Nor Istiqomah
Program Studi Kesehatan Masyarakat, Fakultas Ilmu Kesehatan, Universitas Pekalongan

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Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil Istiqomah, Nor; Umarghanies, Sarah Safira; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.17 KB) | DOI: 10.22146/ijcn.18364

Abstract

Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.
RASISME DALAM KEPEMIMPINAN DI INDONESIA (PERSPEKTIF HADIS) Istiqomah, Nor
Jurnal Ilmiah Ilmu Ushuluddin Vol 17, No 1 (2018)
Publisher : Fakultas Ushuluddin dan Humaniora UIN Antasari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18592/jiu.v17i1.2037

Abstract

Cases of racism have occurred in the early days of the emergence of Islam, which later became the political legitimacy in which in the leadership space in the Arabian Peninsula the tribe of Quraish is a tribe that dominates. This is reinforced by the argument of hadith which became the basis of that legitimacy. Nonetheless, in fact, there are many other propositions that seem quite contrary to the proposition, such as the Qur?an and other hadith. Therefore, the hadith about political racism which in this case about the domination of tribal leadership of Quraish becomes important to be reinterpreted by using hermeneutic point of view and contextualization of hadith. With this view, the election of a leader is not based on a particular tribe, although assessing of the leadership qualities of the future leader as well as his responsibility in carrying out the mandate of the leader. In the context of Indonesian, the dominance of a tribe in political space is controlled by the political interest of various circles, such as political elites and radical groups. The view that political domination held by a particular group is only used as a ?scapegoat? to overthrow the political opponents.
Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil Istiqomah, Nor; Umarghanies, Sarah Safira; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18364

Abstract

Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.
APLIKASI SEMIOTIKA NARATIF A. J. GREIMAS TERHADAP KISAH THALUT DALAM AL-QUR’AN Istiqomah, Nor
QOF Vol 1, No 2 (2017)
Publisher : LP2M IAIN KEDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/qof.v1i2.919

Abstract

This paper aimed to explore the interpretation of the story of Thalut in QS. al-Baqarah: 246-251 using the semi-narrative theory of A.J. Greimas as an analytical tool. This structural theory is expected to explore the structure text of the text of the Quran. In addition, the narrative semiotics theory also opens up a new understanding of the text by looking at the inner structure and inner structure of the text. This understanding is not new, but it is able to bring meaning that is slightly diverse than most. The findings of the authors obtain that the story of Thalut in the Quran at least contains two structures of the narrative meaning of the text, namely the birth and the mind. The understanding gained from the textual structure of the narrative text is the existence of segments that describe how the Thalut struggle to save people from religious, socio-political and even moral crisis with the support of prayer, belief and knowledge. However, he is hindered by his hesitant and arrogant nature. As we know from the inner structure of the text, the story of Thalut in QS. Al-Baqarah: 246-251 shows how the verse describes the spirit of a person in reaching a business which in psychology studies is known also with the phenomenon of will (conation). In addition, the author sees the existence of other elements such as cultural inheritance (cultural transfered) that occurred in the Children of Israel. With the theory of narrative semiotics, the text of the Quran becomes more broadly meaningful and not only fixated on textual understanding.
RASISME DALAM KEPEMIMPINAN DI INDONESIA (Perspektif Hadis) Istiqomah, Nor
Jurnal Ilmiah Ilmu Ushuluddin Vol 17, No 1 (2018)
Publisher : Fakultas Ushuluddin dan Humaniora UIN Antasari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.008 KB) | DOI: 10.18592/jiu.v17i1.2037

Abstract

Cases of racism have occurred in the early days of the emergence of Islam, which later became the political legitimacy in which in the leadership space in the Arabian Peninsula the tribe of Quraish is a tribe that dominates. This is reinforced by the argument of hadith which became the basis of that legitimacy. Nonetheless, in fact, there are many other propositions that seem quite contrary to the proposition, such as the Qur’an and other hadith. Therefore, the hadith about political racism which in this case about the domination of tribal leadership of Quraish becomes important to be reinterpreted by using hermeneutic point of view and contextualization of hadith. With this view, the election of a leader is not based on a particular tribe, although assessing of the leadership qualities of the future leader as well as his responsibility in carrying out the mandate of the leader. In the context of Indonesian, the dominance of a tribe in political space is controlled by the political interest of various circles, such as political elites and radical groups. The view that political domination held by a particular group is only used as a “scapegoat” to overthrow the political opponents.
Hoax Dalam Perspektif Hermeneutika Hadis Nurun Najwah Istiqomah, Nor
Jurnal Living Hadis Vol 2, No 1 (2017)
Publisher : UIN Sunan Kalijaga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.922 KB) | DOI: 10.14421/livinghadis.2017.1534

Abstract

Artikel ini akan mengeksplorasi bagaimana kasus penyebaran berita hoax dalam tekstualisasi hadis. Dengan menggunakan metode pemahaman hadis Nurun Najwah, artikel ini mengungkap ide dasar yang ditangkap dari hadis tentang berita hoax yang dihasilkan dengan melihat konteks historis dan korelasi teks dengan ayat-ayat al-Qur’an dan teks hadis lainnya yang tematik serta melihat dari data-data sejarah dan data-data pengetahuan lainnya. Dengan itu, akan didapat ide dasar teks yang kontekstual dan fungsional yang dihadirkan dari data-data konteks sekarang.
PROFIL POTENSI PENYAKIT AKIBAT KERJA TAHAPAN PEMBATIKAN Latif, Rr. Vita Nur; Ristiawati, Ristiawati; Istiqomah, Nor
Unnes Journal of Public Health Vol 5 No 4 (2016): Unnes Journal Of Public Health
Publisher : Universitas Negeri Semarang in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.984 KB) | DOI: 10.15294/ujph.v5i4.11282

Abstract

Abstrak &nbsp; Batik diakui UNESCO sebagai budaya milik Indonesia. Pembatikan masih menggunakan bahan baku berbahaya. Salah satu tuntutan AFTA (ASEAN Free Trade Area) 2015 yaitu meningkatkan kualitas dan perlindungan produk dalam negeri (batik) untuk dapat bersaing dengan produk luar negeri, dimana dalam proses produksinya memperhatikan aspek kesehatan dan keselamatan kerjanya. Penelitian ini bertujuan mengidentifikasi gangguan kesehatan yang muncul pada tahapan pembatikan yang nantinya dapat menjadi dasar rekomendasi substitusi bahan dan metode dalam tahapan pembatikan. Penelitian ini berupa survey analitik dengan metode deskriptif analitik. Populasi penelitian ini adalah seluruh pekerja industri batik di Kota Pekalongan pada 634 industri batik. Sampel pada penelitian ini sejumlah 80 responden yang diambil secara random sampling. Ditemukan gangguan kesehatan pada pekerja batik berupa gangguan kapasitas paru 67,5%; penurunan fungsi penglihatan 33,8%; dermatitis ekstrimitas 30%. Sebaran pekerja dengan gangguan kapasitas paru, penurunan fungsi penglihatan, dan dermatitis ekstrimitas terbanyak ditemukan pada tahap pelekatan lilin, berturut-turut 64,8%; 48,1%; dan 66,7%. &nbsp; Abstract &nbsp; Batik is recognized by UNESCO as Indonesian indigenous culture. Batik processing was still using dangerous material. One of AFTA 2015 requirements was to increase quality and protectionto domestic product for commpeting with foreign product, whith paying attention to health and safety. This study aimed to identify health disorders in batik processing for being the rasionale for material and method substitution recommandation in batik processing. This was descriptive analitic survey. The population was all workers in all batik industries (634 industries) in Pekalongan City. There were 80 respondents which were choosen ramdomly as sample. It was indentified that the health disorders in batik industries workers were vital lung capacity abnormalities (33.8%), optical degeneration and dermatitis extremities (30%). Health disorders were mostly found in waxing process; they were vital lung capacity abnormalities (64.8%), optical degeneration (48.1%) and dermatitis extremities (66.7%).
HUBUNGAN TINGKAT KELEMBABAN RUMAH TINGGAL DENGAN KEJADIAN TUBERKULOSIS PARU DI WILAYAH KECAMATAN TULIS KABUPATEN BATANG Indriyani, Novita; Istiqomah, Nor; Anwar, M Choiroel
Unnes Journal of Public Health Vol 5 No 3 (2016): Unnes Journal Of Public Health
Publisher : Universitas Negeri Semarang in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v5i3.11311

Abstract

Salah satu penyakit menular yang menjadi perhatian dan masalah kesehatan masyarakat di wilayah Kecamatan Tulis adalah TB paru yang meningkat setiap tahunnya, dengan angka prevalensi tahun 2014 sebesar 83,4/100.000 penduduk. Salah satu faktor yang mempengaruhi adanya agen bakteri tuberkulosis yaitu lingkungan rumah tinggal. Tujuan penelitian mengetahui hubungan tingkat kelembaban rumah tinggal dengan kejadian TB paru di wilayah kecamatan Tulis. Desain penelitian case control, variabel bebas yang diteliti yaitu tingkat kelembaban, dan variabel confounding adalah luas ventilasi, keberadaan jendela, pencahayaan, suhu. Sampel penelitian&nbsp; 70 responden, terdiri dari 35 kasus dan 35 kontrol. Hasil analisis bivariat uji chi square bahwa ada hubungan antara tingkat kelembaban (p=0,004 OR=4,792) dan pencahayaan (p=0,031 OR=3,273) dengan TB paru. Analisis multivariat yang terbukti sebagai faktor resiko adalah tingkat kelembaban (OR=3,801) dikontrol pencahayaan (OR=1,456).
DETERMINAN STUNTING PADA SISWA SD DI KABUPATEN PEKALONGAN Latif, Rr. Vita Nur; Istiqomah, Nor
Unnes Journal of Public Health Vol 6 No 1 (2017): Unnes Journal Of Public Health
Publisher : Universitas Negeri Semarang in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.22 KB) | DOI: 10.15294/ujph.v6i1.14108

Abstract

Stunting is often referred to as short stature as a manifestation of chronic malnutrition. It is often not realized at the age of five, and realized at primary school age. Prevalence of stunting children in Indonesia at 2007 was 37%, whereas in Pekalongan Regency reached 42,2%. Based on previous study, risk factors related with stunting were family factors, diet, and socioeconomic conditions. This study aimed to analyze the association between genetic factors, intake, socio-demography, CED malnutrition, and anatomical defects with the incidence of stunting among primary school students in Pekalongan Regency. This research was cross sectional. Sampling technique used was proportional random sampling until 93 respondents were collected. Stunting data were collected by anthropometry assessment, while socio-demography data were collected by indepth interview with open ended question to parents. Data were analyzed with chi square test. It showed that the parents’ height (genetic) was significantly associated with stunting (p=0.000). However, socio-demographic (p=0.093), intake (p=0.093), CED malnutrition or head circumference status (p=0.119), and anatomical defects (p=0.133) were not significantly associated with stunting. Parents’ height factors (hereditary) was associated with stunting among primary school students.
AKTIFITAS ANTIBAKTERI EKSTRAK BUNGA KAKTUS PAKIS GIWANG (Euphorbia milii) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Pirmansyah, Diki; Istiqomah, Nor; Anwar, M. Choeroel
Pena Medika Jurnal Kesehatan Vol 7, No 01 (2017): PENA MEDIKA JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v7i01.534

Abstract

Aktifitas Antibakteri Ekstrk Bunga Kaktus Pakis Giwang (Euphorbia milii) Terhadap Pertumbuhan Bakteri Staphylococcus aureus. Semakin tingginya permasalahan kesehatan yang disebabkan oleh mikrooganisme sekarang ini sangat sering terjadi, penyebabnya sendiri apakah sistem imun tubuh kita yang semakin menurun karena faktor eksternal, atau mikroorganisme yang sudah mulai resiten dengan berbagai macam obat dan antibiotik komersil dikarenakan mutanisasi dari mikroorganisme tersebut, sehingga meningkatnya faktor resistensi bakteri terhdap antibiotik. Penelitian ini menggunakan metode eksperimental Quasi dengan desain faktorial, untuk mengetahui pengaruh konsentrasi ekstrak bunga pakis giwang (Euphorbia milii) terhadap pertumbuhan bakteri Staphylococcus aureus, dengan konsentrasi bertingkat yaitu 20%, 40%, 60%, 80%,  dan 100% untuk uji daya hambat menggunakan lubang sumuran terhadap Staphylococcus aureus dengan metode difusi media nutrient agar plate. Dengan uji statistik deskriptif terbukti ada perluasan diameter zona hambat dari konsentrasi eksrak 20% hingga 100%, dapat dibuktikan dengan means diameter masing-masing konsentrasi dari konsentrasi rendah ke konsentrasi tinggi antara lain 13,75 mm, 15 mm, 16,88 mm, 18,25 mm, dan 26,25 mm. Uji ANOVA menjelaskan adanya perbedaan dari perbandingan konsentrasi, hasil perbedaan menunjukan signifikansi yang bermakna dengan tingkat kepercayaan 95% dan α 0,05 karena nilai sig. ANOVA 0.000 < 0.05, dipertegas dengan pembuktian F(hitung) lebih besar dari F(tabel) (33,306 > 3,055). Maka Ho ditolak sehingga terdapat perbedaan yang signifikan pada zona hambat dari masing-masing perbandingan konsentrasi ekstrak bunga pakis giwang (Euphorbia milii) pada percobaan secara in vitro.Kata kunci      : Euphorbia milii, Konsentrasi ekstrak, Staphylococcus aureus