Doddy M. Soebadi
Department of Urology, Faculty of Medicine/Airlangga University, Soetomo Hospital, Surabaya, Indonesia.

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THE DIFFERENCE OF PAIN PERCEPTION BETWEEN KETOPROFEN SUPPOSITORY AND 1% PERIPROSTATIC LIDOCAINE INJECTION Azis, Abdul; Djatisoesanto, Wahjoe; Soebadi, Doddy M.; Hakim, Lukman; Budiono, Budiono
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.63

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Objective: To compare the pain control results of ketoprofen suppository and periprostatic injection of lidocaine 1% for prostate biopsy. Material & Method: A total of 30 patients who underwent transrectal ultrasound guided prostate biopsy were randomized into 2 groups. Group 1 consisted of 15 patients received 200 mg of ketoprofen suppository. Group 2 received 1% periprostatic lidocaine injection. A visual analog scale was used to assess the pain score during prostate biopsy. Statistical analysis of pain scores was performed using independent t-test and Pearson correlation test. Results: The 2 groups were homogenous in age and prostate volume. There was significant difference in pain score among groups 1 and 2 during prostate biopsy (mean VAS ± SD 0,8 ± 0,8 and 4,5 ± 1,6 respectively, p < 0,0001). There was no significant correlation between pain perception with age (p = 0,779), or prostate volume (p = 0,389) in both groups. Conclusion: Periprostatic lidocaine injection is more effective for decreasing the pain for prostate biopsy compared to ketoprofen suppository. Keywords: Prostate biopsy, pain, transrectal ultrasonography, periprostatic nerve block, visual analog scale.
THE EFFECT OF THE DURATION OF INHALED NICOTINE EXPOSURE TO THE NUMBER OF LEYDIG, SPERMATOGONIUM, AND SERTOLI CELLS ON THE SPRAGUE-DAWLEY STRAIN WHITE RATS Hoesain, Fadil Pramudhya; Soebadi, Doddy M.; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.596

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Objective: To analyze the differences of the number of Leydig, spermatogonium, and Sertoli cells in mice, after being given nicotine inhalation, and the effect of recovery when nicotine stopped. Materials &amp; Methods: This is experimental studies with a post-test only control group design. The sample used was 36 adult male mice (10-12 weeks) (Rattus Norvegicus) Sprague-Dawley strain, which were divided into three groups. P1 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days, P2 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days and was free of treatment for 15 days. The control group (NC) has no treatment at all. Histological examination and calculation of Sertoli cells, Leydig cell, and spermatogonium were processed within 1 hour after terticular sample collection. Then carried out to statistical analysis. 100x and 400x magnification is used to obtain the histopathological. Results: Post-hoc LSD test for each variable (Leydig cells, Sertoli cells, and spermatogonium), showed that the NC group had a significantly higher number compared to group P1. P2 group has a significantly higher number compared to group P1. There is no significant difference between the NC group and the P2 group. There was a structural difference in the sample testicles which exposed to nicotine. Conclusion: Nicotine exposure with a dose of 4 mg/kg/day for 15 days has a significant effect on decreasing the number of Leydig cells, spermatogonium cells, and Sertoli cells in rats and giving a free-treatment period for 15 days, giving the testis time to do recovery and regeneration (the reversible damage of testicular structure).
THE EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON GLOMERULUS AND PROXIMAL KIDNEY TUBULES DAMAGE WHICH RECEIVED CISPLATIN EXPOSURE ON SPRAGUE DAWLEY MICE Rakhmatiar, Fadhilla; Soebadi, Doddy M.; Soetojo, Soetojo
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.597

Abstract

Objective: To analyze the protective effect of Vitamin E on cisplatin toxicity in Sprague Dawley mice nephrons. Material &amp; Methods: This is an experimental study using post-test only control group design, the subject was white male mice (Rattus Norvegicus) adult Sprague Dawley strain (10-12 weeks) of 24 rats divided into four groups. Negative control group (CN) got normal saline 0.9% intraperitoneal 1 cc, Positive control group (CP) got cisplatin 5 mg/kgBB, group P1 got vitamin E 50 mg/kgBB and Cisplatin 5 mg/kgBB, and P2 group got vitamin E 200 mg/kgBB plus cisplatin 5 mg/kgBB intraperitoneal. Cisplatin is conducted in the third week in each treatment group through intraperitoneal injection. Vitamin E is administrated per sonde for the first three weeks resumed on the fourth week to the seventh week. At the end of the seventh week, nephrectomy was performed on the treatment group to analyze the kidney damage. Histopathological observation is performed using a light microscope with a magnification of one hundred and four hundred times magnification. Results: Cisplatin administration resulted in significant tubular and glomerular damage compared to the control group. Increasing the dose of vitamin E in mice that received cisplatin resulted in significant nephron damage compared to the group who received cisplatin alone. Conclusion: Cisplatin administration results in nephrotoxicity in mice. The administration of high dose Vitamin E resulted in increased nephrotoxicity in mice that received cisplatin.
CORRELATION BETWEEN PROSTATIC URETHRAL ANGLE WITH CLINICAL PARAMETERS AND BOO IN LUTS ASSOCIATED WITH BPH Santoso, Kristian Yoci Santoso Yoci; Soebadi, Doddy M.; Djatisoesanto, Wahjoe; Budiono, Budiono
Indonesian Journal of Urology Vol 20 No 1 (2013)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v20i1.43

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Objective: We investigated the correlation of the PUA on clinical parameters and bladder outlet obstruction (BOO) in men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Material &amp; Method: This study was performed between January to April 2011. A cross sectional analysis of 24 men with LUTS associated BPH aged &gt; 50 years was performed. Patients underwent evaluation including International Prostatic Symptom Score (IPSS), transrectal ultrasonography, uroflowmetry, and pressure-flow study. Statistical analysis was performed to evaluate correlation of the PUA on clinical parameters and bladder outlet obstruction (BOO). Results: A total of 24 patients, aged 51 to 78 years were enrolled in this study. The mean value of total IPSS, prostate volume, PUA, and Qmax was 22 (range 7-35), 34,4 cm3 (range 21–70 cm3), 37,3° (range 25°–55°), and 10,5 mL/s (range 4,2–17,9 mL/s), respectively. Pearson’s correlation analysis showed that PUA was not significantly correlated with IPSS (p = 0,117), Qmax (p = 0,434), total prostate volume (p = 0,213). Patients with increased PUA (PUA &gt; 35°) had higher incidence and degree of BOO (p &lt; 0,05). Conclusion: PUA may be one method to assess the presence of BOO in men with LUTS associated BPH. Our investigation suggest that PUA may help in the treatment of individuals by better predicting their likely classification from a pressure-flow study.Keywords: Prostatic urethral angle, benign prostatic hyperplasia, lower urinary tract symptoms, bladder outlet obstruction.
ESWL FOR RENAL AND URETERAL STONES Ridha, Muhammad; Soebadi, Doddy M.
Indonesian Journal of Urology Vol 21 No 1 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i1.27

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Objective: To report patient characteristics and results of Huikang HK-V extracorporeal shockwave lithotripsy (ESWL) machine for renal and ureteral stones. Material &amp; methods: We retrospectively analyzed medical records of all patients treated with ESWL using HK-V deviceat Department ofUrology Soetomo Hospital from May2011 - February 2012. Results: There were 241 selected patients, consisted of 148 men (61.4%) and 93 women (38.6%). Mean age was 47.8 years (range 7-87). ESWL was conducted to 130 single stones and 111 multiple stones, using fluoroscopy as guidance for 166 patients, ultrasound for 31 patients (12.9%) and both for 44 patients (18.3%). Stone location was 109 in lower pole(41%), 69 in middle pole(26%), 41 in proximal ureter (16%), 28 in upper pole (11%), 14 at renal pelvis (5%), 1 at distal ureter(0.3%) and 2 staghorn stone (0.7%).There were 130 patients with stone less than 10 mm (53.9%), 102 with stone 10-20 mm (42.3%), and 9 more than 20 mm (3.7%). There were slightly more left-sided treatment was 141 patients (58.5%). Of 181 patients with hydronephrosis (75%), 104 had DJ stent inserted (43.2%). Overall, we found 158 patients (65.5%) were stone free after treatment, 49 patients (20.3%) with residual stones less than 4 mm and 34 patients (14.1%) had more than 4 mm residuals. Conclusion: ESWL is the treatment of choice for simple renal and ureteral stones less than 20 mm (opaque and non opaque).Keywords:Extracorporeal Shockwave Lithotripsy, renal stones, ureteral stones.
CORRELATION OF ROUTINE URINE CULTURE AND STONE CULTURE TO POST-OPERATIVE SIRS Indrawan, Taufik; Hardjowijoto, Sunaryo; Soebadi, Doddy M.; Juniastuti, Juniastuti; Budiono, Budiono
Indonesian Journal of Urology Vol 21 No 1 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i1.21

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Objective: This study evaluated the correlation between preoperative urine culture and intraoperative stone culture and the impact of stone culture findings on post-operative systemic inflammatory response syndrome. Material &amp; Method:Patients with kidney stones who underwent percutaneous nephrolithotomy (PCNL) from February to May 2012 were prospectively analyzed. A pre-operative urine culture was obtained in the morning before the operation, fragmented stone collected were cultured in Departement of Microbiology. Patients were monitored closely in the postoperative period for signs of systemic inflammatory response syndrome (SIRS). Results:A total of 33 patients underwent PCNL and examined for urine cultures, stone culture and postoperative SIRS, 15 (45.45%) patients with positive urine culture, 18 patients (54.54%) with positive stone culture but only 1 patient (3.03%) had same pathogen (p = 0.629). Ten patients (55.6%) with positive stone cultures had evidence of systemic inflammatory respose syndrome postoperatively. The calculated stone culture value for sensitivity, specificity, positive predictive value and negative predictive value were 100%, 65.2%, 55.6%, and 100%. Preoperative hydronephrosis (p = 0.003) and operative time (p = 0.001) are identified as the key risk factors for SIRS after PCNL.Conclusion: Positive stone culture are better predictors for SIRS after PCNL. Stone culture examination is an essential in directing the proper antibiotic therapyin patients with SIRS after PCNL.  Keywords: Percutaneous nephrolithotomy (PCNL), urine culture, stone culture, systemic inflammatory response syndrome after PCNL.
ANTIBIOTIC PROPHYLAXIS WITH DIFFERENT ANTIBIOTIC REGIMEN IN PROSTATE BIOPSY PATIENTS Wibisono, Dimas Sindhu; Soebadi, Doddy M.; Soetojo, Soetojo; Budiono, Budiono
Indonesian Journal of Urology Vol 20 No 1 (2013)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v20i1.42

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Objective: To know the incidence of urinary tract infection (UTI) with different antibiotic prophylaxis for transrectal ultrasonography (TRUS) prostate biopsy. Material &amp; Method: The study included 34 patients at Soetomo Hospital Surabaya, who were divided into 2 groups, each group consisting of 17 patients. In the first group patients received 1000 mg of ciprofloxacin orally, in the second group cefotaxime 1000 mg iv was given prior to biopsy. The two groups were compared in terms of UTI incidence as observed from the blood levels of leukocytes, C-reactive protein (CRP) and urine culture 3 days after the procedure. Results: Based on blood leukocyte levels, there was no statistically significant difference between the two groups (p = 0,74 and p = 0,42). So was the comparison of CRP levels. There was no other significant difference found (p = 0,53 and p = 0,27). From the results of urine culture, the ciprofloxacin group had positive urine culture results lower than the cefotaxime group (29,4% : 35,3%), although it was not statistically significant (p = 1,0). Conclusion: Based on the parameters of blood leukocytes levels, CRP and urine culture, there were no differences in the incidence of UTI after biopsy in the two groups.Keywords: TRUS prostate biopsy, UTI, ciprofloxacin, cefotaxime.
THE DIAGNOSTIC VALUE OF PROCALCITONIN FOR EARLY DETECTION OF UROSEPSIS Nasution, M. Andriady S.; Hardjowijoto, Sunaryo; Soebadi, Doddy M.; Aryati, Aryati; Pujiraharjo, Widodo J
Indonesian Journal of Urology Vol 19 No 1 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i1.53

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Objective: To study procalcitonin as an early and accurate marker for urosepsis. Material & Method: We performed a diagnostic study of procalcitonin, CRP and peripheral blood leucocyte in 21 patients. Patients included 12 urosepsis patients with urosepsis, and 9 trauma patients without urosepsis. This study was conducted from September 2010 to December 2010. Results: Mean and standard deviation of procalcitonin level in urosepsis patients was 27,9 ± 30,7 ng/ml, CRP was 8,9 ± 7,9 mg/l and blood leucocyte was 15125,0 ± 8969,9 mm3. Sensitivity of procalcitonin in diagnosis of urosepsis was 83,3%, specificity was 77,8%, positive predictive value was 83,3%, negative predictive value was 77,8%, positive odds ratio was 3,75 and negative odds ratio was 0,2. Diagnostic value of procalcitonin was better compared to CRP and blood leucocyte. In the receiver operating characteristics (ROC) plot, area under the curve (AUC) for procalcitonin, blood leucocyte, and CRP were 0,806 (95% CI = 0,607 – 1,004), 0,773 (95% CI = 0,568 – 0,979), and 0,602 (95% CI = 0,341 – 0,863), respectively. Conclusion: Procalcitonin is an early marker for urosepsis cases with better diagnostic value than CRP and blood leucocyte. Keywords: Urosepsis, Procalcitonin, CRP, Blood Leucocyte.
Peningkatan Keterampilan Konseling Kelompok Keluarga Berencana Pria Menggunakan Alat Bantu di Propinsi Jawa Timur Rizalanda, Sofyan; Soebadi, Doddy M.; Sustini, Florentina
JPMB : Jurnal Pemberdayaan Masyarakat Berkarakter Vol 2 No 1 (2019): Januari-Juli
Publisher : Pusat Penelitian dan Pengembangan Rekarta Mataram

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Abstract

Abstrak: Kegiatan ini dilaksanakan melalui kerjasama dengan Kelompok Keluarga Berencana Pria di Propinsi Jawa Timur. Adapun tujuannnya adalah untuk menyelesaikan masalah yang dihadapi oleh Kelompok Keluarga Berencana Pria di Propinsi Jawa Timur, yaitu terbatasnya pengalaman dan bekal untuk memberikan konseling kepada calon peserta vasektomi yang ada di wilayahnya. Permasalahan tersebut menjadi salah satu penyebab rendahnya kesertaan vasektomi di Propinsi Jawa Timur. Hasil pelaksanaan kegiatan menunjukkan bahwa, pemberian pelatihan konseling dan peralatan pendukung konseling vasektomi dapat meningkatkan kemampuan konseling para ketua kelompok Keluarga Berencana Pria, sehingga hal tersebut meningkatkan jumlah peserta vasektomi. Alat pendukung konseling yang paling banyak menarik peserta vasektomi adalah manekin/boneka tiruan dari organ kelamin pria.Abstract: This activity was carried out in collaboration with the Men's Family Planning Group in East Java Province. The purpose was to solve the problems faced by the Male Family Planning Group in East Java Province. They were limited experience and provisions to provide counseling to prospective vasectomy participants in their area. They were some of the causes of low vasectomy in East Java Province. The results of the implementation of the activity show that the provision of counseling training and supporting equipment for vasectomy counseling improve the counseling capacity of the leaders of the Men's Family Planning group, so that they increase the number of vasectomy participants. The counseling supporting tools that attracts most vasectomy participants is mannequins / artificial dolls from the male genital organs.