Dewi Isadiartuti
Dept of Pharmaceutics, Faculty of Pharmacy, Airlangga University, Darmawangsa Dalam Surabaya-Indonesia

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KARAKTERISASI KOMPLEKS INKLUSI ASAM MEFENAMAT - B-SIKLODEKSTRIN YANG DIBUAT DENGAN METODE FREEZE DRYING Setyawan, Dwi; Isadiartuti, Dewi
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.651 KB)

Abstract

Characterization of mefenamic acid- ,8-cyclodextrin inclusion complexes by freeze dryin method had been studied. Solid state mefenamic acid - B-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamlc acid, B-cyclodextrin, mefenamic acid - B-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscop (FTIR) , Dijferential Thermal Analyzer (DT/1) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and B-lcyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid - B-lcyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid - B-lcyclodextrin inclusion complex showed increasing dissolution rate compared to me?znamic acid - B-cyclodextrin physical mixture and mefenamic acid.
The formation of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrine Isadiartuti, Dewi; ., Suwaldi
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.436 KB) | DOI: 10.14499/indonesianjpharm0iss0pp28-37

Abstract

Phenobarbital, a hypnotic and sedative agent, was found to form inclusion complex with hydroxypropyl-β-cyclodextrine at 1:1 molar ratio. The formation of inclusion complex in the solution was detected due to the increased solubility of phenobarbital and in the solid was confirmed by differential scanning calorimetry, X-Ray diffractometry, and infrared spectroscopy.In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-β-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-β-cyclodextrine.Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-β-cyclodextrine.Key words : phenobarbital, hydroxypropyl-β-cyclodextrine, inclusion complex
Antiseptic activity evaluation of piper leave from Piper betle Linn extract in hand gel antiseptic preparation Sari, Retno; Isadiartuti, Dewi
INDONESIAN JOURNAL OF PHARMACY Vol 17 No 4, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.263 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

It is known that piper leaves (sirih) from Piper betle Linn has been used traditionally as medicine, for example for mouthwash and wound curing. The usage of hand gels antiseptic preparation was getting increased in the current time as the incidence of desease caused by virus and bacteria like SARS appears.This research was aimed to develop preparation of hand gels from piper leaves extract obtained from extraction with hot water. The formulation of gels were made using 5%, 10%, 15%, 20% and 25% of piper leaves extract in Carbopol gel base. The evaluation of antiseptics activity was carried out using the Replica method. A series of test was done by pouring the gels at hand palm and slightly tap the thumb fingerprint to nutrient agar media. The media was incubated at 37°C for 24 hours,and the number of colonies of microorganism was counted. The antiseptic activity of the gels also compared with two hand gels antiseptic preparation containing ethanol and triclosan as antiseptic agentThe result showed that the piper leaves extract gels had a transparent pale yellow performance. The gel preparation with concentration of 15% extract had activity to reduce the microorganism of skin normal flora up to 50%. Yet the 25% concentration of piper leave extract could eliminate all the microorganism. It was also known that the 15% piper leaves extract gel had no significance different with the ethanol preparation, since the 20% and 25% piper leaves extract gels had similar antiseptic activity to the triclosan preparation.Key words: piper leaves extract, gel, antiseptic activity, replica methods
The thermodynamics of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrin Martodihardjo, Suwaldi; Isadiartuti, Dewi
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.749 KB) | DOI: 10.14499/indonesianjpharm0iss0pp57-62

Abstract

Cyclodextrins are cyclic oligosaccharides which have been used extensively to improve the solubility in the formation of inclusion complex. The ability of cyclodextrin to form an inclusion complex has been attributed to factors including size of cyclodextrin cavity to the guest molecule and thermodynamics of their interactions.In this study, complex formation of phenobarbital and hidroxypropyl-β-cyclodextrin in the acetate buffer 0.01 M pH 4.4 and phosphate buffer 0.01 M pH 7.4 all with μ =0.10 and at temperatures of 32.o, 37.o, and 42o±0.5oC were determined.The results showed that phenobarbital formed inclusion complex with hidroxypropyl-β-cyclodextrin. The interaction shown a negative enthalphy (ΔH < 0 ), a spontaneous processes (ΔG < 0) and an increase in the entropy of the system (ΔS > 0).Key words : phenobarbital and hidroxypropyl-β-cyclodextrin, inclusion complex, thermodynamics
EDUKASI TEHNIK ASEPTIK SEDIAAN STERIL BAGI TENAGA KESEHATAN DI FASILITAS PELAYANAN KESEHATAN KABUPATEN SUMBA TIMUR NTT Isadiartuti, Dewi; Sugiyartono, Sugiyartono; Sari, Retno; Rijal, Muh Agus S; Retnowati, Dini
Jurnal Layanan Masyarakat (Journal of Public Services) Vol 4, No 1 (2020): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v4i1.2020.237-242

Abstract

The Government through Permenkes 72/2016 on Pharmaceutical Services Standards in Hospitals has provided guidance on the regulation of pharmaceutical service standards. Pharmaceutical services in the field of management of sterile preparations is one aspect that receives attention, because it will affect the quality of services provided to sufferers. East Sumba Regency is one of the East Nusa Tenggara provinces located in Eastern Indonesia. East Sumba Regency has a large enough population but health workers in health care facilities have limitations in getting the latest information. To answer this condition, training was held in collaboration with IAI PC East Sumba. The aim of the training is to increase the knowledge and skills of aseptic techniques for sterile preparations for health workers in health care facilities so that the quality of health services can be improved. The training was given in the form of lectures consisting of compatibility and stability material for parenteral preparations and dispensing materials for sterile preparations followed by the practice of aseptic techniques for sterile preparations. The training activity was attended by 49 participants consisting of pharmacists, nurses, midwives and pharmaceutical technical personnel who worked in hospitals, health services, health centers, clinics, and pharmacies in Sumba (East, Central and West). From the results of the evaluation of the activity, it was known that the participants gained knowledge and increased knowledge about the basic principles of aseptic techniques and there was an increase in the participants' understanding of the material provided.abstrakPemerintah melalui Permenkes 72/2016 tentang Standar Pelayanan Kefarmasian di Rumah Sakit telah memberikan arahan mengenai pengaturan standar pelayanan kefarmasian. Pelayanan kefarmasian di bidang pengelolaan sediaan steril merupakan salah satu aspek yang mendapat perhatian, karena akan memengaruhi mutu pelayanan yang diberikan kepada penderita. Kabupaten Sumba Timur merupakan salah satu wilayah propinsi Nusa Tenggara Timur yang terletak di Indonesia Bagian Timur. Kabupaten Sumba Timur memiliki jumlah penduduk yang cukup besar akan tetapi tenaga kesehatan di fasilitas pelayanan kesehatan memiliki keterbatasan dalam mendapatkan informasi terbaru. Untuk menjawab kondisi tersebut diadakan pelatihan bekerjasama dengan IAI PC Sumba Timur. Tujuan pelatihan adalah untuk meningkatkan pengetahuan dan ketrampilan tehnik aseptik sediaan steril bagi tenaga kesehatan di fasilitas pelayanan kesehatan agar mutu pelayanan kesehatan dapat meningkat. Pelatihan diberikan dalam bentuk ceramah terdiri dari materi kompatibilitas dan stabilitas sediaan parenteral dan materi dispensing sediaan steril dilanjutkan dengan praktek tehnik aseptik sediaan steril. Kegiatan pelatihan diikuti 49 peserta yang terdiri dari apoteker, perawat, bidan dan tenaga teknis kefarmasian yang bekerja di Rumah Sakit, Dinas Kesehatan, Puskesmas, Klinik, dan Apotek sedaratan Sumba (Timur, Tengah, dan Barat). Dari hasil evaluasi kegiatan diketahui peserta mendapatkan penyegaran ilmu dan peningkatan wawasan tentang prinsip dasar tehnik aseptik dan terdapat peningkatan pemahaman peserta terhadap materi yang diberikan.