Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

The Effect of Curcumin on Regression of Liver Fibrosis through Decreased Expression of Transforming Growth Factor-β1 (TGF-β1) Supriono, Supriono; Nugraheni, Asri; Kalim, Handono; Eko, Mudjiwijono Handaru
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.463

Abstract

BACKGROUND: Transforming growth factor (TGF)-β1 has a pivotal role in liver fibrogenesis. Curcumin effectively prevent the progression of liver fibrosis through inhibition of TGF-β1/Sma and drosophila MAD (Smad) signaling pathway. However, the role of curcumin in the regression of liver fibrosis is still unknown. This study investigated the role of curcumin and TGF-β1 in liver fibrosis regression.METHODS: An experimental Wistar rat model included 6 treatment groups as well as positive and negative control groups. The treatment and positive control groups were injected with carbon tetrachlorid (CCl4) for 9 weeks to induce liver fibrosis. After cessation of injection, 3 of the treatment groups were given curcumin and 3 were given carboxymethylcellulose (CMC) for 2, 5 and 9 weeks, while the positive control was untreated. The negative control was injected with normal saline. TGF-β1 liver tissue levels were analyzed by ELISA, while the TGF-β1 expression in liver cells was analyzed by immunohistochemical assay. The metavir score was used to assess the degree of liver fibrosis. Values of p<0.05 were regarded as statistically significant.RESULTS: Nine weeks of CCl4 injection induced liver fibrosis (metavir F3); and significantly increased TGF-β1 levels and expression in tissues (p=0.00, p=0.021, respectively). Curcumin administration decreased levels and expression of TGF-β1 in the liver and accelerated regression of liver fibrosis. There was a significant correlation between duration of administration of curcumin with an expression of TGF-β1 in the liver tissue (r=0.87; p<0.00).CONCLUSION: Curcumin accelerates regression of liver fibrosis, likely through decreasing of TGF-β1 expression in the liver.KEYWORDS: curcumin, TGF-β1, liver fibrosis regression, CCl4, animal model
Co-Authors ., Yudi Fikra ?kananda, Aj?ng Divi? Abdi, Lulus Prasetyo ACHMAD RIFAI Agus Dwi Atmoko Al-Musadieq, . Amanda, Ayulia Andreas Andreas Anggrainy, Agnes Christy Anugrah, Rita Ardelia, Ardelia Azalia, Rahmanita Baskara, Andika Yoga Bogi Pratomo Budi Herlianto Danis Imam Bachtiar Diana, Dinda Mei Dwi Anita, Desy Melania edy susanto Eko, Mudjiwijono Handaru Elza Zuhry Enni Savitri Faida, Annisa Nur FANDI ACHMAD Fathoni, Rinaldy Achmad Roberth Febriyan, Firman Fitria Sari, Syahra Ariesta Gurindawangsa, Saga Ardian Gustria, Dendy Derganata Handono Kalim Harijono Achmad Hedayanti, Nor Hendri, Nur Agus Willy Herawan, Bagus Nur I Ketut Wiryajati I Nyoman Wahyu Satiawan Ida Bagus Fery Citarsa Ihsan, Dinda Juniantoko, Ardy Dwi Kesuma, Nurmalaika Ayuni Kriestian, Muhammad Kusumasari, Angelina Diah L?stari, Im?yla ?knis Maharani, Aulia Devi Manggala, Bhirawa Marzuki, Mochammad Jalalul Mochammad Al Musadieq Mukaromah, Nazilatul Mukhammad Kholid Mawardi Mustaring Mustaring Najamudin Najamudin Narindra, Raka Argiansyah Arya Nаdiyаh, Inаs Аrfiеny Hаlimаtus Noraimah, Noraimah Nugraheni, Asri Nurbaiti Nurbaiti Nurisa, Fadhila Oktavia, Miftahur Rohmah Pang?stu, R?gina H?idy Pangestuti, Edriana Praja, Dedy Indra Pratama, Rilian Pratiwi, Septhea Dwi Pratomo, Bramantyo Wahyu Prayunantyo, Bintan Purboningrum, Elok Lestyani Puspita Sari, Ika Septiana Putra P., Andika Restu Putra, Firmansyah Dwi Putri, Azizah Dwiyana Rakhmawati, Rizka Ramadhanu, Arizky Kautsar Ramadhany, Fitriana Fajrin Restu Agusti Rizaldy, Mohamad Rizki Yudhi Dewantara, Rizki Yudhi Rizky Amelia Sakinah, Mazidatus Salsabiila, Adhinta Salsabila, Khansa Sanchia Sariayu, Martha Vira Seno D. Panjaitan Shidqi, Mu’adz Simamora, Bambang Petrus Sitanggang, Christina Rimbun S L Solekhah, Puput Sri Herianingrum, Sri Subandi, Mukhamad Suharyono Suharyono Suksmadana, I Made Budi Surya, R.Adri Satriawan Syahputra, Reza Dimas Syifa Mustika Tarsono Tarsono Topowijono, Topowijono Topowijono, Topowijono Triwiyana, Komang Pandu Tsabit, Muchtar Waty, Septi Ambar Wibowo, Bogi Pratomo Wilujeng, Ulya Hasna Yanti, Novrika Yesi Mutia Basri Yovianingtyas, Clarissa Yudhakusuma, Ahmad Iradat Yulius Duma Zahra, Wiyadindi Novian Zakiyah Zakiyah Zirman Zirman, Zirman Zulkifli, Fahmy