Articles

Optimalisasi Pelayanan Nasabah Bank dengan Teori Antrian Saleh, Chairul
UNISIA No 19: Tahun XIII Triwulan 4 1993
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/unisia.v0i19.5342

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IDENTIFIKASI SENYAWA METABOLIT SEKUNDER EKSTRAK N-HEKSANA DAUN BERWARNA MERAH DARI SYZYGIUM MYRTIFOLIUM WALP. Novianti, Tri; Saleh, Chairul; Erwin, Erwin
JURNAL KIMIA MULAWARMAN Vol 17 No 1 (2019)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v17i1.432

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Pucuk Merah (Syzygium myrtifolium Walp.) is one of the plants belonging to the genus Syzygium family Myrtaceae. This study has been carried out to isolate and identify secondary metabolite from red leaf of Syzygium myrtifolium Walp. This research was conducted by extracting Syzygium myrtifolium Walp. leaf with Etanol followed by partition using n-Hexane, n-Hexane extact was separated by Coloum Chromatography with system isokratik. The separation of produce a compounds isolated as white powder. The result of GC-MS analysis was suggested 3 major compounds that 1-Octadecene; bis (2-ethylhexyl) hexanedioic; and bis (2-ethylhexyl) phthalate with a molecules weight in a row 252; 370 and 390.
ISOLATION OF STEROID COMPOUNDS IN THE N-HEKSANA FRACTION FROM JARUM TUJUH BILAH LEAVES EXTRACT (LEUENBERGERIA BLEO (KUNTH) D.C.) Yana, Yuli; Saleh, Chairul; Hindryawati, Noor
JURNAL KIMIA MULAWARMAN Vol 17 No 1 (2019)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v17i1.904

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This study aims to find secondary metabolites isolated from the leaves of the Jarum Tujuh Bilah (Leuenbergeria bleo (Kunth) D.C.). The method used was maceration, fractionation and column chromatography and was identified using Fourier Transformra Infra Red (FT-IR). The phytochemical preliminary test of the n-hexane fraction contains the steroid secondary metabolite compound. The results of column chromatography produced 75 vial bottles which were then identified by thin layer chromatography and produced 8 combined fractions (A-H fraction) based on the similarity of characterization, from the 8 fractions D and E forming yellow crystals. The yellow crystals formed are then cleaned and recrystallized to produce 11.7 mg white amorphous crystals. Compounds are characterized by FTIR spectrometers. Based on FTIR analysis, isolates showed IR spectrum ? max cm-1: 3375; 2927,98; 2852,18; 1680; 1462,51; 1376.81; 1329.74; 1043,92; 1022.02 and 956.27. Based on the results obtained by isolates, it is suspected that the compound is a steroid sterol.
Cellulose production from modified cassava skin 2-mercaptobenzotiazole for controlling cadmium (II) metal pollution Yusuf, Bohari; Alimuddin, Alimuddin; Saleh, Chairul; Rahayu, Desy Ridho
Jurnal Sains Dasar Vol 3, No 2 (2014): Jurnal Sains Dasar
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (965.166 KB) | DOI: 10.21831/jsd.v3i2.4143

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The research study of cadmium (II) metal ion adsorption in a solution by 2-mercaptobenzotiazole modified cellulose and unmodified cellulose had been done. The aims of this research are to know the ability of 2-mercaptobenzotiazole modified and unmodified celluloses for adsorbing cadmium (II) metal ion with the composition of modification. The modification processes of cellulose were done by the composition variation between cellulose and MBT of 1:1, 1:2, and 1:3. The adsorption process of metal ions by 2-mercaptobenzotiazole modified cellulose were done by shaking at pH 3, 4, 5, 6, 7, 8, and 9 with the effect of metal ions concentration of 0.05; 0.1; 0,15; 0,2, and 0,25 mg/L. The analysis of functional groups of cellulose-MBT and cellulose unmodified was using FTIR Spectrophotometer. The analysis of cadmium (II) concentration metal ions as cadmium metals were done by atomic absorption spectrophotometer (AAS). The result of this research showed that on the functional groups which derived from FTIR spectrum, there was some similarity of functional groups between unmodified cellulose and MBT-cellulose which could be seen from the wave length of C-S stretching at 663.51 cm-1; functional group of C-H aromatic stretching at 3749.62 cm-1; functional group of C-N at 1319.31 cm-1, and functional group of C=N that came from diazole  functional group (-N=C-S) which could be seen at 1597.06 cm-1. The optimum adsorption metal ions cadmium by MBT-cellulose happened at 1:2 composition modification, pH 4, and at the concentration of 0.2 mg/L.   Key words: adsorption, modified, cadmium (II) metal ion, cellulose, 2-merkaptobenzotiazole
TEST PHYTOCHEMICAL, TOXICITY AND ANTIBACTERIAL ACTIVITY FRACTION LEAF EXTRACT VARIOUS MAHANG (M acarang apruinosa (Miq.) Mull. Arg.) AGAINST Escherichia coli AND Staphylococcus aureus -, Mustafidah; Saleh, Chairul; -, Alimuddin
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2014
Publisher : PROSIDING SEMINAR KIMIA

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Phytochemical, to xicity and antibacterial act ivity tests of total extract, fractions of n-heksana, ethyl acetate and ethanol-water fro m mahang leaf (Macaranga pruinosa (M.) M. A.) fro m KRUS (Kebun Raya Unmul Samarinda), East Kalimantan has been carried out. Based on the secondary metabolites phytochemical test of the (Macaranga pruinosa (M.) M. A.) leaf show that total extract is contain alkaloid and steroid. n-hexane fraction is contain alkaloid and steroid. Ethyl acetate fract ion is contain steroid. Ethanol-water fract ion is contain alkaloid and phenolic. Brine shrimp lethality test values obtained Lethal Concentration 50 % (LC 50 ) total extract 27,5036 ppm , n-heksana fraction 12,0773 pp m, ethyl acetate fraction 23719,2305 ppm and ethanol-water fraction 250,0384 ppm. Antibacteria act ivity test of extracts for Staphylococcus aureus bacteria (positive Gram) and Escherichia coli (negative Gram) minimum inhibitor consentration of 0-1 % (b/v) fro m ext ract fractions of n-heksana and fractions ethyl acetate for Staphylococcus aureus bacteria and fractions ethyl acetate for Escherichia coli bacteria.
STUDI DOCKING MOLEKULAR SENYAWA KUERSETIN DAN HESPERITIN SEBAGAI INHIBITOR SEL KANKER DENGAN AUTODOCK VINA Muttaqin, Hevin; Saleh, Chairul; Gunawan, Rahmat
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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Kuersetin dan Hesperitin merupakan turunan dari senyawa Flavonoid yang berbeda kelas, Kuersetin kelas Alkohol, sedangkan Hesperetin kelas Alkanon. Docking Molekular, suatu ilmu penelitian secara in silico atau via perangkat lunak (program komputer) dan ditujukan untuk memprediksikan interaksi antara ligan (key) dengan reseptor (lock) dari ikatan hidrogen yang terbentuk. Autodock VINA adalah salah satu program Docking Molekular yang ada, diciptakan oleh Dr. Oleg Trott untuk meningkatkan efisiensi waktu pengerjaan dan akurasi dalam analisa. Dalam penelitian ini masing-masing dari senyawa Kuersetin dan Hesperitin akan di-Docking terhadap dua macam contoh reseptor, sel kanker otak (1S63) dengan ligan aslinya 778 dan sel kanker paru-paru (2ITO) dengan ligan aslinya IRESSA, terlebih dahulu dilakukan optimasi geometri, minimisasi energi juga validasi metode. Penelitian iniditujukan untuk menjelaskan perbandingan Kuersetin, Hesperitin dan ligan-ligan asli sebagai kandidat bahan obat anti kanker. Percobaan Docking, memberikan hasil Kuersetin dan Hesperitin membentuk ikatan hidrogen terhadap asam amino dari masing-masing reseptor. Hal ini menunjukkan bahwa Kuersetin dan Hesperitin memiliki kemampuan sebagai inhibitor, terutama pada sel kanker paru-paru (2ITO), karena potensi keduanya lebih baik dari ligan IRESSA. Walaupun Kuersetin dan Hesperitin tak memiliki potensi lebih baik dari ligan 778 pada sel kanker paru-paru, keduanya masih dapat digunakan sebagai bahan obat alternatif dari anti kanker.
UJI FITOKIMIA, TOKSISITAS DAN AKTIVITAS ANTIOKSIDAN ALAMI DAUN TUMBUHAN KELAKAI (Stenochlaena palustris) DENGAN METODE DPPH Tahir, Bonita; Saleh, Chairul; Pasaribu, Subur P
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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The phytochemical test, brine shrimp lethality test and activity antioxidant test and secondary metabolits of kelakai(Stenochlaena Palustris) leaves have been researched. The leaves samples are extract with solvent methanol by masseration method and that is concentrated by using rotary evaporator. The methanol crude extract obtained are fractioned with solvent n-hexane and. Solvent ethyl acetat.Based on secondary metabolits phytochemical test of kelakai leaves showed that methanol raw extract contains steroid, alkaloid and flavonooid. n-hexane fraction extract contains steroid and alkaloid Ethyl acetat fraction extract contains alkaloid, steroid, flavonoid and saponin.In brine shrimp lethality test, the increase larvae death and data was yielded recorded and processed using SAS Probit Analysis to determine the lethal concentration 50 % (LC 50 ) value. The results of this test obtained data and showed that the most active fraction is ethyl acetat fraction extract withvalue of LC 50 was equel to 88,8477 ppm.Based on the antioxidant activity conducted by scavenging activity of DPPH usedspectrophotometry. Based on the result be held researched was obtained that Inhibition Concentration 50% (IC 50 ) that methanol raw extract value of 185,92 ppm, n-hexane fraction value of 520,64 ppm and athyl acetat fraction 107,49 ppm and vitamin C is value of 3,064 ppm, can be axpressed that the result of this test showed that the most active fraction is ethyl acetat with value of IC 50 equel to 107,49 ppm.
UJI TOKSISITAS DAN PENENTUAN AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH DARI METABOLIT SEKUNDER FRAKSI n-HEKSAN, ETIL ASETAT DAN METANOL-AIR DAUN SISIK NAGA (Drymoglossum piloselloides [Linn.] Pr.) -, Erwin; Sari, Dwi Fitria; Saleh, Chairul
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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Phytochemical, toxicity test had been done that used Brine shrimp (Brine shrimp lethality test) and antioxidant activity test using methanol extract from sisik naga leaf (Drymoglossum piloselloides (Linn). Pr) fraction that taken from Kutai Kartanegara, East Kalimantan. Sisik naga leaf was extracted by methanol and then concentrated using rotary evaporator. Then that crude extract was fractioned by n-hexane, ethyl acetate and methanol-water. Based on phytochemical test of the sisik naga leaf show that crude methanol extract, n-hexane fraction and ethyl acetate fraction was contain alkaloid, flavonoid and steroid at methanol-water fraction was contain alkaloid and phenol. Brine shrimp lethality test show that lethality level of Artemia Salina (L) that used Probit SAS Analyze to determine value of Lethal Concentration 50% (LC 50 ). The test showed that the most active was crude n-Hexane extract with LC 50 value of 0,0910 ppm. Antioxidant activity test of extracts from crudge methanol and some variations fractioned using DPPH radical reduction (2,2 -diphenyl-1-picrylhydrazil) using Spectrophotometer. The test showed that the most active and recommended to used as antioxidant is methanol-water fraction with IC 50 values is at 74.51 ppm and LC 50 values is at 87749.9219 ppm.
PENURUNAN GARAM KLORIDA AIR LAUT DENGAN MEMANFAATKAN MODIFIKASI PATI DARI LIMBAH BONGGOL PISANG AMBON (Musa paradisiaca var sapientum) Rabbani, Aulia Husna; -, Alimuddin; Saleh, Chairul
JURNAL KIMIA MULAWARMAN Vol 13 No 1 (2015)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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The research of desalination the sea water by utilization of the strach bump a “Pisang Ambon (Musa paradisiaca var sapientum)” modification has been done. Modification of starch bump “Pisang Ambon (Musa paradisiaca var sapientum)” had be a ability better than starch bump “Pisang Ambon (Musa paradisiaca var sapientum)” in the levels of chloride. The variation upon which to do to absorb chloride of sea water which are starch, starch been activated NaOH and starch acetate bump of a “Pisang Ambon (Musa paradisiaca var sapientum)”. Where The characteristic of the third ingredients were done by analysis FT-IR that showed the spectrum in the wavenumber of each of which are read the force –OH,C-H streaching, C-H bending, CO ester in the spectrum of starch and starch been activated with NaOH and then are read the ester C=O in the wave number of 1751,36/cm and C-O ester and forth on the wave number of 1234,44/cm to the full spectrum of starch acetate. The rendemen a modification of the starch was also shown the modified starch in the bump a “Pisang Ambon (Musa paradisiaca var sapientum)” then more starch obtained. And which after passed a sample of starch bumb “Pisang Ambon (Musa paradisiaca var sapientum)” wet sea water left in levels chloride 20.160,77 mg/L, in the starch bump “Pisang Ambon (Musa paradisiaca var sapientum)” dry sea water left in levels of chloride 19.783,23 mg/L, in the starch bump “Pisang Ambon (Musa paradisiaca var sapientum)” have been activated with NaOH wet sea water left in the levels of chloride 19.405,68 mg/L, in the starch bump “Pisang Ambon (Musa paradisiaca var sapientum)” have been activated with NaOH dry sea water left in levels of chloride 19.028,14 mg/L and in the starch acetat bump “Pisang Ambon (Musa paradisiaca var sapientum)” sea water left in levels of chloride 18.461,83 mg/L.Keywords: the water of the sea, salt chloride, spectrum FTIR, starch and modification of starch bump a Pisang Ambon (Musa paradisiaca var sapientum)
AKTIVITAS ANTIHIPERGLIKEMIK DARI EKSTRAK ETANOL DAN n-HEKSANA DAUN KEMBANG BULAN [Tithonia diversifolia A.Gray] PADA TIKUS PUTIH JANTAN Darmawi, Ary Rizki; Saleh, Chairul; Kartika, Rudi
JURNAL KIMIA MULAWARMAN Vol 12 No 2 (2015)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Phytochemical test and antihyperglicemic activity from ethanol extract dan n-hexane extract from kembang bulan (Tithonia diversifolia A.Gray) leaf has been carried out. Based on the test result of phytochemistry of secondary metabolites compounds from kembang bulan (Tithonia diversifolia A.Gray) leaf showed that ethanol extract fraction containing flavonoid, fenolik, alkaloid and saponin. Whereas at n-hexane extract fraction containing alkaloid, saponin and steroid. Antihyperglicemic activity test using the method of glucose tolerance where a white male rats got induced by sucrose. Measurement of blood sugar levels using glucometer and glucose test strip. From this test shows that the most active fractions to reduce blood sugar levels was ethanol extract with a dose of 77 mg/kg BB with percentage of blood sugar levels reduction in the amount of 54.15 % it was close with reduction percentage from acarbose as positive control in the amount of 55.57 %.
Co-Authors -, Hamsiana Adi Prasodjo Agung Prasetyo Akbar, Fath Ali Akbar, Fath Ali Alimuddin - Alimuddin Alimuddin Alpina Nora Kaban, Alpina Nora Ana Arum Sari, Ana Arum Ardiansyah - Arifah, Churniati Nur Ariwan Joko Nusbantoro, Ariwan Joko Ary Rizki Darmawi, Ary Rizki Aulia Husna Rabbani, Aulia Husna Azhar Seli Apriani, Azhar Seli Bohari Yusuf Bonita Tahir, Bonita Daniel -, Daniel Daniel Daniel Daniel Tarigan Desy Ridho Rahayu Djihan Ryn Pratiwi, Djihan Ryn Dwi Fitria Sari, Dwi Fitria Eko Haryanto Elean, Samuel Erwin - Erwin E Erwin Erwin Eva Marliana, Eva Fadillah, Fahmi Farida Amir, Farida Fauziah, Nadiya Ayu Fiktor Boni Pasilala, Fiktor Boni Hammamiyah, Ulinnuha Hasan Sastra Negara Hevin Muttaqin, Hevin Husnul Chatimah, Husnul Istihana Istihana, Istihana Jaya, Edi Novian Jaya, Edi Novian Juwita, Retno Karisnawati, Deni Karlina, Dessy KHOIRUN NISAK Kusumaningrum, Indah Yulia Lidiawati, Tri Eva Liniawati, Septi Roro M.Riza Agus Pramana, M.Riza Agus Markus Apriono, Markus Mawaddah, Izkia Medi Hendra, Medi Mira Wahyuni, Mira Mujahidin, Muhamad Mustafidah -, Mustafidah Nadhirah -, Nadhirah Noor Hindryawati, Noor Nur Aini Haryati, Nur Aini Nuranda, Apri P., Ade Trisna Panannangan, Josua K. Panannangan, Josua K. Pangaribuan, Fransiscus X. Rico Pasaribu, Yohana Pebrina Pratiwi, Ricka Indria Precelia, Sari Clara Priambodo, Widyanto Saptawan RAHMAT GUNAWAN Ravensca, Irene Rindawati, Novi Rochman, Mayasari Azhari Rohmat Hidayat Rudi Kartika, Rudi Saibun Sitorus, Saibun Sinukaban, Karolina Sitompul, Citra Uli Sitompul, Citra Uli Solechan Solechan Soma, Yolanda V. A Subagyono, RR Dirgarini Julia Nurlianti Subur P Pasaribu Sumarni, Feni Sunardi Sunardi Syafriyanti, Yuly Tasik Sinta, Tasik Tri Novianti, Tri Tria Annisa Rizky, Tria Annisa Ulfa Mutia, Ulfa Wajdie, Farid Winni Astuti, Winni Yana, Yuli