Banundari Rachmawati
Dosen Patologi Klinik, Fakultas Kedokteran, Universitas Diponegoro

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EFFECTIVENESS OF BROWN ALGAE EXTRACT TO REDUCE SERUM MALONDIALDEHYDE AND PROTEIN CARBONYL LEVELS IN STREPTOZOTOCIN-INDUCED SPRAGUE DAWLEY RATS Batubara, Lusiana; Kristina, Tri N.; Rachmawati, Banundari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): July-December 2016
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v7i2.1172

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Introduction: Brown algae (Sargassum duplicatum) contains bioactive compound with natural antioxidant that may potentially decrease lipid peroxidation and protein oxidation process in diabetes mellitus. Objective: to prove the effectiveness of brown algae extract administration (150mg/kgBW; 300mg/kgBW and 450 mg/kGBW respectively) in reducing serum MDA and PCO levels in streptozotocin-induced sprague dawley rat. Methods: This experiment study used the post test only control group design. Twenty eight (28) Sprague dawley rats induced with Streptozotocin (STZ) 40 mg/kgBW (i.p) were divided into four groups (n=7). The first group was diabetic non treated group (control). The second to fourth groups were the diabetic rats which given brown algae extract (150mg/kgBW; 300mg/kgBW and 450 mg/kgBW respectively) for 30 days. Serum MDA and PCO levels were examined by using ELISA method. Data were analyzed using one way ANOVA.Results: There were no significant differences in serum MDA levels among groups (p=0,405). However, serum PCO level in group administered with 450mg/kgBW of brown algae extract decreased significantly compared to control group (p=0.001), group administered with 150mg/kgBW (p=0.001) and 300mg/kgBW (p=0,037). Conclusion: Administration of brown algae extract did not decrease serum MDA levels significantly. Administration of 450mg/kgBW brown algae extract is effective to decrease serum PCO level significantly.
PENGARUH SUPLEMENTASI β-CAROTENE TERHADAP KADAR GLUKOSA DARAH DAN KADAR MALONDIALDEHIDA PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI STREPTOZOTOCIN Soviana, Elida; Rachmawati, Banundari; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.768 KB) | DOI: 10.14710/jgi.2.2.41-46

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Background : Hyperglycemia on diabetes mellitus can cause increasing of free radicals production. Free radicals caused lipid peroxidation reaction by forming malondialdehyde (MDA). ?-carotene has antioxidant activity may inhibit the formation of ROS.Objective : To prove the effect of multilevel doses ?-carotene 1 mg/kg BW, 20 mg/kg BW and 20 mg/kg BW on alternate days within 30 days orally supplementation on blood glucose level and MDA level on Sprague Dawley male rats induced by streptozotocin (STZ). Methods : Thirty rats were randomly divided into 5 groups: X1=Negative control/diabetic, X2 (STZ 40 mg/kg BW + BC 1 mg/kg BW), X3 (STZ 40 mg/kg BW + BC 10mg/kg BW), X4 (STZ 40 mg/kg BW + BC 20 mg/kg BW), X5 (technic control/non diabetic). ?-Carotene supplementation was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP and MDA level by ELISA with TBARS methods. Data was analized using paired t-test, wilcoxon, one way anova and post hoc bonferroni. Results : there was a significant difference of blood glucose level (p = 0,0001) and MDA level (p = 0,0001) after suplementation ?-carotene on alternate days within 30 days orally. ?-carotene 10 mg/kg BW was the most effective and efficient dose to lowering blood glucose, while 20 mg/kg BW to lowering MDA level. Conclusion : The multilevel doses ?-carotene (1 mg/kg BW, 10 mg/kg BW and 20 mg/kg BW) on alternate days within 30 days orally supplementation can decrease blood glucose and MDA level. ?-carotene 10 mg/kg BW is the most effecetive and efficient to decrease blood glucose and ?-carotene 20 mg/kg BW to decrease MDA level.
PERBEDAAN KADAR SGOT DAN SGPT ANTARA SUBYEK DENGAN DAN TANPA DIABETES MELLITUS Reza, Ahmad; Rachmawati, Banundari
DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO )

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Latar Belakang: Diabetes Mellitus (DM) masih menjadi sebuah masalah yang serius di kesehatan global terbesar di abad ke-21 ini. Penyakit DM dapat menyebabkan banyak komplikasi salah satunya kelainan penyakit hati. Pemeriksaan kadar SGOT dan SGPT diperlukan untuk meningkatkan kewaspadaan terhadap komplikasi yang didapat dari pasien DM.Tujuan: Membuktikan perbedaan kadar SGOT dan SGPT antara subyek dengan dan tanpa DM.Metode: Jenis penelitian ini adalah observasional analitik dengan pendekatan case control. Data dari semua subyekDM dan subyek tanpa DM di RSUP Dr. Kariadi Semarang yang berusia 20-79 tahun dari tahun 2013 sampai tahun  2016 yang didapatkan dari Instalasi Rekam Medis dan Instalasi Laboratorium  RSUP Dr. Kariadi Semarang. Data dianalisis menggunakan program SPSS.Hasil: Terdapat 25 subyek DM dan 25 subyek tanpa DM. Mayoritas pasien berumur 20-66 tahun. Hasil penelitian didapatkan,rata-rata kadar SGOT pada subyek DM didapatkan45,64 IU/L,kadar SGOT minimum didapatkan 11 IU/L dan maksimum didapatkan 190 IU/L. Rata-rata kadar SGPT pasien DM adalah 54,12 IU/L dengan kadar SGPT minimum 11 IU/L dan maksimum 309 IU/L.  Pada subyek tanpa DM didapatkan rata-rata kadar SGOT 24,32 IU/L, dengan kadar SGOT maksimum adalah 59 IU/L dan minimum 13 IU/L. Rata-rata kadar SGPT pada subyek tanpa DM adalah 42,32 IU/L dengan kadar minimum 23 IU/L dan maksimum 132 IU/L. Berdasarkan analisis bivariat penelitian kadar SGOT dan SGPT antara subyek DM dan subyek tanpa DM menunjukkan nilai p = 0,047 dan p = 0,573.Simpulan: Terdapat perbedaan kadar SGOT antara subyek DM dan subyek tanpa DM dan tidak terdapat perbedaan kadar SGPT antara subyek DM dan subyek tanpa DM.
SUPLEMENTASI FOLATE, KADAR HOMOCYSTEINE, NITRIC OXIDE DAN PETANDA RETINOPATI DIABETIK STUDI PADA TIKUS SPRAGUE DAWLEY DIABETES Rachmawati, Banundari
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

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Folate supplementation homocysteine, nitric oxide levels and marker for diabetic retinopathy: Study on Sprague Dawley diabetic ratsIntroduction: Diabetic retinopathy (DR) is the leading cause of blindness among diabetes mellitus (DM) patients. Hyperhomocysteinemia (HHcy) is reported to increase the risk for DM complications, however, the underlying mechanism is still unclear. Retina is particularly vulnerable to oxidative stress due to a high demand for oxygen. Hyperglycemia stimulates retinal oxidative stress and increases Nitric Oxide (NO). NO contributes to the regulation of retinal blood vessel function and the occurrence of retinopathy. The administration of folic acid (FA) 0.65 mg/day on HHcy subject, decrease serum Hcy by 42%. This study was aimed to analyze the effect of folate administration on Hcy, NO levels and markers of DR (VEGF serum).Methods: An experimental study using a randomized controlled group pretest posttest design was conducted in UGM Yogyakarta. The total of 40 male Sprague Dawley rats were divided into 5 groups: negative control and the other four group were induced with Streptozotocin 40 mg/kgBW intraperitoneal. Intervention group were given FA 2, 4, 8 ppm through a nasogastric tube for 30 days. Before and after intervention, serum Hcy, NO and VEGF were assessed, and Wilcoxon tests were used to measure the difference ofit.Result: Administration of 8 ppm FA significantly decreased serum Hcy (p=0.043), NO levels (p=0.043) but not for markers of DR.Conclusion: Folic acid supplementation of 8 ppm gives benefits to diabetic rats.Keywords: Diabetic retinopathy, homocysteine, NO, VEGFABSTRAKPendahuluan: Retinopati diabetik (RD) merupakan komplikasi diabetes mellitus yang dapat menjadi salah satu penyebab kebutaan. Hyperhomocysteinemia (HHcy) meningkatkan risiko komplikasi diabetes, namun bagaimana interaksinya masih belum jelas. Retina sangat peka terhadap stres oksidatif karena kebutuhan O2 yang tinggi sedangkan hiperglikemi akan memacu retinal oxidative stres dan peningkatan nitric oxide (NO). NO berperan pada regulasi fungsi pembuluh darah retina dan terjadinya retinopati. Pemberian folic acid (FA) 0,65 mg/hr pada subyek HHcy menurunkan Hcy serum 42%. Tujuan penelitian ini adalah menganalisis pengaruh pemberian folate terhadap kadar Hcy, NO dan petanda RD (VEGF serum)Metode: Penelitian ini bersifat eksperimental dengan rancangan randomized controlled group pretest posttest design. Penelitian dilakukan di LPPT unit IV UGM Yogyakarta. Sampel 40 tikus Sprague Dawley jantan, umur 2-3 bulan, BB 190-275 g dibagi 5 kelompok: kelompok kontrol negatif dan 4 kelompok lain diinduksi dengan STZ 40mg/kgBB intra peritoneal. Kelompok intervensi diberi FA 2, 4, 8 ppm (sonde) selama 30 hari. Kemudian diperiksa kadar Hcy, VEGF, NO serum. Perbedaan parameter sebelum dan sesudah intervensi dianalisis dengan uji Wilcoxon.Hasil: Pemberian FA 8 ppm menurunkan secara bermakna kadar Hcy (p=0,043), NO serum (p=0,043) dan tidak menurunkan petanda RD (VEGF serum) secara bermakna.Simpulan: Pemberian FA 8 ppm bermanfaat pada tikus diabetes.
HUBUNGAN NEUTROPHYL LYMPHOCYTE RATIO DENGAN C-REACTIVE PROTEIN PADA PASIEN STROKE NON HEMORAGIK Itami, Mila Niqi; Rachmawati, Banundari; Limijadi, Edward Kurnia Setiawan; Retnoningrum, Dwi
DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO )

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Latar Belakang: Stroke merupakan suatu penyakit kegawatan, dapat menyebabkan kematian, dan juga dapat menyebabkan kecacatan. Oleh sebab itu, diperlukan indikator inflamasi berupa Neutrophyl-Lymphocyte Ratio (NLR) dari pemeriksaan hitung jenis leukosit dan C-Reactive Protein (CRP) yang merupakan reaktan tahap akut yang sensitivitasnya tinggi, dapat mendeteksi rendahnya tingkat inflamasi pada pasien stroke non hemoragik. Tujuan : Menganalisis hubungan antara NLR dan  CRP pada pasien penderita stroke non hemoragik Metode : Penelitian  ini  merupakan  penelitian  observasional  analitik  dengan rancangan  cross-sectional. Subjek  penelitian  adalah  34  pasien  stroke  non hemoragik  di  Rumah  Sakit  Nasional  Diponegoro  dan  RSUD  Dr. Adhyatma Semarang. Pengambilan sampel dilakukan dengan cara consecutive sampling yang memenuhi kriteria inklusi dan eksklusi.Uji statistik menggunakan uji Spearman. Hasil : Dari 34 sampel, didapatkan  laki-laki 18 orang  (52,94%) dan  perempuan 16 orang (47,05%), rerata usia 58,06 ± 1,33 tahun. Diperoleh hubungan positif sedang dan bermakna antara NLR dan CRP pada pasien stroke non hemoragik dengan hasil (r= 0,449; p=0,008). Simpulan : Terdapat hubungan positif sedang antara NLR dengan CRP pada pasien stroke non hemoragikKata Kunci: Neutrophyl-Lymphocyte Ratio (NLR), C-Reactive Protein (CRP), stroke non hemoragik.
PENGARUH PEMBERIAN Zn TERHADAP KADAR GLUKOSA DARAH DAN KADAR SUPEROKSIDA DISMUTASE PADA TIKUS WISTAR YANG DIINDUKSI STREPTOZOTOCIN Kartika, Nadini; Rachmawati, Banundari; Johan, Andrew
Jurnal Kesehatan Vol 9, No 1 (2016): Jurnal Kesehatan
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jurkes.v9i1.3410

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Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Giving Zn could reduce the reactivity of ROS due to hyperglycemia by increasing SOD status. Zinc ability as an antioxidant also can improve blood glucose level in diabetes mellitus patients. To prove the effect of Zn with the doses of 3 mg/kg BW and 5 mg/kg BW for 30 days onblood glucose and SOD levels in Wistar rats induced by STZ. Twenty-eight rats were divided into 4 groups includes K1 as a negative control group, K2 as a positive control group that is induced by STZ 40 mg/kg BW, K3 as? group that is induced by STZ 40 mg/kg BW and Zn were given at a dose of 3 mg/kg BW for 30 days orally and K4 as aa group that is induced by STZ 40 mg/kg BW and Zn were given at a dose of 5 mg/kg BW for 30 days orally. Examination of blood glucose levels used GODPAP methods and SOD levels checked with a colorimeter method. Data were analyzed using Paired T-Testsand Wilcoxon tests. There was a significant decrease in blood glucose levels after administration of 3 mg/kg BW Zn (p = 0,003) and 5 mg/kg BW (p = 0.018) for 30 days in Wistar rats induced by STZ. There was no significant increase in SOD levels after administration of 3 mg/kg BW Zn (p = 0,120) but a significant increase in SOD levels after administration of 5 mg/kg BW Zn (p = 0,038) for 30 days in Wistar rats induced by STZ. Administration of 5 mg/kg BW Zn for 30 days showed a better effect on blood glucose and SOD levels in Wistar rats induced by STZ when compared with administration of 3 mg/kg BW Zn.
PERBEDAAN JUMLAH LEUKOSIT, NEUTROFIL DAN LIMFOSIT ABSOLUT PADA PENDERITA DM TIPE 2 TERKONTROL DAN TIDAK TERKONTROL Santoso, Sanjaya; Rachmawati, Banundari; Retnoningrum, Dwi
DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO )

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Latar Belakang : Diabetes melitus tipe 2 merupakan salah satu masalah kesehatan yang serius dan merupakan 1 dari 4 penyakit tidak menular yang angka kejadiannya terus bertambah yang ditandai dengan inflamasi kronik karena terjadi resistensi insulin sehingga kadar glukosa darah meningkat. Kondisi glukosa darah yang tinggi menyebabkan pembentukan radikal bebas sehingga timbul stres oksidatif  dan memicu proses inflamasi. Proses inflamasi yang terjadi dapat meningkatkan sitokin proinflamasi yang dapat mempengaruhi kadar leukosit, neutrofil dan limfosit dalam darah.Tujuan : Membuktikan perbedaan jumlah leukosit, neutrofil dan limfosit absolut pada penderita DM tipe 2 terkontrol dan tidak terkontrolMetode :  Jenis penelitian observasional dengan pendekatan crossectional.  Total sampel  adalah 60 responden yang terdiri dari 30  subyek DM tipe 2 terkontrol dan 30 subyek DM tipe 2 tidak terkontrol. Sampel merupakan pasien RSUP dr.Kariadi Semarang yang memenuhi kriteria inklusi. Analisis yang digunakan adalah uji - Independent T Test.Hasil :  Rerata jumlah leukosit, neutrofil dan limfosit absolut pada penderita DM tipe 2 terkontrol adalah   11,47 ± 1,63 x103/µl ; 9,15 ± 1,67  x103/µl ; 1,37 ± 0,23 x103/µl. Rerata jumlah leukosit, neutrofil dan limfosit absolut pada penderita DM tipe 2 tidak terkontrol adalah   10,02 ± 1,36 x103/µl ; 7,41 ± 1,31  x103/µl ; 1,74 ± 0,24 x103/µl. Penderita DM tipe 2 tidak terkontrol memiliki jumlah limfosit absolut yang lebih tinggi secara bermakna (p<0,05) tetapi memiliki jumlah leukosit dan neutrofil absolut yang lebih rendah namun tidak bermakna (p>0,05)  dibanding  penderita DM tipe 2 terkontrol.Kesimpulan :  Terdapat perbedaan jumlah limfosit absolut pada penderita DM tipe 2 terkontrol.
PERBEDAAN INDEX ERITROSIT PADA PASIEN ANEMIA GAGAL GINJAL KRONIK DAN THALASSEMIA MAYOR Budiwiyono, Yoanita Pratiwi; Rachmawati, Banundari; Hendrianingtyas, Meita
DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO )

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Latar Belakang: Pasien GGK dan thalassemia keduanya mengalami anemia mikrositik hipokromik. Beberapa rumus index eritrosit dapat digunakan sebagai parameter penapisan thalassemia. Beberapa contohnya yaitu: Mentzer Index (MI), RBC distribution width index (RDWI), Hisham Index (HI) dan Hameed Index (HA).Tujuan: Membuktikan perbedaan index eritrosit pada pasien gagal ginjal kronik dan thalassemia.Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan belah lintang. Masing-masing populasi berjumlah 40 orang. Data Complete Blood Count (CBC) yang didapat dengan menggunakan alat analisa hematologi otomatis dimasukkan ke dalam rumus MI, RDWI, HI, dan HA. Uji statistik menggunakan uji T tidak berpasangan.Hasil: Rerata MI pada GGK yaitu 28,03 dan pada thalassemia yaitu 20,24 . Rerata RDWI pada GGK yaitu 399,64 dan pada thalassemia yaitu 402,01. Rerata HI pada GGK yaitu 132,39 dan pada thalassemia yaitu 138,49. Rerata HA pada GGK yaitu 14,37 dan pada thalassemia yaitu 23,8. Terdapat perbedaan bermakna antara dua kelompok pada MI (p=0,00) dan HA (p=0,01). Tidak terdapat perbedaan bermakna antara dua kelompok pada RDWI (p=0,917) dan HI (p=0,448).Kesimpulan: Terdapat perbedaan MI dan HA, tetapi tidak terdapat perbedaan pada RDWI dan HI antara 2 kelompok.
EFEK SUPLEMENTASI β-CAROTENE TERHADAP KOLESTEROL TOTAL, TRIGLISERIDA DAN MALONDIALDEHID PADA TIKUS SPRAGUE DAWLEY YANG DIABET Ermawati, Devi; Rachmawati, Banundari; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.108 KB) | DOI: 10.14710/jgi.2.2.47-52

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Background : diabetes mellitus (DM) is associated with increased total cholesterol and triglyceride, also well characterized by increased malondialdehyde production. ?-carotene has antioxidant activity, glycemic and lipid control. Objective : to analyze the effect of ?-carotene on total cholesterol, triglyceride and MDA on diabetic Rattus norvegicus sprague dawley. Methods : thirty rats were randomly divided into 5 groups : 1 (STZ), 2 (STZ+?-carotene 1 mg/kg BW), 3 (STZ+?-carotene 10 mg/kg BW), 4 (STZ+?-carotene 20 mg/kg BW), 5 (normal). Streptozotocin induced intraperitoneal 40 mg/kg BW. ?-carotene was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP, total cholesterol by CHOD-PAP, triglyceride by GPO and MDA by ELISA with TBARS methods. Hypothesis test used one way anova then followed by post hoc bonferroni to analyze the efficient dose effect. Results : there was a significant difference of total cholesterol (p=0.002) after ?-carotene 10 mg/kg BW supplementation on alternate days within 30 days orally. ?-carotene 10 mg/kg BW was the most efficient dose to lowering total cholesterol. There were significant differences of triglyceride (p=0.0001) and MDA (p=0.0001) after ?-carotene 1, mg/kg BW, 10 mg/kg BW and 20 mg/kg BW supplementation on alternate days within 30 days orally. ?-carotene 10 mg/kg BW was the most efficient dose to lowering triglyceride, while 20 mg/kg BW to lowering MDA. Conclusion : ?-carotene 10 mg/kg BW is the most efficient dose to lowering total cholesterol and triglyceride. ?-carotene 20 mg/kg BW is the most efficient dose to lowering MDA.
Effect of zinc supplementation on triglyceride and malondialdehyde levels: study on diabetic Wistar rats induced with streptozotocin Ryadinency, Resty; Hadisaputro, Suharyo; Rachmawati, Banundari
Medical Journal of Indonesia Vol 27, No 2 (2018): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.971 KB) | DOI: 10.13181/mji.v27i2.1417

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Background: Diabetes mellitus is associated with increased blood glucose and triglyceride levels, which can lead to an oxidative stress. Zinc (Zn) is a micronutrient that has antioxidant properties and involved in lipid and glucose metabolism. This study aimed to evaluate the effect of zinc on the levels of fasting blood glucose (FBG), triglycerides (TG), and malondialdehyde (MDA) in male diabetic Rattus norvegicus Wistar rats.Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 40 mg/kg BW streptozotocin (STZ) and confirmed by FBG level higher than 200 mg/dL after 2 weeks. The rats were randomly divided into three groups: control group (STZ), treatment I (STZ + zinc 5 mg/kg BW), and treatment II (STZ + zinc 10 mg/kg BW). Zinc was administered by oral gavage for 30 days. At the end of the experiment, levels of FBG, TG, and MDA were measured. Data were analyzed using paired t-test or Wilcoxon test as appropriate.Results: Supplementation of 5 mg/kg zinc significantly decreased the levels of FBG (pre-intervention: 328.95±70.90 mg/dL, post-intervention: 144.35±34.27 mg/dL, p&lt;0.05), TG (pre-intervention: 252.48±26.30 mg/dL, post-intervention: 147.90±12.18 mg/dL, p&lt;0.05), and MDA (pre-intervention: 12.11±6.46 nm/mL, post-intervention: 4.75±2.34 nm/mL, p&lt;0.05). Moreover, supplementation of 10 mg/kg zinc decreased the levels of TG (pre-intervention: 275.62±56.25nm/mL, post-intervention: 165.58±22.63 nm/mL, p&lt;0.05) and MDA (pre-intervention: 13.08±6.60 nm/mL, post-intervention: 5.08±2.40 nm/mL, p&lt;0.05).Conclusion: Supplementation of zinc significantly reduced the levels of FBG, TG, and MDA in diabetic rats.