Muchlis Achsan Udji Sofro
2Staf Pengajar Bagian Ilmu Penyakit Dalam FK UNDIP/RSUP Dr. Kariadi Semarang

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Leucine Intake as Determinant of Muscle Strength and Gait Speed in the Elderly Ratmawati, Ratmawati; Fatimah-Muis, Siti; Sofro, Muchlis Achsan Udji
Jurnal Gizi dan Pangan Vol. 15 No. 1 (2020)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.321 KB) | DOI: 10.25182/jgp.2020.15.1.19-26

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The purpose of this study was to analyse the intake of leucine as a determinant of muscle strength and gait speed in the elderly. This research is a cross-sectional study that involved 132 elderly people in the community (34 men and 98 women), aged 60–69 years. Data were obtained from interviews, physical examinations (body weight, body height, muscle mass, muscle strength, and gait speed), as well as food recall 3x24 hours. The statistical analysis employed Pearson’s correlation coefficient and multiple linear regression. Intake of leucine was positively correlated with muscle strength (r=0.3; p<0.001) and gait speed (r=0.244; p<0.05). It was not inta
PENGARUH SUPPLEMENTASI PROBIOTIK DAN SELENIUM TERHADAP RESPON IMUN NLR (NEUTROPHIL LYMPHOCYTE COUNT RATIO) , HAEMOGLOBIN DAN ALBUMIN PADA TIKUS WISTAR YANG DIINDUKSI MYCOBAKTERIUM TUBERCULOSIS Widiastuti, Yuliati; S.S, Darmono; Sofro, Muchlis Achsan Udji
Journal of Nutrition College Vol 8, No 1 (2019): Januari 2019
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.066 KB) | DOI: 10.14710/jnc.v8i1.23811

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Latar belakang : Penyakit    tuberkulosis  (TBC)  paru   merupakan masalah   kesehatan masyarakat global termasuk   Indonesia. Penyakit tuberkulosis paru pada umumnya terjadi malnutrisi akibat efek samping obat anti tuberculosis, yang menyebabkan gangguan saluran cerna dan respon imunitas. Probiotik dan Selenium diduga memiliki efek menguntungkan respon imunitas dan status gizi pada pasien terinfeksi tuberculosisTujuan : Untuk menganalisis pengaruh pemberian suplementasi probiotik dan selenium  terhadap NLR ( Neutrophill Ratio Lymphocyte ), Hemoglobin dan Albumin pada tikus wistar yang diinduksi Mycobacterium tuberculosis.Metode : Penelitian eksperimen dengan rancangan Randomized Post test Control Group Design. Dua puluh delapan tikus Wistar dibagi 4 kelompok, kelompok 1 : kelompok kontrol hanya diberikan OAT, kelompok 2 : probiotik + OAT, kelompok 3 : selenium + OAT serta kelompok 4 : probiotik dan selenium + OAT. Setelah diinduksi 14 hari, hewan diberikan perlakuan selama 28 hari. Analisis data menggunakan Anova, Post Hoc atau Kruskal Wallis, Mann Whitney pada tingkat kemaknaan p<0.05. Hasil : Terjadi penurunan kadar NLR, peningkatan kadar Hemoglobin dan Albumin  pada tikus kelompok 1 (p<0.05), kelompok 2 (p<0.05) serta kelompok 3 (p<0.05). Efektifitas pemberian probiotik dan selenium paling kuat terdapat pada NLR, Hemoglobin dan AlbuminSimpulan : Suplementasi probiotik dan selenium selama 28 hari mampu meningkatkan sistem imunitas ( NRL ), Hemoglobin dan Albumin  pada kelompok perlakuan lebih baik dibanding kelompok kontrol.  
Faktor Risiko yang Mempengaruhi Kepatuhaan Terapi Antiretroviral (ARV) pada Pasien HIV/AIDS di RSUD Abepura Jayapura Pariaribo, Konstantina; Hadisaputro, Suharyo; Widjanarko, Bagoes; Sofro, Muchlis Achsan Udji
Jurnal Epidemiologi Kesehatan Komunitas Vol 2, No 1: Februari 2017
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (11858.762 KB) | DOI: 10.14710/jekk.v2i1.3966

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Background: HIV/AIDS is a major problem in many countries. Antiretroviral (ARV) has become the solution for preventing the pandemic disease. This research aimed to find out risk factors, which affected the HIV/AIDS patients adherence to the antiretroviral (ARV) therapy. The research took place at RSUD Abepura in Jayapura.Method: The research applied an analytical observational design with a case control, which was supported by qualitative data. There were 86 respondents involved, consisting of 43 case and 43 control respondents. Samples collection used a Simple Random Sampling. Instruments used for this study were questioners and indepth interviews. Data analysis included univariate and bivariate analyses using a chi-square test. In addition, it also performed a multivariate analysis using logistic regression test.Results: The research found three risk factors that affected the HIV/AIDS patients adherence to ARV: occupation (p = 0.005; OR = 4.472; 95% CI = 1.633-12.245), inaccessibility to health care center (p = 0.008; OR = 3.675; 95% CI = 1.476-9.146), lacking family supports (p=0.013; OR =3.606; 95% CI = 1.398-9.146). Other factors, sex, age, knowledge, apathetic manner,side-effect history, therapeutic tenure, ethnic background, counseling personnel, health care provider attitude, religious approach, alternative medicine intake, and herbal medicine use, did not have significant affects.Conclusion: Factors that affected the ARV therapy adherence were occupation, inaccessibility to health care center, and lacking family supports.
Antiretroviral Side Effects on Adherence in People Living with HIV/AIDS Arisudhana, Gede Arya Bagus; Sofro, Muchlis Achsan Udji; Sujianto, Untung
Nurse Media Journal of Nursing Vol 8, No 2 (2018): (DECEMBER 2018)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.199 KB) | DOI: 10.14710/nmjn.v8i2.20742

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Background: Antiretroviral therapy is a lifelong treatment in people living with HIV/AIDS (PLWHA). Adherence is the key to the effectiveness of antiretroviral therapy. The administration of antiretroviral has some side effects that may affect patient adherence.Purpose: This study aimed to examine the impacts of antiretroviral side effects on adherence in PLWHA.Methods: This study used a correlational research design. The samples were 78 patients receiving antiretroviral therapy at the tropical disease and infection polyclinic in a hospital in Semarang. Purposive sampling was used to recruit the samples. Data on side effects of antiretroviral were obtained based on the patients’ reports, while data on adherence of pill consumption were obtained through the calculation of pills using pill count adherence rate. The collected data were analyzed using the Fisher’s exact test.Results: Results showed that the side effects of antiretroviral therapy influenced the antiretroviral adherence (p<0.001). Most of the side effects of antiretroviral reported by participants were nausea and dizziness. Some participants also reported weakness, difficult to concentrate, and diarrhea.Conclusion: The side effects of antiretroviral had negative impacts on patients’ antiretroviral therapy adherence. Therefore, nurses and health care providers of PLWHA should be able to recognize and give concern on antiretroviral side effect management.
HUBUNGAN TINGKAT DEPRESI DENGAN KUALITAS HIDUP PASIEN HIV/AIDS DI RSUP.DR.KARIADI SEMARANG Hapsari, Elyana; Sarjana, Widodo; Sofro, Muchlis Achsan Udji
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.46 KB)

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Latar Belakang : Epidemi HIV AIDS saat ini telah melanda seluruh negara di dunia. Semarang adalah penyumbang angka HIV/AIDS terbesar di Jawa Tengah. Penyakit HIV AIDS telah menimbulkan masalah yang cukup luas terhadap individu yang terinfeksi yakni meliputi masalah fisik,sosial, dan emosional. Salah satu masalah emosional terbesar yang dihadapi ODHA adalah depresi. Kasus depresi pada ODHA ini diperkirakan mempunyai frekuensi mencapai 60% dari total kasus depresi yang ada. Depresi yang berkelanjutan akan menyebabkan penurunan kondisi secara fisikdan mental, sehinggasangat berpengaruh terhadap kualitas hidup ODHA.Tujuan : Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara depresi dengan kualitas hidup serta mengetahui apakah terdapat hubungan antara faktor demografi dengan kualitas hidup pasien HIV/AIDS di RSUP Dr. Kariadi Semarang.Metode : Penelitian ini merupakan penelitian observasional denganrancangan penelitian Cross sectiona). Tingkat depresi dan kualitas hidup diukur dari skor pada kuesioner BDI dan WHO-QOL. Sampel penelitian berjumlah 92 orang yaitu pasien HIV/AIDS di Poli Penyakit Tropis dan Infeksi RSUP. Dr. Kariadi Semarang yang memenuhi kriteria inklusi. Teknik pengambilan sampel pada penelitian ini dilakukan dengan metode non probability sampling melalui consecutive sampling. Analisis data penelitian menggunakan uji Chi Square.Hasil : Dari hasil analisis menunjukkan adanya hubungan antara depresi dengan kualitas hidup pada domain lingkungan (p =0,037 , α = 0,05), serta didapatkan pula adanya hubungan antara lama menderita dengan kualitas hidup pada domain psikologis (p =0,009 , α = 0,05).Kesimpulan : Terdapat hubungan yang bermakna antara depresi dengan kualitas hidup pada domain lingkungan dan hubungan yang bermakna antara lama menderita dengan kualitas hidup domain psikologis.
Wanita 30 Tahun dengan Sepsis, Infeksi Kulit dan Jaringan Lunak, dan Obesitas Widinartasari, Franzeska Anna Dewi Mursita; Sodiq, Muhammad Ali; Sofro, Muchlis Achsan Udji
Jurnal Penyakit Dalam Indonesia Vol 4, No 2 (2017)
Publisher : Jurnal Penyakit Dalam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obesitas meningkatkan morbiditas dan mortalitas melalui efeknya terhadap hampir semua sistem kekebalan tubuh manusia. Obesitas memiliki efek terhadap respon imun sehingga meningkatkan kerentanan terhadap infeksi. ß lactamase adalah enzim bakterial yang menginaktivasi antibiotik ß-lactam dengan cara hidrolisis. Salah satu kelompok penghasil ß lactamases, yaitu extended-spectrum ß lactamases (ESBLs), memiliki kemampuan untuk menghidrolisis dan menyebabkan resistensi terhadap berbagai antibiotik terbaru. Manajemen infeksi kulit dan jaringan lunak (skin and soft tissue infection/SSTI) dengan infeksi polimikrobial dan multi drug resistance dapat menjadi suatu masalah yang menantang. Kami melaporkan sebuah kasus mengenai pasien obesitas dengan SSTI polimikrobial. bPasien tersebut menunjukkan tanda dan gejala klinis sepsis dengan gangguan ginjal akut. Dengan resusitasi cairan, pemberian antibiotik dini, dan tindakan bedah, pasien mengalami perbaikan klinis. Kunci untuk manajemen pasien dengan SSTI yang berat memerlukan kewaspadaan awal dan tindakan debridement bedah. Klinisi perlu mempertimbangkan terapi antibiotik empiris kombinasi dini pada SSTI. Kata Kunci: ESBL, infeksi, jaringan lunak, kulit, obesitas, saluran kencing, sepsis  A 30 Years Old Woman with Sepsis, Skin and Soft Tissue Infection, and ObesityObesity increases morbidity and mortality through its multiple efects on nearly every human system. Obesity has efect on the immune response which leads to susceptibility to infections. ß lactamases are bacterial enzymes that inactivate ß-lactam antibiotics by hydrolysis. One group of ß lactamases, extended-spectrum ß lactamases (ESBLs), have the ability to hydrolyse and cause resistance to various types of the newer ß-lactam antibiotics. The management of skin and soft tissue infection with polymicrobial infection and multi drug resistance can be challenging problem. We present a case of an obese patient with polymicrobial SSTI. bPatient showed clinical sign of sepsis with acute kidney injury. With fluid rescucitation, early antibiotic administration and surgical treatment, she gained clinical improvement. The key to successful management of patients with severe skin and soft tissue infection are early recognition and complete surgical debridement. Clinicians need to consider appropriate early empirical antibiotic combination therapy coverage or the use of combination therapy to treat SSTI.
EFFECT OF CONSUMING RED DRAGON FRUIT (HYLOCEREUS COSTARICENSIS) JUICE ON THE LEVELS OF HEMOGLOBIN AND ERYTHROCYTE AMONG PREGNANT WOMEN Widyaningsih, Ari; Setiyani, Onny; Umaroh, Umaroh; Sofro, Muchlis Achsan Udji; Amri, Faisal
Belitung Nursing Journal Vol 3, No 3 (2017): May-June 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.204 KB) | DOI: 10.33546/bnj.97

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Background: Iron deficiency is the most common cause of anemia during pregnancy. Red  dragon fruit is assumed having much iron to increase hemoglobin and erythrocyte level.Objective: This study aims to examine the effect of dragon fruit juice on levels of hemoglobin and erythrocytes. Methods: This was a quasi experimental research with non-equivalent control group design. There were 34 respondents recruited in this study using consecutive sampling. The samples were divided into intervention group (17 respondents) and control group (17 respondents). Data were analyzed using Independent t-test and Paired t-test.Results: There was a statistically significant effect of red dragon fruit juice Hb level on the 7th day of intervention with p-value 0.037 (<0.05), but there was no significant effect on hemoglobin level in the 14th day of intervention with p-value 0.140 (>0.05). This study also revealed that there was a statistically significant effect of red dragon fruit juice on pregnant women's erythrocyte level on the 7th day with p-value 0.025 (<0.05), but there was no significant effect on the erythrocyte level in the 14th day of intervention with p-value 0.094 (> 0.05). Conclusion: There was a statistically significant effect of red dragon fruit juice on hemoglobin and erythrocyte levels. This study provides the insight of knowledge that the red dragon fruit juice can be an alternative treatment to deal with anemia among pregnant women.
Pengaruh pemberian ekstrak daun Alfalfa (Medicago sativa) terhadap profil lipid dan kadar malondialdehida tikus hiperkolesterolemia Darni, Joyeti; Tjahjono, Kusmiyati; Sofro, Muchlis Achsan Udji
Jurnal Gizi Klinik Indonesia Vol 13, No 2 (2016): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22750

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Background: Hypercholesterolemic as an indicator of cardiovascular disease is a major cause of morbidity and mortality in the world. Increased oxidative stress in hypercholesterolemic triggers lipid peroxidation effect directly on the cell membrane damage and initiate various diseases. The use of natural materials with relatively few side effects is an hypercholesterolemic management alternative. Experimental studies showed that Alfalfa leaf extract had an effective antioxidant activity.Objective: To determine the effect of Alfalfa leaf extract on serum lipids and malondialdehyde (MDA) level of hypercholesterolemic rats.Method: Pre-posttest randomized control group used twenty-eight male Sprague-Dawley rats were randomly divided into four groups, hypercholesterolemic without treatment (control), hypercholesterolemic with extract at dose 20 mg/200 g/d (X1), dose 40 mg/200 g/d (X2), dose 60 mg/200 g/d (X3) for 21 days after the rats got hypercholesterolemic. Serum lipid was measured by CHOD-PAP method and level of MDA plasma was measured by TBARS method. A hypothesis test was analyzed by One Way ANOVA continued by Post hoc LSD test.Results: Alfalfa extract significant decrease in serum total cholesterol (114.18±3.0 mg/dl; p<0.001). LDL cholesterol level was the lowest in group X3 (45.26±6.03 mg/dL; p<0.001), and triglycerides level was the lowest in group X3 (77.33±2.69 mg/dL; p<0.001). There were no differences in MDA plasma level was the lowest in the group X3 (2.07±0.09 nmol/ml; p<0.001) and a significant increase in serum HDL cholesterol (43.21±7.80 mg/dL; p<0.001).Conclusion: The treatment of Alfalfa (Medicago sativa) leaf extract gives an effect of lower total cholesterol, LDL cholesterol, triglycerides, MDA and gives an effect higher HDL cholesterol.
Pemberian kombinasi probiotik dan zinc terhadap perubahan kadar hemoglobin, albumin, dan indeks massa tubuh pada pasien tuberkulosis paru Arifah, Meika Rahmawati; Darmono, Darmono; Sofro, Muchlis Achsan Udji
Jurnal Gizi Klinik Indonesia Vol 13, No 1 (2016): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.23024

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Background: TB patients are generally the most productive age group and suffer from chronic energy deficiency. Therefore, patients with TB requires a combination of chemotherapy and supplementary feeding as probiotics and zinc to boost the immune response and nutritional status.Objective: To analyze the effect of a combined of probiotics and zinc on the changes of hemoglobin, albumin level, and BMI.Method: This study is a quasi-experimental, randomized design with pre-post test control group involving 52 respondents. They were divided into two groups. The treatment group was given a combination of 1 capsule of probiotics (2 billion probiotics) and zinc 20 mg per day for 28 days. The analysis is paired t-test, independent t-test, Mann-Whitney, Pearson, Spearman, Covariance.Results: There was an increase in hemoglobin (p=0.01), albumin (p=0.01) and BMI (p=0.01). There is no difference between the two groups in the levels of hemoglobin parameter (p=0.21) and BMI (p=0.12), whereas there is a difference parameter albumin levels (p=0.01). The effectiveness of interventions is 4% for hemoglobin levels, 16% to albumin, and 1% for IMT.Conclusion: Probiotics and zinc for 28 days in patients with pulmonary tuberculosis may increase levels of hemoglobin, albumin, and BMI, but there is no significant difference in the changes of BMI. The most powerful influence of intervention effectiveness is on albumin.
Perbedaan Tingkat Stres, Cemas, dan Depresi antara Terapi Efavirenz dengan Nevirapine (Studi Penderita HIV/AIDS di poli VCT-CST RSUP Dr. Kariadi Semarang) Muflihatunnaimah, Muflihatunnaimah; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji
Jurnal Penyakit Dalam Indonesia Vol 5, No 2 (2018)
Publisher : Internal Medicine Department, Faculty of Medicine Universitas Indonesia-RSCM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (479.916 KB) | DOI: 10.7454/jpdi.v5i2.177

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Pendahuluan. Terapi Antiretroviral (ARV) terbukti bermanfaat untuk mengurangi kemunduran sistem imunitas penderita HIV/AIDS. Jenis terapi ARV yang diberikan adalah Efavirenz (EFV) dan Nevirapine (NVP) yang memiliki efek samping neuropsikiatri seperti stres, cemas, dan depresi. Studi ini dilakukan untuk mengetahui perbedaan tingkat stres, cemas dan depresi antara terapi Duviral (Zidovudin dan Lamivudin) dan EFV dengan Duviral (Zidovudin dan Lamivudin) dan NVP pada penderita HIV/AIDS.Metode. Jenis penelitian yang digunakan berupa penelitian observasional dengan desain cross sectional. Pengambilan sampel dilakukan dengan cara consecutive sampling. Data penelitian didapatkan dari kuesioner data demografi dan DASS. Sampel yang digunakan adalah 130 pasien rawat jalan HIV/AIDS di poliklinik VCT-CST RSUP Dr. Kariadi Semarang.Hasil. Berdasarkan penelitian yang dilakukan, diketahui hasil uji beda rerata tingkat stres antara terapi EFV dengan terapi NVP dengan nilai p=0,048 (p<0,05). Tidak ada perbedaan tingkat cemas dan depresi antara terapi EFV dengan terapi NVP dengan nilai p=0,166 (p>0,05) dan nilai p=0,104 (p>0,05).Simpulan. Terdapat perbedaan bermakna tingkat stres antara terapi EFV dengan NVP, dan tidak ada perbedaan bermakna tingkat cemas dan depresi antara terapi EFV dengan terapi NVP pada penderita HIV/AIDS di RSUP Dr. Kariadi Semarang.Kata Kunci: Cemas, Depresi, Duviral, EFV, HIV/AIDS, Nevirapine, Stres The Distinction in Level of Stress, Anxiety, and Depression between Efavirenz with Nevirapine Therapies (Study on HIV/AIDS-infected patients at VCT-CST clinic Dr.Kariadi Hospital Semarang)Introduction. Antiretroviral therapy (ARV) has been proved useful to reduce the deterioration of the immune system on HIVAIDS-infected patients. EFV and NVP therapy primarily can cause neuropsychiatric side effects, particularly stress, anxiety, and depression. This study aimed to identify the distinction in levels of stress, anxiety, and depression between Duviral (Zidovudin dan Lamivudin) and EFV with Duviral (Zidovudin dan Lamivudin) and NVP therapy in HIV/AIDS-infected patients in Dr. Kariadi Hospital Semarang. Methods. This is an analytical observational study with cross-sectional approach. The subjects were taken using consecutive sampling method. The data used in this study was obtained from demographic data questionnaire and DASS. Samples were outpatients HIV/AIDS in VCT-CST clinic RSUP Dr. Kariadi Semarang. Results. The mean result in stress levels between Efavirenz with Nevirapine therapy was p=0.048 (p<0.05). No significant differences were found in the level of anxiety and depression between Efavirenz with Nevirapine therapy; p-value was 0.166 (p>0.05) and 0.104 (p>0.05), respectively. Conclusions. There was a significant difference in stress levels between EFV with NVP therapy, but no significant differences were found in the level of anxiety and depression between EFV with NVP therapy on HIV/AIDS-infected patients at Dr. Kariadi Hospital Semarang.