Rianto Setiabudy
Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta

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Comparison of the efficacy and safety of isepamicin plus metronidazole and amikacin plus metronidazole in intra-abdominal infections Philippi, Bernardus; Lalisang, Toar J.M.; Th-Akib, Husniah; Setiabudy, Rianto; Hudiono, Johannes; Darmansjah, Iwan
Medical Journal of Indonesia Vol 10, No 2 (2001): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.04 KB) | DOI: 10.13181/mji.v10i2.11

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Intra-abdominal infections due to penetrating wound through the abdominal wall or rupture of the gastrointestinal tract are acute conditions requiring prompt surgical intervention and the use of appropriate antimicrobial agents. Isepamicin is an effective aminoglycoside against various Gram-negative pathogens causing intra-abdominal infections. The objective of the present study is to compare the efficacy and safety of isepamicin (15 mg/kgBW IV o.d.) with amikacin (7.5 mg/kgBB b.i.d.), in conjunction with metronidazole for both drugs. An open, randomized, parallel design was applied in this trial. The subject allocation ratio for isepamicin: amikacin is 2:1. Out of 50 patients enrolled in this study, 27 fuffilled the criteria for safety and efficacy population, and 46 for intent-to-treat population. In the safety and efficacy population, the clinical success rare for isepamicin and amikacin group did not differ significantly (i.e., 95% and 100%, respectively). In the intent-to-treat population, the clinical success rates for isepamicin and amikacin group were also insignifficantly different (i.e., 97% and 100%, respectively). The rates of bacteriological elimination for isepamicin and amikacin, were 95% and 100%, respectively in the efficacy and safety population, and 90% and 93%, respectively in the intent-to-treat population. Streptococci and staphylococci were the most frequent (40%) pathogens isolated from pus, and Acinetobacter anitratus (55%) was the most common one isolated from blood. In the efficacy and safety population, the mean (± SD) length of hospital stay in the isepamicin and amikacin groups was 10.7 ± 3.9 and 11.1 ± 3.8 days, respectively, while in the intent-to-treat population, the mean (± SD) length of hospital stay in the isepamicin and amikacin groups was 10.1 ± 3.4 and 10.5 ± 3 days, respectively. In the present study, both aminoglycosides were well tolerated and there was no patient withdrawal associated with side effect. It is concluded that for intra-abdominal infections, intravenous isepamicin given once daily is as effective as intravenous amikacin given twice daily in combination with metronidazole. (Med J Indones 2001; 10: 88-94)Keywords : Isepamicin, amikacin, inta-abdominal infections
Effect of a combination of Phaseolus vulgaris L. extract and acarbose on postprandial glucose level after cooked rice intake in healthy volunteers Zulkarnain, Robby; Setiawati, Arini; Setiabudy, Rianto
Medical Journal of Indonesia Vol 18, No 1 (2009): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.441 KB) | DOI: 10.13181/mji.v18i1.335

Abstract

Aim This study was aimed to measure the effects of combination Phaseolus vulgaris extract and acarbose compared to acarbose alone on postprandial glucose concentration in healthy volunteers after cooked rice intake.Methods Blood sample were obtained at several time points up to three hours after cooked rice intake. The parameter for postprandial glucose concentration is the area under the curve (AUC) of glucose concentration vs.time for three hours after cooked rice intake.Results After taking this combination, postprandial glucose concentration was reduced by 21.6%, while the reduction by acarbose alone was 22.9%.Conclusions The reduction of postprandial glucose concentration after administration of this combination was not significantly different compared to that after administration of acarbose alone. (Med J Indones 2009; 18: 25-30)Keywords: Phaseolus vulgaris extract, acarbose, postprandial glucose concentration
Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials Louisa, Melva; Takeuchi, Madoka; Takeuchi, Masahiro; Nafrialdi, Nafrialdi; Setiabudy, Rianto
Medical Journal of Indonesia Vol 19, No 3 (2010): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.487 KB) | DOI: 10.13181/mji.v19i3.406

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Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population.Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the efficacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used.Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profile.Conclusion The efficacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (Med J Indones 2010; 19: 205-12)Key words: exenatide, incretin, liraglutide, sitagliptin, type-2 diabetes, vildagliptin
Rational Use of Drugs and Traditional Herbal Medicine Setiabudy, Rianto
Medical Journal of Indonesia Vol 19, No 1 (2010): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.91 KB) | DOI: 10.13181/mji.v19i1.554

Abstract

[No Abstract Available]
CYP2A6 gene polymorphisms impact to nicotine metabolism Muliaty, Dewi; Yusuf, Irawan; Setiabudy, Rianto; Wanandi, Septelia I.
Medical Journal of Indonesia Vol 19, No 1 (2010): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1042.323 KB) | DOI: 10.13181/mji.v19i1.377

Abstract

Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensive nicotine metabolism. In the CYP2A6 gene, several polymorphic alleles have been reported such as CYP2A6*4, CYP2A6*7, CYP2A6*9, and CYP2A6*10 which are related to decreasing nicotine metabolism activity. The variation of nicotine metabolism activity could alter nicotine plasma levels. Smokers need a certain level of nicotine in their brain and must smoke regularly because of nicotine’s short half-life; this increases the number of smoked cigarettes in extensive metabolizers. Meanwhile, in slow metabolizers, nicotine plasma level may increase and results in nicotine toxicity. This will eventually lower the risk of dependence. (Med J Indones 2010; 19:46-51)Keywords: cotinine, hepatic cytochrome P450 2A6, smoking behavior
A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital Soetikno, Vivian; Effendi, Imam; Nafrialdi, Nafrialdi; Setiabudy, Rianto
Medical Journal of Indonesia Vol 18, No 2 (2009): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.008 KB) | DOI: 10.13181/mji.v18i2.348

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Aim Dose adjusment and drug selection is important in patient with renal dysfuction.This study was aimed to assess the accuracy of dose adjustment and drug selection for renal dysfunction patient at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital, Jakarta.Methods Patients ≥ 18 years old with estimated creatinine clearance < 60 mL/minute based on Cockroft-Gault formula were included in this study. The drugs assessed were those excreted by the kidney or having nephrotoxic effect. The appropriateness of drug selection is assessed based on the preserce or not contraindication or potential of drug-drug interaction. The accuracy of dose adjustment were assessed based on information available in various textbooks, literatures, and drug brochures. Data were collected between May to July 2007.Results Data obtained from 43 patients met the inclusion criterias demonstrated that 164 out of 385 drug prescriptions were mainly eliminated by the kidney or have nephrotoxic characteristic. Out of 164 drug prescriptions, 142 (86.5%) were appropriately adjusted, while the other 22 (13.5%) were inappropriately adjusted for the dose. There was only one contraindication for the usage of the drug and 15.1% potentially drug interaction.Conclusion Dose adjustment and drug selections in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital are conducted appropriately. (Med J Indones 2009; 18: 108-13)Key words: renal dysfunction, drug interaction, contraindication, dose adjusment
Primaquine decreased plasma concentration of ritonavir: single- and repeated-dose study in Sprague Dawley rats Louisa, Melva; Soetikno, Vivian; Nafrialdi, Nafrialdi; Setiabudy, Rianto; Suyatna, Frans D.
Medical Journal of Indonesia Vol 20, No 3 (2011): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.476 KB) | DOI: 10.13181/mji.v20i3.449

Abstract

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats.Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonavir 20 mg/kg BW + ketokonazole 10 mg/kg BW. Ketokonazole was used as positive control of ritonavir metabolism inhibitor. In the repeated-dose study, thirty Spraque Dawley male rats were randomly allocated to receive ritonavir 20 mg/kg BW/day or ritonavir 20 mg/kg BW/day + primaquine 1.2 mg/kg BW/day or ritonavir 20 mg/kg BW/day + rifampicin 100 mg/kg BW/day. Rifampicin was used as a positive control of ritonavir metabolism inducer.Results: In the single-dose study, ketokonazole increased the area under the plasma concentration (AUC) of ritonavir (↑114.8%, p< 0.05), while primaquine tended to decrease the AUC of ritonavir (↓ 32.6%, p> 0.05). Repeated-dose study showed that rifampicin decreases the AUC of ritonavir (↓ 42.8%, p< 0.001), and primaquine decreased the AUC of ritonavir plasma concentration (↓ 46.6%, p< 0.001).Conclusion: Concomitant administration of primaquine and ritonavir decreases the AUC of ritonavir. This effect may result in the insufficient concentration of ritonavir as anti-HIV, which may lead to treatment failure with ritonavir. (Med J Indones 2011; 20:190-4)Keywords: drug interaction, metabolism, primaquine, ritonavir
The safety and efficacy of feracrylum as compared to silver sulfadiazine in the management of deep partial thickness burn: A clinical study report Moenadjat, Yefta; Setiabudy, Rianto; Astrawinata, Dalima A.W.; Gumay, Saukani
Medical Journal of Indonesia Vol 17, No 4 (2008): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5963.531 KB) | DOI: 10.13181/mji.v17i4.329

Abstract

Instead of haemostatic effect, feracrylum provides antibacterial activity; wound improvement has been clinically proven. Feracrylum is a water soluble mixture of incomplete ferrous salt of polyacrylic acid containing 0.05 to 0.5% of iron in physiologic solution (0.85% solution of sodium chloride). A clinical study on safety and efficacy of feracrylum compared to silver sulfadiazine (SSD) was conducted in burn management, since with the widely use of SSD, the sulfadiazine’s disadvantages lead to wound healing impairment. In this open, randomized, controlled study, feracrylum and SSD were topically applied, each on different side of the burnt areas in parts of body for a treatment period of eleven days. Of eight enrolled patients, seven patients completed the study; one patient withdrew due to acute burn complication. On day 7th and 11th, the re-epithelialization in group receiving feracrylum increased as the raw surface area reduced. Mean percentages of epithelialization on both evaluation days in Feracrylum group were 70.53±24.298 and 81.71±28.922, respectively, which were higher than SSD group (66.15±25.080 and 64.64±74.684 respectively). Feracrylum was found to be safe and well tolerated. This study showed a clinical difference although it was not significant statistically. (Med J Indones 2008; 17: 259-71)Keywords: Feracrylum, silver sulfadiazine, wound management
TMEPAI genome editing in triple negative breast cancer cells Wardhani, Bantari W.K.; Puteri, Meidi U.; Watanabe, Yukihide; Louisa, Melva; Setiabudy, Rianto; Kato, Mitsuyasu
Medical Journal of Indonesia Vol 26, No 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (607.158 KB) | DOI: 10.13181/mji.v26i1.1871

Abstract

Background: Clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) is a powerful genome editing technique. It consists of RNA-guided DNA endonuclease Cas9 and single guide RNA (gRNA). By combining their expressions, high efficiency cleavage of the target gene can be achieved, leading to the formation of DNA double-strand break (DSB) at the genomic locus of interest which will be repaired via NHEJ (non-homologous end joining) or HDR (homology-directed repair) and mediate DNA alteration. We aimed to apply the CRISPR/Cas9 technique to knock-out the transmembrane prostate androgen-induced protein (TMEPAI) gene in the triple negative breast cancer cell line.Methods: Designed gRNA which targets the TMEPAI gene was synthesized, annealed, and cloned into gRNA expression vector. It was co-transfected into the TNBC cell line using polyethylenimine (PEI) together with Cas9-GFP and puromycin resistant gene vector. At 24-hours post-transfection, cells were selected by puromycin for 3 days before they were cloned. Selected knock-out clones were subsequently checked on their protein levels by western blotting.Results: CRISPR/Cas9, a genome engineering technique successfully knocked-out TMEPAI in the Hs578T TNBC cell line. Sequencing shows a frameshift mutation in TMEPAI. Western blot shows the absence of TMEPAI band on Hs578T KO cells.Conclusion: TMEPAI gene was deleted in the TNBC cell line using the genomic editing technique CRISPR/Cas9. The deletion was confirmed by genome and protein analysis.
Oxygen Hyperbaric Therapy in Patients with Radiation Proctitis Sidik, Suyanto; H, Daldiyono; Setiabudy, Rianto; Gondowiardjo, Soehartati; Yuwono, Vera
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 1, April 2007
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Background: Cervical cancer is the most common female malignancy in developing countries, including Indonesia. It usually occurs at the age of 20 years, reaches the peak incidence at the age of 35-55 years, and afterwards, the incidence declines. Radiotherapy is the most important treatment method in cervical cancer, especially for local advanced stage or stage IIb-IVa. It is also effective for the early stage. Oxygen hyperbaric therapy (OHBT) is defined as 100% oxygen (O2) administration of 2-3 ATA (Absolute Atmospheres) pressures in a high-pressure room. OHBT accelerates wound healing by improving oxygen perfusion around the wound and by increasing angiogenesis through Nitric Oxide Synthetase (NOS). Methods: The study was conducted at Cipto Mangunkusumo hospital, while OHBT was provided at Dr. Mintoharjo Navy Hospital. Block randomization was performed, Resulting 32 patients in OHBT group and 33 patients in control group; both groups were at normal distribution. The prevalence of radiation proctitis in OHBT and control group was determined using chi-square test. Results: By comparing the prevalence of radiation proctitis between OHBT and the control group, show that OHBT could decrease proctitis prevalence by p = 0.03. Conclusions: This study indicates that OHBT may reduce the prevalence of radiation proctitis. The OHBT is save and secure to the patients.   Keywords: OHBT, cervical cancer, radiotherapy, radiation proctitis
Co-Authors Adi Hidayat Adi K Aman, Adi K Akmal Taher Ali Baziad Ali Sulaiman Arini Setiawati Aru W Sudoyo Bambang Sutrisna Bernardus Philippi Beti E. E Dewi, Beti E. E Cosphiadi Irawan, Cosphiadi Daldiyono H Dalima A.W. Astrawinata Dewi Muliaty Djajadiman Gatot Djumhana Atmakusuma, Djumhana Elly Herwana, Elly Frans D. Suyatna Hafilah, Siti Harapan Parlindungan Ringoringo, Harapan Parlindungan Harry Isbagyo, Harry Haryana, Sofia M Husniah Th-Akib I Dewa G. Ugrasena, I Dewa G. Imam Effendi INDRAYANI, LENNY Inge A. Kristanti Irawan Yusuf IRAWAN, COSPHIADY Iskandar Wahidiyat, Iskandar Iwan Darmansjah Johannes Hudiono Jusman, Sri W Kanadi Sumapradja Kartini, Diani Kato, Mitsuyasu Laurentius A. Lesmana Lestari Rahayu Madoka Takeuchi Masahiro Takeuchi Melva Louisa Muchtaruddin Mansyur Murdani Abdullah Murti Andriastuti, Murti Nafrialdi Nafrialdi Novi Yantih Nurul Akbar Nuzirwan Acang, Nuzirwan Panjaitan, Mercy T. Primariadewi Rustamadji Puteri, Meidi U. Rahajuningsih Dharma Rahayuningsih Setiabudy, Rahayuningsih Rejeki, Marliana Sri Riadi Wirawan Rikarni Rikarni, Rikarni Robby Zulkarnain Rulina Suradi, Rulina Sapatawati Bardososono, Sapatawati Saptawati Bardososono, Saptawati Saukani Gumay Septelia I. Wanandi Sidartawan Soegondo Sjaifoellah Noer Soehartati Gondowiardjo Sonar S. Panigoro Suyanto Sidik Tambunan L Tambunan, Tambunan L Toar J.M. Lalisang Unggul Budihusodo Vera Yuwono Vivian Soetikno Wahono Sumaryono Wardhani, Bantari W.K. Watanabe, Yukihide Wawaimuli Arozal Yahdiana Harahap Yefta Moenadjat Zita Arieselia