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STUDI IN SILICO: PREDIKSI POTENSI 6-SHOGAOL DALAM ZINGIBER OFFICINALE SEBAGAI INHIBITOR JNK Tiring, Sri Sulystyaningsih Natalia Daeng; Bare, Yohanes; Maulidi, Andri; S, Mansur; Nugraha, Fitra Arya Dwi
Al-Kimia Vol 7, No 2 (2019): DECEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v7i2.10638

Abstract

Type 2 Diabetes Mellitus (T2DM) is a metabolic disease characterized by hyperglycemia and insulin resistance. T2DM therapy against c-Jun N-terminal kinase (JNK) is one of the recovery solutions using bioactive compounds from ginger. 6-shogaol is bioactive compounds of ginger that has antioxidant properties. The purpose of this study is to analyze the potential of 6-shogaol as a JNK inhibitor. JNK protein (ID: 464Y) was obtained from Protein Data Bank (PDB) through 6-shogaol ligand (CID: 5281794) obtained from the PubChem database. Protein docking protein and ligand use Hex 8.0.0 software while visualization and analysis using Discovery Studio client 4.0. The results showed that 6-shogaol was predicted to have potential as a JNK inhibitor. Proving this by finding five amino acid residues (TRY223, LEU210, THR103 ALA214, ARG107) with an energy of -236.29cal/mol. We found the type of hydrogen bonds and the van der waals forces formed. The interaction of ligand and protein successfully inactivates JNK and stops pancreatic ? cell dysfunction. 6-shogaol has pharmacological properties as a JNK,T2DM. 
IN SILICO INSIGHT THE PREDICTION OF CHLOROGENIC ACID IN COFFEE THROUGH CYCLOOXYGENASE-2 (COX2) INTERACTION Bare, Yohanes; Sari, Dewi Ratih Tirto; Rachmad, Yoga Tribakti; Krisnamurti, Gabriella Candrakirana; Elizabeth, Agustina; Maulidi, Andri
Biogenesis: Jurnal Ilmiah Biologi Vol 7, No 2 (2019)
Publisher : Jurusan Biologi Universitas Islam Negeri (UIN) Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v7i2.9847

Abstract

Inflammation was signs of pathological or abnormality in tissue to give an alert as a trouble signal to the system. Therapeutic using NSAIDs has some side effects. This research explored the potential role of chlorogenic acid as natural therapeutic compound to inhibit the inflammation target such as COX-2 by interaction model. The research method used in this study was the molecular docking approach, which binds ligand and protein. Protein data provided by Protein Data Bank (ID: 6cox) while, chlorogenic acid obtain from PubChem (CID: 1794427). We docked COX-2 and chlorogenic acid using Hex 8.0.0. Visualization and analysis of the molecular interactions of chlorogenic acid and COX-2 conducted by the Discovery Studio Client 4.1 software. Chlorogenic acid has a high permeability and is easily absorbed based on five Lipinski Rule. Interestingly, we found Fifteen amino acid was binding with chlorogenic acid that formed by hydrogen bond and van der Waals.The interaction between ligand-protein results in energy binding -327.59cal/mol. Chlorogenic acid has a potential role to inhibit inflammation pathway by inhibiting COX-2. We predicted chlorogenic acid has a potential as therapy anti-inflammatory to suppress COX-2 as mediator inflammation.
HERPETOFAUNA DIVERSITY AT MUNGGU VILLAGE, LANDAK REGENCY, WEST KALIMANTAN PROVINCE, INDONESIA Maulidi, Andri; Jakaria, Mohamad; Fitriyana, Nurul; Rizki, Muhammad
Biogenesis: Jurnal Ilmiah Biologi Vol 7, No 2 (2019)
Publisher : Jurusan Biologi Universitas Islam Negeri (UIN) Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v7i2.10072

Abstract

A large number of forests at Munggu Village, Ngabang District, Landak Regency have been converted into oil palm and rubber plantations. As consequences, natural habitats in the region have been fragmented and species diversity, including herpetofauna, has been decreased. This study aimed to assess herpetofauna diversity in four different habitats in Munggu Village: (1) forests, (2) Landak river, (3) tourist areas, and (4) rubber plantations. Data collection used Visual Encounter Survey (VES) for 8 days.[u1]  The results showed that the total of 24 herpetofauna species: 15 amphibians? species (4 families) and 9 reptiles species (6 families) have been recorded from the four sampled areas. Of the four locations 11 species were found in river habitat in the forest, 4 species in the location of Landak river, 8 species in tourism sites and 9 species in rubber plantations. The Shannon-Wiener (H') diversity index in all four habitats was classified as moderate. In the river location in the forest, H' was 2.14, in the Landak river it was 1.28, in the tourism sites it was 1.71 and in the rubber plantation it was 1.87. However, the evenness index (E) for the herpetofauna community in all four locations was >0.80. Habitat loss and habitat destruction are among the causes of decline in amphibian and reptile populations. Knowing the diversity of herpetofauna, it is hoped that the community and stakeholders can collaborate to secure the herpetofauna in Munggu Village.
VARIOUS VEGETATION MODIFIES THE DIVERSITY OF HERPETOFAUNA IN WONOSOBO AGRICULTURAL LANDSCAPE Kurniawan, Nia; Yanuwiadi, Bagyo; Priambodo, Bagus; Maulidi, Andri; Kurnianto, Agung Sih
Journal of Environmental Engineering and Sustainable Technology Vol 4, No 2 (2017)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (652.373 KB) | DOI: 10.21776/ub.jeest.2017.004.02.10

Abstract

Human population growth has rapidly conversed the natural environment into agricultural and plantation area in Indonesia. This phenomenon resulted a reduction and fragmentation habitats, and led to the loss of biodiversity. By exploring Wonosobo, we were able to analyse the herpetofauna composition on three different habitat, including river, salak plantation [Salacca zalacca (Gaert.) Voss], and paddy fields. We identified 17 species (60,7%) from river, 15 species (53,6%) from paddy field, and 13 species (46,4%) from salak plantation. Shannon-wiener index diversity (H’) categorized herpetofauna diversity in all three habitats as medium. Meanwhile, the evenness index (E) showed that herpetofauna community in river classified as unstabile (E=0.7302). River was predicted be functioned as transit area for herpetofauna to hunt. There were no herpetofauna species predominating all three habitats, and this indicating that the ecosystem balance was well preserved. This study revealed that agriculture and plantation area affected the herpetofauna composition, yet it still able to maintain the diversity well. In addition, the water bodies, including river and irrigation in agriculture and plantation area, should be maintained its quality as it plays an important part in herpetofauna conservation. Keywords: fragmentation, herpetofauna composition, habitat
Snapshot of an On-Going Trade in Reptile Wholesaler, Kebumen, Central Java: Preparation, Trading, and Conservation Implications Kurniawan, Nia; Nugraha, Fitra Arya; Maulidi, Andri; Firdaus, Anggun Sausan; Kadafi, Ahmad Muammar; Kurnianto, Agung Sih
Indonesian Journal of Environment and Sustainable Development Vol 9, No 1 (2018)
Publisher : Graduate Program

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (974.566 KB) | DOI: 10.21776/ub.jpal.2018.009.01.02

Abstract

Indonesia is known as one of the highest supplier on animal illegal trading, especially reptile. The objectives of this study are to reveal the preparation proccess of reptiles in the wholesaler and the flow of illegal trade through deep interview and observation in Kebumen Regency, Central Java, Indonesia. The results showed that wholesaler did some specific processes towards reptile. As much as 289 reptiles were observed to be traded in various conditions. Dry season affect the amount of animal sold. Chinese Ratsnake (Ptyas korros) and Reticulated Python (Malayopython reticulatis) became the most traded commodity within reptile trading, and is reported to be exported to other countries. Trafficking of adult reptiles could threaten their wild population, yet the level of exploration and monitoring toward reptile’s wild population are still low.Keywords: Kebumen, reptile, trade, population, wholesaler
MICROSATELLITE MARKER FOR CROSS-SPECIES AMPLIFICATION: STUDY CASE FOR INDONESIAN SUNDALAND PYTHON (SERPENTES: PYTHONIDAE) Maulidi, Andri; Fatchiyah, Fatchiyah; Hamidy, Amir; Kurniawan, Nia
The Journal of Experimental Life Science Vol 8, No 1 (2018)
Publisher : Graduate School, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2018.008.01.10

Abstract

The python of Indonesian Sundaland has been traded for its distinct skin colour and patterns. The need for rapid method in cross-species amplification for Indonesian Sundaland python is useful to contribute in management of sustainability harvesting system. In this research, we screened 10 microsatellite primers which are previously used for Australian, New Guinean, Chinese and Burmese pythons and 7 potentially amplifiable primers for African and Asian reptiles. Python breitensteini showed a greater number of alleles (2-8 alleles) than Python bivittatus (1-3 alleles) and Python brongersmai (1-2 alleles). The observed and expected heterozygosity for all species were ranged from 0 to 1.00 and 0 to 0.79, respectively. According to the high cross-species amplification rates, 15 out of 17 primers were useful in assessing the genetic diversity and conservation genetic of Indonesian Sundaland python. Among the 15 primers, MS3 generated the highest number of allele for P. breitensteini (8 alleles), P. bivittatus (3 alleles), and P. brongersmai (2 alleles). We proposed MS3 locus as a suitable marker for Indonesian Sundaland python.Keywords: microsatellite, Python, Sundaland.
FISHERMEN’S PERSPECTIVE ON HERPETOFAUNA: A CASE STUDY FROM KUALA TUNGKAL, TANJUNG JABUNG BARAT, JAMBI Kurniawan, Nia; Firdaus, Anggun Sausan; Nugraha, Fitra Arya Dwi; Maulidi, Andri; Kurnianto, Aguung Sih
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.01.01

Abstract

The population of herpetofauna (Class: Reptilia, Amphibia) is continuously declining throughout the world. Moreover, habitat changes such deforestation drive rapidly to declining process. Human communities play an important role in conserving the herpetofauna by maintaining and improving the harmonious relationship between human and environment. Therefore, these association will strongly support the conservation of herpetofauna and their habitats. This study is aimed to survey the herpetofauna communities, explore the local people perspective on herpetofauna, and the relationship between human and herpetofauna. We found 12 species observed in this survey that included to 3 order of herpetofauna: anura, squamata and testudines. Local people recognized herpetofauna species around them well and do not harm them because of their roles, such as part of nature (39%), bioindicator (33%), myth (17%), and economic value (11%). We also revealed the local knowledge on herpetofauna, as 14 local names and their roles. Despite Kuala Tungkal is a strategic area for the national port development that probably impacts herpetofauna microhabitat, it needs serious attention on herpetofaunal issues.
PENGEMBANGAN SIM BIODATA MAHASISWA UNTUK PENINGKATAN KUALITAS PRODI PENDIDIKAN BIOLOGI FKIP UNIVERSITAS TANJUNGPURA Daningsih, Entin; Candramila, Wolly; Panjaitan, Ruqiah Ganda Putri; Titin, Titin; Wahyuni, Eko Sri; Maulidi, Andri
ICoTE Proceedings Vol 2 (2018): ICoTE Proceedings 2
Publisher : ICoTE Proceedings

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.907 KB)

Abstract

Sistem Informasi Manajemen (SIM) merupakan hal penting bagi suatu program studi. Penggunaan SIM dapat membantu suatu Program Studi dalam melakukan pengorganisasian data yang lebih baik sekaligus membuat keputusan yang tepat. Paper ini mendeskripsikan penyediaan data melalui SIM Biodata Mahasiswa untuk meningkatkan kemudahan pengolahan data Prodi Pendidikan Biologi FKIP Untan. SIM diunggah ke dalam data sistem yang tersedia di Universitas. Ketersediaan SIM menjaring data 385 mahasiswa dari 451 total mahasiswa Pendidikan Biologi FKIP Untan angkatan 2012 hingga 2018. SIM biodata menampilkan data jumlah mahasiswa masing-masing angkatan, jenis kelamin, jalur masuk, agama, rata-rata IPK mahasiswa per angkatan, serta data pekerjaan orang tua mahasiswa. Data dapat digunakan untuk akreditasi, monitoring, evaluasi mahasiswa, dan perencanaan pengembangan program studi termasuk rencana strategis. SIM biodata Mahasiswa sebaiknya dihubungkan dengan Siakad Universitas dan disempurnakan. AbstractManagement Information Systems (MIS) is important for a Study Program. The use of MIS can help a Study Program in organizing better data while making the right decisions. This paper describes the provision of data through the MIS Biodata Students to increase the ease of processing the Biology Education Study Program of FKIP Untan. MIS is uploaded into system data available at the University. MIS availability captures data on 385 students from 451 total students of Biology Education Study Program class 2012 to 2018. The biodata MIS displays data on the number of students in each generation, gender, entry point, religion, average student GPA per generation, and parents’ job. Data can be used for accreditation, monitoring, student evaluation, and study program development planning including strategic plans. MIS Biodata Students should be connected with the University Academic and refined. 
STUDI IN SILICO PREDIKSI POTENSI 6-GINGEROL SEBAGAI INHIBITOR C-JUN N-TERMINAL KINASES (JNK): PREDICTION POTENTIAL OF 6-GINGEROL AS C-JUN N-TERMINAL KINASES (JNK): IN SILICO APPROACH Bare, Yohanes; Maulidi, Andri; Sari, Dewi Ratih Tirto; Tiring, Sri Sulystyaningsih Natalia Daeng
Jurnal Jejaring Matematika dan Sains Vol. 1 No. 2 (2019): Edisi Desember 2019
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.v1i2.211

Abstract

Revolusi industri 4.0 mendorong pendidikan harus sesuai perkembangan teknologi. Penggunaan in silico merupakan metode dalam bidang biologi yang menggunakan komputer dan internet dalam kajiannya. Penyembuhan penyakit diabetes melitus tipe 2 (DMT2) menjadi perhatian dalam kajian in silico. Senyawa 6-gingerol dari jahe diinteraksikan dengan protein JNK. Tujuan dari penelitian dari penelitian ini untuk menganalsisi potensi 6-gingerol sebagai inhibitor JNK.  Penelitian ini menggunakan metode in silico. Protein JNK (ID: 464Y) diperoleh dari Protein Data Bank (PDB) sedangkan ligan 6-gingerol (CID: 44559528) diperoleh dari database PubChem. Ligan dan protein diinteraksikan menggunakan HEX 8.0.0, visualisasi dan analisis data menggunakan Discovery studi client 4.1. Analisis yang dikaji adalah jumalah residu asam amino yang berinteraksi dengan JNK, ikatan hidrogen, dan energi yang dibentuk.  Interaksi 6-gingerol dan JNK terdapat dua residu Arg107 dengan ikatan hidropobik dan Ser217 dengan ikatan hydrogen. Gaya van der Waals yang terbentuk pada residu asam amino ALA74, GLN75, ALA211, ALA214, LYS106, THR213, THR103, GLN1022, GLU384, dan HIS104. Energi yang terbentuk adalah -299.65cal/mol. Ligan 6-gingerol diprediksi memiliki potensi sebagai inhibitor JNK.