Cissy B Kartasasmita
Faculty of Medicine, Padjadjaran University, Bandung

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REAKSI SILANG RESPONS IMUN HUMORAL VIRUS A/H1N1 PANDEMI/2009 DAN SEASONAL/2006 PADA REMAJA PERIODE KELAHIRAN TAHUN 1990-1996 DHAMAYANTI, MEITA; ACHMAD, TRI HANGGONO; KARTASASMITA, CISSY B; IDJRADINATA, PONPON
Indonesian Journal of Applied Sciences Vol 3, No 2 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8874.663 KB) | DOI: 10.24198/.v3i2.16830

Abstract

The immunogenicity and safety of the new, Indonesian DTwP-HB-Hib vaccine compared to the DTwP/HB vaccine given with the Hib vaccine Bachtiar, Novilia Sjafri; Rusmil, Kusnandi; Sudigdoadi, Sunarjati; Kartasasmita, Cissy B; Hadyana, Hadyana
Paediatrica Indonesiana Vol 57 No 3 (2017): May 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.392 KB) | DOI: 10.14238/pi57.3.2017.129-37

Abstract

Background Haemophilus influenzae type b (Hib) causes infection with predominant manifestations of pneumonia, meningitis, and other invasive diseases, occurring primarily in children aged under 2 years, particularly in infants.  The World Health Organization (WHO) and Indonesian Technical Advisory Group for Immunization recommend to include the Hib vaccine into the national immunization program. The newly developed DTwP-HB-Hib combination vaccine is anticipated to be the preferred choice for Hib vaccine introduction; it is efficient, simple, and has higher coverage.Objective To evaluate the immunogenicity and safety of a new, combined Bio Farma DTwP-HB-Hib vaccine, compared to the registered Hib monovalent vaccine given simultaneously with the local DTwP-HB vaccine, when used as the primary vaccination of Indonesian infants.Methods A prospective, randomized, open-label, phase II study was conducted on the DTwP-HB-Hib vaccine compared to the Hib (registered) vaccine given simultaneously with the DTwP-HB vaccine, in Bandung from July 2011 to January 2012. Infants were serially vaccinated at 6-11, 10-15, and 14-19 weeks. Serological assessments were done prior to the first vaccine dose and 28 days after the third dose. Safety was assessed from the time of first injection until 1 month after the last injection.Results Of 220 healthy infants enrolled, 211 completed the study, with 105 receiving the combined vaccine and 106 the two separate vaccines. All vaccines were well tolerated. No differences in rates of local and systemic reactions were seen between the two methods of administration. No serious adverse events were considered to be related to the vaccines. In the DTwP-HB-Hib primary-vaccination group, at least 98% of the infants reached protective levels of antibodies (seropositivity) against the antigens employed in the vaccines while 96% in the control group.Conclusion The DTwP-HB-Hib combined vaccine is immunogenic and safe, as well as comparable to the Hib vaccine given simultaneously with to the DTwP-HB vaccine.
Pengaruh Pemberian Vitamin C terhadap Perubahan Kadar Total Antioksidan Serum pada Penderita Tuberkulosis Paru Anak Zakiyyah, Eki Rakhmah; Gurnida, Dida A; Kartasasmita, Cissy B
Sari Pediatri Vol 16, No 2 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.676 KB) | DOI: 10.14238/sp16.2.2014.110-4

Abstract

Latar belakang. Pada penderita tuberkulosis (TB) paru, terjadi peningkatan Reactive Oxygen Species (ROS) yang menyebabkan kebutuhan antioksidan meningkat sehingga terjadi penurunan kadar antioksidan serum. Pemberian vitamin C dapat meningkatkan kadar total antioksidan serum.Tujuan. Mengetahui pengaruh vitamin C terhadap kadar total antioksidan serum pada penderita TB paru.Metode. Penelitian uji klinis samar tunggal acak terkontrol dilaksanakan bulan April-Juli 2013. Tigapuluh orang penderita TB paru yang baru didiagnosis dilibatkan, berusia 1-14 tahun. Penelitian dilakukan di poli anak Rumah Sakit Dr. Hasan Sadikin Bandung dan RSUD Cibabat, Dibagi 2 kelompok, yaitu mendapat vitamin C dan plasebo, dilakukan selama 2 minggu. Pemeriksaan kadar total antioksidan serum dilakukan sebelum dan sesudah pemberian vitamin C dan plasebo. Perhitungan statistik dengan analisis varian two-way ANOVA digunakan untuk menganalisis perubahan kadar total antioksidan serum berdasarkan waktu (faktor A), pengaruh perlakuan (faktor B), dan interaksi di antara keduanya.Hasil. Subjek terdiri dari 22 anak laki-laki dan 8 perempuan. Tidak terdapat perbedaan bermakna pada usia, jenis kelamin, berat badan, tinggi badan, status gizi, dan asupan gizi pada kedua kelompok. Terdapat perbedaan bermakna pada perubahan kadar total antioksidan serum berdasarkan waktu (p=0,01) dan interaksi antara perubahan kadar total antioksidan serum berdasarkan waktu dengan perlakuan (p=0,01).Kesimpulan. Penelitian ini menunjukkan pemberian vitamin C bermanfaat dalam meningkatkan kadar total antioksidan serum pada penderita TB paru
Prevalence and Risk Factors of Asthma in Children Aged 13-14 Years Rosalina, Ina; Kartasasmita, Cissy B; Soepriadi, Myrna
Paediatrica Indonesiana Vol 38 No 11-12 (1998): November 1998
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2405.592 KB) | DOI: 10.14238/pi38.11-12.1998.265-72

Abstract

To determine the asthma prevalence and the role of some risk factors of asthma in children aged 13-14 years in Bandung, a study was conducted from April to May 1996 using using the International Study of Asthma and Allergies in childhood (ISAAC) written questionnaire. The study was conducted in 12 Junior high schools (SMP), selected by multistage population random sampling from 6 district in municipality of Bandung. A total of 3118 questionnaires were collected. The cumulative prevalence of asthma was 6.4% and the 12 month prevalence was 2.6%. The prevalence was higher in male, with a ratio of male : female of 1.48:1. The prevalence of asthma increased significantly in children with history of atopy in the family (OR 6.1; p<0.01); however no significant differences was found between children with one or both parents having history of atopy. The prevalence of asthma in smoking children, maternal and room mates had also increased significantly (OR = 2.1; 2.3; 2.6 and p=<0.05;<0.01;<0.01 respectively). However there was no significant effect of paternal smoking (p=0.074). The use of mosquito spray in the bedroom and having pets showed no effect on the prevalence of asthma (p=0.86 and 0.56 respectively).