Purwantyastuti Purwantyastuti
Departemen Farmakologi Fakultas Kedokteran UI

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Lipid peroxides level in the Indonesian elderly Purwantyastuti, Purwantyastuti; Kamso, Sudijanto; Suyatna, F. D.
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.299 KB) | DOI: 10.13181/mji.v14i2.174

Abstract

A cross-sectional study was done to see the possible association of plasma lipid peroxides in the elderly with age and other factors. Plasma lipid peroxides is a product of free radical reactions which according to the latest theory of aging is the cause of aging process. Lipid peroxides were also found high in coronary heart disease. Four hundred forty relatively healthy elderly, age 55-85 years, were randomly chosen from free living elderly under guidance of health care centers (PUSKESMAS) in Jakarta. Anamnesis and physical examination were done in the morning in the health centers. Blood samples were taken in fasting conditions, plasma lipids and lipid peroxides were measured according to standard methods. There was an age difference of lipid peroxides level in the elderly, which increased with age up to 70 years old. Elderly 70 years old and over had low plasma lipid peroxides. The level was not related to high plasma lipids. Higher level was found when more chronic degenerative diseases were found. (Med J Indones 2005; 14: 71-7)Keywords: lipid peroxides, aging
Prevalensi dan Determinan Sindrom Metabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya Kamso, Sudijanto; Purwantyastuti, Purwantyastuti; Lubis, Dharmayati Utoyo; Juwita, Ratna; Robbi, Yull Kurnia; Besral, Besral
Jurnal Kesehatan Masyarakat Nasional Vol. 6 No. 2 Oktober 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.257 KB) | DOI: 10.21109/kesmas.v6i2.110

Abstract

Data tentang faktor-faktor yang berhubungan dengan sindrom metabolik pada kelompok eksekutif di Indonesia yang diperlukan untuk upaya pencegahan penyakit kardiovaskular sangat terbatas. Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan sindrom metabolik pada kelompok eksekutif. Penelitian dilakukan di Jakarta dan sekitarnyadengan menggunakan rancangan cross sectional. Jumlah responden yaitu 220 orang eksekutif laki-laki dan 68 orang eksekutif wanita. Pengumpulan data dilakukan dengan pengukuran antropometri, analisis biokimia darah, analisis asupan makanan, pengukuran angka stres, dan pengukuranindeks aktivitas. Analisis regresi logistik ganda dilakukan untuk mengetahui hubungan beberapa independen variabel dengan dependen variabel. Analisis ini menghasilkan indeks massa tubuh (overweight, odds ratio (OR) = 5,54; obesitas, OR = 7,44) dan rasio total kolesterol/high density lipoprotein (HDL)-kolesterol (OR = 8,83) sebagai determinan sindrommetabolik pada kelompok eksekutif. Penelitian ini menunjukkan bahwa pemeriksaan profil lipid dan pengukuran antropometri sederhana yang teratur pada kelompok eksekutif penting dilakukan untuk mendeteksi risiko sindrom metabolik.Kata kunci: sindrom metabolik, kelompok eksekutif, antropometriAbstractAvailable datas on metabolic syndrome among Indonesian executives are limited, despite the fact of the importance of these data for cardiovaskular prevention. The objective of this study was to assess prevalence of metabolic syndrome and its associations between anthropometric measures, lipid profiles, blood pressure, nutrient intakes, and life style in executive group. A cross sectional study was undertaken in some factoriesin Jakarta, using multistage random sampling. The respondents were 287 executives, 219 male and 68 female. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake, stress score, and activity index assessment. Multiple logistic regression analysis used to assess associations between independent variables and metabolic syndrome. This study showed that body mass index (overweight, odds ratio (OR) = 5,54; obesity, OR = 7,44) and ratio serum total cholesterol to high density lipoprotein (HDL)-cholesterol (OR = 8,83) were potential determinants of metabolic syndrome. This study shows the importance ofroutine check of lipid profile, blood pressure, and simple anthropometric assessment to detect the risk of metabolic syndrome in the elderly.Key words: metabolic syndrome, executive group, antropometric
Potensi Asam Amino pada Tempe untuk Memperbaiki Profil Lipid dan Diabetes Mellitus Utari, Diah M.; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Jurnal Kesehatan Masyarakat Nasional Vol. 5 No. 4 Februari 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.806 KB) | DOI: 10.21109/kesmas.v5i4.137

Abstract

Prevalensi penyakit degeneratif dari tahun ke tahun meningkat akibat perubahan gaya hidup, khususnya perubahan pola makan. Walaupun tempe sebagai makanan tradisional Indonesia yang banyak dikonsumsi masyarakat karena mudah diperoleh dan harga terjangkau, tidak banyakyang mengetahui manfaat tempe bagi kesehatan. Tempe lama dikenal sebagai sumber protein yang dikonsumsi oleh kalangan masyarakat berpenghasilan rendah. Kajian lebih mendalam mengenai kandungan gizi dan manfaat tempe dan bagi kesehatan, khusus sebagai pencegah penyakit degeneratif perlu dilakukan. Proses fermentasi kedelai menjadi tempe mengakibatkan perubahan zat gizi dan non gizi yang mengakibatkan manfaat tempe jauh lebih baik dibandingkan kedelai. Protein tempe lebih mudah di cerna tubuh, sedangkan asam amino arginin yang meningkat hampir dua kali lipat pada tempe, sangat tinggi manfaatnya bagi kesehatan terutama dalam memperbaiki profil lipid dan diabetes mellitus. Mempertimbangkan hal tersebut tempe dapat dipertimbangkan sebagai pangan fungsional yangbermanfaat bagi kesehatan.Kata kunci: Tempe, protein, arginin, profil lipid, diabetes mellitusAbstractDegenerative diseases prevalence had been arining over years. One of the causes is the life style changes including eating pattern. Tempeh, an Indonesian soybean traditionally fermented food, was known and consumed by almost all Indonesian people. However, only a few know the health benefit of tempeh. Tempeh was also welknown and cheap protein source food affordable for the poor. Hence, there is a need to explore the nutritious content of tempeh and health benefit of it deeper such as in preventing degenerative diseases. Fermentation process of soybean to becometempeh had improved nutrient and non-nutrient contents that make tempeh better than soybean. Tempeh protein is more digestible than soybean and the arginine content increases twice, that could improve lipid profile and diabetes mellitus. Tempeh could be considered as functional food having health benefit.Key words: Tempeh, protein, arginine, lipid profile, diabetes mellitus
Nutritional status of hyperlipidemics elderly in Indonesia according to body mass lndex (study in four Indonesian big cities) Kamso, Sudijanto; Purwantyastuti, Purwantyastuti; Rumawas, Yohanna S.P.; Lukito, Widjaja
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.283 KB) | DOI: 10.13181/mji.v14i2.184

Abstract

The objective of this study was to assess the nutritional status of hyperlipidemics elderly. A cross sectional study was undertaken in 4 big cities in Indonesia using multistage random sampling. The respondents were 656 hyperlipidemics and non hyperlipidemics elderly who were the subsample of 1261 sample of a larger population study. Data were collected through anthropometric measurements and biochemical blood analysis. To determine the nutritional status by Body Mass Index (BMI) the criteria used for elderly men and women are as follows, underweight BMI ≤ 18.5 kg/m2, normoweight BMI 18.5 - 24.9 kg/m2, overweight BMI 25 - 29.9 kg/m2, and obese BMI ≥ 30 kg/m2. To determine lipid status, the criteria used are as follows, hyperlipidemics elderly, those who had plasma total cholesterol ≥ 240 mg/dl and or triglycerides ≥ 200 mg/dl. Prevalence of hyperlipidemics in elderly women is higher then elderly men, 56.2% vs 47.0%. The BMI of hyperlipidemics is mostly overweight (60.4%) and obese (57.1%) for elderly men; and mostly normoweight (59.1%) and overweight (59.5%) for elderly women. The prevalence of hyperlipidemics among undernourished elderly men and women were also quite high, 38.7% and 31.6% respectively. (Med J Indones 2005; 14: 97-100)Keywords : BMI, hyperlipidemics, elderly
Determinants of systolic blood pressure in Indonesian elderly men: In factor analysis perspective (A study in four Indonesian big cities) Kamso, Sudijanto; Purwantyastuti, Purwantyastuti
Medical Journal of Indonesia Vol 15, No 2 (2006): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.753 KB) | DOI: 10.13181/mji.v15i2.224

Abstract

The objective of this study was to assess the determinants of systolic blood pressure in elderly men. A cross sectional study was undertaken in 4 big cities in Indonesia using multistage random sampling. The respondents were 320 elderly men who were the sub-sample of 981 sample of a larger population study. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake assessment, activity index and stress score. Two type of statistical analysis techniques were used to determine the determinants of systolic blood pressure in elderly men; multiple regression analysis and factor analysis. This study shows that determinants of systolic blood pressure, analyzed with these two types of analysis, multiple regression and factor analysis, resulting in no contradictory result. Direct multiple regression analysis to all independent variables showed that there was correlation between systolic blood pressure with fat mass, and LDL cholesterol. Multiple regression analysis to components resulting from factor analysis showed that there was positive correlation between systolic blood pressure with fat mass, body mass index (BMI), sum of skin-folds and waist circumference. (Med J Indones 2006; 15:115-20) Keywords: Systolic blood pressure, fat mass, LDL cholesterol, body mass index, sum of skin-folds, waist circumference, elderly men
Level of Exposure of Childhood Tuberculosis with Adult Pulmonary Tuberculosis Household Contacts Asyary, Al; Eryando, Tris; Purwantyastuti, Purwantyastuti; Junadi, Purnawan; Clark, Carol; Teijlingen, Edwin van
Jurnal Kesehatan Masyarakat Nasional Volume 12, Issue 1, August 2017
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.799 KB) | DOI: 10.21109/kesmas.v12i1.1469

Abstract

AbstractPulmonary tuberculosis (TB) in children is a neglected global health problem, with an increasing proportion of TB cases in Indonesia. Children with TB are most often impacted by TB transmission in the population at large, especially adult TB that exists in the child’s household. This study aimed to find protective factors that can keep children healthy despite household adult TB contacts. This study reports on 132 respondents with a case-control study conducted at nine referred hospitals and several health centers based on medical records at Special Region of Yogyakarta Province. The study lasted from January to December 2014, while the data analysis was used by both of bivariate (chi-square) and multivariate (multiple logistic regression) analysis. The study found that healthy houses, especially those with healthy bedrooms and fewer exposures to adult TB sufferer, influenced by confounder variables, protected children from TB even though they were exposed to adult TB in their environment. Longer periods of living together is not a risk factor for children to contract TB when living with adult TB patients at home. However, this risk increases with frequent exposure among children to adult TB patients at home. AbstrakTuberkulosis paru (TB) pada anak kian menjadi masalah kesehatan global yang masih terlupakan seiring dengan peningkatan proporsi TB di Indonesia. Penularan penyakit ini di populasi umum seringkali berdampak pada anak, terlebih ketika kontak TB terjadi di rumah tangga. Penelitian ini bertujuan untuk memperoleh faktor protektif sehingga anak tetap sehat meskipun memiliki kontak dengan penderita TB dewasa serumah. Penelitian ini dilakukan dengan pendekatan kasus-kontrol pada 132 responden anak yang berasal dari delapan rumah sakit rujukan dan beberapa puskesmas di Provinsi Daerah Istimewa Yogyakarta. Penelitian dilakukan dalam periode Januari hingga Desember 2014 yang hasilnya dianalisis dengan uji bivariat (kai kuadrat) dan multivariat (regresi logistik ganda). Hasil penelitian menunjukkan bahwa rumah yang memenuhi syarat kesehatan, yakni ruang tidur yang sehat, serta paparan yang jarang diterima dari penderita TB dewasa mampu memproteksi anak agar tetap sehat meskipun tinggal serumah dengan penderita dewasa penyakit ini. Penelitian ini menyimpulkan bahwa lama tinggal bersama bukanlah faktor risiko penyakit TB pada anak.Hal ini karena meskipun lama tinggal bersama antara penderita TB dewasa dengan anak, namun apabila memiliki paparan yang jarang, hal ini pun tidak signifikan menjadikan anak untuk terkena TB.
Safety of Annona muricata Extract Supplementation for Colorectal Cancer Patients Indrawati, Lili; Purwantyastuti, Purwantyastuti; Abdullah, Murdani; Surono, Ingrid S; Basir, Ibrahim
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.141 KB) | DOI: 10.24871/1732016170-175

Abstract

Background: People have used Annona muricata leaves traditionally as tea drinks. Traditional use of A. muricata leaves is as an infusion which is closed to water extract. The potential health benefit of A. muricata tea leaves that is traditionally used for maintaining health which lately is being used by cancer patients. Therefore it is urgent to verify the safety of A. muricata leaves extract.  Method: A randomized double blind placebo controlled trial was conducted on 30 colorectal cancer out patients who had undergone primary tumor resection. Twenty eight subjects completed the study, divided into two groups, namely ethanol-soluble fraction of A. muricata leaves water extract (ESFAM) (n = 14), and placebo (n = 14) for 8 weeks. Peripheral blood samples were withdrawn from subjects by venipuncture at baseline and at the end of the study period.Results: The effect on bone marrow can be considered to be safe.  The measure in indices of organs function, i.e liver and kidney also showed similar results and within normal range after supplementation. The dose given to the subjects is safe and highly tolerable, as shown by very few (6.7%) of patients complained intolerable adverse effects.  Conclusion: This study indicates the safety of  ESFAM  supplementation. 
Prevalensi dan Determinan Sindrom Metabolik pada Kelompok Eksekutif di Jakarta dan Sekitarnya Kamso, Sudijanto; Purwantyastuti, Purwantyastuti; Lubis, Dharmayati Utoyo; Juwita, Ratna; Robbi, Yull Kurnia; Besral, Besral
Jurnal Kesehatan Masyarakat Nasional Vol. 6 No. 2 Oktober 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.257 KB) | DOI: 10.21109/kesmas.v6i2.110

Abstract

Data tentang faktor-faktor yang berhubungan dengan sindrom metabolik pada kelompok eksekutif di Indonesia yang diperlukan untuk upaya pencegahan penyakit kardiovaskular sangat terbatas. Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan sindrom metabolik pada kelompok eksekutif. Penelitian dilakukan di Jakarta dan sekitarnyadengan menggunakan rancangan cross sectional. Jumlah responden yaitu 220 orang eksekutif laki-laki dan 68 orang eksekutif wanita. Pengumpulan data dilakukan dengan pengukuran antropometri, analisis biokimia darah, analisis asupan makanan, pengukuran angka stres, dan pengukuranindeks aktivitas. Analisis regresi logistik ganda dilakukan untuk mengetahui hubungan beberapa independen variabel dengan dependen variabel. Analisis ini menghasilkan indeks massa tubuh (overweight, odds ratio (OR) = 5,54; obesitas, OR = 7,44) dan rasio total kolesterol/high density lipoprotein (HDL)-kolesterol (OR = 8,83) sebagai determinan sindrommetabolik pada kelompok eksekutif. Penelitian ini menunjukkan bahwa pemeriksaan profil lipid dan pengukuran antropometri sederhana yang teratur pada kelompok eksekutif penting dilakukan untuk mendeteksi risiko sindrom metabolik.Kata kunci: sindrom metabolik, kelompok eksekutif, antropometriAbstractAvailable datas on metabolic syndrome among Indonesian executives are limited, despite the fact of the importance of these data for cardiovaskular prevention. The objective of this study was to assess prevalence of metabolic syndrome and its associations between anthropometric measures, lipid profiles, blood pressure, nutrient intakes, and life style in executive group. A cross sectional study was undertaken in some factoriesin Jakarta, using multistage random sampling. The respondents were 287 executives, 219 male and 68 female. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake, stress score, and activity index assessment. Multiple logistic regression analysis used to assess associations between independent variables and metabolic syndrome. This study showed that body mass index (overweight, odds ratio (OR) = 5,54; obesity, OR = 7,44) and ratio serum total cholesterol to high density lipoprotein (HDL)-cholesterol (OR = 8,83) were potential determinants of metabolic syndrome. This study shows the importance ofroutine check of lipid profile, blood pressure, and simple anthropometric assessment to detect the risk of metabolic syndrome in the elderly.Key words: metabolic syndrome, executive group, antropometric
Potensi Asam Amino pada Tempe untuk Memperbaiki Profil Lipid dan Diabetes Mellitus Utari, Diah M.; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Jurnal Kesehatan Masyarakat Nasional Vol. 5 No. 4 Februari 2011
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.806 KB) | DOI: 10.21109/kesmas.v5i4.137

Abstract

Prevalensi penyakit degeneratif dari tahun ke tahun meningkat akibat perubahan gaya hidup, khususnya perubahan pola makan. Walaupun tempe sebagai makanan tradisional Indonesia yang banyak dikonsumsi masyarakat karena mudah diperoleh dan harga terjangkau, tidak banyakyang mengetahui manfaat tempe bagi kesehatan. Tempe lama dikenal sebagai sumber protein yang dikonsumsi oleh kalangan masyarakat berpenghasilan rendah. Kajian lebih mendalam mengenai kandungan gizi dan manfaat tempe dan bagi kesehatan, khusus sebagai pencegah penyakit degeneratif perlu dilakukan. Proses fermentasi kedelai menjadi tempe mengakibatkan perubahan zat gizi dan non gizi yang mengakibatkan manfaat tempe jauh lebih baik dibandingkan kedelai. Protein tempe lebih mudah di cerna tubuh, sedangkan asam amino arginin yang meningkat hampir dua kali lipat pada tempe, sangat tinggi manfaatnya bagi kesehatan terutama dalam memperbaiki profil lipid dan diabetes mellitus. Mempertimbangkan hal tersebut tempe dapat dipertimbangkan sebagai pangan fungsional yangbermanfaat bagi kesehatan.Kata kunci: Tempe, protein, arginin, profil lipid, diabetes mellitusAbstractDegenerative diseases prevalence had been arining over years. One of the causes is the life style changes including eating pattern. Tempeh, an Indonesian soybean traditionally fermented food, was known and consumed by almost all Indonesian people. However, only a few know the health benefit of tempeh. Tempeh was also welknown and cheap protein source food affordable for the poor. Hence, there is a need to explore the nutritious content of tempeh and health benefit of it deeper such as in preventing degenerative diseases. Fermentation process of soybean to becometempeh had improved nutrient and non-nutrient contents that make tempeh better than soybean. Tempeh protein is more digestible than soybean and the arginine content increases twice, that could improve lipid profile and diabetes mellitus. Tempeh could be considered as functional food having health benefit.Key words: Tempeh, protein, arginine, lipid profile, diabetes mellitus
Safety of Annona muricata Extract Supplementation for Colorectal Cancer Patients Indrawati, Lili; Purwantyastuti, Purwantyastuti; Abdullah, Murdani; Surono, Ingrid S; Basir, Ibrahim
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.141 KB) | DOI: 10.24871/1732016170-175

Abstract

Background: People have used Annona muricata leaves traditionally as tea drinks. Traditional use of A. muricata leaves is as an infusion which is closed to water extract. The potential health benefit of A. muricata tea leaves that is traditionally used for maintaining health which lately is being used by cancer patients. Therefore it is urgent to verify the safety of A. muricata leaves extract.  Method: A randomized double blind placebo controlled trial was conducted on 30 colorectal cancer out patients who had undergone primary tumor resection. Twenty eight subjects completed the study, divided into two groups, namely ethanol-soluble fraction of A. muricata leaves water extract (ESFAM) (n = 14), and placebo (n = 14) for 8 weeks. Peripheral blood samples were withdrawn from subjects by venipuncture at baseline and at the end of the study period.Results: The effect on bone marrow can be considered to be safe.  The measure in indices of organs function, i.e liver and kidney also showed similar results and within normal range after supplementation. The dose given to the subjects is safe and highly tolerable, as shown by very few (6.7%) of patients complained intolerable adverse effects.  Conclusion: This study indicates the safety of  ESFAM  supplementation.