Bambang Sigit Riyanto
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LEVEL OF INTERLEUKIN-6 IN OBESE PEOPLE WITH AND WITHOUT INSULIN RESISTANCE Safitri, Nedya; Riyanto, Bambang Sigit; Asdie, H. Ahmad Husain
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground. Obesity is one of the risk factor for type 2 diabetes mellitus characterized by insulin resistance, decrease insulin secretion and hyperglycemia. Chronic inflammation has been proposed to have an important role in the pathogenesis of obesity related insulin resistance. A number of studies have indicated that several humoral markers of inflammation are elevated in people with obesity and type 2 diabetes mellitus, because adipose tissue secretes a number of proinflammatory cytokines, including interleukin-6. The level of plasma IL-6 is increase in obese people.Objective. To investigate the mean of difference in the level of IL-6 in obese people with and without insulin resistance.Subjects and Method. The study design was cross-sectional. It was conducted in obese people with BMI ≥ 25 kg/m2. Insulin resistance were measured with HOMA-IR methode, calculated using the following formula: fasting serum glucose X fasting plasma insulin/22,5. Insulin resistance was defined when HOMA-IR > 2,77. Interlukin-6 was measured with Quantikine High Sensitivity human IL-6 ELISA. Difference of mean of IL-6 level was analyzed by student’s t-test for normal distribution and Mann- Whitney U-test if distribution was not normal.Results. There were 56 subjects, 24 (42,9%) subjects with insulin resistance and 32 (57,1%) subjects without insulin resistance. Obese people with insulin resistance had higher mean level of IL-6 than obese people without insulin resistance, although the difference was not significant (20,05±8,59 vs 18,98±8,15 pg/ml; p=0,639; 95% CI -5,58-3,46).Conclusion. There was no difference in the mean of IL-6 level in obese people with and without insulin resistance. Keywords. IL-6, obese, insulin resistance 
MODEL TEMAN APOTEKER: ALTERNATIF MODEL INTERVENSI APOTEKER BAGI PASIEN TUBERKULOSIS Yasin, Nanang Munif; Wahyono, Djoko; Riyanto, Bambang Sigit; Puspitasari, Ika
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 6, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.350

Abstract

Tingginya prevalensi tuberkulosis (TB) di Indonesia memerlukan keterlibatan apoteker dalam pelayanan pasien TB. Penelitian ini bertujuan untuk mengidentifikasi jenis pelayanan TB, mengembangkan model intervensi, dan mengembangkan tools dan rencana intervensi apoteker bagi pasien TB.   Penelitian ini merupakan jenis penelitian observasional yang terdiri dari tiga tahapan  yaitu focus grup discussion (FGD), pengembangan model intervensi, dan pengembangan tools dan rencana model intervensi apoteker. Instrumen yang digunakan adalah panduan FGD dan kuesioner pelayanan TB. FGD membahas pelayanan pada pasien TB dan dihadiri oleh apoteker dan programmer TB di puskesmas dan Rumah Sakit Khusus Paru Respira di Yogyakarta. Data FGD didukung oleh hasil kuesioner yang diisi sebelum FGD. Pengembangan  model intervensi terdiri dari tahap identifikasi kebutuhan pharmaceutical care, penentuan outcome, dan kompilasi akhir model intervensi apoteker. Pengembangan tools model intervensi apoteker berbasis berbagai literatur dan hasilnya dievaluasi oleh pakar.  Data penelitian dianalis secara deskriptif dan analisis kualitatif. Hasil FGD dan kuesioner menunjukkan bahwa keterlibatan apoteker masih terbatas dan hanya  4 (21%) yang pernah mendapatkan pelatihan TB. Semua petugas TB sudah melakukan edukasi namun materi yang diberikan sangat beragam dan belum terstruktur. Sebanyak 15 (78,9%) apoteker melakukan monitoring efek samping, 10 (52,6%) monitoring interaksi obat,  10 (52,6%) monitoring respon klinik,   16 (84,2 %)  monitoring kepatuhan pasien, 2 (10,5%) melakukan home care dan 18 (94,7%) telah berbagi peran dengan perawat. Melalui formulasi hasil studi pustaka, studi pendahuluan, dan FGD diperoleh rekomendasi bahwa peran apoteker dalam pelayanan TB dapat ditingkatkan melalui model intervensi yang mencakup 5 aspek penting yaitu training, education, monitoring, adherence, dan networking yang disingkat TEMAN Apoteker. Selanjutnya Model TEMAN Apoteker diterjemahkan dan dijabarkan dalam 6 bentuk tools yaitu modul, booklet, leaflet, poster, buku panduan pelaksanaan dan lembar dokumentasi pharmaceutical care. Model TEMAN Apoteker yang komprehensif dapat menjadi alternatif model intervensi dalam meningkatkan peran apoteker pada pelayanan pasien TB.
MODEL TEMAN APOTEKER: ALTERNATIF MODEL INTERVENSI APOTEKER BAGI PASIEN TUBERKULOSIS Yasin, Nanang Munif; Wahyono, Djoko; Riyanto, Bambang Sigit; Puspitasari, Ika
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 6, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.235 KB) | DOI: 10.22146/jmpf.350

Abstract

Tingginya prevalensi tuberkulosis (TB) di Indonesia memerlukan keterlibatan apoteker dalam pelayanan pasien TB. Penelitian ini bertujuan untuk mengidentifikasi jenis pelayanan TB, mengembangkan model intervensi, dan mengembangkan tools dan rencana intervensi apoteker bagi pasien TB.   Penelitian ini merupakan jenis penelitian observasional yang terdiri dari tiga tahapan  yaitu focus grup discussion (FGD), pengembangan model intervensi, dan pengembangan tools dan rencana model intervensi apoteker. Instrumen yang digunakan adalah panduan FGD dan kuesioner pelayanan TB. FGD membahas pelayanan pada pasien TB dan dihadiri oleh apoteker dan programmer TB di puskesmas dan Rumah Sakit Khusus Paru Respira di Yogyakarta. Data FGD didukung oleh hasil kuesioner yang diisi sebelum FGD. Pengembangan  model intervensi terdiri dari tahap identifikasi kebutuhan pharmaceutical care, penentuan outcome, dan kompilasi akhir model intervensi apoteker. Pengembangan tools model intervensi apoteker berbasis berbagai literatur dan hasilnya dievaluasi oleh pakar.  Data penelitian dianalis secara deskriptif dan analisis kualitatif. Hasil FGD dan kuesioner menunjukkan bahwa keterlibatan apoteker masih terbatas dan hanya  4 (21%) yang pernah mendapatkan pelatihan TB. Semua petugas TB sudah melakukan edukasi namun materi yang diberikan sangat beragam dan belum terstruktur. Sebanyak 15 (78,9%) apoteker melakukan monitoring efek samping, 10 (52,6%) monitoring interaksi obat,  10 (52,6%) monitoring respon klinik,   16 (84,2 %)  monitoring kepatuhan pasien, 2 (10,5%) melakukan home care dan 18 (94,7%) telah berbagi peran dengan perawat. Melalui formulasi hasil studi pustaka, studi pendahuluan, dan FGD diperoleh rekomendasi bahwa peran apoteker dalam pelayanan TB dapat ditingkatkan melalui model intervensi yang mencakup 5 aspek penting yaitu training, education, monitoring, adherence, dan networking yang disingkat TEMAN Apoteker. Selanjutnya Model TEMAN Apoteker diterjemahkan dan dijabarkan dalam 6 bentuk tools yaitu modul, booklet, leaflet, poster, buku panduan pelaksanaan dan lembar dokumentasi pharmaceutical care. Model TEMAN Apoteker yang komprehensif dapat menjadi alternatif model intervensi dalam meningkatkan peran apoteker pada pelayanan pasien TB.
Dukungan sosial dan kualitas hidup orang dengan HIV/AIDS Mardia, Mardia; Ahmad, Riris Andono; Riyanto, Bambang Sigit
Berita Kedokteran Masyarakat (BKM) Vol 33, No 3 (2017)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.155 KB) | DOI: 10.22146/bkm.12563

Abstract

Quality of life among people living with HIV/AIDS based on criteria diagnosis and other factors in Surakarta PurposeThis study aimed to determine the quality of life among people living with HIV/AIDS based on the criteria for diagnosis and other factors.MethodsThis study was conducted in the VCT clinic hospital of Dr. Moewardi. The population was HIV-positive patients with antiretroviral therapy. Data collection conducted through medical records and interview to patients. ResultsOut of a total of 89 respondents, 66.29% were males and 71.91% were aged between 26-45 years. We found significant correlations for diagnosis of HIV/AIDS, opportunistic infections, time since HIV diagnosis, duration of ARV therapy, social support, modes of transport, sex, age, and marital status with the quality of life. Multivariate analysis obtained by each variable showed the strongest association with the quality of life was time since diagnosis, social support and duration of ARV therapy. ConclusionThe quality of life was better for those who have been diagnosed with HIV/AIDS ≥ 32 months, with social support, and who have been undergoing antiretroviral therapy ≥ 29 months. Improved counseling in the early days of ARV therapy is necessary to always maintain the treatment and provide support for their social life.
LEVEL OF INTERLEUKIN-6 IN OBESE PEOPLE WITH AND WITHOUT INSULIN RESISTANCE Safitri, Nedya; Riyanto, Bambang Sigit; Asdie, H. Ahmad Husain
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4381.112 KB) | DOI: 10.22146/acta interna.3861

Abstract

ABSTRACTBackground. Obesity is one of the risk factor for type 2 diabetes mellitus characterized by insulin resistance, decrease insulin secretion and hyperglycemia. Chronic inflammation has been proposed to have an important role in the pathogenesis of obesity related insulin resistance. A number of studies have indicated that several humoral markers of inflammation are elevated in people with obesity and type 2 diabetes mellitus, because adipose tissue secretes a number of proinflammatory cytokines, including interleukin-6. The level of plasma IL-6 is increase in obese people.Objective. To investigate the mean of difference in the level of IL-6 in obese people with and without insulin resistance.Subjects and Method. The study design was cross-sectional. It was conducted in obese people with BMI ≥ 25 kg/m2. Insulin resistance were measured with HOMA-IR methode, calculated using the following formula: fasting serum glucose X fasting plasma insulin/22,5. Insulin resistance was defined when HOMA-IR > 2,77. Interlukin-6 was measured with Quantikine High Sensitivity human IL-6 ELISA. Difference of mean of IL-6 level was analyzed by student’s t-test for normal distribution and Mann- Whitney U-test if distribution was not normal.Results. There were 56 subjects, 24 (42,9%) subjects with insulin resistance and 32 (57,1%) subjects without insulin resistance. Obese people with insulin resistance had higher mean level of IL-6 than obese people without insulin resistance, although the difference was not significant (20,05±8,59 vs 18,98±8,15 pg/ml; p=0,639; 95% CI -5,58-3,46).Conclusion. There was no difference in the mean of IL-6 level in obese people with and without insulin resistance. Keywords. IL-6, obese, insulin resistance