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Journal : YARSI Medical Journal

EFFECTS OF STROBILANTHES CRISPUS EXTRACT ON THE APOPTOTIC PATHWAY OF HUMAN LIVER CARCINOMA CELL LINES Endrini, Susi; Suherman, Suherman; Rahmat, Asmah; Ismail, Patimah; Taufiq-Yap, Y.H; Othman, Fauziah
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v15i1.998

Abstract

Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effectof S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.
Co-Authors Abdullah Abdullah Abram, Paulus H Abram, Paulus Hengky Abubakar, Muhammad Silmi Hi Achi Rinaldi, Achi Achmad Praptijanto Agus Jatmiko, Agus Ahmad, Defri Ahmad, Defri Akhsan Akib, Akhsan Akmarina, Wina Amalia, Iin Ambar Yuswi Perdani, Ambar Yuswi Andi Nuddin Andi Tanra Tellu Andika Eko Prasetiyo, Andika Eko Andrian Haro, Andrian Anggraeni, Atika Dhiah Anggraeni, Sri Prastiti Kusuma Anggraini Puspita Sari Anif Rizqianti Hariz Anis Fataturrohmah, Anis Anisa, Risa Arifin Nur Arridho, Rizky Gunawan Aryanti R, Dwi Aryza, Solly Aryza, Solly Asmah Rahmat Asmara, Nur Asmaul Husna Badrujaman, Aip Badrujaman, Aip Baharuddin Hamzah Bakhtiar Bakhtiar Bakti Jos Bambang Dwi Argo Bambang Sri Anggoro Bambang Tri Nugroho Bambang Wahono Bertus, M. Yusi Prilina Buhaerah Buhaerah, Buhaerah Cholyubi Jusuf Dalimunthe, Sholatia Desti, Etti Devi, Monica Shinta Diah Ratu Sari Harahap, Diah Ratu Sari Dian Widi Astuti, Dian Widi Didi D. 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