Siti Setiati
Divisi Geriatri Departemen Ilmu Penyakit Dalam FKUI/RSCM

Published : 43 Documents
Articles

The prevalence of orthostatic hypotension and its risk factors among 40 years and above adult population in Indonesia Setiati, Siti; Sutrisna, Bambang; Prodjosudjadi, Wiguno
Medical Journal of Indonesia Vol 13, No 3 (2004): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.511 KB) | DOI: 10.13181/mji.v13i3.150

Abstract

Factors associated with orthostatic hypotension such as age, drug induced hypotension, hypertension and diabetes mellitus have still been debatable. Most of previous studies were conducted in subjects 65 years or older, only a few were done in subjects from younger to older adults. The purpose of this study is to find the prevalence and predictor factors of orthostatic hypotension among adult population aged 40 years and above in Indonesia. This study is a part of Indonesian Hypertension Epidemiologic Survey. A random sample of 4436 subjects aged 40–94 years was obtained from various municipalities in every big island in Indonesia. Orthostatic testing, assesment of history of medical conditions (diabetes mellitus, stroke, and hypertension), blood pressure measurement and use of anti-hypertensive medications were performed. A stepwise logistic regression was used to determine the significant predictor of orthostatic hypotension. A total of 561 persons (12.6%) experienced orthostatic hypotension. Central α2-agonist and other centrally acting drug is the only anti hypertension medicine which influences orthostatic hypotension. Multivariate analysis showed that high systolic and diastolic blood pressures were predictor factors of orthostatic hypotension. The use of anti-hypertensive medicine was a protective factor for orthostatic hypotension. This study confirms the conclusion that age is not a predictor factor for orthostatic hypotension. In fact, the existence of comorbidities in the subjects such as hypertension (high systolic and diastolic blood pressure) is a predictor factor, while the use of anti-hypertensive medication is a protective factor. (Med J Indones 2004; 13: 180-9) Keywords: adult, orthostatic hypotension, prevalence, risk factor
The effect of Ramadhan fasting on kidney function among elderly patients Setiati, Siti; Haricahyo, Suksmono; Rahardjo, Pudji; Hakim, Lukman; Supartondo, Supartondo; Rahardjo, Tri B.W.
Medical Journal of Indonesia Vol 9, No 1 (2000): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (594.385 KB) | DOI: 10.13181/mji.v9i1.649

Abstract

[no abstract available]
The Effect of Branched Chain Amino Acids and L-Ornithine L-Aspartate Combination as The Late Evening Snacks on Nutritional Status and Minimal Hepatic Encephalopathy in Liver Cirrhosis Tenda, Eric Daniel; Hasan, Irsan; Sanityoso, Andri; Setiati, Siti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground:Minimal hepatic encephalopathy (MHE) in liver cirrhotic patients is critical manifestation of low grade hepatic encephalopaty (HE), is caused quality of life decrease and risk of deteriorating into distinct HE. The study was conducted to asses the effect of combination of branched-chain amino acids (BCAA) and L-ornithine L-aspartate (LOLA), which was given late evening, on nutritional status and degree of HE.Method: This single-blind randomized study was conducted on liver cirrhotic outpatients in hepatology clinic of Cipto Mangunkusumo Hospital period June 2011-June 2012. The study subjects were divided into two groups, group of late evening snack (LS) and day snack (DS). Each group was supplemented with combination of milk of BCAAs and LOLA (3.7 g/serving). Evaluation based on history, physical examination, laboratory tests and critical flicker frequency (CFF) was performed one month after the intervention. Data were statistically analyzed with SPSS 15.Results: Thirty-two patients whose the inclusion criteria were divided into 16 subjects for each group, LS and DS. After one month of the intervention, the average level of prealbumin for DS group was increased statistically significant (p < 0.001), but not significant for LS group (p = 0.259). The increase of average body weight,mid-arm muscle circumference (MAMC) and CFF test result in both groups. There was no improvement on subject global assessment (SGA) score after one month intervention in both groups.Conclusion: This study proved that giving combination of BCAAs and LOLA may improve the condition of MHE, however for nutritional status can not be assessed. Keywords: minimal hepatic encephalopathy, BCAAs, LOLA, prealbumin, SGA score, nutritional status
Total Lymphocyte Count as a Nutritional Parameter in Hospitalized Patients Gunarsa, Ralph Girson; Simadibrata, Marcellus; Syam, Ari Fahrial; Timan, Ina Susianti; Setiati, Siti; Rani, Abdul Aziz
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Background: Nowadays, there are still many malnourished patients during hospitalization, which comprises around 45-50% patients. Malnutrition is related to increased mortality and morbidity rate; therefore, nutritional state should be assessed in hospitalized patients. Total lymphocyte count (TLC) is related to decreased body function in malnutrition and it is a means of nutritional assessment. Until now, there is no data showing association between malnutrition and TLC in hospitalized patients in Indonesia. The objective of this study was to identify the association between malnutrition and TLC < 1,200 cell/mm3 in hospitalized patients. Method: This study was a cross-sectional study. Subjects were new patients hospitalized at internal medicine ward of Cipto Mangunkusumo Hospital. Patients were collected by consecutive sampling. We conducted the study between April and May 2008. Fifty four patients were assessed for malnutrition by the subjective global assessment (SGA) and they also had undergone complete blood count. TLC was numbered with routine complete blood count test. Patients were classified into malnutrition according to SGA. TLC was classified with cut-off point of 1,200 cell/mm3. Statistical analysis included Chi-square test, which was used to compare proportion. Results: There were 52% malnourished patients, 33% patients with TLC < 1,200 cell/mm3, 57% patients with malnutrition and TLC < 1,200 cell/mm3. This study showed that there was an association between malnutrition and TLC < 1,200 cell/mm3 (p = 0.001). Moreover, there was also significant association between severe malnutrition (SGA C) with TLC < 900 cell/mm3 (p = 0.02). Conclusion: There is an association between malnutrition and TLC < 1,200 cell/mm3.   Keywords: malnutrition, total lymphocyte count, body mass index, subjective global assessment
Proportion and Factors Associated with Zinc Deficiency in Acute Diarrhea Patients Oto, Budi Tan; Simadibrata, Marcellus; Dillon, Drupadi Harnopidjati Singh; Setiati, Siti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Background: Zinc may affect the intestinal immune response. No data has been available on zinc deficiency in adult patients with diarrhea, especially for Indonesian population. Zinc metabolism, etiologies, pathogenesis and clinical course of diarrhea may have various effects on zinc concentration in different population. This study aimed to determine the proportion of zinc deficiency in patients with acute diarrhea, including its associated factors. Method: A cross-sectional study was conducted in patients with acute diarrhea at outpatient clinics and emergency wards of four hospitals between August 2010 and March 2011. A serum zinc concentration of < 10.7 µmol/L was set as cut-off value for zinc deficiency. Data was analyzed by using Chi-square test. Results: There were 101 subjects, 54.5% were female, the median age was 26 years, median duration of acute diarrhea was 5 days, and the median frequency was 6 times/day. About 95% patients had nutritional status of subjective global assessment (SGA) A and the mean value of body mass index was 19.3 ± 0.70 kg/m2. Approximately 88.1% patients had severe infective diarrhea based on hydration status. About 69.3% patients were zinc deficient with the mean serum zinc concentration of 9.26 ± 2.95 µ mol/L. We found a significant correlation between the severity of diarrhea and zinc deficiency in patients with acute diarrhea. Conclusion: The proportion of zinc deficiency in acute diarrhea patients was quite large although the mean serum zinc level was still below the National Health and Nutrition Examination Survey (NHANES) reference value. The severity of diarrhea has been proven to be significant that affects zinc deficiency in acute diarrhea patients. Keywords: zinc deficiency, acute diarrhea, adult
Pengaruh Pajanan Sinar Ultraviolet B Bersumber dari Sinar Matahari terhadap Konsentrasi Vitamin D (25(OH)D) dan Hormon Paratiroit pada Perempuan Usia Lanjut Indonesia Setiati, Siti
Jurnal Kesehatan Masyarakat Nasional Vol. 2 No. 4 Februari 2008
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.797 KB) | DOI: 10.21109/kesmas.v2i4.257

Abstract

Berbagai penelitian menunjukkan bahwa defisiensi vitamin D dan hiperpara-tiroidisme sekunder menimbulkan dampak serius pada kesehatan, antara lain meliputi osteoporosis, osteomalasia, kelemahan otot, jatuh dan fraktur osteoporotik. Tujuan penelitian ini adalah (1) mengetahui pengaruh pajanan UVB sinar matahari pada konsentrasi 25(OH)D dan hormon paratiroid (PTH) perempuan usia lanjut Indonesia. (2) mendapatkan saat dan lama pemajanan yang optimal. Penelitian uji klinik acak terbuka ini melibatkan 74 perempuan berusia 60 - 90 tahun yang tinggal di 4 panti werda di Jakarta dan Bekasi. Randomisasi dilakukan untuk memisahkan kelompok studi dan kontrol. Kelompok kontrol hanya mendapat kalsium 1000 mg/hari, sedang kelompok intervensi dipajankan dengan matahari selama 6 minggu. Hasil yang diukur sebelum dan sesudah 6 minggu pemajanan adalah konsentrasi 25(OH)D, PTH, dan ion kalsium. Ditemukan bahwa, waktu pemajanan yang optimal adalah 1 jam sebelum dan sesudah tengah hari. Prevalensi defisiensi vitamin D pada wanita usia lanjut adalah 35,1%. Pada kelompok terpajan, konsentrasi 25(OH)D meningkat lebih tinggi daripada yang tidak dipajan (51,8% vs 12,5%). Hasil tambahan adalahrerata asupan kalsium 248 mg/hari, dan rerata asupan vitamin D 28 IU/hari.Kata kunci: Defisiensi vitamin D, perempuan usia lanjut, hormon paratiroidAbstractMany studies showed that vitamin D deficiency and secondary hyper-parathyroidism cause serious impact on health including osteoporosis, osteomalacia, paralysis, fall, and osteoporotic fracture. This study was conducted to compare the effect of UVB from sunlight exposure in combination with calcium supplementation, and control (calcium only) on the vitamin D status and parathyroid hormone (PTH) concentration in Indonesian elderly women. This study was a randomized clinical trial in institutionalized care unit. Subjects included 74 elderly women with a mean age 71 years. Intervention was random allocation of UVB from sunlight exposure at 0.6 MED/hour noted in the UV meter on the face and both arms and calcium 1000 mg, three times per week for 6 weeks, and without treatment (calcium 1000 mg only). Main outcome measured were fasting serum levels of 25(OH) D, PTH, and calcium ion at 0 and 6 weeks in both treatment and control groups. The incidence of vitamin D deficiency in this population study was 35.1 %. In the treatment group, 25(OH) D increased from 59.1 nmol/L to 84.3 nmol/L (mean value after 6 weeks of sunlight exposure) with only a slight increase of 25(OH) D in the control group (51.8% vs 12.5%). 25(OH)D deficient levels in 15 out 16 subjects became normal after 6 weeks of sun exposure. There was no change of PTH levels in both groups. Additional results of this study are mean calcium intake of 248 mg/day and vitamin D intake of 28 IU/day.Keywords: Vitamin D deficiency, elderly women, parathyroid hormone
Efek Puasa terhadap Kecepatan Sekresi Saliva Suatu Kajian pada Lansia di Bulan Ramadhan Nasrul, M.; Tanti, Ira; Setiati, Siti; Rahardjo, Tri Budi W.
Journal of Dentistry Indonesia Vol 7, No 3 (2000): December
Publisher : Faculty of Dentistry, University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.727 KB) | DOI: 10.14693/jdi.v7i3.714

Abstract

Until recently it was believed that saliva production diminishes with increasing age physiologically. In relation to prosthodontics, the saliva production is high correlated with the adhesive function for prostheses. It is known that the Moslem Indonesian Elderly People do fasting during Ramadhan Month. The effect of fasting in decreasing saliva production has been studies. In this regard 62 elderly people, 60 - 75 years old, consisted of 25 men and 37 women were observed. The result showed that the mean of saliva production before fasting was 30.9677 ml/mm while during fasting the figure showed 26.0339 ml/mm. Using "t" test it was significant difference between saliva production before and during fasting. It is concluded that fasting affected the decreasing of saliva production.
Total Lymphocyte Count as a Nutritional Parameter in Hospitalized Patients Gunarsa, Ralph Girson; Simadibrata, Marcellus; Syam, Ari Fahrial; Timan, Ina Susianti; Setiati, Siti; Rani, Abdul Aziz
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/122201189-94

Abstract

Background: Nowadays, there are still many malnourished patients during hospitalization, which comprises around 45-50% patients. Malnutrition is related to increased mortality and morbidity rate; therefore, nutritional state should be assessed in hospitalized patients. Total lymphocyte count (TLC) is related to decreased body function in malnutrition and it is a means of nutritional assessment. Until now, there is no data showing association between malnutrition and TLC in hospitalized patients in Indonesia. The objective of this study was to identify the association between malnutrition and TLC < 1,200 cell/mm3 in hospitalized patients. Method: This study was a cross-sectional study. Subjects were new patients hospitalized at internal medicine ward of Cipto Mangunkusumo Hospital. Patients were collected by consecutive sampling. We conducted the study between April and May 2008. Fifty four patients were assessed for malnutrition by the subjective global assessment (SGA) and they also had undergone complete blood count. TLC was numbered with routine complete blood count test. Patients were classified into malnutrition according to SGA. TLC was classified with cut-off point of 1,200 cell/mm3. Statistical analysis included Chi-square test, which was used to compare proportion. Results: There were 52% malnourished patients, 33% patients with TLC < 1,200 cell/mm3, 57% patients with malnutrition and TLC < 1,200 cell/mm3. This study showed that there was an association between malnutrition and TLC < 1,200 cell/mm3 (p = 0.001). Moreover, there was also significant association between severe malnutrition (SGA C) with TLC < 900 cell/mm3 (p = 0.02). Conclusion: There is an association between malnutrition and TLC < 1,200 cell/mm3.   Keywords: malnutrition, total lymphocyte count, body mass index, subjective global assessment
Proportion and Factors Associated with Zinc Deficiency in Acute Diarrhea Patients Oto, Budi Tan; Simadibrata, Marcellus; Dillon, Drupadi Harnopidjati Singh; Setiati, Siti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/122201172-78

Abstract

Background: Zinc may affect the intestinal immune response. No data has been available on zinc deficiency in adult patients with diarrhea, especially for Indonesian population. Zinc metabolism, etiologies, pathogenesis and clinical course of diarrhea may have various effects on zinc concentration in different population. This study aimed to determine the proportion of zinc deficiency in patients with acute diarrhea, including its associated factors. Method: A cross-sectional study was conducted in patients with acute diarrhea at outpatient clinics and emergency wards of four hospitals between August 2010 and March 2011. A serum zinc concentration of < 10.7 µmol/L was set as cut-off value for zinc deficiency. Data was analyzed by using Chi-square test. Results: There were 101 subjects, 54.5% were female, the median age was 26 years, median duration of acute diarrhea was 5 days, and the median frequency was 6 times/day. About 95% patients had nutritional status of subjective global assessment (SGA) A and the mean value of body mass index was 19.3 ± 0.70 kg/m2. Approximately 88.1% patients had severe infective diarrhea based on hydration status. About 69.3% patients were zinc deficient with the mean serum zinc concentration of 9.26 ± 2.95 µ mol/L. We found a significant correlation between the severity of diarrhea and zinc deficiency in patients with acute diarrhea. Conclusion: The proportion of zinc deficiency in acute diarrhea patients was quite large although the mean serum zinc level was still below the National Health and Nutrition Examination Survey (NHANES) reference value. The severity of diarrhea has been proven to be significant that affects zinc deficiency in acute diarrhea patients. Keywords: zinc deficiency, acute diarrhea, adult
The Effect of Branched Chain Amino Acids and L-Ornithine L-Aspartate Combination as The Late Evening Snacks on Nutritional Status and Minimal Hepatic Encephalopathy in Liver Cirrhosis Tenda, Eric Daniel; Hasan, Irsan; Sanityoso, Andri; Setiati, Siti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/1332012151-156

Abstract

ABSTRACTBackground:Minimal hepatic encephalopathy (MHE) in liver cirrhotic patients is critical manifestation of low grade hepatic encephalopaty (HE), is caused quality of life decrease and risk of deteriorating into distinct HE. The study was conducted to asses the effect of combination of branched-chain amino acids (BCAA) and L-ornithine L-aspartate (LOLA), which was given late evening, on nutritional status and degree of HE.Method: This single-blind randomized study was conducted on liver cirrhotic outpatients in hepatology clinic of Cipto Mangunkusumo Hospital period June 2011-June 2012. The study subjects were divided into two groups, group of late evening snack (LS) and day snack (DS). Each group was supplemented with combination of milk of BCAAs and LOLA (3.7 g/serving). Evaluation based on history, physical examination, laboratory tests and critical flicker frequency (CFF) was performed one month after the intervention. Data were statistically analyzed with SPSS 15.Results: Thirty-two patients whose the inclusion criteria were divided into 16 subjects for each group, LS and DS. After one month of the intervention, the average level of prealbumin for DS group was increased statistically significant (p < 0.001), but not significant for LS group (p = 0.259). The increase of average body weight,mid-arm muscle circumference (MAMC) and CFF test result in both groups. There was no improvement on subject global assessment (SGA) score after one month intervention in both groups.Conclusion: This study proved that giving combination of BCAAs and LOLA may improve the condition of MHE, however for nutritional status can not be assessed. Keywords: minimal hepatic encephalopathy, BCAAs, LOLA, prealbumin, SGA score, nutritional status
Co-Authors Abdul Aziz Rani Aida Lydia, Aida Alimuddin, Suriani Alvina Widhani, Alvina Andreas Arie Setiawan, Andreas Arie Andri Sanityoso Ardi Ardian, Ardi Ari F Syam Ari Fahrial Syam Arya Govinda Roosheroe, Arya Govinda Aulia Rizka, Aulia Ayatullah Khomaini Bambang Setyohadi Bambang Sutrisna Budi I Santoso, Budi I Budi Tan Oto Catarina Budyono, Catarina Ceva W Pitoyo CHAIDIR A MOCHTAR, CHAIDIR A Cleopas M Rumende, Cleopas M Dadang Makmun Dharmeizar Dharmeizar Diana, Nyimas Dita Adhitianingsih, Dita Djumhana Atmakusuma, Djumhana Drupadi Harnopidjati Singh Dillon Dyah Purnamasari Edy Rizal Wahyudi Em Yunir, Em Eric Daniel Tenda Esthika Dewiasty, Esthika Euphemia Seto, Euphemia Findy Prasetyawaty, Findy Firtantyo A Syahputra, Firtantyo A Ginova Nainggolan Harrina E Rahardjo, Harrina E Harry Isbagio Herikurniawan, Herikurniawan Heru Sundaru Idrus Alwi Ika P Wijaya, Ika P Ika Prasetya Wijaya, Ika Prasetya Ina Susianti Timan Indra G Mansur, Indra G Indra Wijaya Ira Tanti Iris Rengganis Irsan Hasan Jimmy Tesiman, Jimmy Joedo Prihartono Junizaf Junizaf Kuntjoro Harimurti Laura A Siahaan, Laura A Lugyanti Sukrisman Lukman Hakim M Sadikin M Yamin M. Nasrul, M. Marcel Prasetyo Marcellus Simadibrata Martini, Rose D Marulam Panggabean, Marulam Meilania Saraswati Merry Christianie, Merry Muhammad Yamin Mulyana, Roza Murdani Abdullah Nadia Ayu Mulansari, Nadia Ayu Nafrialdi Nafrialdi Nanang Sukmana Noto Dwimartutie Nur Riviati, Nur Partini P Trihono, Partini P Pradana Soewondo Pudji Rahardjo Purwita W Laksmi, Purwita W Purwita Wijaya Laksmi Rachmat Hamonangan, Rachmat Radhiyatam Mardhiyah, Radhiyatam Ralph Girson Gunarsa Retnosari Andrajati Rino A Gani Rochani Sumardi, Rochani Rudy Hidayat Saraswati, Mita Hafsah Simon Salim Siti A Nuhonni, Siti A Stevent Sumantri, Stevent Suksmono Haricahyo Supartondo Supartondo Tedjasaputra, Shirly Elisa Teguh H Karjadi, Teguh H Tirza Z Tamin Tities Anggraeni Indra, Tities Anggraeni Tri B.W. Rahardjo Tri Budi W. Rahardjo vera vera, vera Vidhia Umami, Vidhia Wasilah Rochmah Widayat Djoko Santoso, Widayat Djoko Wiguno Prodjosudjadi Wulyo Rajabto Yulia Trisna, Yulia