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Artemisia annua Leaf Extract Increases GLUT-4 Expression in Type 2 Diabetes Mellitus Rat Kartikadewi, Arum; Prasetyo, Awal; Budipradigdo, Lisyani; Nugroho, Heri; Tjahjono, Kusmiyati; Lelono, Arthur
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.531

Abstract

BACKGROUND: The depletion of glucose transporter 4 (GLUT-4) affects blood glucose level in the type 2 diabetes mellitus (T2DM) patient. Herbals supplementation such as Artemisia annua is known to posses an antidiabetic potency, but its effect on long term glucose control marker, glicated hemoglobin (HbA1C) and muscle GLUT-4 expression still has not been investigated.METHODS: Twenty Wistar rats were divided into four groups (five rats per group). The C1 group was consist of healthy control rats and C2 group was consist of diabetic control rats. Diabetic condition was induced by giving high lard fat diet for 28 days, followed with 30 mg/kgBW of Streptozotocin injection at the 29th day. Meanwhile, T1 and T2 group were consist of diabetic rats, which were supplemented with 50 mg/kgBW and 100 mg/kgBW of Artemisia annua leaf extract, respectively. GLUT-4 expression and HbA1C level were measured at the 14th day post-treatment.RESULTS: The GLUT-4 was expressed 1.8 and two times higher in T1 and T2 group, respectively, compared to C2 group. Meanwhile, HbA1C level in C2 group was two times higher than C1 group (11.95±2.52 compared to 5.61±2.69, p<0.01). Further, the administration of 100 mg/ kgBW Artemisia annua extract caused a slight reduction of HbA1C (11.95±2.52 compared to 8.18±3.53, p>0.05)CONCLUSION: Muscle cell’s GLUT-4 in T1 and T2 group was expressed increasingly and significantly different compared to the C2 group. HbA1C level in T2 was slightly reduced although no significant different compared to C2 group.KEYWORDS: Artemisia annua, GLUT-4, HbA1C, type 2 diabetes mellitus
Faktor Risiko Penyakit Ginjal Kronik Diabetes (PGK-DM) pada Diabetes Mellitus Tipe-2 (Studi di RSUD DR Soedarso Kota Pontianak Provinsi Kalimantan Barat) Rini, Sulistio; Hadisaputro, Suharyo; Lestariningsih, Lestariningsih; Nugroho, Heri; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2159.764 KB) | DOI: 10.14710/jekk.v3i2.4029

Abstract

Background: Prevalence of type-2 diabetes mellitus have increased significantly. The increasing number of people with diabetes has a major impact on the development of chronic diabetic kidney disease. The research was aimed to clarify several risk factors of chronic diabetic kidney disease on type-2 diabetes mellitus (CDK-DM).Method: The research was based on case control study design. The number of respondents was 140 respondents consisting 70 cases and 70 controls that met the criteria of inclusion and exclusion. The cases were patients with type-2 chronic diabetic kidney disease stadium 2-5. The controls were patients with type-2 chronic diabetic kidney disease with blood sugar levels ≥ 200 mg / dL. The data were then analyzed using logistic regression.Results: The result shows that risk factors of chronic diabetic kidney disease in type-2 diabetes mellitus are diabetes in family (OR = 6,732; 95% CI = 2,623- 17,276), high blood pressure (OR = 6,760; 95% CI = 2,190- 20,867), lack of physical activities (OR = 4,367 95% CI = 1,823-10,462) and lack of family support (OR = 4,203; 95% CI = 1,437-12,295). The probability of chronic diabetic kidney disease occurrence in type-2 diabetes mellitus when four risk factors exist are 96,71%.Conclusion: The host factors have important role of chronic diabetic kidney disease in type 2 diabetes mellitus . The factors proven to be risk factors for occurrence of chronic diabetic kidney disease in type 2 diabetes mellitus were diabetic in the family, Hipertension, poor physical exercise and family Support. 
HUBUNGAN ANTARA LINGKAR PINGGANG DENGAN KOMPOSISI LEMAK TUBUH DAN INDEKS MASSA TUBUH: STUDI PADA PENDERITA DIABETES MELITUS TIPE 2 Nurhasanah, Nurhasanah; Muis, Siti Fatimah; Murbawani, Etisa Adi; Probosari, Enny; Nugroho, Heri
JNH (Journal of Nutrition and Health) Vol 7, No 3 (2019): JNH (JOURNAL OF NUTRITION AND HEALTH)
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (624.491 KB) | DOI: 10.14710/jnh.7.3.2019.43-49

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ABSTRAKLatar belakang: Obesitas merupakan faktor risiko mayor terjadinya diabetes melitus (DM), berhubungan dengan penumpukan jaringan lemak tubuh. Banyak metode untuk mengukur jaringan lemak diantaranya indeks massa tubuh (IMT), lingkar pinggang (LP) dan Bioelectrical impedance analysis (BIA). Distribusi lemak tubuh lebih berperan dalam menentukan risiko terjadinya DM dibandingkan IMT.Tujuan: untuk mengetahui hubungan LP dengan komposisi lemak tubuh dan IMT pada penderita DM tipe 2.Metode: Penelitian cross sectional pada penderita DM tipe 2 yang berobat ke RSUD Tugu Semarang bulan September 2018-Maret 2019, n= 80 orang, dengan consecutive sampling. Uji normalitas data dengan Kolmogorov-Smirnov, jika data normal dilanjutkan uji korelasi Pearson dan jika data tidak normal dilanjutkan uji korelasi Spearman?s rho.  Hasil: LP memiliki hubungan signifikan, positif dan moderat dengan persentase total lemak tubuh (p <0,001, r = 0,451), hubungan signifikan, positif dan kuat dengan persentase lemak viseral (p <0,001, r= 0,693) dan lemak subkutan (p <0,001, r = 0,518). LP memiliki hubungan signifikan, positif dan sangat kuat dengan IMT (p <0,001, r = 0,801).Simpulan: LP memiliki hubungan positif kuat dengan lemak viseral, lemak subkutan dan IMT pada penderita DM tipe 2.Kata Kunci: lingkar pinggang, komposisi lemak tubuh, IMT, DM tipe 2
PENGARUH MODEL PEMBELAJARAN LEARNING CYCLE 5E TERHADAP HASIL BELAJAR MATEMATIKA Nugroho, Heri
HISTOGRAM: Jurnal Pendidikan Matematika Vol 2, No 1 (2018): Histogram
Publisher : STKIP Andi Matappa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.051 KB) | DOI: 10.31100/histogram.v2i1.112

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Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika pada materi teorema Pythagoras. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 2 Tuntang. Pengambilan sampel dilakukan dengan teknik Cluster Random Sampling dan diperoleh siswa kelas VIIIE sebagai kelas eksperimen dan VIIIG sebagai kelas kontrol. Uji beda rerata kemampuan awal siswa dengan menggunakan uji Mann-Whitney menghasilkan nilai signifikansi 0,851 (lebih dari 0,05), artinya kondisi awal kedua kelas seimbang. Hasil uji beda rata-rata mengahasilkan nilai signifikansi sebesar 0,024 (kurang dari 0,05). Hal ini berarti terdapat perbedaan yang signifikan antara rerata kedua kelas, maka disimpulkan terdapat pengaruh model pembelajaran Learning Cycle 5E terhadap hasil belajar matematika bagi siswa kelas VIII SMP Negeri 2 Tuntang.
Beberapa Faktor yang Berpengaruh terhadap Kejadian Diabetes Mellitus Tipe 2 pada Wanita Usia Subur (WUS) di RSUD Kota Madiun Ardiani, Hanifah; Hadisaputro, Suharyo; Lukmono, Djoko Trihadi; Nugroho, Heri; Suryosaputro, Antono
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9990.892 KB) | DOI: 10.14710/jekk.v3i2.4026

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Background : Women of reproductive age with Diabetes Mellitus (DM) who were married having a risk complications of pregnancy, either on mother and her baby. Study on risk factors of DM in women of reproductive age was a rare, they have never done on women of reproductive age that married. The objective of this study was to prove some variables that influence to DM in women of reproductive age.Method : An observasional analytic was conducted with case-control study design. Populations in this study were women of reproductive age 20-49 years that check blood sugar at Madiun Regional Hospital. The samples in this study were 54 cases and 54 controls by consecutive sampling. Data were analyzed by chi-square and logistic regression.Results : Women of reproductive age with 2 and 3 quartile stress scores had risk 4,12 (95% CI=1,42-11,92) and 5,64 (95% CI=1,19-16,55) greater for DM than the comparison group. Women of reproductive age with physical activity <600 MET had risk 4,33 times greater for DM than ≥ 600 MET (95% CI = 1,71-10,96).Conclusion : Variables levels of carbohydrate and fat consumption were not associated with DM. Physical activity and stress levels were evident influece DM occurence in women of reproductive age.
Faktor Risiko yang Berpengaruh terhadap Terjadinya Hipertensi pada Penderita Diabetes Melitus Tipe II di Wilayah Puskesmas Kabupaten Pati Sari, Gracilaria Puspa; Chasani, Shofa; Pemayun, Tjokorda Gde Dalem; Hadisaputro, Suharyo; Nugroho, Heri
Jurnal Epidemiologi Kesehatan Komunitas Vol 2, No 2: Agustus 2017
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.003 KB) | DOI: 10.14710/jekk.v2i2.3996

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Background: The prevalence of hypertension in type 2 diabetic patients is 1,5-3 times higher than it is in nondiabetic individuals This chronic condition accelerates macrovascular complications. Research about risk factors of hypertension in type 2 diabetic patients is still rare because its causes multifactorial. The objectives of this research is to explain the risk factors affecting hypertension in type 2 diabetic patients.Methods: An observational studies with case-control study design in Primary Healthcare Centers patients in Pati District. Patients with hypertension in type 2 diabetes are the case, while the type 2 diabetes patients without hypertension are the control. There were 57 cases and 57 controls included. Data were obtained from medical records and qualitative interviews. Chi-square test in bivariate and multiple logistic regression in multivariate analysis.Results: Factors that influence hypertension in type 2 diabetic patients were physical activity (OR=6,4; 95% CI: 2,18 - 18,77; p=0,001), diabetes duration ≥ 5 years (OR=5,4; 95% CI: 1,97 - 14,704; p=0,001), and medication adherence (OR=3,6; 95% CI: 1,32 - 9,83; p=0,012). Other risk factors i.e age ≥45 years, male, diet compliance, history of hypertension, smoking, salt consumption, coffee consumption, and sleep duration were not significantly influenced.Conclusion: In this study, physical activity, diabetes duration, and DM medication adherence are risk factors that influence of hypertension in type 2 diabetic patients. 
Faktor Risiko yang Berpengaruh Terhadap Status Kontrol Glikemik pada Kehamilan dengan Diabetes Melitus (Studi Kasus Kontrol Pasien di Beberapa RS di Kota Semarang) Meiwarnis, Resna; Soejoenoes, Ariawan; Nugroho, Heri; Hadisaputro, Suharyo; Setyawan, Henry
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 2: Agustus 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.292 KB) | DOI: 10.14710/j.e.k.k.v1i2.3947

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Background : The number of diabetes patients was higher in women than men. The high prevalence in women occurs in pregnant women because of the increasing age of childbearing. Commonly, pregnancy in women with diabetes was associated with morbidity and mortality.  Data obtained from Diabetic  Department  King’s  College  Hospital mentioned that  during  pregnancy, a good control of maternal diabetes cause a progressive decline in blood glucose control. The purpose of this research is to explain some risk factors related to glycaemic control status in pregnancy with diabetes mellitus. Methods : This research was an observational study using case control design by using retrospective approach. The population of this study is all cases of pregnancy with diabetes with  the number of sample was 62 people, consist of 31 cases and 31 control with consecutive  sampling. In this research, cases sample selection was chosed from pregnant women with diabetes who come to Tugurejo Hospital, Semarang City Hospital and Roemani Hospital during 2015. Control sample selection was chosed from non pregnant women with diabetes who come to Tugurejo Hospital, Semarang City Hospital and Roemani Hospital during 2015. Results : The pattern of taking medications that was not good (p= 0,002; aOR= 7,2; 95%CI= 1,9-17,2) was risk factors of poor glycaemic control status with probability event amounted was 70,0%. Conclusion : The risk factors to glycaemic control status in pregnancy with diabetes was the pattern of taking medications that was not good. Background  :Thenumber  ofdiabetes  patients  washigher  inwomen  thanmen.Thehigh prevalence   in   women   occurs   in   pregnant   women   because   of   the   increasing   age   of childbearing.  Commonly,  pregnancy  inwomen  withdiabetes  wasassociated  withmorbidity andmortality.  Dataobtained  fromDiabetic  Department  King’s  College  Hospital  mentioned that  during  pregnancy,  agood  control  ofmaternal  diabetes  cause  aprogressive  decline  in bloodglucosecontrol.Thepurposeof thisresearchisto explainsomeriskfactorsrelatedto glycaemiccontrolstatusinpregnancywithdiabetesmellitus.Methods  :Thisresearch  wasanobservational  studyusingcasecontrol  design  by  using  a retrospective  approach.  Thepopulation  ofthisstudyisallcasesofpregnancy  withdiabetes with  the  number  of  sample  was  62  people,  consist  of  31  cases  and  31  control  with consecutive  sampling.  In  this  research,  cases  sample  selection  was  chosed  from  pregnant women   with   diabetes   who   come   to  Tugurejo   Hospital,   Semarang   City   Hospital   and Roemani  Hospital  during  2015.  Control  sample  selection  was  chosed  from  non  pregnant women   with   diabetes   who   come   to  Tugurejo   Hospital,   Semarang   City   Hospital   and RoemaniHospitalduring2015.Results:Thepatternoftakingmedications  thatwasnotgood(p=0,002;aOR=7,2;95% CI=1,9-17,2)was   risk  factors   of  poor  glycaemic   control   status  with  probability   event amountedwas70,0%.Conclusion  :Theriskfactorstoglycaemiccontrolstatusinpregnancywithdiabeteswasthe patternoftakingmedicationsthatwasnotgood.
Faktor-Faktor Risiko Kejadian Kaki Diabetik pada Penderita Diabetes Melitus Tipe 2 (Studi Kasus Kontrol di RSUP dr. M. Djamil Padang) Rina, Rina; Setyawan, Henry; Nugroho, Heri; Hadisaputro, Suharyo; Pemayun, Tjokorda Gde Dalem
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 2: Agustus 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2396.077 KB) | DOI: 10.14710/j.e.k.k.v1i2.3943

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Background : Diabetic foot is one of the chronic complications of diabetes mellitus and are the most feared by people who suffer of diabetes mellitus as it can lead to disability or even death. This more specific research on risk factors of the ethnic communities of the Minangkabau society. The purpose of this research is to prove the factors related to the incidence of diabetic foot in people with type 2 diabetes mellitus.Methods : The research applied with mix method were quantitative as the main approach (case control design) and qualitative as support (indepth interview). Target population is all people with a diagnosis of type 2 diabetes mellitus in Padang City, West Sumatera Province there were 172 respondent involved, consisting of 86 cases and 86 controls with concequtive sampling technique. Data analysis included univariat and bivariat analysis using the chi square test and mu ltivariate analysis using multiple logistic regression test.Results : Factors proven to correlate with the incidence of diabetic foot in patients with type 2diabetes mellitus are deformities in legs (p=<0,001), habit of smoking (p=<0,001), age ≥45 years (p=<0,001; OR=27,6; 95%CI=3,96-193,23), a series of ulceration on the legs (p=0,001;), and hypertension (p=0,001), with the probability of 95,88%. Protective factors on the incidence of diabetic foot in patients with type 2 diabetes mellitus is a gender (p=0,002).Conclusion : Risk factors to the incidence of diabetic foot are related of the deformities in the foot, smoking, age, leg ulceration and hypertension
Faktor Risiko Penyakit Ginjal Kronik Diabetes (PGK-DM) pada Diabetes Mellitus Tipe-2 (Studi di RSUD DR Soedarso Kota Pontianak Provinsi Kalimantan Barat) Rini, Sulistio; Hadisaputro, Suharyo; Lestariningsih, Lestariningsih; Nugroho, Heri; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 1: Februari 2018
Publisher : Sekolah Pascasarjana Universitas Diponegoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (51.096 KB)

Abstract

Background: Prevalence of type-2 diabetes mellitus have increased significantly. The increasing number of people with diabetes has a major impact on the development of chronic diabetic kidney disease. The research was aimed to clarify several risk factors of chronic diabetic kidney disease on type-2 diabetes mellitus (CDK-DM).Method: The research was based on case control study design. The number of respondents was 140 respondents consisting 70 cases and 70 controls that met the criteria of inclusion and exclusion. The cases were patients with type-2 chronic diabetic kidney disease stadium 2-5. The controls were patients with type-2 chronic diabetic kidney disease with blood sugar levels ≥ 200 mg/dL. The data were then analyzed using logistic regression.Results: The result shows that risk factors of chronic diabetic kidney disease in type-2 diabetes mellitus are diabetes in family (OR = 6,732; 95% CI = 2,623- 17,276), high blood pressure (OR =6,760; 95% CI = 2,190- 20,867), lack of physical activities (OR = 4,367 95% CI = 1,823-10,462) and lack of family support (OR = 4,203; 95% CI = 1,437-12,295). The probability of chronic diabetic kidney disease occurrence in type-2 diabetes mellitus when four risk factors exist are96,71%.Conclusion: The host factors have important role of chronic diabetic kidney disease in type 2 diabetes mellitus . The factors proven to be risk factors for occurrence of chronic diabetic kidney disease in type 2 diabetes mellitus were diabetic in the family, Hipertension, poor physical exercise and family Support.
Faktor Risiko Kejadian Nefropati Diabetika pada Wanita Wahyuningsih, Sri; Nugroho, Heri; Suhartono, Suhartono; Hadisaputro, Suharyo; Adi, Mateus Sakundarno
Jurnal Epidemiologi Kesehatan Komunitas Vol 4, No 1: Februari 2019
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.799 KB) | DOI: 10.14710/jekk.v4i1.4426

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Background: Diabetic nephropathy was the most frequent complication in diabetics. The prevalence in women at South East Asia country was higher than men, that different than in Europe, American and African. It's a controversial thing. There was no research about the risk factors for diabetic nephropathy in women in Indonesia.Methods: The purpose of this study was to determine the risk factors for stage 3-5 diabetic nephropathy in women. This research used case-control study design. The cases were women with stage 3-5 diabetic nephropathy. Sampling by consecutive sampling technique by comparing the age of the case. Data were analyzed statistically by univariate, bivariate and multivariate using multiple logistic regression analysis.Results: The results of the analysis showed that the risk factors for stage 3-5 diabetic nephropathy were hyperuricemia (OR:9.6; 95%CI:1.870-45.799), lack of physical activity (OR:9.5; 95%CI:1.693-53,287), blood sugar level ≥126 mg/dl (OR:14.7; 95% CI:1.487-145.846), history of oral contraceptive use (OR:7.3; 95%CI:1.254-42.716) and history of obesity (OR:8.9; 95%CI:1.195-65.766).Conclusion: It is recommended for diabetics people to control uric acid levels, fasting blood glucose, body weight and does enough physical activity. For oral contraceptives users it is recommended to consult with a doctor during consumption.