Nendyah Roestijawati
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Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers Roestijawati, Nendyah; Maurits, Lintje Setyawati; Sugiyanto, Sugiyanto
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.42-48

Abstract

BACKGROUNDCadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers.METHODSThe study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test.RESULTSMean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p<0.05) and between blood Cd levels and IGF-1 (p <0.05).CONCLUSIONSThere was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.
High serum iron and zinc decrease glutathione S-transferase among women with breast cancer Roestijawati, Nendyah; Ernawati, Dwi Arini; Krisnansari, Diah
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.25-30

Abstract

BACKGROUNDBreast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.METHODSAn observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.RESULTSThe results showed that there was a significant relationship of serum iron with GST (r=-0.487; p<0.05) and serum zinc with GST (r=-0.409; p<0.01).CONCLUSIONOur study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.
Analisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di instalasi farmasi Rumah Sakit Margono Soekarjo Purwokerto Astuti, Nurul Istiqomah Tri; Suliyanto, Suliyanto; Roestijawati, Nendyah
Performance Vol 25 No 2 (2018): Performance
Publisher : Faculty of Economics and Business Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.986 KB)

Abstract

Tujuan penelitian ini adalah untuk menganalisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di Instalasi Farmasi RS Margono Soekarjo Purwokerto. Jenis penelitian ini menggunakan survei dengan kuisioner yang diberikan kepada pasien rawat jalan RS Margono Soekarjo Purwokerto. Metode pengambilan sampel menggunakan non-probability consecutive sampling, yaitu sampel diambil dari responden yang memenuhi kriteria pemilihan sampel hingga jumlah subjek terpenuhi yaitu 110 responden. Validitas data menggunakan korelasi product moment. Teknik analisis data menggunakan path analysis dengan dibantu software SPSS 20. Hasil analisis data penelitian ini didapatkan hasil bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap waktu tunggu antrian pengambilan obat, kesalahan pemberian obat, dan komunikasi apoteker pasien. Penggunaan Computer Physician Order Entry (CPOE), waktu tunggu antrian pengambilan obat, komunikasi apoteker, dan mutu pelayanan berpengaruh terhadap kepuasan pelanggan dengan arah positif.  Kesalahan pemberian obat tidak berpengaruh terhadap kepuasan pelanggan. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap mutu pelayanan di Instalasi Farmasi RS Margono Soekarjo Purwokerto, namun berpengaruh terhadap kepuasan pelanggan di Instalasi Farmasi S Margono Soekarjo Purwokerto.
SPATIAL MODELING OF THE SPREAD OF SCABIES AND ENVIRONMENTAL SANITATION AS A RISK FACTOR AMONG SCHOOLCHILDREN: A CASE-CONTROL STUDY Wibowo, Yudhi; Roestijawati, Nendyah; Krisnansari, Diah; Purnomo, Agoes Y
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.625 KB) | DOI: 10.18051/UnivMed.2020.v39.55-62

Abstract

BACKGROUND Scabies is a World Health Organization neglected tropical disease common in children in low-and middle-income countries. The prevalence of scabies, especially in tropical countries, is still quite high at more than 200 million cases per year. Transmission of scabies is predominantly via skin-to-skin contact. The purpose of the study was to determine the epidemiology of clinical scabies among schoolchildren and spatial modeling using geographic information systems (GIS).METHODSA study of unmatched case-control design with a ratio of 1: 1 was performed to identify specific risk factors of scabies. Cases were patients with clinical scabies and controls were healthy people in the area. A total of 100 students were involved in the study. Simple and multiple logistic regression was used to test any association between the variables. Geographical Information Systems (GIS) modeling was used to determine the spatial distribution of clinical scabies based on 69 cases.RESULTThere was a significant association between the level of environmental sanitation and the prevalence of clinical scabies (OR = 2.53;95% C.I. 1.11-5.74). Multivariate analysis showed that the level of environmental sanitation was significant (AOR = 3.05;95% C.I. 1.19-7.81). Risk factors for developing clinical scabies increased to 3 times after considering other risk factors, namely gender, age group and respondent education level. Analysis of average nearest neighbor distance showed that the spatial distribution of clinical scabies was clustered. CONCLUSIONSThe distribution of clinical scabies was spatial clustering, and prediction of transmission in a clockwise direction with Southeast and Northwest ellipses.
ANALISIS PENGGUNAAN COMPUTER PHYSICIAN ORDER ENTRY (CPOE) TERHADAP MUTU PELAYANAN DAN KEPUASAN PELANGGAN DI INSTALASI FARMASI RUMAH SAKIT MARGONO SOEKARJO PURWOKERTO Astuti, Nurul Istiqomah Tri; Suliyanto, Suliyanto; Roestijawati, Nendyah
Performance: Jurnal Personalia, Financial, Operasional, Marketing dan Sistem Informasi Vol 25 No 2 (2018): Performance
Publisher : Faculty of Economics and Business Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.986 KB)

Abstract

Tujuan penelitian ini adalah untuk menganalisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di Instalasi Farmasi RS Margono Soekarjo Purwokerto. Jenis penelitian ini menggunakan survei dengan kuisioner yang diberikan kepada pasien rawat jalan RS Margono Soekarjo Purwokerto. Metode pengambilan sampel menggunakan non-probability consecutive sampling, yaitu sampel diambil dari responden yang memenuhi kriteria pemilihan sampel hingga jumlah subjek terpenuhi yaitu 110 responden. Validitas data menggunakan korelasi product moment. Teknik analisis data menggunakan path analysis dengan dibantu software SPSS 20. Hasil analisis data penelitian ini didapatkan hasil bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap waktu tunggu antrian pengambilan obat, kesalahan pemberian obat, dan komunikasi apoteker pasien. Penggunaan Computer Physician Order Entry (CPOE), waktu tunggu antrian pengambilan obat, komunikasi apoteker, dan mutu pelayanan berpengaruh terhadap kepuasan pelanggan dengan arah positif.  Kesalahan pemberian obat tidak berpengaruh terhadap kepuasan pelanggan. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap mutu pelayanan di Instalasi Farmasi RS Margono Soekarjo Purwokerto, namun berpengaruh terhadap kepuasan pelanggan di Instalasi Farmasi S Margono Soekarjo Purwokerto.