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SENYAWA ANTIMALARIA DARI JAMUR ENDOFITIK TUMBUHAN SAMBILOTO (ANDOGRAPHIS PANICULATA NEES) Elfita, Elfita; Muharni, Muharni; Munawar, Munawar; Salni, Salni; Oktasari, Ade
Jurnal Natur Indonesia Vol 13, No 2 (2011)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.93 KB) | DOI: 10.31258/jnat.13.2.123-129

Abstract

Plants have been the chief source of compounds of medicine for thousand of years. Plants are also the source ofmany medicines for the majority of the world?s population. The role of biotechnology is very important for multiplying,conserving the spesies, and enhancing the production of secondary metabolites. Endophytic are microbes thatinhabit plants are currently considered to be a wellspring of novel secondary metabolites offering the potensial formedical and industrial exploitation. Plants with ethnobotanical history, for example sambiloto (Andographispaniculata Nees) are likely candidates for finding bioactive compounds. Isolation begin with cultivation of Aspergillusflavus fungi in 2 liter of Potato Dextrose Broth media for four weeks. Media is extracted into the solvent n-hexaneand ethylacetate following by evaporation. Ethylacetate extracts were separated by chromatography techniquesin order to get pure compound in the form of white crystal. Phytochemical tests showed that the isolated compoundis alkaloid. The molecular structure of the isolated compound was determined based on spectroscopic data,including UV, IR, 1H-NMR, 13C-NMR, HMQC, and HMBC spectrum. The compound was determined as7-hydroxypiranopiridin-4-on with molecule formula C8H7NO2 (Mr=149). The compound has antimalarial activityagainst Plasmodium falciparum 3D7, with IC50 values 0,201 ?M.
Kulit Kacang Tanah (Arachis hypogaea L.) sebagai Adsorben Ion Pb(II) Oktasari, Ade
ALKIMIA Vol 2 No 1 (2018): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.485 KB) | DOI: 10.19109/alkimia.v2i1.2258

Abstract

An experiment on Pb (II) metal ion adsorption using peanut (Arachis hypogea L.) shell without activation (KK), acid-activated (KKA), and base-activated (KKB) has been conducted. Peanut shell powder was activated using H3PO4 and KOH to improve adsorption effectivity and capacity. Characterization results using FT-IR spectrophotometer showed peak at 3410 and 2901 cm-1 indicated OH dan CH aliphatic from framework of cellulose. Optimum condition of Pb(II) adsorption for KK, KKA and KKB was occurred at the same optimum pH, that was pH 5, with contact time 60, 90 and 70 min, respectively. The adsorption kinetic parameter of Pb(II) ion for KK, KKA, and KKB followed pseudo second order kinetic with rate constants (k) in order of 12.279, 4.149, and 32.258 g mmol-1 min-1, with maximum adsorption capacity based on Langmuir isotherm model of 0.598, 0.505, and 0.622 mmol g-1, and adsorption energy of 26.735, 25.789, and 29.245 kJ mol-1, respectively. The results indicated that KOH-activated peanut (Arachis hypogea L.) shell has good adsorption affinity for Pb(II) with highest adsorption capacity compare to those from non-activated and acid-activated.