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EFEK HEMOSTATIS EKSTRAK METANOL DAUN SISIK NAGA (Drymoglossum Piloselloides Presl.) PADA TIKUS JANTAN (Rattus norvegicus L.) Rahayu, Ika; Kuncoro, Hadi; Ibrahim, Arsyik
Journal of Tropical Pharmacy and Chemistry Vol 2 No 3 (2013): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.953 KB) | DOI: 10.25026/jtpc.v2i3.61

Abstract

The research is The Hemostatic Effect of Sisik Naga Leaves (Drymoglossum Piloselloides  Presl.) Metanol Extract of Rat (Rattus norvegicus L.) has been done. This reseach’s purposes to determine the hemostatic effect, optimum dose and optimum measured time of Sisik Naga Leaves extract with bleeding time as its parameter used tail bleeding. Dose of Sisik Naga extract are 12.5 mg/kgBW, 25 mg/kgBW, and 50 mg/kgBW and NaCMC has been used as negative control, they were given twice a day in one day treatment. Tail bleeding by cutting the rat’s tail has been done on 12th, 24th, and 36th hour after the treatment. The result data was analyzed with two way Analysis of Varian (Anava) and followed BNJD test. The test results showed that bleeding time of negative control NaCMC is 143.15 seconds and bleeding time of Sisik Naga leaves extract with dose 12.5 mg/kgBW on 12th hours 82.62 second, 24th hours 60.27 second, 36th hours 76.36 second, dose 25 mg/kgBW on 12th hours 65.76 second, 24th hours 39.33 second, 36th hours 90.02 second, and dose 50 mg/kgBW on 12th hours 53.97 second, 24th hours 23.82 second, 36th hours 72.85. The best dose which optimum effect of hemostatic is 50 mg/kgBW with measured time on 24 hours after orally extract. Keyword : hemostatic, Drymoglossum Piloselloides  Presl., bleeding time   Abstrak Telah dilakukan penelitian efek hemostatis ekstrak metanol daun Sisik Naga (Drymoglossum Piloselloides  Presl.) pada tikus jantan (Rattus norvegicus L.). Penelitian ini bertujuan untuk mengetahui efek hemostatis, dosis dan waktu pengukuran optimum ekstrak Sisik Naga dengan mengukur waktu perdarahan pada tikus menggunakan metode tail bleeding. Dosis uji ekstrak daun Sisik Naga yang digunakan adalah 12,5 mg/kgBB, 25 mg/kgBB dan 50 mg/kgBB dengan kontrol negatif NaCMC yang diberikan per oral dua kali sehari selama satu hari. Pengukuran waktu perdarahan adalah 12 jam, 24 jam dan 36 jam setelah pemberian ekstrak. Data dianalisis dengan Anava dua arah yang dilanjutkan dengan uji lanjutan BNJD. Hasil penelitian menunjukkan bahwa rata-rata waktu perdarahan kontrol negatif NaCMC adalah 143,15 detik dan rata-rata waktu perdarahan ekstrak daun Sisik Naga pada dosis 12,5 mg/kgBB pada 12 jam 82,62 detik, 24 jam 60,27 detik, 36 jam 76,36 detik, dosis 25 mg/kgBB pada 12 jam 65,76 detik, 24 jam 39,33 detik, 36 jam 90,02 detik, dan dosis 50 mg/kgBB 12 jam 53,97 detik, 24 jam 23,82 detik, 36 jam 72,85 detik. Dosis yang paling efektif sebagai hemostatis adalah pada dosis 50 mg/kgBB dengan waktu pengukuran yang paling efektif yaitu 24 jam setelah pemberian ekstrak. Kata kunci : Hemostatis, Drymoglossum Piloselloides  Presl., waktu perdarahan
Hubungan antara Polimorfisme Gen VEGF-A dengan Perkembangan Ulkus Diabetika Rahayu, Ika
Jurnal Kedokteran Meditek VOL. 24 NO. 66 APRIL-JUNI 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i66.1642

Abstract

Diabetes melitus (DM) merupakan suatu gangguan metabolik yang ditandai oleh hiperglikemia kronik. Hal ini disebabkan oleh kelainan sekresi insulin, gangguan kerja insulin atau gangguan keduanya. Sebanyak 12-25% pasien DM memunyai risiko untuk mengalami ulkus diabetika. Ulkus diabetika merupakan komplikasi yang sering terjadi pada pasien DM tipe 1 dan 2.Diabetes melitus merupakan suatu model prototopikal pada kejadian gangguan penyembuhan luka. Individu dengan DM menunjukkan kemampuan angiogenesis abnormal pada beberapa organ. Gen Vascular Endothelial Growth Factor-A (VEGF), merupakan gen yang menyandi polipeptida VEGF. Studi fungsional yang telah dilakukan mengindikasikan bahwa polimorfisme pada gen ini memengaruhi ekspresi mRNA. Ekspresi mRNA memunyai peranan penting pada proses penyembuhan luka.Kata Kunci : Diabetes melitus, ulkus diabetika, polimorfisme gen VEGF, VEGF-A
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN SIKAP KERJA SAMA DAN HASIL BELAJAR SISWA PADA PEMBELAJARAN TEMATIK DI SDN KENCANA INDAH II Rahayu, Ika; Yulistiani, Irna
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 1 No. 2 (2016): Vol. 1 No. 2, Juni 2016
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.183 KB) | DOI: 10.36989/didaktik.v1i2.28

Abstract

The problem of this research is to increase cooperation attitude and student learning outcomes through the implementation model of Problem Based Learning on thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency. This study aims to determine the attitude of cooperation and improvement of student learning outcomes through the implementation model of Problem Based Learning in Scene 1 Indahnya Mutual Subtheme 1 Nation Cultural Diversity in Class IV. As the subjects in this study is the fourth grade students of SDN Kencana Indah 2 as a single class of 33 students. The research object of this class action is the improvement of the attitude of cooperation and student learning outcomes at 1 beauty togetherness theme of cultural diversity subtema one nation by using model Problem Based Learning. Implementation of a class action (PTK) was done 2 cycles and each cycle is done with 2 meetings and at the end of each cycle of observation to determine the result of increased cooperation attitude and student learning outcomes. The results of the research can be argued that the percentage of category cooperative attitude of students the observation of the first cycle of the first meeting included the category "Not Visible" reached 57.7%; category "Start Invisible" reached 72.7%; category "Start Developing" reached 39.4%; and the category "have been entrenched" reached 15.2%, while in the second cycle in the category "Not Visible" reached 15.2%; category "Start Invisible" reached 42.4%; category "Start Developing" reached 33.3%; and the category "have been entrenched" reached 93.9%. Besides the increase occurred in student learning outcomes of the first cycle that 45.5% to 84.8% in the second cycle. Thus it can be argued conclusion that the application of the model of Problem Based Learning can improve the attitude of cooperation and student learning outcomes in thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency.