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Journal : Majalah Kedokteran Bandung

EKSTRAK AIR DAUN PADI MEMPERBAIKI HEMATOPOESIS PADA TIKUS YANG TERPAJAN PLUMBUM Santosa, Budi; Sunoko, Henna Ria; Sukeksi, Andri
Majalah Kedokteran Bandung Vol 47, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Plumbum (Pb) asetat menyebabkan gangguan hematopoesis melalui hambatan biosintesis heme dan defisiensi enzim G-6PD yang menimbulkan penurunan hemoglobin dan jumlah eritrosit, serta peningkatan sel retikulosit. Ekstrak daun padi mengandung protein metallothionein yang mengikat Pb. Tujuan penelitian adalah membuktikan ekstrak daun padi memperbaiki gangguan hematopoesis pada tikus terpajan Pb. Metode penelitian adalah randomized post test only control-group design, 28 tikus dibagi ke dalam 4 kelompok yaitu 1 kelompok kontrol dan 3 kelompok perlakuan. Kelompok kontrol dan perlakuan dipajan Pb 0,5 g/kgBB/hari dan kelompok perlakuan diberi ekstrak daun padi 0,2; 0,4; 0,8 setiap hari melalui sonde sampai minggu ke-8. Hari terakhir  minggu ke-8 diperiksa jumlah kadar Hb menggunakan cyanmethemoglobin dan jumlah eritrosit diukur menggunakan haematology analyzer, serta retikulosit menggunakan pengecatan BCB. Tempat penelitian dilaksanakan di LPPT UGM dan laboratorium biomedik UNIMUS Semarang, Maret?Mei 2014. Perbedaan antarkelompok untuk kadar Hb dan jumlah eritrosit dilakukan uji one way enzyme linked immunosorbent assays (ANOVA) dan Kruskal-Wallis untuk jumlah retikulosit. Hasil penelitian menunjukkan kadar Hb rata-rata mengalami kenaikan tidak bermakna (p=0.81), jumlah eritrosit rata-rata tidak ada perbedaan antara kelompok kontrol dan perlakuan (p=0,83), jumlah retikulosit rata-rata menurun bermakna dari kelompok kontrol sampai perlakuan (p=0,00). Simpulan, ekstrak daun padi mampu memperbaiki hematopoesis pada tikus terpajan Pb. [MKB. 2015;47(2):84?90]Kata kunci: Ekstrak daun padi, hematopoesis, pajanan Pb, tikusRice Leaf Water Extract Improves Hematopoiesis in Lead-Exposed Rats  Abstract Plumbum ( Pb ) acetate leads to hematopoiesis disruption by inhibiting heme biosynthesis and creating G-6PD enzyme deficiency, leading to decreased hemoglobin concentration and red cell count as well as  increased reticulocyte cells. Rice leaf extract contains metallothionein proteins that bind Pb. This study aimed to prove the ability of rice leaf extract wa to improve hematopoiesis disorder conditions in rats exposed to Pb. The method used was the randomized post-test only control group design. Twenty eight rats were divided into 4 groups: 1 control group and 3 treatment groups . In the control group and the treatments groups, the experimental rats were treated with 0.5 g/kg/day Pb. The treatment groups were treated by 0.2, 0.4, and 0.8 rice leaf extract, respectively, every day for 8 weeks. On the last day of the 8th week, blood samples were collected for Hb concentration measurements using cyanmethemoglobin and the erythrocytes and reticulocytes number were counted using a hematology analyzer and BCB, respectively. This study was conducted in LPPT UGM and Biomedicine UNIMUS in March?May 2014. The differences between groups in hemoglobin and erythrocyte parameters were tasted  using one way ANOVA while  Kruskal-Wallis test was used for the reticulocyte count. The results show that rice leaf extract treatment to rats exposed to Pb did not affect Hb (p=0.81) and erythrocytes count  (p=0.83), However, the mean reticulocyte count decreased significantly in Pb-exposed rats treated with rice leaf extract (p=0.00). In conclusion, rice leaf extract is able to improve hematopoiesis in rats exposed to Pb. [MKB. 2015;47(2):84?90]Key words: Hematopoiesis, Pb, rice leaf extract, rat DOI: 10.15395/mkb.v47n2.458
Co-Authors Abdurrahman, Ahmad Fauzan Abdurrahman, Ahmad Fauzan Abiyoga, Gerald Arsa Adhiyaksa Ade Lia D. Safitri Adrianus Yosep Ago, Adrianus Yosep Agus Sasmito Aribowo Agustin Rahmawati Ahmad Juni Haryanto, Fandi Ahmad Warsun Ali Ridho Barakbah Ana Hida, Yeni Danga Andri S, Andri Andri Sukeksi Anin, Vitry Agrida Anindita, Cipta Ayu Anissa Wulandari, Anissa Antariksa Antariksa Ari Yanuar Ridwan, Ari Yanuar Ari Yanuar, Ari Arief Kurniawan Bambang Utoyo Boli Samun, Thomas Aquino Boyke Frahmana, Boyke Budi Sulistyo Budianto, Anwar Budiyono Budiyono Buru, Romika Jibrael Choirida, Saskia Dyah Dalin, Yulianus Dani Satyawan Das Neves, Lucia Ximenes De Jesus, Julio Rodrigues Debby Rahmawati Deniswara, Cindy Dessyanto Boedi P Dessyanto Boedi Prasetyo Destaria Madya Verawaty, Destaria Madya Deswalantri, Deswalantri Dida Diah Damayanti Didi Setya, Didi Didik Sumanto Dinda Sekar Putri, Dinda Sekar Djoko Legono Dwi Aries Himawanto Dwi Sulistyoningsih Dwiska Aini Nurrahma, Dwiska Aini Dyah, Saskia Eka Fitasari Eka Puji Hastuti, Eka Puji Ekawati, Fitri Eko Prasetyo Nugroho Endang Purwaningsih Erik Kurniawan, Erik Ethica, Stalls Norma Fajar Kurnia Fani Yayuk Supomo Fatwa Tentama Fauzia Hulopi Frumen, Maksimus Gesi, Rofinus Gita Purnama Sari, Gita Purnama Gunarto Gunarto Hairurraziqin Hairurraziqin, Hairurraziqin Hananta, Yan’s Dianaga Hani Purnamasari, Hani Hariyadi Hariyadi Hariyana, Bambang Helmi Helmi Hengky Novarianto Henna Ria Sunoko, Henna Ria Henna Rya Sunoko Henna Rya Sunoko Herry Sofyan Hertanto Wahyu Subagio Hertanto Wahyu Subagyo Heru Cahya Rustamaji Hidayat, Wahyu Sunan Horna, Horna Hosang, Meldy Husada, Hendrianto I Ketut Eddy P, I Ketut I Ketut Eddy P. I Made Tasma Ial Irwan Arahman, Ial Irwan Indra Perwira, Rifki Irfan Suliansyah Ismail Maskromo Ismawati Ismawati Janggakadu, Arnold Hina Jerrystama Abipradja, Jerrystama Juwairiah Juwairiah Juwita Ratna Dewi Kale, Barnese Nelce Kamin, Yusri bin Karuniawati, Fenty Kgs Ahmadi Khoiriyatuinnisa, Khoiriyatunnisa Kisdjamiatun RMD Kumala, Sella Candra Indah Laba, Ferdinandus Laga Bahi, Titus Kobo Lanang, Fransiskus Limahekin, Donatus Aribeda Lisa Dwi Wulandari Lisyani S Lisyani Suratmo, Lisyani Maharani, Dias Mandasari, Fika Mangaras Yanu Florestiyanto, Mangaras Yanu Markus Priharjanto, Markus Martin Simanjuntak Martins, Arcanjo Mawardi, Sukmawati Maya Putri Arumsari, Maya Putri Mema Ma?u, Damianus Merkurius Memet, Antonius Mona Nabilah, Mona Muhamad Yunus Muhammad Riski, Muhammad Muljawan, Rikawanto Eko Nanda, Angelica Mega Ni Putu Aniek Mahayani, Ni Putu Aniek Niken Puruhita Ningsih, Teti Kusuma Njurumana, Yermias Yiwa Noverita Rochsitasari, Noverita Nugroho, Febri Satrio Nuruddin Nuruddin Nurul Qomariyah Ola, Ramdan Oliver Samuel Simanjuntak Panjang, Meha Tara Pereira, Gregorio Perwira, Rifki Petronius, Zakarias Magnus Pramono Sasongko Prasetyo, Muhammad Bagus Prasetyo, Nanda Isdian Prastiyanto, Muhammad Evy Primasari, Maria Purnadi, Purnadi Purnawan Purnawan Purnomo, Hendy Putra, Gregorius Guruh Handaya Putra, Ludfie Hardian Qosim, Muchamad Nur Ragil Saptaningtyas, Ragil Rahmat Adeputra, Rahmat Rahmawati, Atina Rahmawati, Atina Ranny Wahyu Ningrat Ratna Wulan Sari Ratomesang, Richardo Pelipus Boru Rejeki, VG. Sri Riangsari, M.F. Devita Rifki Indra Perwira Rifky Satya Wicaksono, Rifky Satya Rini Megawati Rio Aurachman, Rio Rizalditya, Putra Bintang Rozana Rozana, Rozana Rr. M.I. Retno Susilorini Rudi Theo Satrio, Rudi Theo Rusdiana, Endang Saja, Bernardus Bode Santosa, Joko Budi Sartini, Iis Sihombing, Ezra Siti Aisah Slamet Riyadi Soares, Rosalino De jesus Sofi Fauziah, Sofi Sofyan Cholid, Sofyan Solkhanuddin, Solkhan Sri Darmawati Sri Subanti Sugiyono Sugiyono Suhartono Suhartono SUHARYANTO SUHARYANTO Suliana, Gatut Suliana, Gatut Sumiyarti Sumiyarti, Sumiyarti Supriyadi Supriyadi Susilorini, Rr. M. I. Retno Susilorini, Rr.M.I Rretno Susilorini, Rr.M.I. Retno Tahta Alfina Tantalu , Lorine Tantalu, Lorine Tantalu, Lorine Tatty Ermin Taus, Dominika Sone Tiananda Widyarini Timba, Margaretha Kahi Titi Murniati Tri Kuat, Tri Tulalo, Meity Aneke Tulalo, Meity Aneke Umar Affandi Untung Sugiarti Veronika Veronika Waenah . . Wahon, David Dolu Aman Wahyu Ari Widiyastuti, Wahyu Ari Wardhana, Punto Aji Wijiati, Irma Wilis Kaswidjanti Wirawan Wirawan Wona, Yosevina Ximenes Guterres, Anapula Do Rosario Yan Indra Putra, Yan Indra Yanuar, Masnia Mahardi Yosua Yosua Yoyon K. Suprapto Yoyon K. Suprapto Yuhefizar Yuhefizar Yurinda Amalia, Yurinda Zela Ubaidillah