Noormartany Noormartany
Departemen Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung

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KESESUAIAN HASIL PEMERIKSAAN ANTIBODI VIRUS HERPES SIMPLEKS METODE ENZYME-LINKED IMMUNOFILTRATION ASSAY DENGAN ENZYME-LINKED IMMUNOSORBENT ASSAY Immanuel, Victor; Noormartany, Noormartany; Dewi, Nina Susana
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Infeksi virus herpes simpleks (HSV) merupakan infeksi yang disebabkan oleh HSV tipe 1 (HSV-1) dan HSV tipe 2 (HSV-2). HSV-1 biasanya menyebabkan penyakit orofasial, sedangkan HSV-2 biasanya menyebabkan infeksi perigenital. Diagnosis infeksi HSV ditegakkan berdasarkan anamnesis, pemeriksaan fisis, dan laboratorium. Metode deteksi anti-HSV metode enzyme-linked immunosorbent assay (ELISA) memiliki sensitivitas 93?100% dan spesifisitas 95?100%, sedangkan metode enzyme-linked immunofiltration assay (ELIFA) memiliki sensitivitas 83,36?97% dan spesifisitas 83,93?98%. Tujuan penelitian adalah menilai kesesuaian hasil pemeriksaan anti-HSV antara metode ELIFA dan ELISA. Bila terdapat kesesuaian yang baik maka metode ELIFA dapat menggantikan metode ELISA. Penelitian dilakukan di laboratorium klinik RSUP Dr. Hasan Sadikin Bandung sejak bulan Januari?Mei 2011. Rancangan penelitian adalah potong lintang. Subjek penelitian adalah serum penderita tersangka infeksi HSV. Dilakukan analisis statistik untuk menilai agreement Kappa. Sebanyak 66 sampel diperiksa anti-HSV metode ELIFA dan ELISA. Hasil pemeriksaan IgM anti-HSV antara metode ELIFA dan ELISA memiliki kesesuaian baik (p<0,001; K=0,621), hasil pemeriksaan IgG anti-HSV-1 antara metode ELIFA dan ELISA memiliki kesesuaian sedang (p<0,001; K=0,533), dan hasil pemeriksaan IgG anti-HSV-2 antara metode ELIFA dan ELISA memiliki kesesuaian kurang (p=0,006; K=0,260). Simpulan, hanya pemeriksaan IgM anti-HSV metode ELIFA yang memiliki hasil kesesuaian baik dengan metode ELISA, sedangkan pemeriksaan IgG anti-HSV metode ELIFA memiliki kesesuaian sedang atau kurang. [MKB. 2012;44(3):152?8].Kata kunci: IgM anti-HSV, IgG anti-HSV, kesesuaian, metode ELIFA, metode ELISA Agreement of Herpes Simplex Virus Antibody Test Result between Enzymelinked Immunofiltration and Enzyme-linked Immunosorbent Assay MethodsHerpes simplex virus (HSV) infections are very common and are caused by HSV type 1 (HSV-1) and HSV type 2 (HSV-2). HSV-1 being mostly associated with orofacial disease, whereas HSV-2 is usually associated with perigenital infection. Diagnosis of HSV infection is established based on history, physical and laboratory examination. Enzyme-linked immunosorbent assay (ELISA) method to detect anti-HSV has a sensitivity 93?100% and specificity 95?100%, whereas enzyme-linked immunofiltration assay (ELIFA) has a sensitivity 83.36?97% and specificity 83.93?98%. The aim of this study was to assess the agreement of anti-HSV between ELIFA and ELISA methods. This study was conducted in the clinical laboratory RSUP Dr. Hasan Sadikin Bandung since January to May 2011. The study design was cross sectional. Subjects of this study were serum of patients suspected HSV infection. Statistical analysis was performed to assess Kappa agreement. A total of 66 samples were examined anti-HSV using ELIFA and ELISA method. There was good agreement between test results of anti-HSV IgM ELIFA and ELISA method (p<0.001, ?=0.621), moderate agreement between test results of anti- HSV-1 IgG ELIFA and ELISA method (p<0.001, ?=0.533), and fair agreement between test results of anti-HSV-2 IgG ELIFA and ELISA method (p=0.006, ?= 0.260). In conclusions, only the anti-HSV IgM ELIFA method has good agreement with ELISA. DOI: http://dx.doi.org/10.15395/mkb.v44n3.86 
Korelasi Jumlah CD4 Dan Total Lymphocyte Count (Tlc) pada Penderita HIV/AIDS dengan dan tanpa Terapi Antiretroviral Sulianto, Ivana Agnes; Indrati, Agnes R; Wisaksana, Rudi; Noormartany, Noormartany
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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ABSTRAK Jumlah CD4 merupakan parameter laboratorium yang digunakan untuk memulai dan memantau terapi antiretroviral (ART) pada penderita HIV/AIDS. Namun pemeriksaan jumlah CD4 membutuhkan peralatan laboratorium yang mahal dan tenaga terlatih. World Health Organization (WHO) merekomendasikan total lymphocyte count (TLC) sebagai pengganti CD4 dalam memulai terapi. Penelitian ini bertujuan untuk melihat korelasi antara jumlah CD4 dan TLC pada data dasar, pemantauan pertama dan kedua penderita HIV/AIDS sebagai dasar digunakannya TLC untuk pemantauan terapi. Penelitian ini merupakan penelitian observasional analitik dan bagian dari penelitian kohort IMPACT (Integrated Management for Prevention And Care and Treatment of  HIV/AIDS) pada pasien HIV/AIDS di RS. Dr. Hasan Sadikin Bandung. Data tersebut dibagi menjadi kelompok tanpa ART dan dengan ART, masing-masing kelompok dibagi berdasarkan jenis kelamin. Analisis korelasi dilakukan pada data CD4 dan TLC dari tiap kelompok.Penelitian ini menggunakan 2239 data. Korelasi antara CD4 dan TLC pada data dasar pria tanpa ART adalah 0.644 (p=0.01), wanita tanpa ART adalah 0.74 (p=0.01), pria dengan ART 0.67 adalah (p=0.01), wanita dengan ART adalah adalah 0.601 (p=0.01). Korelasi antara CD4 dan TLC pemantauan pertama pria tanpa ART 0.56 (p=0.01), wanita tanpa ART adalah 0.606 (p=0.01), pria dengan ART adalah 0.569 (p=0.01), wanita dengan ART adalah 0.466 (p=0.01). Korelasi antara CD4 dan TLC pemantauan kedua pria tanpa ART adalah 0.697 (p=0.01), wanita tanpa ART adalah 0.306 (p=0.01), pria dengan ART adalah 0.556 (p=0.01), wanita dengan ART adalah 0.561 (p=0.01).  Kesimpulan :  terdapat korelasi yang baik antara jumlah CD4 dan TLC, sehingga TLC dapat digunakan sebagai alternatif pemantauan terapi sebelum penderita melakukan pemeriksaan CD4.   Kata kunci: CD4, HIV/AIDS, terapi antiretroviral, total lymphocyte count
DETEKSI NATRIUM/IODIDE SYMPORTER (NIS) PADA GALUR SEL KANKER PAYUDARA SKBR3 DENGAN IMUNOSITOFLUORESENS Elliyanti, Aisyah; Wikayani, Tenny Putri; Noormartany, Noormartany; Masjhur, Johan S.; Achmad, Tri Hanggono
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Galur sel SKBR3 adalah model kanker payudara positif human epidermal growth factor receptor2 (HER2). Pemberian kemoterapi memperlihatkan respons lengkap hanya pada 50% pasien kanker payudara dengan tipe positif HER2. Kemampuan jaringan tumor menangkap dan mengakumulasi iodium radioaktif dihubungkan dengan ekspresi natrium/iodide symporter (NIS). Tujuan penelitian ini adalah menilai ekspresi dan distribusi NIS pada galur sel SKBR3 serta menilai efek induksi epidermal growth factor (EGF) pada ekspresi NIS menggunakan imunositofluoresens-ISF. Penelitian ini dilakukan di Laboratorium Kultur Sel, Fakultas Kedokteran Universitas Padjadjaran (FKUP) mulai bulan September 2013 sampai dengan April 2014. Sel SKBR3 ditumbuhkan pada plat kultur dan ditunggu hingga konfluen 70%. Sel dibagi atas dua kelompok, yaitu kelompok yang diberi induksi dan kontrol. Induksi EGF diberikan dengan dosis 50 ng/mL. Pemeriksaan ISF menggunakan antibodi primer rabbit polyclonal antibody anti NIS dan antibodi sekunder goat anti rabbit IgG polyclonal antibody. Data hasil pengamatan dinilai secara semikuantitatif. Natrium/iodide symporter tampak terekspresi dan terdistribusi di sitoplasma. Sel yang diinduksi dengan EGF memperlihatkan peningkatan ekspresi NIS di sitoplasma dan distribusinya di membran sel secara bermakna. Sel SKBR3 mengekspresikan NIS yang terdapat di sitoplasma. Induksi EGF meningkatkan ekspresi NIS dan distribusinya di membran sel. Temuan ini dapat mengarah potensi kemampuan sel kanker payudara menangkap dan mengakumulasikan iodium radioaktif. [MKB. 2016;48(1):15?8] Kata kunci: Ekspresi NIS , galur sel SKBR3, kanker payudara, imunositofluoresensDetection of Natrium/Iodide Symporter (NIS) in SKBR-3 Breast Cancer Cell Line Using ImmunocytofluoresenceAbstractSKBR-3 cell line is a breast cancer model for human epidermal growth factor receptor2 (HER2) positive. Only 50% of patients of this type have fully responded to chemotherapy. Natrium iodide symporter expression correlates with the uptake and ability of cells to accumulate radioiodine. The aim of this study was to examine natrium/iodide symporter (NIS) expression and its distribution with and without epidermal growth factor (EGF) treatment using immunocytofluoresence (ICF). This study was conducted at the Cell Culture Laboratory, Faculty of Medicine, Universitas Padjadjaran from September 2013 to April 2014. SKBR3 cells were cultured until 70% confluent. Cells were then divided into two groups: treatment group and control group. The treatment group was treated with EGF 50 ng/mL. Cells were incubated with primary antibody rabbit polyclonal antibody anti-NIS, and then were followed with secondary-antibody goat polyclonal antibody to rabbit. Data from the observation were then assessed semi-quantitatively. Natrium/iodide symporter was seen to be expressed and distributed in the cytoplasm. Cells induced by EGF showed significant increase in NIS expression in cytoplasm and its distribution in cell membrane. It is concluded that the SKBR3 cells express NIS in cytoplasm and that EGF induction increases NIS expression and distribution in cell membrane. This finding leads to a potential ability of breast cancer cells to uptake and accumulate radioiodine. [MKB. 2016;48(1):15?8]Key words: Breast cancer, cell line SKBR-3, immunocytofluoresence, NIS expression DOI: 10.15395/mkb.v48n1.728
KADAR N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE SEBAGAI PREDIKTOR LUARAN KLINIS SINDROM KORONER AKUT Tandhana, Florencia Idajanti; Noormartany, Noormartany; Aprami, Toni M.; Tristina, Nina
Majalah Kedokteran Bandung Vol 44, No 2 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Kadar N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma dapat menggambarkan tingkat keparahan iskemia walaupun tidak terjadi nekrosis, iskemia yang transien dapat meningkatkan peregangan dinding jantung yang akan menginduksi sintesis dan pelepasan brain natriuretic peptide (BNP) yang sebanding dengan tingkat keparahan iskemia. Tujuan penelitian untuk mengetahui apakah kadar NT-proBNP pada penderita sindrom koroner akut (SKA) dapat digunakan sebagai parameter prediktor luaran klinis. Penelitian dilakukan sejak bulan Januari hingga Maret 2010. Subjek penelitian penderita SKA yang datang ke Unit Gawat Darurat Rumah Sakit Dr. Hasan Sadikin Bandung dan telah didiagnosis klinis sesuai kriteria World Health Organization. Pada subjek yang memenuhi kriteria inklusi dilakukan pemeriksaan kadar NT-pro BNP dengan metode electrochemiluminescence immunoassay, cardiac troponin T (kuantitatif), dan creatine kinase muscle brain (enzimatik). Analisis data uji normalitas menggunakan one-sample Kolmogorov-Smirnov test, analisis regresi logistik multipel untuk mengetahui parameter prediktor luaran klinis penderita SKA. Dari 83 subjek yang ikut dalam penelitian, didapatkan nilai prediksi kadar NT-proBNP sebesar 1,00 sehingga bukan merupakan prediktor utama luaran klinis, koefisien ? NTproBNP sebesar 0,001 menyatakan bahwa setiap penambahan 1.000 pg/mL variabel NT-proBNP akan menambah lama perawatan 1 hari. Pada subjek SKA dengan luaran (outcome) sembuh nilai prediksi cTnT lebih baik sebagai faktor prediktor dibandingkan dengan konsentrasi NT-proBNP (OR=32,53; 95%IK; 0,58?1.819,26). Simpulan, NT-proBNP bukan merupakan prediktor utama luaran klinis pada SKA. Kadar NT-proBNP lebih dari 826,7 pg/mLterdapat kemungkinan prognosis yang buruk sampai dengan kematian. [MKB. 2012;44(2):106?13].The Role of NT-proBNP as Clinical Outcome Predictor for Acute Coronary SyndromesPlasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels may reflect the severity of ischemia, although there is no necrosis. A transient ischemia which can increase the heart wall stretch would induces BNP synthesis and release. Synthesis and release of BNP are comparable with the severity of ischemia. The aim of this study was to analyze whether NT-proBNP levels in patients with acute coronary syndrome (ACS) can be used as a predictor for clinical outcome. Studies was held since January to March 2010. Subject were patients with ACS who came to emergency room Dr. Hasan Sadikin Hospital Bandung and were clinically diagnosed according to World Health Organization criteria. Subjects which were suited with the inclusion criteria, stored until assayed. NT-pro BNP concentration was examined by electrochemiluminescence immunoassay method along with creatine kinase muscle brain (enzymatic method) and cardiac troponin T (quantitative method). Statistical analysis was performed using the one-sample Kolmogorov-Smirnov test for verifying normality, normally distributed data were analyzed using parametric analysis and abnormal distributed data was assayed using multiple logistic regression analysis to determine the parameters which can be used as predictor for clinical outcome in patients with ACS. Multiple logistic regression analysis on 83 subjects showed predictive value of NT-proBNP levels with OR=1.00, which mean there was no different likelihood in patients with high and low concentration of NT-proBNP to have longer hospitality duration. NT-proBNP ? coefficient of 0.001 states that every addition of 1,000 pg/mL of NT-proBNP concentration will increase the length of hospitality duration for one day. On convalesce subjects, the most significant predictive value for predicting clinical outcome cTnT was more better than NT-proBNP concentration in patients with ACS (OR=32.53, 95%CI; 0.58?1,819.26). In conclusions, NT-proBNP is not a major predictor of clinical outome in ACS. NT-proBNP levels of >826.7 pg/mL implies a poor prognosis to death. [MKB. 2012;44(2):106?13]. DOI: http://dx.doi.org/10.15395/mkb.v44n2.132 
Korelasi Jumlah CD4 dan Total Lymphocyte Count (TLC) pada Penderita HIV/AIDS dengan dan tanpa Terapi Antiretroviral Sulianto, Ivana Agnes; Indrati, Agnes R.; Wisaksana, Rudi; Noormartany, Noormartany
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v1i1.1516

Abstract

Jumlah CD4 merupakan parameter laboratorium yang digunakan untuk memulai dan memantau terapi antiretroviral (ART) pada penderita HIV/AIDS. Pemeriksaan jumlah CD4 membutuhkan peralatan laboratorium yang mahal dan tenaga terlatih. World Health Organization (WHO) merekomendasikan total lymphocyte count (TLC) sebagai pengganti CD4 dalam memulai terapi. Penelitian ini bertujuan untuk melihat korelasi antara jumlah CD4 dan TLC pada data dasar, pemantauan pertama dan kedua penderita HIV/AIDS sebagai dasar digunakannya TLC untuk pemantauan terapi. Penelitian ini merupakan penelitian observasional analitik dan bagian dari penelitian kohort IMPACT (Integrated Management for Prevention And Care and Treatment of HIV/AIDS) pada pasien HIV/AIDS di RS Dr. Hasan Sadikin Bandung. Data tersebut dibagi menjadi kelompok tanpa ART dan dengan ART, masing-masing kelompok dibagi berdasarkan jenis kelamin. Analisis korelasi dilakukan pada data CD4 dan TLC dari tiap kelompok. Penelitian ini menggunakan 2.239 data. Korelasi antara CD4 dan TLC pada data dasar pria tanpa ART adalah 0,644 (p=0,01), wanita tanpa ART adalah 0,74 (p=0,01), pria dengan ART 0,67 adalah (p=0,01), wanita dengan ART adalah adalah 0,601 (p=0,01). Korelasi antara CD4 dan TLC pemantauan pertama pria tanpa ART 0,56 (p=0,01), wanita tanpa ART adalah 0,606 (p=0,01), pria dengan ART adalah 0,569 (p=0,01), wanita dengan ART adalah 0,466 (p=0,01). Korelasi antara CD4 dan TLC pemantauan kedua pria tanpa ART adalah 0,697 (p=0,01), wanita tanpa ART adalah 0,306 (p=0,01), pria dengan ART adalah 0,556 (p=0,01), wanita dengan ART adalah 0,561 (p=0,01). Simpulan, terdapat korelasi yang baik antara jumlah CD4 dan TLC, sehingga TLC dapat digunakan sebagai alternatif pemantauan terapi sebelum penderita melakukan pemeriksaan CD4. CORRELATION OF CD4 AND THE TOTAL NUMBER OF LYMPHOCYTE COUNT (TLC) IN HIV/AIDS PATIENTS WITH AND WITHOUT ANTIRETROVIRAL THERAPYCD4 count is a marker for initial and follow up antiretroviral therapy (ART) in HIV/AIDS patients. It requires expensive equipment and skill to performed. World Health Organization (WHO) recommends total lymphocyte count (TLC) as a substitute marker for CD4 count to start ART. The aim of this study is to evaluate the correlation between CD4 count and TLC in baseline and follow up data as a guide for follow up therapy. This study was an analytical observational study of HIV/AIDS patients data in Dr. Hasan Sadikin Hospital Bandung. It is part of IMPACT (Integrated Management for Prevention And Care and Treatment of  HIV/AIDS) study. The sample of 2,239  was divided into non ART and ART groups. The data was analyzed using correlation analysis. The results showed that the correlation between CD4 and TLC at baseline in male without ART was 0.644 (p=0.01), female without ART was 0.74 (p=0.01), male with ART was 0.67 (p=0.01), and female with ART was 0.601 (p=0.01). The correlation between CD4 and TLC at first follow up in male without ART was 0.056 (p=0.01), female without ART was 606 (p=0.01), male with ART was 0.569 (p=0.01), female with ART was 0.466 (p=0.01). The correlation between CD4 and TLC at second follow up in male without ART was 0.697 (p=0.01), female without ART was 0.306 (p=0.01), male with ART was 0.556 (p=0.01), female with ART was 0.561 (p=0.01). In conclusion, there is a good correlation between CD4 count and TLC so that TLC can be used as an alternative marker for follow up therapy.
KADAR HEMOGLOBIN RETIKULOSIT DI ANEMIA DAN NONANEMIA AKIBAT DEFISIENSI BESI ABSOLUT DI GAGAL GINJAL TERMINAL TERKAIT HEMODIALISIS (Reticulocyte Hemoglobin Level of Absolute Iron Deficiency Anemia and NonAbsolute Iron Deficiency Anemia In End State Renal Disease Undergoing Maintenance Hemodialysis) Rachmiwatie, Amelia; Noormartany, Noormartany; Gondodiputro, Rubin Surachno; Prihatni, Delita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1256

Abstract

Absolute Iron Deficiency Anemia (IDA) is one of the complications in the End State Renal Disease (ESRD) patients undergoingmaintenance hemodalysis, with an incidence of 76.4%. If this condition is not properly addressed, it can lead to impaired cardiac functionand increased mortality. The incidence of this case is between 30?45%. The determination of the iron status in ESRD patients wqs setby the Perhimpunan Nefrologi Indonesia 2011 using serum ferritin and transferrin saturation, but they do not provide a meaningfulchange in the value of the initial state of the iron deficiency. This condition should be examined with other parameters combination aswell as those influenced by diurnal variation and infection-inflammation condition. Reticulocyte hemoglobin (Ret-He) parameter canbe used as a marker of bone marrow iron availability because these reticulocytes are young erythrocytes released from the bone marrowinto the circulation. These conditions were circulated only within a short time about 1-2 days before becoming mature erythrocytes. Theaim of this study was to determine the Ret-He level diferentiation between absolute IDA and non absolute IDA states in ESRD patientswhom underwent maintenance hemodialysis. This research was conducted in the Laboratory of Clinical Pathology-RSHS-Bandung fromSeptember 2012 to June 2013. The study design was cross-sectional. All subjects were ESRD patients undergoing hemodialysis maintenancefor at least three (3) months and consisted of absolute IDA and non-absolute IDA based on the results of the ferritin and transferrinsaturation calculations according to the criteria of Pernefri 2011 Reticulocyte hemoglobin levels were checked using a fluorescenceflowcitometry principle in the automated hematology analyzer. In this study it was found that the Ret-He mean in the absolute IDA was26.1 pg/cell and 35.9 pg/cell in non absolute IDA. Statistical analysis was performed using Independent T-test. A total of 61 undergoingmaintenance hemodialysis subjects participating in this study comprised patients with absolute IDA and non-absolute IDA who met theinclusion and exclusion criteria. It can be concluded that the Ret-He level in statistical analysis showed absolute IDA which was meaningfullower than nonabsolute IDA in ESRD patients undergoing maintenance hemodialysis (p<0.001).
Frekuensi Pemeriksaan Kehamilan, Konseling Laktasi, dan Pemberian Air Susu Ibu Eksklusif Djami, Moudy Emma Unaria; Noormartany, Noormartany; Hilmanto, Dany
Jurnal Kesehatan Masyarakat Nasional Vol 7. No. 12 Juli 2013
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.792 KB) | DOI: 10.21109/kesmas.v7i12.330

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Pemberian air susu ibu (ASI) eksklusif pada bayi penting karena erat hubungannya dengan kelangsungan hidup bayi, pertumbuhan dan perkembangan yang optimal serta peningkatan kualitas generasi berikutnya. Penelitian ini bertujuan menentukan hubungan frekuensi pemeriksaan kehamilan dan konseling laktasi dengan pemberian ASI eksklusif. Rancangan penelitian adalah kohor historikal. Analisis multivariabel dilakukan menilai hubungan dan faktor paling dominan antara variabel bebas (frekuensi pemeriksaan kehamilan dan konseling laktasi), variabel perancu (pengetahuan, pendidikan, pekerjaan, paritas dan tingkat pendapatan keluarga) dan variabel terikat (ASI eksklusif). Pada analisis regresi logistik ditemukan pengetahuan sebagai faktor paling dominan dalam pemberian ASI eksklusif (OR = 4,30; 95% CI = 1,98 - 9,31). Pengetahuan yang baik tentang ASI eksklusif meningkatkan pemberian ASI eksklusif 4,30 kali lebih besar. Kesimpulan penelitian ini adalah semakin sering frekuensi pemeriksaan kehamilan akan semakin tinggi pemberian ASI eksklusif, serta semakin sering pemberian konseling laktasi oleh tenaga kesehatan semakin tinggi pemberian ASI eksklusif.Exclusive breastfeeding is important because it is connected with infant survival, optimal growth and development and improving the quality of the next generation. This study aims to analyze and determine the frequency of prenatal care and relationship counseling lactation with exclusive breastfeeding. A historical cohort study design and bivariate and multivariable analyzes performed to look for association and dominant factor among the independent variables (frequency of prenatal care and counseling lactation), confounding variables (knowledge, education, employment, parity and level of family income) with the dependent variable (exclusive breastfeeding). In the logistic regression analysis found knowledge as a dominant factor in the exclusive breastfeeding (OR = 4,30; 95% CI = 1,98 _ 9,31). The conclusion of this study is that the more often the frequency of antenatal care will increase exclusive breastfeeding, and the more lactation counseling given by health provider during antenatal visit will increase exclusive breastfeeding.
PENGELOLAAN SUMBER DAYA MANUSIA LABORATORIUM KLINIK Noormartany, Noormartany
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 1 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i1.354

Abstract

Clinical laboratories should have higher competitiveness and healthiness to be survived in the globalization era. The very basic assets are vision, mission, and objectives which are agreed upon them. To establish these objectives are required the availability of the human resources which can perform professionally. They can serve efficiently and effectively due to their increasing professionalism. This happened by a continuing enhanced development of the human resources. The only way to achieve this objective is by effecting the Total Quality Management which emphasizes the personal development through an objective appraisal system
ANGKA FIB-4 DAN HIGHLY ACTIVE ANTI RETROVIRAL THERAPY DI ANTARA PASIEN PENGIDAP INFEKSI HIV A, Liliana; Noormartany, Noormartany; AK, Sugianli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1071

Abstract

Liver disease in patients with HIV infection can be caused by hepatotropical virus co infection or as a side effect of antiretroviraltherapy. The cause of HAART effects on liver fibrosis among patients with HIV infection is not yet known. The monitoring of the incidenceof liver fibrosis can be done with non-invasive markers, such as FIB 4 score. FIB-4 score is calculated by the formula: Age x AST/totalplatelet x ?ALT. This is carried out to know the comparison of the FIB-4 score in HIV patients before and after first-line HAART therapy,with or without HCV coinfection. This study was a comparative analysis of retrospective data of patients at the Outpatient Teratai Clinic,Dr. Hasan Sadikin Hospital, from 2003 through 2013. The research subjects consisted of 64 patients with HIV infection who receivedfirst-line HAART therapy for more than 12 months. Statistical analysis was performed by Wilcoxon test for two paired samples. Themedian scores of FIB-4 from HIV infection patients with or without HCV co infection before and after the administration of first-lineHAART therapy were 0.854 and 0.906 (p=0.837). The HCV co infected patients had median scores of FIB-4 before and after treatment at0.854 and 0.899 (p=0.204). Those without HCV co infection had median scores of FIB-4 before and after treatment at 2.726 and 0.912(p=0.013).Treatment with first-line HAART did not lead to a change in the FIB-4 score. Those who were co infected with HCV showed nodifferences in the FIB-4 scores before and after treatment with first-line HAART.