E. Elsa Herdiana Murhandarwati
Bagian Parasitologi, Fakultas Kedokteran, Universitas Gajah Mada, Jogjakarta, Indonesia

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HUBUNGAN JENIS BREEDING SITES DAN KEPADATAN LARVA DENGAN KASUS MALARIA DI WILAYAH PT. FREEPORT INDONESIA KABUPATEN MIMIKA TAHUN 2013-2017: PENDEKATAN SPASIAL-TEMPORAL Wiariyanti, Wafiyyah Rizki; Murhandarwati, E. Elsa Herdiana; Fuad, Anis
Berita Kedokteran Masyarakat (BKM) Vol 35, No 10 (2019)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.254 KB) | DOI: 10.22146/bkm.47232

Abstract

Jenis breeding sites dan kepadatan larva dengan kasus malaria di wilayah PT. Freeport Indonesia tahun 2013-2017: pendekatan spasial-temporalPurpose: This study aims to determine the relationship between breeding sites and larval density in malaria cases in the Lowland region of PT. Freeport Indonesia Mimika Regency 2013-2017.Method: This study uses secondary data from PT. Freeport Indonesia in 2013 - 2017. The data used in this study included malaria case data, breeding sites and breeding sites and larval density in the lowland PTFI area from 2013-2017. Data analysis included descriptive analysis to see the distribution picture, bivariate analysis to examine the relationship between variables and spatial analysis to find out the distribution of cases and breeding sites.Results: The number of malaria cases from 2013-2017 in the Lowland PTFI region was 267 (37%) from a total population of 713 people. The highest case occurred in 2014 as many as 70 cases. Distribution of cases based on sex occurs mostly in men, in the age group of 46-50 years, based on the relatively equal employment status between employees and non-employees and based on the location, many occur in Kuala Kencana. Types of breeding sites with larvae density have a significant relationship (p <0.0001), larvae density with malaria cases also have a significant relationship (p 0.0013 and r 0.40) especially density in xpool which has a density of 2.01/dip.Conclusion: Distribution of malaria cases focused on locations where employees live and locations with high mobility. The types of breeding sites are related to larval density. The highest density of larvae is found in breeding sites of the xpool type. Larval density and malaria cases have a significant relationship with larvae density in the xpool breeding site.
Faktor-Faktor yang Mempengaruhi Ketepatan Diagnosis Malaria di Puskesmas Kabupaten Belu Nusa Tenggara Timur Mau, Fridolina; Murhandarwati, E. Elsa Herdiana
Media Penelitian dan Pengembangan Kesehatan Vol 25, No 2 Jun (2015)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.992 KB)

Abstract

Pengobatan malaria di Kabupaten Belu Propinsi Nusa Tenggara Timur berdasarkan pada diagnosisklinis dan mikroskopis. Angka kesalahan diagnosis mikroskopis malaria dilaporkan masih tinggi, di atasnilai toleransi kesalahan diagnosis menurut Kementerian Kesehatan &gt;5%. Tujuan penelitian ini untukmengetahui faktor-faktor penyebab kesalahan diagnosis malaria di Puskesmas. Rancangan penelitianini adalah explorasi dan observasional secara potong lintang terhadap 16 mikroskopis sampel dalammendiagnosis mikroskopis malaria. Penelitian dilakukan di 10 puskesmas Kabupaten Belu dari bulanApril hingga Juni 2012. Hasil pengamatan menunjukkan faktor yang mempengaruhi kesalahan diagnosisadalah kelengkapan mempersiapkan alat dan bahan sebelum pengambilan darah (p &lt; 0,029), tidakmelakukan sediaan darah tipis (p &lt; 0,07), menggunakan Kaca Sediaan (KS) bekas/slide bekas (p &lt;0,08) hasil pewarnaan Sediaan Darah (SD) tidak baik (p &lt; 0,02), kurang pengalaman kerja (p &lt; 0,029)dan kurang pelatihan (p &lt;0,08). Penilaian terhadap mikroskopis dilakukan oleh expert microscopistyang tersertifiasi dan ditemukan responden memiliki nilai Kappa jelek (0,00-0,20) sebanyak 35,2%.
Evaluation of artemisinin-based combination therapy (ACT) to uncomplicated falciparum malaria patients in Purworejo District, Central Java, Indonesia Bia, Michael Bhadi; Murhandarwati, E. Elsa Herdiana; F Lobo, Neil; A Hawley, William; Supargiyono, .
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 1 (2016)
Publisher : Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1401.807 KB) | DOI: 10.19106/JMedSci004801201605

Abstract

Artemisinin-based Combination Therapy (ACT) to treat uncomplicated Plasmodiumfalciparum malaria has been applied in Purworejo District, Central Java, Indonesia, since2004. However evaluation of the two ACT regimens used ie: Artesunate Amodiaquine(AAQ) and Dihydroartemisinin-Piperaquine (DHP) co-administered with Primaquine (PQ)has not been performed. This study aims to evaluate the efficacy and side effects ofAAQ+PQ and DHP+PQ treatment in uncomplicated falciparum malaria in Purworejo. Inthis descriptive and observational study, 46 Pf infected patients who fullfill the inclusionand exclusion criterias were recruited from December 2010 to August 2011. StandardACT treatment were given to the patients followed by WHO drug efficacy evaluation for28 days. The clinical symptoms and adverse events was also evaluated over the course ofthe treatment. From all recruited subjects, 37 patients received DHP+PQ and 9 patientsreceived AAQ+PQ. On the DHP+PQ treated patient, all subjects were free of asexualand sexual parasites by Day-3 while on AAQ+PQ treated patient, this parasite clearancewas achieved faster as early as on D-2 at the latest. On the otherhand, the disappearanceof fever was also last longer in DHP+PQ treated patient which in one patient last onD-14, while in AAQ+PQ treated patient, the symptom of fever dissappeared by D-2at the latest. No Early or Late Treatment Failures were found on either DHP+PQ orAAQ+PQ treatment as well as clinical and parasitological failures. However, the presenceof adverse events cause by both drugs should not be ignored to ensure drug compliance.
FEATURE ANALYSIS FOR STAGE IDENTIFICATION OF PLASMODIUM VIVAX BASED ON DIGITAL MICROSCOPIC IMAGE Nugroho, Hanung Adi; Maysanjaya, I Md. Dendi; Setiawan, Noor Akhmad; Murhandarwati, E. Elsa Herdiana; Oktoeberza, Widhia K.Z
Indonesian Journal of Electrical Engineering and Computer Science Vol 13, No 2: February 2019
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v13.i2.pp721-728

Abstract

Plasmodium parasite is identified to confirm malaria disease.  Paramedics need to observe the presence of this parasite prepared on thick and thin blood films under microscope.  However, false identification still occurs which is caused by human factor during the examination.  Thus, malaria identification based on digital image processing has been widely developed to overcome the error possibility.  This paper proposes a scheme to identify and classify the stages of Plasmodium vivax parasite on digital microscopic image of thin blood films based on feature analysis.  Shape and texture features are extracted from segmented parasite objects.   Feature selection based on wrapper method is then conducted to obtain relevant features which may contribute in improving the classification result.  The classification process is conducted based on Naïve Bayes classifier.  The performance of proposed method is evaluated using 73 digital microscopic images of P.vivax parasite on thin blood films comprising of 29 trophozoites, 10 schizonts and 34 gametocytes stages.  By using six selected features including perimeter, dispersion, mean of intensity, ASM, contrast GLCM and entropy GLCM, the proposed scheme achieves the best classification rate with the accuracy, sensitivity and specificity of 97.29%, 97.30% and 97.30%, respectively.  This indicates that the proposed scheme has a potential to be implemented in the development of a computerised aided malaria diagnosis system for assisting the paramedics.