat retrospektif. Tujuan penelitian ini untuk mengetahui karakteristik pasien (jenis kelamin, usia, status pendidikan, durasi rawat inap dan keadaan pulang pasien), pola pengobatan dan kesesuaian terapi (jenis obat, dosis obat dan cara pemberian) dengan Standar Pelayanan Medis (SPM), dan mengetahui interaksi obat yang terjadi. Hasil dari penelitian ini, karakteristik pasien (jenis kelamin 63,49% pada wanita, usia 31,75% 20-29 tahun, status pendidikan SD 31,7%, durasi rawat inap 30,1% 7-14 hari, keadaan pulang pasien 88% membaik), pola pengobatan (jenis obat 80,16%, dosis obat 78,57%, cara pemberian 91,27%), kesesuaian terapi (jenis obat 73,01%, dosis obat 78,57%, cara pemberian 96,03%) dan interaksi yang terjadi adalah interaksi antar obat skizofrenia (100 kasus) dan interaksi obat skizofrenia dengan obat lain (34 kasus). Kata kunci : Skizofrenia, Retrospektif, Standar Pelayanan Medis (SPM), Karakteristik pasien, Pola Pengobatan, Kesesuaian Terapi ABSTRACT Schizophrenia represent the very complex trouble psychiatric which can generate at most good problem sis, psychology and also social. This research conducted by using descriptive device non-analytic having the character of retrospective. This research target to know the patient characteristic (gender, age, education status, time take care to lodge and circumstance come home the patient), medication pattern and according to therapy (drug type, dose medicines and way of gift) with the Medical Service Standard (SPM), and know the interaction medicines that happened. Result from this research, patient characteristic (gender 63,49% at woman, age 31,75% 20-29 year, status education SD 31,7%, time take care to lodge 30,1% 7-14 day, circumstance come home the patient 88% good), medication pattern (type medicines 80,16%, dose medicines 78,57%, way gift 91,27%), according to therapy (type medicines 73,01%, dose medicines 78,57%, way gift 96,03%) and interaction that happened interaction usher the drug schizophrenia (100 case) and interaction medicines the schizophrenia with the other drug (34 case). Keyword : Schizophrenia, Retrospective, Medical Service Standard (SPM), Patient Characteristic, Medication Pattern, According to Therapy, Drug Interaction.