Taniawati Supali
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta.

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Treatment of Wuchereria kalimantani infection in Presbytis cristata with a single dose of CGI 18041 Supali, Taniawati; Rukmono, Bintari; Wibowo, Heri; Ekarina, Rita; Kurniawan, Agnes; Wardhani, Endang S.; Purnomo, Purnomo; Haerani, Tjahaya; Partono, Felix
Medical Journal of Indonesia Vol 6, No 1 (1997): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.467 KB) | DOI: 10.13181/mji.v6i1.800

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[no abstract available]
HUBUNGAN ANTARA INFEKSI CACING DAN ALERGI Yolazenia, Yolazenia; Supali, Taniawati; Wibowo, Heri
Jurnal Ilmu Kedokteran Vol 4, No 2 (2010): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (39.246 KB) | DOI: 10.26891/JIK.v4i2.2010.71-78

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Many researches showing the evidence of a reverse relation between helminthiasis and allergic diseases in tropicaldeveloping countries, supported by hygiene hypothesis. There is relationship between the inflammation caused byallergic and helminthiasis. Both, allergic and helminthiasis, show the increase of IgE level, eosinophilia, mastocytosis,and release of IL-4, IL-5 and IL-13 cytokines by Th2. Several mechanisms explaining the decrease of allergicmanifestation in people with helminthiasis are polyclonal IgE blocking, suppression of anti-inflammatory cytokines(IL-10 and TGF-â), and IgG4 blocking antibody.
Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 34, No 2 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.121-128

Abstract

BackgroundSoil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.MethodsAn experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. ResultsOf the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). ConclusionsIn children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.
Plasmodium falciparum infection and the risk of anemia in school children Tan, Suriyani; Supali, Taniawati; Wibowo, Heri
Universa Medicina Vol 32, No 2 (2013)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.128-134

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BACKGROUNDAccording to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum. The purpose of the present study was to determine any association between Plasmodium falciparum infection and anemia in school children.METHODSThis was an observational study with cross-sectional approach. A total of 540 whole blood samples of school children after administration of anthelminthic treatment for 30 days, were collected for measurement of hemoglobin concentration and preparation of Giemsa-stained thin and thick blood smears.The species of Plasmodium was confirmed by real-time polymerase chain reaction (PCR). Chi-square and prevalence ratio (PR) tests were used to determine the relationship between Plasmodium falciparum infection and anemia.RESULTSThe prevalence of Plasmodium infection in school children of malarial endemic areas was 3.51%. There were 43 cases of anemia with 41 cases of mild anemia and 2 cases of moderate anemia. Among the 41 mild cases of anemia,Plasmodium falciparum infection was found in only 3 cases. The 2 cases of moderate anemia and the remaining 38 cases of mild anemia were not caused by Plasmodium falciparum infection. Subjects with Plasmodium falciparum infection had a 1.91-fold higher risk of suffering from anemia than subjectswithout Plasmodium falciparum infection, but not significant (PR=1.91; 95% C.I.=0.65-5.62).CONCLUSIONSPlasmodium falciparum infection did not significantly increase the risk of anemia in school children. Efforts to improve strategies for controlling anemia and malaria are needed.
Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Buana, Ria; Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.206-212

Abstract

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.
The profile of codon 200 β-tubulin gene of Ascaris lumbricoides L. and Trichuris trichiura L. from infected people in Nangapanda Sub-district, East Nusa Tenggara Yuliana, Yuliana; Djuardi, Yenny; Supali, Taniawati
Medical Journal of Indonesia Vol 27, No 4 (2018): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.746 KB) | DOI: 10.13181/mji.v27i4.1935

Abstract

Background: The mass administration of anthelmintic such as albendazole is one of the strategies for eliminating soil-transmitted helminth (STH) infection. The widespread and long-term use of anthelmintics can cause resistance. The research on animals shows that factor that the single-nucleotide polymorphism (SNP) codon 200 β-tubulin gene of the worms is one of the factors that can cause the decreased efficacy of anthelmintics. This study aimed to determine the bases of codon 200 in A. lumbricoides and T. trichiura, which infect the people in Nangapanda, East Nusa Tenggara.Methods: The worm samples were obtained from the intestinal helminth-infected patients from Nangapanda Sub-district. The DNA from the worm tissues were isolated, amplificated by polymerase chain reaction (PCR), and sequenced. The sequencing results were aligned to the reference sequence to obtain the codon bases in the 200 β-tubulin gene.Results: TTC constitute the codon bases in the 200 β-tubulin gene found in two A. lumbricoides and one T. trichiura.Conclusion: The SNP codon 200 β-tubulin gene was absent in A. lumbricoides or T. trichiura worms that were examined in this study.
Ende Diabetes Study: diabetes and its characteristics in rural area of East Nusa Tenggara Waspadji, Sarwono; Soewondo, Pradana; Subekti, Imam; Soebardi, Suharko; Harbuwono, Dante S.; Pramono, Laurentius A.; Supali, Taniawati
Medical Journal of Indonesia Vol 22, No 1 (2013): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.721 KB) | DOI: 10.13181/mji.v22i1.517

Abstract

Background: There are only few studies about diabetes in rural area in Indonesia. Epidemiological study are needed to formulate health policy of disease management in specific area. The aim of this study was to find the prevalence of diabetes and knowledge of diabetes among the community in Nangapanda Village, Ende District, East Nusa Tenggara.Methods: A cross-sectional study “Ende Diabetes Study” was conducted in Nangapanda Village. This study use cluster random sampling method to a total number of 19756 residents in Nangapanda village. From the sampling frame of 1800 adult subjects who underwent screening with glucometer in 2008 and 2009, 125 subjects have been diagnosed as diabetes or impaired fasting glucose (IFG). All of the subjects who were diagnosed as diabetes or IFG from the previous screening and 218 subjects from control (normal subjects in the 2008 and 2009 screening) were included in the present study. Each subject underwent general anamnesis, nutritional interview, complete physical examinations, and laboratory test (blood and urine). The data were analyzed using SPSS 13.0.Ressult: There were 343 subjects in this study. The prevalence of diabetes in Nangapanda using blood glucose criteria (using fasting and post-glucose load values) was 2%; using post glucose load criteria, the prevalence of DM was 1.56%; while with HbA1c criteria, the prevalence was 2.83%. The prevalence of impaired glucose tolerance (IGT) was 2.2%, and IFG was 6.2%. A number of 71.1% Nangapanda residents have sufficient knowledge about diabetes.Conclusion: Prevalence of diabetes in Nangapanda (using fasting and post-glucose load criteria) was 2% and 1.56% (using post-glucose load values). As much as 71.1% of Nangapanda residents have sufficient knowledge about diabetes. (Med J Indones. 2013;22:30-8)Keywords: Diabetes mellitus, Ende Diabetes Study, prevalence, rural Indonesia
HUBUNGAN INFEKSI CACING USUS DAN ATOPI PADA ANAK SEKOLAH DASAR Harminarti, Nora; Supali, Taniawati; Wibowo, Heri
Majalah Kedokteran Andalas Vol 32, No 1: April 2008
Publisher : Faculty of Medicine Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22338/mka.v32.i1.p56-69.2008

Abstract

AbstrakPeningkatan kasus alergi di wilayah yang berhasil menurunkan infeksi keca-cingan dibandingkan dengan yang infeksi kecacingannya masih tinggi membuat hubungan respon imun terhadap infeksi cacing usus dan alergi sangat penting untuk dipelajari. Hal ini di dukung oleh laporan mengenai rendahnya prevalensi atopi pada penderita infeksi cacing usus akibat kemampuan cacing memodulasi respon IgE poliklonal yang dapat menekan atopi/alergi. Adanya laporan kontroversial dengan hasil yang sebaliknya menjadikan hubungan cacing dan alergi semakin menarik untuk dipelajari lebih lanjut. Penelitian ini bertujuan untuk mengetahui hubungan infeksi cacing usus dengan manifestasi atopi pada anak Sekolah Dasar di desa Anaranda dan Nangapanda, kabupaten Ende, Flores, Nusa Tenggara timur (NTT). Atopi dilihat dari tes uji kulit (skin prick test) yang positif terhadap aero-allergen (tungau debu rumah dan kecoa) dan food-allergen (kacang). ELISA digunakan untuk menentukan kadar IgE total. Di Anaranda lebih banyak ditemukan atopi (80,0%) dan infeksi cacing usus (75,6%) dibandingkan dengan Nangapanda yang prevalensi atopi 61,8% dan cacing usus 65,5%.Tidak ditemukan pengaruh infeksi cacing usus terhadap atopi (p=0,469). Kadar IgE total secara signifikan lebih tinggi pada yang atopi (p=0,031), sedangkan pada yang terinfeksi cacing usus tidak berbeda bermakna (p=0,607). Dari penelitian ini dapat disimpulkan infeksi cacing usus tidak mempengaruhi manifestasi atopi pada anak-anak Sekolah Dasar di daerah endemis cacing usus.Kata kunci: infeksi cacing usus, atopi, IgE total, anak Sekolah DasarAbstractThe reports of increasing allergy in areas of decreased helminth infestation compared with the endemic areas make the study of the correlation between helminth infestations and allergy very important. It is also supported by researchers showing that low atopy prevalence in helminth infested humans is caused by helminth ability in modulating IgE polyclonal response which could suppress atopy/allergy. On the contrary, some researchers also show different results and make this correlation interesting for further study. This study aimed to determine relationship between helminth infestation and atopy in school children in Anaranda and Nangapanda villages at Ende district, Flores, Nusa Tenggara Timur (NTT). Helminth infestation status was determined by microscopic examination, while skin prick test was performed to study the prevalence of atopy for aeroallergen (mite and cockroach) and food allergenARTIKEL PENELITIAN59(peanut). ELISA was used to determine the titer of total IgE. Atopy is more prevalent in Anaranda (80.0%) where helminth infestation was also higher (75.6%), while in Nangapanda atopy is 61.8% and helminth prevalence is 65.5%. We found no impact on intestinal helminth infection to atopy (p=0.469). Total IgE titer is significantly higher in atopic children (p=0.031) while not significantly different in intestinal helminth infested children (p=0.607). We conclude that intestinal helminth infestation does not affect atopy manifestation in elementary school children in endemic area.Keywords: Intestinal helminth infection, atopy, Total IgE, elementary school children
PERBANDINGAN UJI DIAGNOSTIK MINI FLOTAC DENGAN KATO-KATZ SEBELUM DAN SESUDAH PENGOBATAN ALBENDAZOL DOSIS TUNGGAL PADA ANAK YANG TERINFEKSI CACING USUS Sari, Monica Puspa; Supali, Taniawati; Wibowo, Heri
Jurnal Kedokteran Meditek Vol. 21 No. 55 Januari - April 2015
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

AbstrakUntuk memantau pengobatan anthelmintik, diperlukan teknik pemeriksaan yang lebih akurat dan sensitif dibandingkan dengan  Kato-Katz yang merupakan teknik standar yang ada saat ini.  Penelitian ini merupakan uji diagnostik yang dilakukan terhadap anak sekolah dasar dilakukan pada bulan Maret 2013 di Kelurahan Kalibaru, Kecamatan Cilincing, Jakarta Utara. Sampel tinja diperiksa menggunakan metode Kato-Katz dan Mini FLOTAC sebelum dan sesudah  pemberian obat albendazol 400 mg dosis tunggal pada hari ke 7,14, dan 21. Dari 209 subyek penelitian, terjaring 197 subyek yang bersedia ikut serta.  Sebelum pengobatan, sensitivitas dan NPV (negative predictive value)   Kato-Katz     dan  Mini FLOTAC masingâ??masing 94%, 96%  dan 81%, 88% terhadap infeksi A. lumbricoides. Terhadap T. trichiura 88%, 92% dibandingkan Mini FLOTAC 100%. Nilai kappa agreement antara teknik Kato-Katz dan Mini FLOTAC adalah 0.773 untuk diagnosis infeksi A. lumbricoides dan 0.895 untuk  infeksi T. trichiura. Terhadap Ascaris,  19.79% tergolong infeksi ringan dengan Kato-Katz. Sedangkan 25.88% tergolong infeksi ringan dengan Mini FLOTAC. Terhadap Trichuris,  34.51% tergolong infeksi ringan dengan Kato-Katz dan 42.13% tergolong infeksi ringan dengan Mini FLOTAC. Setelah diberikan pengobatan, Kato-Katz lebih sensitif dibandingkan  Mini FLOTAC dalam mendeteksi infeksi A. lumbricoides, terutama pada hari  7 dan 14 dan sebaliknya Mini FLOTAC lebih sensitif terhadap infeksi T. trichiura.Teknik Mini FLOTAC dapat dipakai sebagai alternatif dari teknik Kato-Katz dalam mendeteksi infeksi cacing usus dan lebih sensitif mendeteksi T. trichiura dibanding Kato-Katz.  Kata Kunci : Kato-Katz, Mini FLOTAC, Albendazol, Infeksi cacing usus  Abstract            To monitor anthelmintic treatment, will require examination techniques that are more accurate and sensitive than the Kato-Katz technique which is the current standard. This study is a diagnostic examination performed on primary school children. It was conducted in March 2013 in   Kalibaru village, Cilincing Sub-District, North Jakarta. Stool samples were examined using the Kato-Katz  and Mini FLOTAC methods on day 7,14, and 21 after the administration of a single dose of 400 mg albendazole. Of the 209 study subjects, 197 subjects were willing to participate. Before treatment, the sensitivity and the NPV (negative predictive value) against A. lumbricoides infection were 94%,96%, respectively for Kato-Katz and 81%, 88%, respectively for Mini FLOTAC. For T. trichiura, sensitivity and the NPV of Kato-Katz were 88%, 92%, respectively,while for Mini FLOTAC both values were 100%. Kappa value of agreement between Kato-Katz and Mini FLOTAC techniques was 0.773 for the diagnosis of A. lumbricoides infection and 0.895 for T. trichiura. For Ascaris, 19.79% versus 25.88% of infected children have light infection by Kato-Katz and Mini FLOTAC, respectively. For Trichuris, 34.51% versus 42.13% of infected children have light infection with Kato-Katz and Mini FLOTAC, respectively. After the treatment was given,  Kato-Katz  was more sensitive compared to Mini FLOTAC in detecting A. lumbricoides infection, especially at day 7 and day 14. On the contrary, Mini FLOTAC was more sensitive in detecting T. trichiura infection. The Mini FLOTAC technique can be used as an alternative for Kato-Katz in detecting  helminth infections. Mini FLOTAC was more sensitive to detect T. trichiura compared to Kato-Katz.  Keywords  :  Kato-Katz, Mini FLOTAC, Albendazole, Soil transmitted helminthes