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The DiabCare Asia 2008 study – Outcomes on control and complications of type 2 diabetic patients in Indonesia Soewondo, Pradana; Soegondo, Sidartawan; Suastika, Ketut; Pranoto, Agung; Soeatmadji, Djoko W.; Tjokroprawiro, Askandar
Medical Journal of Indonesia Vol 19, No 4 (2010): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.097 KB) | DOI: 10.13181/mji.v19i4.412

Abstract

Aim: To collect information on diabetes management, diabetes complications, and awareness of self-control in diabetic population of the country. This study also evaluated the physician perspectives, psychological aspects, and quality of life of diabetic patients.Methods: This was a non-interventional, cross-sectional study, which recruited 1832 patients from secondary and tertiary medical centers across Indonesia. Data on demography, medical history, risk factors and clinical examination reports including laboratory assessments were collected from medical records of patients. Blood samples of all patients were collected for centralized HbA1c measurements.Results: Among 1832 patients, 1785 individuals were eligible for analysis. The mean age of the patients was 58.9+9.6 years. The mean duration of diabetes was 8.5+7.0 years. Majority (97.5%) of the patients had type 2 diabetes. 67.9% had poor control of diabetes (A1c:8.1 ± 2.0%). 47.2% had FPG>130 mg/dL (161.6±14.6 mg/dL). Dyslipidemia was reported in 60%  (834/1390) and 74% (617/834) of those received lipid lowering treatment. Neuropathy was most common  complication (63.5%); other complications were: Diabetic retinopathy 42%, nephropathy 7.3%, severe late complications 16.9%, macrovascular complications 16%, microvascular complications 27.6%. About 81.3% of patients were on OADs (± insulin), 37.7% were on insulin (±OADs). Majority used biguanides followed by sulfonylureas. Human insulin was used by 73.2%, premix regimen 58.5%, analogues usage was 24.9%. Majority of the WHO-5 well being index responses fell in positive territoryConclusion: Poor glycaemic control in majority of patients is a concern. There is a need for a large proportion of patients to be adjusted to more intensive pharmacotherapy and a multi-disciplinary approach for management should be adopted. The study fi ndings should be communicated to policymakers and physicians to help them provide proper healthcare and its facilities in Indonesia. (Med J Indones 2010; 19:235-44)Keywords: DiabCare, DiabCare Indonesia, Diabetes complications, Dyslipidaemia, Glycaemic control, Hypertension.
KENDALI GLIKEMIK PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN DAN TANPA TUBERKULOSIS PARU Wahiduddin, Wahiduddin; Pranoto, Agung; Sudjarwo, Sudjarwo
Media Kesehatan Masyarakat Indonesia Vol 15, No 1: MARET 2019
Publisher : Faculty Of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (22.115 KB) | DOI: 10.30597/mkmi.v15i1.5292

Abstract

Kendali glikemik merupakan hal yang penting bagi penyandang Diabetes Melitus (DM) karena berimplikasi terhadap upaya pengelolaan DM. Tuberkulosis (TB) paru merupakan salah satu komplikasi yang banyak pada pasien DM yang berhubungan dengan proses dan hasil pengobatan penyakit tersebut. Penelitian bertujuan mengetahui kendali glikemik berdasarkan parameter kadar Glukosa Darah Puasa (GDP), glukosa darah 2 jam post prandial (GD2JPP) dan HbA1c pada pasien diabetes melitus tipe 2 (DMT2) yang mengalami TB paru. Penelitian potong-lintang dilakukan pada 45 subyek DMT2 dengan TB paru dan 45 subyek DMT2 tanpa TB paru yang berobat jalan di dua rumah sakit di Surabaya. Hasil pemeriksaan GDP, GD2JPP, dan HbA1c yang dianalisis secara deskriptif, ditampilkan berupa nilai rerata dan Standar Deviasi (SD). Diperoleh rerata dan SD adalah GDP (202,11 ± 78,68 mg/dl), GD2JPP (283,20 ± 107,20 mg/dl), dan HbA1c (11,20 ± 2,61%) pada subyek DMT2 dengan TB paru sedangkan pada subyek DMT2 tanpa TB paru diperoleh GDP (175,29 ± 61,38 mg/dl), GD2JPP (208,22 ± 75,60 mg/dl), dan HbA1c (9,34 ± 2,22%). Nilai rerata GDP, GD2JPP dan HbA1c pasien DMT2 dengan TB paru lebih tinggi daripada DMT2 tanpa TB paru. Hal ini menunjukkan kriteria pengendalian DM yang belum mencapai sasaran sehingga perlu dilakukan upaya pemantauan kendali glikemik yang lebih baik
The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Pranoto, Agung; Pudjiati, Satiti Retno; Wirohadidjojo, Yohanes Widodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.
KELISTRIKAN DAN PEMROGRAMAN TRAINER PEMOTONG DAN PENGHITUNG BERBASIS ELEKTRO PNEUMATIK DENGAN KONTROLLER PLC PRANOTO, AGUNG
Jurnal Rekayasa Mesin Vol 2, No 01 (2014): JRM: volume 02 Nomor 01 Tahun 2014
Publisher : Jurnal Rekayasa Mesin

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Abstract

  Abstrak Dalam proses belajar mengajar adanya media pembelajaran tambahan sangat dibutuhkan untuk meningkatkan kompetensi mahasiswa. Media pembelajaran ini berupa suatu trainer. Pada tugas akhir ini akan di rancang sebuah trainer pemotong dan penghitung berbasis elektro pneumatik dengan kontroller menggunakan PLC. Perencanaan trainer ini diawali dengan mengetahui dan memahami  prinsip  kerja dari sistem kelistrikan dan sistem otomasi. Dari perancangan trainer pemotong dan penghitung berbasis elektro pneumatik dengan kontroller menggunakan PLC ini diharapkan dapat membantu mempermudah mahasiswa dalam menguasai pemrograman PLC dan sistem instalasi kelistrikannya. Dalam trainer ini sistem kelistrikan berfungsi untuk penentuan unit input dan output  beserta sistem wiringnya. Inputan pada trainer ini meliputi sensor  tombol – tombol, sensor proximity, dan sensor limit switch, sedangkan outputan meliputi motor DC dan valve. Setelah sistem kelistrikan dipasang  langkah selanjutnya adalah membuat program. Sebelum membuat program dilakukan penyusunan algoritma program  yang berfungsi untuk menentukan arah cara kerja trainer. Setelah itu kemudian dibuat dalam bentuk list program dengan menggunakan software cx programmer. Langkah terakhir ialah tahap pengujian cara kerja. Dalam pengujian ini ada dua tahap pengujian. Pengujian pertama ialah pengujian system kelistrikan. Hasilnya system wiring sudah terpasang semua antara unit input dan unit output. Tahap ke dua adalah pengujian program dengan cara menjalankan trainer. Hasilnya trainer dapat berjalan sesuai dengan algoritma cara kerja yang sebelumnya dibuat. Hasil pengujian dari dua tahap tersebut,  trainer pemotong dan penghitung dapat berjalan dengan baik hal ini menunjukkan antara sistem kelistrikan wiring dan sistem pemogramannya sudah benar. Kata Kunci : Pemrograman PLC, Trainer Pemotong dan Penghitung
Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2 Thamrin, Husin; Sutjahjo, Ari; Pranoto, Agung; Soelistijo, Soebagijo Adi
Biomolecular and Health Science Journal Vol 2, No 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.341 KB) | DOI: 10.20473/bhsj.v2i2.14964

Abstract

Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an  significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found  normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031  Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.