Asri Rahmawati
Program Studi Teknik Kimia, Fakultas Teknik, Universitas Negeri Semarang

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PEMANFAATAN KULIT BUAH NAGA (Dragon Fruit) SEBAGAI PEWARNA ALAMI MAKANAN PENGGANTI PEWARNA SINTETIS Handayani, Prima Astuti; Rahmawati, Asri
Jurnal Bahan Alam Terbarukan Vol 1, No 2 (2012): December 2012
Publisher : Semarang State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jbat.v1i2.2545

Abstract

Kulit buah naga merupakan limbah hasil pertanian yang mengandung zat warna alami antosianin cukup tinggi. Antosianin merupakan zat warna yang berperan memberikan warna merah yang berpotensi menjadi pewarna alami untuk pangan dan dapat dijadikan alternatif pengganti pewarna sintetis yang lebih aman bagi kesehatan. Pengambilan zat warna antosianin dilakukan dengan metode ekstraksi. Pelarut yang digunakan adalah aquades. Variabel penelitian antara lain varietas buah naga, konsentrasi asam sitrat dalam pelarut, suhu ekstraksi, dan waktu ekstraksi. Potongan kulit buah naga diekstraksi dengan pelarut aquades dan asam sitrat dengan perbandingan tertentu, pada suhu ekstraksi 25-800C dan waktu ekstraksi 0,5-3 jam. Analisis kadar antosianin dilakukan dengan analisa antosianin metode Glusti dan Wrolstad. Hasil percobaan diperoleh bahwa varietas buah naga daging merah menghasilkan kadar antosianin terbesar 22,59335 ppm. Selain itu kadar antosianin terbesar diperoleh pada variasi pelarut aquades:asam sitrat (5:1) 26,4587 ppm, variasi pada suhu kamar menghasilkan 21,5028 ppm dan waktu pengadukan  3 jam menghasilkan 23,3027 ppm. Pewarna alami ini telah diaplikasikan pada makanan dan diujikan pada tikus putih, hasil uji coba menunjukkan pewarna buah naga dapat dipakai sebagai pewarna alami makanan. Dragon fruit peel is agricultural waste which contains quite high natural pigments of anthocyanins. Anthocyanin is a dye that potentially provides a red natural colorant for food and alternatively used as synthetic dye which is safe for health. In this study, the process of taking anthocyanin was conducted using extraction method. The solvent used was distilled water. The variables observed in the research include dragon fruit varieties, the concentration of citric acid in the solvent, extraction temperature, and extraction time. The dragon fruit peel was extracted using solvents of distilled water and citric acid at a certain ratio, at extraction temperature varies from 25-80oC with the extraction time varies from 0.5 to 3 hours. The analysis of anthocyanin concentration was conducted by using Glusti and Wrolstad method. The experimental result shows the red dragon fruit varieties produced the greatest concentration of anthocyanin (22.59335 ppm). Moreover, the result shows the greatest concentration of anthocyanin obtained from the following variations, i.e. the 5:1 solvent ratio of distilled water : citric acid produces 26.4587ppm,  the extraction at room temperature produced 21.5028 ppm, and the extraction for 3 hours stirring produced 23.3027 ppm. The extracted dragon fruit dye has been applied for food and tested on white mice; the test result shows the dye can be used as a natural food dye.
Correlation of Expression p16 on Genital Wart Lesions with Various Degrees of Cervical Dysplasia Rahmawati, Asri; Damayanti, Damayanti; SP, Cita Rosita; Lumintang, Hans
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.416 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Introduction: Infection of Human Papillomavirus (HPV) can cause condylomata acuminata. High-risk HPV types have proteins E6 and E7 called “oncoprotein” for its role in the occurrence of cancer. E7 protein causing no active bond pRb and E2F is regulated by CDK inhibitors, such as p16INK4a . Overexpression p16INK4a could be obtained from pre cancerous lesions. Pap smear, the standard screening method, is performed to detect early malignancy of the cervix, but have low sensitivity. The presence of tumor markers, p16INK4 ,will help early detection of malignancy. Purpose: To evaluate the profile of p16INK4a expression in condylomata acuminata lesions with various degrees of cervical dysplasia. Methods: Discriptive, observational, cross seetional study by performed p16INK4a immunohistochemical examination in lesions condylomata acuminata and cytologic examination on cervical biopsy. Results: Results of cervical cytology (pap smear) from 18 samples showed Low-grade Squamous Intraepithelial Lesions (LSIL) in 10 patients (55.6%) and Negative for Intraepithelial Lesion or Malignancy (NILM) in 8 patients (44.4%). Immunohistochemical examination obtained p16INK4a expression with score of 1 (sporadic) in 8 patients (44.4%), with score of 2 (focal) in 7 patients (38.9%) and with score of 3 (diffuse) in 3 patients (16.7%).  From 3 patients with diffuse expression of p16INK4a , 2 patients (66,6%) showed LSIL from cytology cervix and 1 patient (33,3%) revealed NILM. Spearman correlation test results showed no significant correlation between p16INK4a expression in cervical dysplasia with p = 0.24 (p> 0,05). Conclusion: There were three samples of diffuse, with most of Low-grade Squamous Intraepithelial Lesions (LSIL) in cervical dysplasia, it indicates there is a potential of p16INK4a as a marker of malignancy in condylomata acuminata. Key words : condylomata acuminata, p16INK4a , cervical dysplasia.
Faktor-Faktor yang Berhubungan dengan Tingkat Kecemasan pada Pasien Preoperative di RS Mitra Husada Pringsewu Vellyana, Diny; Lestari, Arena; Rahmawati, Asri
Jurnal Kesehatan Vol 8, No 1 (2017): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.106 KB) | DOI: 10.26630/jk.v8i1.403

Abstract

All of the nursing intervention in hospital was not certainly be positively accepted by patients. People ability has different, so that can arise the stress condition or anxiety. The prevalence of anxiety in America were more than 28%. The age who get anxiety were 9-17 years, 13% age of 18-54 years, 16% age of 55 and 11.4%  of elderly. Women have risk to anxiety, two times than man. This study was to know the factors that related to anxiety level in Preoperative patient in Mitra Husada Hospital, Pringsewu, in 2016. The method of this study was a correlation with using cross sectional approach. The population were 58 respondents. Technique of sampling was using accidental sampling. Data were analyzed by univariat and bivariat using Chi square. The result showed that there were a relationship of gender, age, and economic status (p-value<0.05) and there were not a relationship of level of education variable (p-value>0.05) with the anxiety level of Preoperative patient in Mitra Husada Hospital, Pringsewu.
Correlation of Expression p16 on Genital Wart Lesions with Various Degrees of Cervical Dysplasia Rahmawati, Asri; Damayanti, Damayanti; SP, Cita Rosita; Lumintang, Hans
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Fakultas Kedokteran Universita Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.416 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Introduction: Infection of Human Papillomavirus (HPV) can cause condylomata acuminata. High-risk HPV types have proteins E6 and E7 called ?oncoprotein? for its role in the occurrence of cancer. E7 protein causing no active bond pRb and E2F is regulated by CDK inhibitors, such as p16INK4a . Overexpression p16INK4a could be obtained from pre cancerous lesions. Pap smear, the standard screening method, is performed to detect early malignancy of the cervix, but have low sensitivity. The presence of tumor markers, p16INK4 ,will help early detection of malignancy. Purpose: To evaluate the profile of p16INK4a expression in condylomata acuminata lesions with various degrees of cervical dysplasia. Methods: Discriptive, observational, cross seetional study by performed p16INK4a immunohistochemical examination in lesions condylomata acuminata and cytologic examination on cervical biopsy. Results: Results of cervical cytology (pap smear) from 18 samples showed Low-grade Squamous Intraepithelial Lesions (LSIL) in 10 patients (55.6%) and Negative for Intraepithelial Lesion or Malignancy (NILM) in 8 patients (44.4%). Immunohistochemical examination obtained p16INK4a expression with score of 1 (sporadic) in 8 patients (44.4%), with score of 2 (focal) in 7 patients (38.9%) and with score of 3 (diffuse) in 3 patients (16.7%).  From 3 patients with diffuse expression of p16INK4a , 2 patients (66,6%) showed LSIL from cytology cervix and 1 patient (33,3%) revealed NILM. Spearman correlation test results showed no significant correlation between p16INK4a expression in cervical dysplasia with p = 0.24 (p> 0,05). Conclusion: There were three samples of diffuse, with most of Low-grade Squamous Intraepithelial Lesions (LSIL) in cervical dysplasia, it indicates there is a potential of p16INK4a as a marker of malignancy in condylomata acuminata. Key words : condylomata acuminata, p16INK4a , cervical dysplasia.
PENGETAHUAN KELUARGA YANG BAIK DAPAT MENURUNKAN FREKUENSI KEKAMBUHAN PADA PASIEN SKIZOFRENIA Rahmawati, Asri
Jurnal Ilmiah Kesehatan Vol 3, No 5 (2014): Jurnal Ilmiah Kesehatan
Publisher : STIKes Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35952/jik.v3i5.141

Abstract

Perhatian Keluarga Menurunkan Frekuensi Kekambuhan Pada Pasien Skizofrenia Rahmawati, Asri
Jurnal Ilmiah Kesehatan Vol 2, No 4 (2013): Jurnal Ilmiah Kesehatan
Publisher : STIKes Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35952/jik.v2i4.63

Abstract

Peran keluarga dalam bentuk dukungan perhatian sangat penting terhadap pasien gangguan jiwa, karena keluarga adalah system pendukung utama yang memberikan perawatan langsung pada klien, bila keluarga memahami kebutuhan anggotanya, maka keluarga akan memberikan dukungan untuk keberhasilan dalam pengobatan. Jenis penelitian ini kuantitatif dengan pendekatan Cross Sectional, tehnik sampling menggunakan accidental sampling. Data dikumpulkan menggunakan kuesioner, Uji hipotesis bivariat menggunakan Chi square. Hasil uji statistic Chi Square didapatkan nilai p value < 0,002 < 0,05 yang artinya Ho ditolak, ada hubungan perhatian keluarga dengan tingkat kekambuhan pasien skizofrenia di ruang rawat inap RSJ Propinsi Lampung. Didapatkan OR 5,714 yang berarti responden dengan kurang perhatian, beresiko 5,714 kali anggota keluarganya mengalami kekambuhan cepat. Saran pada penelitian ini yaitu Diharapkan dapat menambah informasi bagi petugas kesehatan rumah sakit jiwa, sehingga mau meningkatkan tehnik penyampaian informasi kepada semua keluarga pasien jiwa, dan dapat memotivasi keluarga termotivasi untuk dapat meningkatkan dukungan pada pasien jiwa.
Hubungan Motivasi Belajar Dengan Prestasi Belajar Pada Mahasiswa Tingkat I Program Studi D III Keperawatan Stikes Muhammadiyah Pringsewu Tahun 2011 Rahmawati, Asri
Jurnal Ilmiah Kesehatan Vol 3, No 5 (2014): Jurnal Ilmiah Kesehatan
Publisher : STIKes Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35952/jik.v3i5.53

Abstract

Tenaga kesehatan yang berkualitas adalah tenaga kesehatan yang mempunyai kemampuan soft skills dan hard skills yang seimbang, dimana kemampuan hard skills dapat dilihat dari prestasi belajar. Tujuan penelitian ini untuk mengetahui hubungan antara motivasi belajar dengan prestasi belajar. Jenis penelitian ini kuantitatifdengan pendekatan crossectional, tehnik sampling menggunakan total populasi. Data dikumpulkan menggunakan kuesioner, Uji hipotesist menggunakan Chi square. Hasil penelitian univariat menunjukkan mahasiswa yang mempunyai motivasi belajar tinggi 61,9 %, motivasi belajar rendah 38,1%, dan dari hasil penelitian bivariat didapatkan adanya hubungan antara motivasi belajar dengan prestasi belajar (p=0,00 ) OR 19.375. Saran pada penelitian ini yaitu hendaknya orang tua dapat selalu membantu memberikan motivasi dan pengawasan pada anaknya dalam hal pembelajaran