p-Index From 2015 - 2020
5.786
P-Index
Articles

Found 1 Documents
Search
Journal : Jurnal Natural

ANTIDIABETIC ACTIVITY OF LEAVES ETHANOL EXTRACT CHROMOLAENA ODORATA (L.) R.M. KING ON INDUCED MALE MICE WITH ALLOXAN MONOHYDRATE Marianne, Marianne; Lestari, Dwi; Sukandar, Elin Yulinah; Kurniati, Neng Fisheri; Nasution, Rosnani
Jurnal Natural Volume 14, Number 1, March 2014
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Chromolaena odorata or Tekelan has been used traditionally to cope with diabetes mellitus, but the scientific evidence as antidiabetic agent has not been previously reported. Therefore, it is necessary to test the antidiabetic activity using ethanol extract of the tekelan leaves in male mice induced by alloxan. Mice were induced intravenously by alloxan dose of 55 mg/kg bw. After 7 days, mice were diabetic ( KGD 200 mg/dL ) and were grouped into 6 groups: negative control group (only treated with CMC - Na) , positive control group (glibenclamide 0.45 mg/kg bw) and the 4 other groups were given ethanol extract of Tekelan leaves at doses of 5 , 25 , 125 and 250 mg/kg bw. Dosage administered for 28 days and blood glucose levels was checked every 7 days using a glucotest. Data were analyzed by one-way analysis of variation at 95% confidence level. Ethanol extract of tekelan?s leaves  at doses of 5 , 25 , 125 and 250 mg/kg bw can lower blood levels  from day 7 to day 28 and was significantly different compared to the negative control group ( p 0.05). Ethanol extract of tekelan?s leaves at doses of 5 , 25 , 125 and 250 mg/kg bw showed antidiabetic activity in alloxan-induced mice.
Co-Authors ., Murwati Abdillah, Moch. Fery Adi Widarma, Adi Agung Yulianto Albertus Djoko Lesmono, Albertus Djoko Anggara, Bayu Putra Anik Nuryati, Anik Arta Farmawati Asih Rohmani, Asih Atmini Dhoruri Bambang Susilo Burhan Barid, Burhan Dian Kresnadipayana, Dian Donny Fransiskus Manalu, Donny Fransiskus E. L. Widiastuti, E. L. Edy Purnomo Eka Siswanto Syamsul, Eka Siswanto Elin Yulinah Sukandar Eminugroho Ratna Sari Endah Retnowati, Endah Eva Marliana, Eva Fitriana Yuli S, Fitriana Gusmelia Testiana, Gusmelia Haryanti, Titik Umaiyah Heliani, Leni Sophia Hisyam, Giffari Ibnu Hisyam, Giffari Ibnu I Wayan Suardana Ikhsan, Fahrudi Ahwan Isnaini, Een Lujainatul Isnaini, Fatimah Noor Istiqomah, Nusaibah Al Jumnahdi, Muhammad Karina, Yunia Dwi Kartikaningdyah, Ely Kartikasari, Ratih Indah Ketut Sukiyono Khoiroh, Aisyah Widatul Khomariyah, Nur Lailatul Komang Januartha Putra Pinatih Krahayon, Metri Utami Kurnianto, Fahmi Arif Lily Arsanti Lestari Marianne Marianne Marlina, Eva Maryani Maryani Mila Karmila Mohammad Muktiali Muniroh Munawar Musthofa Musthofa N. Nurcahyani, N. Neng Fisheri Kurniati Novidariyanti, Evira Nugroho, Krishna Fitranto Nurdin Nurdin Nurdin, Elan Artono Nurrohmat Widjajanti, Nurrohmat Parseno Parseno Pratama, Cecep Pratiwi, Inti Nur Tirta Putri Kusumawati Priyono Redy Badrudin, Redy Rini Yulianingsih Riza Agustiani, Riza Rminugroho Ratna Sari Rosnani Nasution Rozaq, Dimas Abdur Rudi Kartika, Rudi Safitri, Hana Ika Sahid Sahid Sanyoto, Nugroho Tri Sanyoto, Nugroho Tri Sari, Rizki Iman Setyaningtyas, Eunice Widyanti Siallagan, Dorsinta Siti Heldyana, Siti Siti Nuryani, Siti Sri Haryani Sudarmin Sudarmin Sugiyono Sugiyono Surakhman, Surakhman Surakhman, Surakhman Susanto, G. N. Triyanto, Lilik Turtiantoro . Ulinnuha, Hilmiyati Utami, Arum Cahyaning Wahida, Iqni’a Fajril Wiryatun Lestariana, Wiryatun Yulaikhah Yulaikhah