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OPTIMASI TABLET FLOATING TEOFILIN MENGGUNAKAN METODE DESAIN FAKTORIAL siswanto, agus; Hapsari, Indri; zulaikha, yusni ulfiani; rosmawati, eva
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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ABSTRACTTheophylline is a drug used in the management of asthma. It has relatively short half-life and narrow therapeutic index with 5-20 ?g/mL serum concentration. Thus, Floating tablet formulations that can increase the bioavailability of the drug. The aims of this study were to determine the effect of the excipient (HPMC K4M CR and NaHCO3) to the quality of tablets and determine the optimum formula of theophylline floating tablet. A 22 randomized factorial design was used in development of theophylline floating tablet with HPMC K4M CR (A) and NaHCO3 (B) as independent variables.The flowability of mass tablet, floating character, and dissolution profile were chosen as dependent variables.The results showed that NaHCO3 was the most important factor on increasing flowability of mass tablet. HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978.
EFFECT OF SELF SURRENDER PRACTICE ON INSULIN RESISTANCE IN INDIVIDUALS WITHTYPE 2 DIABETES MELLITUS WITHOUT DEPRESSION: ASINGLE-BLINDED RANDOMIZED CONTROLLED TRIAL Siswanto, Agus; Juffrie, Muhammad; Rianto, Bambang Udji Djoko; Asdie, H.A.H
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 1 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Self surrender practice (latihanpasrahdiri/LPD) is a form of relaxation therapy that has been increasingly used, not only in the treatment of psychosomatic diseases, but also of other non-psychosomatic diseases. Previous studies reported thatSSP shows modest improvement on clinical parameters of type 2diabetes mellitus(T2DM) patients,not onlydepression symptoms improvement, but also glycemic control.However, the effect of LPD on insulin resistance has not been investigated. The study aimed to investigate the effect of LPD on insulin resistance in T2DM patients without depression. This was a single-blinded, randomized, controlledtrial conducted in outpatient unit of the Department of Internal Medicine, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Central Java.The subjects of the study were T2DM patients aged over 30 yearsand had no depression.Fourthy-four T2DM patients were randomized into two groups as the controlgroup and the treatment group who underwent SSP group for eight weeks. The data of insulin resistancemeasured by HOMA-IR, perceived stress scale (PSS), fasting plasma glucose (FBG), HbA1c, and two hour plasma glucose (PPG)levels of both groups werecollected and statistically analysed.No significantly different in the patient?scharacteristics of both groups was observed.At the end of the study period, the LPD group showed reduction of HOMA-IR and HbA1c but not statistically significant, (?HOMA-IR = -0.39±1.52; p = 0.976; HbA1c=-0.55±0.85%; p = 0.189). The FBG and PPGincreased in the LPD group compared to control but also not statistically significant (?FBG=10.16±50.33; p=0.294; PPG=40.74±69.35; p=0.062). We also observed the decrease of stress level in LPD group compared to control groupbut it was no statistical significance (?PSS=-5.09±6.47; p=0.655).Self surrender practice (LPD) decreasesHOMA-IR, improves glycemic control (HbA1c) and reduces stress levels in T2DM patients without depressionAlthough the theyarenot statisticallysignificant, however they may be clinically significant.
Effects of latihan pasrah diri in quality of life in chronic kidney disease-dialysis patients with depression symptoms Widyaningrum, Widyaningrum; Siswanto, Agus; Djarwoto, Bambang
Acta Interna The Journal of Internal Medicine Vol 3, No 2 (2013): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACTBackground: Patients with chronic kidney disease (CKD) suffering from various physical and emotional symptoms show depression and disturbance in quality of life. Patients with chronic kidney disease have a decreased quality of life, and mortality rate about 22% in every year. Depression in patients with CKD must be managed properly because a large effect on HRQOL (Health Related Quality of Life) and the potential side effects on the management of patients with CKD. Latihan pasrah diri (LPD) is a method combining relaxation and remembrance with a focus on breathing exercises and words contained in the dhikr (relaxation and repetitive prayer). The rise of the relaxation response is expected to improve the symptoms of stress or depressive symptoms, which is expected to improve HRQOL.Objective: This study aimed to determine the effect of LPD on quality of life in hemodialysis patients with depressive symptoms that was compared with controls.Methods: The research constituted the study of Randomized Control Trial. The research was measured the KDQOL-SF scores (Kidney Disease Quality of Life-SF) in subjects with LPD treatment during 21 days, compared with controls. The research was conducted at the Hemodialysis Unit of Dr. Sardjito Hospital, Yogyakarta, from May to June 2012. A total of 36 patients who met the inclusion criteria were randomized and divided into LPD group (n = 18) and control group (n = 18).Results: Found a statistically signifi cant decrease in BDI scores in both groups, 23.00 ± 5.34 to 15.00 ± 8.55 (p = 0.001) in the LPD group and 23.00 ± 5.34 to18.33 ± 6, 66 (p = 0.022) in the control group. KDQOL-SF scores after treatment when compared between the LPD and control groups experienced different changes were statistically signifi cant in domains effects of kidney disease 59.65 ±23.52 compared to 39.41 ± 20.03 (p = 0.022), sleep 69 ± 13.17 compared to 46.53. (p = 0.000), overall health 73.89 ± 16.85 compared to 57.22 ± 19.04 (p = 0.009), pain 64.86 ± 20.80 compared to 42.36 ± 24.90 (p = 0.005), general health 53.88 ±16.05 compared to 47.78 ± 20.74 (p = 0.014), and the physical component scale 35.98 ± 6, 83 compared to 29.12 ± 6.46 (p = 0.004). Despite increased KDQOL-SF domain scores, but there were 2 domains that Δ KDQOL-SF score changes were statistically signifi cantly different compared with the control group, which was the domain of sleep and overall health.Conclusion: Latihan pasrah diri twice a day during 21 days (3 weeks) can improved the quality of life of patients with symptoms depression in CKD patients undergoing hemodialysis in domains of sleep and overall health.Keywords: CKD, depression, latihan pasrah diri, KDQOL-SF.
Correlation between Depressive Symptom Score and Geriatric Handgrip Strength at Nursing Home Province of Yogyakarta Syahri, Ahmad; Siswanto, Agus; Pramantara, I Dewa Putu
Acta Interna The Journal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACTBackground: By the year of 2020, Indonesia’s elderly population will be expected to the fourth highest number in the world after China, India and USA. Special Region of Yogyakarta has the highest percentage that is equal to 13.72%. Depression may increase the risk of mortality, disability and motivation of physical Low grip strength would increase mortality and morbidity in the elderly.Objective: This study aimed to assess the correlation between depressive symptoms and handgrip strength in the elderly population in nursing homes at province of Yogyakarta.Methods: This study was a cross-sectional study that conducted in October 2010 at the nursing home residents. Depression was assessed by the Geriatric Depression Scale Cronbach’s alpha 0.88. Handgrip strength was measured by a handgrip dynamometer. Data of age, education and gender was collected by questionnaire. The study performed statistical tests to assess the correlation of symptoms depression and grip strength.Results: The mean age of subjects was 73.84 ± 8.36 years with 36 subjects (35.3%) were between 60-69 years and 66 subjects (64.7%) were over 70 years. There were 33 men (32.4%) and 69 women (67.6%). MeanGDS score was 12.76 ± 3.22. Handgrip strength in the depression group 16.94 ± 6.96 kg was higher than the non-depressed group 15.23 ± 6.79. There was correlation between severity of depression symptom byhandgrip strength with r = 0.235 (weak correlation) and statistically signifi cant with p = 0.017.Conclusion: The severity of depressive symptom scores was correlated significantly to the handgrip strength in elderly nursing homes in the province of Yogyakarta.Keywords: elderly, nursing homes, depression, handgrip strength.confi dent interval.
Succession of Fungal Community Structure in Degradative Land Caused by Basal Rot Pathogen of Garlic Cahyani, Vita Ratri; Rahayu, Devi Puji; Siswanto, Agus; Prasetyo, Dedy; Hadiwiyono, Hadiwiyono
Sains Tanah - Jurnal Ilmu Tanah dan Agroklimatologi 2014: Articles in Press (Vol. 11 No. 1)
Publisher : Faculty of Agriculture, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15608/stjssa.v0i0.216

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Land degradation causes a decreasement the ability of land in suppressing the development of pathogen FOCe that causes basal rot of garlic. In the garlic planting area in Tawangmangu discovered the fact that productive-suppressive land to FOCe the disease has low incidence (<1%) and degradative-conducive land with high incidens (≥60%). The research aims to study the succession of common fungal community structure and FOCe in the rhizosphere of garlic on both land for garlic plantation. The study was conducted from April to September 2013 in productive-suppressive land (Pancot) and degradative-conducive (Gondosuli) for soil sampling and laboratory analysis in Biologi Tanah UNS for fungi and FOCe analysis. The composite method used for sampling and the garlic rhizosphere samples  which is had healthy plants conditions aged 0, 20, 40, and 60 days after planting (DAP), and the garlic rhizosphere samples with healthy plants and diseased condition aged 80, 100, and 120 days after planting (DAP). Laboratory analysis using PDA culture medium as common fungi growing medium and SFA as a growing medium FOCe then observed population density and diversity. The method was pour plate method with 10-2 to 10-7 dilution. The results showed the population and diversity of fungi and FOCe have dynamics fluctuation. The fungi population in productive-suppressive land lower than degradative-conducive, with each value 108 and 3,5x108 CFU gram-1 soil. FOCe population on degradative-conducive land was higher than productive-suppressive land, and the highest population in both land at age 20 and 100 DAP with a FOCe density of each land about 1,25x107 and 1,66x107 CFU gram-1 soil. During the growth periode of garlic, the fungi diversity on productive-suppressive land always indicate higher than degradative-conducive land.
Correlation between the Symptoms of Depression and Sexual Function in Breast Cancer Patients Receiving Chemotherapy Rohmawati, Dwi; Siswanto, Agus; Kurnianda, Johan; Sofia, Noor Asyiqah
Acta Interna The Journal of Internal Medicine Vol 2, No 1 (2012): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACT             Symptoms of depression and sexual problems that occur among breast cancer patients are a rarely detected and get good handling. Therefore, an early detection for any psychological problems that may affect the sexual life of patients with breast cancer is needed so that the patients can have better life. This study aims to assess the correlation between symptoms of depression and sexual function in women with breast cancer who undergo chemotherapy at Dr. Sardjito Hospital.            Research design was cross sectional. The study necquited 38 breast cancer patients in Tulip outpatients Cancer Clinic in Dr. Sardjito Hospital. Assessment of depressive symptoms used Beck Depression Inventory questionnaire and Female Sexual Function Index to assess sexual function.            The results showed that the proportion of subjects aged 46-55 years at 55.2% followed by 36-45 years of age at 39.5% and aged 26-35 years by 5.3%. The mean age of subjects was 45.4 + 6.5 years. Correlation between symptoms of depression with sexual function among participants was r=- 0.30 with significance p=0.068. Correlation between symptoms of depression with the domains of sexual function domain of desire (r=-0.296, p=0.072), stimulation (r = -0.470, p = 0.003), lubrication (r=-0.353, p=0.030), orgasm (r=-0.223, p=0.179), satisfaction (r=-0.233, p=0.158), pain (r=-0.186, p=0.262).            The conclusion is that there is no correlation between symptoms of depression with sexual function. Keywords: Depression symptoms, Breast Cancer, Sexual Dysfunction
EFFECTS OF LATIHAN PASRAH DIRI ON THE IMPROVEMENT OF DEPRESSIVE SYMPTOMS Hamra, Muhammad Yusuf; Sumardi, Sumardi; Siswanto, Agus; Sofia, Noor Asyiqah
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACTBackground. Depression is more common in persons with chronic illnesses such as diabetes, epilepsy and infection of Human Immunodeficiency Virus (HIV). Depression can make HIV worse. Antidepressant may need, but there can be interaction and side effect when use Antiretroviral (ARV) and antidepressant in combination. Complementary and alternative medicine (CAM) include Latihan Pasrah Diri(LPD) may seem safe to treat depression in HIV patient.Methods. This is a quasi experimental study, participant include outpatient dan inpatient at RSUP Dr. Sardjito, Yogyakarta. They were aged >18 years. After scoring with Zung Self Rating Scale for depression, participants allocated into two groups, with dan without Latihan Pasrah Diri program. Zung Self Rating Scale for depression was evaluated after 1 cycle of program.Result. The means of Zung Self-Rating Depression Scale score before and after LPD were 42,21 ± 9,3 and 35 ± 10,73 (p 0,003). While in control group (without LPD / brief psychotherapy) the means of Zung Self-Rating Depression Scale score before and 3 weeks after brief psychotherapy were 42,93 ± 7.45 and 39,36 ± 7,69 (p 0,019). Statistically there was no significancy in the means of delta Zung Self-Rating Depression Scale in LPD group and control group.Conclusion. It was concluded from this study that there is an influence on the improvement of depressive symptoms post- Latihan Pasrah Diri program to people with HIV / AIDS. Key words: depression, HIV, Latihan Pasrah Diri, Zung Self-Rating Scale
Suksesi Struktur Komunitas Fungi pada Lahan Degradatif oleh Patogen Busuk Pangkal Bawang Putih Cahyani, Vita Ratri; Rahayu, Devi Puji; Siswanto, Agus; Prasetyo, Dedy; Hadiwiyono, Hadiwiyono
Sains Tanah - Jurnal Ilmu Tanah dan Agroklimatologi Vol 11, No 1 (2014)
Publisher : Faculty of Agriculture, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15608/stjssa.v11i1.220

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TITLE : SUCCESSION OF FUNGAL COMMUNITY STRUCTURE IN DEGRADATIVE LAND CAUSED BY BASAL ROT PATHOGEN OF GARLIC. Land degradation causes a decreasement the ability of land in suppressing the development of pathogen FOCe that causes basal rot of garlic. In the garlic planting area in Tawangmangu discovered the fact that productive-suppressive land to FOCe the disease has low incidence (<1%) and degradative-conducive land with high incidens (≥60%). The research aims to study the succession of common fungal community structure and FOCe in the rhizosphere of garlic on both land for garlic plantation. The study was conducted from April to September 2013 in productive-suppressive land (Pancot) and degradative-conducive (Gondosuli) for soil sampling and laboratory analysis in Biologi Tanah UNS for fungi and FOCe analysis. The composite method used for sampling and the garlic rhizosphere samples  which is had healthy plants conditions aged 0, 20, 40, and 60 days after planting (DAP), and the garlic rhizosphere samples with healthy plants and diseased condition aged 80, 100, and 120 days after planting (DAP). Laboratory analysis using PDA culture medium as common fungi growing medium and SFA as a growing medium FOCe then observed population density and diversity. The method was pour plate method with 10-2 to 10-7 dilution. The results showed the population and diversity of fungi and FOCe have dynamics fluctuation. The fungi population in productive-suppressive land lower than degradative-conducive, with each value 108 and 3,5x108 CFU gram-1 soil. FOCe population on degradative-conducive land was higher than productive-suppressive land, and the highest population in both land at age 20 and 100 DAP with a FOCe density of each land about 1,25x107 and 1,66x107 CFU gram-1 soil. During the growth periode of garlic, the fungi diversity on productive-suppressive land always indicate higher than degradative-conducive land.
Optimization of theophylline sustained release tablet formula with HPMC, CMC Na and xanthan gum as matrix component Siswanto, Agus; Soebagyo, Sri Sulihtyowati
INDONESIAN JOURNAL OF PHARMACY Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.129 KB) | DOI: 10.14499/indonesianjpharm0iss0pp143-148

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Theophylline has a relatively short half-life (8,1 jam) with a narrow therapeutic window (10 – 20 μg/mL). Sustained-release formulation can produce more uniform serum concentrations with less fluctuation in peaktrough levels. The physical properties of tablet mass and the release profileof drug from hydrophilic matrices are influenced by properties of matrix components, i.e. HPMC (gelling agent), CMC-Na (did not show initial burst release), and xanthan gum (free flowing).The research was done with simplex lattice design (SLD) by using 3 component, i.e. HPMC (A), CMC-Na (B), and xanthan gum (C). Seven formula were obtained that are F1 (100% A), F2 (100% B), F3 (100% C), F4 (50% A & 50% B), F5 (50% B & 50% C), F6 (50% A & 50% C), dan F7 (33,33% A, 33,33% B, 33,33% C). The Optimization parameters of theophylline sustained-release were flow rate of the tablet mass, the compactibility of the tablet mass, and the release rate of theophylline.Based on SLD model; equations, contour plots, and superimposed of contour plots were obtained, by which the optimum formula was determined.Xanthan gum was the most dominant factor in increasing flowability and compactibility of theophylline tablet mass. HPMC was the most dominant factor in decreasing the dissolution rate of theophylline. The most dominant interaction effect to increase flowability and compactibility was the interaction of HPMC, CMC-Na, and xanthan gum. The most dominant interaction effect to increase correlation coefficient of zero order kinetics was the interaction HPMC and CMC-Na. Based on the superimposed contour plots, tablet formula consisting of HPMC (2,3 %), CMC-Na (18,6 %), and xanthan gum (79,1 %) is the optimum tablet formula.Key words: theophylline, HPMC, CMC-Na, xanthan gum, sustained-release
IN VITRO RELEASE MODELING OF ASPIRIN FLOATING TABLETS USING DDSOLVER Siswanto, Agus; Fudholi, Achmad; Nugroho, Akhmad Kharis; Martono, Sudibyo
INDONESIAN JOURNAL OF PHARMACY Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (939.4 KB) | DOI: 10.14499/indonesianjpharm26iss2pp94

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Aspirin has low solubility in water therefore, dissolution is a rate limiting step for absorption. Floating tablet formulation is designed to improve the bioavailability of aspirin. The objective of this study was to determine in vitro dissolution study of aspirin floating tablet release kinetics model. The floating tablets were prepared by a direct compression method using Methocel K4M CR, NaHCO3, Ethocel, Aerosil, and dicalcium phospate anhydrous as excipients. Tablets were evaluated by different parameters such as physicochemical properties, floating lag time (Flag time), total floating time, and dissolution. The result showed that the tablet mass has good flow properties of 13.54 g/sec. Aspirin floating tablets had a weight uniformity (CV=1.45%), good hardness (6.42kg), and low friability (0.158%). The tablet has a short Flag time of 25.16 sec and long floating time of 8 hours. Dissolution data were evaluated using DDSolver conducted by (1) Statistical parameters: R2adjusted, AIC, MSC; (2) Visual goodness of fit (GOF). The results showed that aspirin floating tablets release kinetics followed the Korsmeyer-Peppas model. Aspirin release occurs through the mechanism of anomalous transport which combines Fickian diffusion and polymer relaxation.Key words: aspirin floating tablet, DDSolver, modeling of drug release
Co-Authors Abdul Rahim Achmad Fudholi Adithya Wahyu Pratama, Adithya Wahyu Ahmad Husain Asdie Ahmad Syahri Akhir Riana Handayani, Akhir Riana Akhmad Kharis Nugroho Anjar Mahardian Kusuma Asdie, H.A.H Ashad, Bayu Adrian Bambang Djarwoto Bambang Udji Djoko Rianto Cahyadi, . Cahyanto, Muhammad Eko Candra, Rudy Dedy Prasetyo Devi Puji Rahayu Dodit Ari Wibowo, Dodit Ari Dwi Hartanti Dwi Rahayuningsih Dwi Rohmawati Eriya, Eriya Fauziati, Ana Gustina Nurkhayatun, Gustina Hadiwiyono Hadiwiyono Hariadi Hariawan Hendri Hendri Heri Tjahjono I Dewa Putu Pramantara Imam Baihaqi, Imam Imani, Rizaldi Lukman Indri Hapsari Iskandar Soedirman, Iskandar Iskandar Sudirman Jasmir, Jasmir Johan Kurnianda Juffrie, Muhammad Kiswoyo . Moeslich Hasanmihardja Mohammad Soleh Mucharomah, Nurul Maghfiroh Muhammad Furqon Muhammad Yusuf Hamra Muin, Natsir Mutiara Poetri Nurtanti, Mutiara Poetri Neneng Ratnasari Noor Asyiqah Sofia Nunuk Aries Nurulita Nurhadi Nurhadi Nursandi, Wahyu Asmoro Nuryanto, . Okprastowo, Rizki Pahlevi B, M. Riza Purnamasari, Sarwinda Purnomo, Luthfan Budi Reza Pramitha Habsari, Reza Pramitha Rosmawati, Eva rosmawati, eva rosmawati, eva Santi Patrinia Feranses Saptono Putro Siregar, Arief Kurniawan Sri Sulihtyowati Soebagyo Sudibyo Martono Sudirman, Iskahar Sumardi Sumardi Suparman Suparman Suprijadi, Sugeng Toscany, Afrizal Nehemia Vita Ratri Cahyani Wibawa, Arief Widya Cahya Ariswati, Widya Cahya Widyaningrum Widyaningrum Yaasin, Muhammad Yekti Mulyani, Yekti Yogi Permana Yuli Asmi Rahman Yuni Ernawati, Yuni Zulaikha, Yusni Ulfiani zulaikha, yusni ulfiani zulaikha, yusni ulfiani