Endang Sutedja
Departemen Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

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AKTIVITAS DEPIGMENTASI FRAKSI N-HEKSANA BUAH MALAKA (PHYLLANTHUS EMBLICA) PADA SEL MELANOSIT MOUSE MELANOMA B16 HINDRITIANI, RETI; SUTEDJA, ENDANG; SETIAWAN, SETIAWAN; SUJATNO, MUCHTAN
Indonesian Journal of Applied Sciences Vol 3, No 1 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/.v3i1.16825

Abstract

AbstractInhibitor of melanin synthesis can be used as depigmenting agent to treat skin hyperpigmentation. Herbal depigmenting agents are increasingly utilized due to their character in inhibiting melanin synthesis without causing melanocyte toxicity. This study was aimed to examine depigmenting activity of n-hexane fraction of Phyllanthus emblica fruit by measuring its melanin synthesisinhibition on melanocyte mouse melanoma B16 cell line. Melanin synthesis inhibition was measured spectrophotometrically by counting the melanin and the activity of tyrosinase. The cytotoxicity of n-hexane fraction on melanocytes was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. This study was conducted on November-December2009 at Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, South Korea. The result of this study indicated that melanin count and tyrosinase activity decreased in a dose-dependent manner of n-hexane fraction of P. emblica fruit (IC50 31.68 and 77.92 ?g/ml, respectively). The viable cells decreased with increasing concentration ofthe n-hexane fraction of P. emblica fruit (LD50 87.39 ?g/ml).Key words: n-hexane fraction, Phyllanthus emblica, depigmenting agent
PENGEMBANGAN FORMULA DAN EVALUASI GEL REJUVENASI DARI ASCORBYL GLUCOSIDE MELALUI SISTEM PENGHANTARAN TEKNOLOGI MACROBEAD® - DEVELOPMENT AND EVALUATION FORMULA GEL REJUVENATION OF ASCORBYL GLUCOSIDE THROUGH TECHNOLOGY DELIVERY SYSTEM MACROBEAD® Handayani, Retty; Sutedja, Endang; Abdassah, Marline Abdassah; Emma Surachman, Emma Surachman
Indonesian Journal of Applied Sciences Vol 4, No 1 (2014)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijas.v4i1.16684

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AbstrakVitamin C dan derivatnya banyak digunakan dalam sediaan kosmetika sebagai pencerah kulit. Pada penelitian ini akan dikembangkan gel rejuvenasi yang mengandung derivat vitamin C ascorbyl glucoside (AA2G) dalam sistem penghantaran macrobead®. Selain sebagai pencerah kulit, AA2G juga dapat dipakai untuk pengelupasan dan peremajaan kulit (rejuvenasi). Persen jeratan ditetapkan terlebih dahulu dengan perbandingan (AA2G: macrobead®) 1:2, 2:2 dan 3:2, basis yang digunakan adalah acrylates copolymer (5%, 10%, 15%) dan alkyl acrylate crosspolymer (0,5%, 1%, 1,5%). Formulasi gel rejuvenasi dibuat dalam variasi konsentrasi AA2G yaitu 1%, 2% dan 3%. Uji efektivitas dilakukan terhadap 30 orang relawan dengan menggunakan punggung tangan bagian kanan. Uji difusi dilakukan selama 360 menit menggunakan sel difusi franz. Hasil penetapan persen jeratan menunjukan perbandingan 1:2 memiliki jeratan terbesar yaitu  88,60%. Basis alkyl acrylate crosspolymer dipilih sebagai basis paling stabil dengan konsentrasi 1%. Hasil penelitian menunjukan tangan yang diolesi formula gel terpilih (1:2) menunjukan perubahan terhadap kulit yaitu kulit lebih cerah, lebih kencang dan lebih halus dibandingkan tangan kiri sebagai kontrol.  Hasil uji difusi menunjukan bahwa formulasi gel rejuvenasi dapat melintasi membran sebesar 0,12% dalam waktu 360 menit.Kata kunci: ascorbyl glucoside, acrylates copolymer, alkyl acrylate crosspolymer, macrobead®, rejuvenasiAbstractVitamin C and its derivatives are widely used in cosmetics as a skin lightening preparations. This research will be developed rejuvenation gel containing vitamin C derivative ascorbyl glucoside (AA2G) in macrobead® delivery system. Beside as a skin lightening, AA2G can also be used for exfoliation and skin rejuvenation. Percent entrapment set beforehand by comparison (AA2G : macrobead®) 1:2, 2:2 and 3:2, the base used is acrylates copolymer (5%, 10%, 15%) and alkyl acrylate crosspolymer (0.5%, 1.0%, 1.5%). Rejuvenation gel formulation is made in various concentration of AA2G is 1%, 2% and 3% . Effectiveness test is carried out on 30 volunteers by using the back of the right hand. Diffusion test is performed for 360 minutes using a Franz diffusion cell. Determining percent entrapment results showed 1:2 ratio has the biggest trap that is 88.60%. Base alkyl acrylate crosspolymer selected as the most stable base with a concentration of 1%. The results showed that smeared hand gel formula selected (1:2) showed changes in the skin is skin brighter, firmer and smoother than the left hand as a control. The test results showed that the diffusion gel formulation of rejuvenation can traverse the membrane of 0.12% within 360 minutes.Key word : ascorbyl glucoside, acrylates copolymer, alkyl acrylate crosspolymer, macrobead®, rejuvenasi
KARAKTERISASI DAN KEKERABATAN JANGGOT KAI (USNEA SPP.) DI PRIANGAN NOER, IIN SUPARTINAH; RAMLAN, ASENG; SUBARNAS, ANAS; SUTEDJA, ENDANG
Indonesian Journal of Applied Sciences Vol 3, No 2 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/.v3i2.16833

Abstract

AbstractTaxonomic study of beard moss (Usnea spp) at Priangan, was carried out by using morphological, anatomical and chemical's characters. Sample have taken from five area, they are Jayagiri conifer forest (Bandung), Rancakalong conifer forest (Sumedang), Kamojang conifer forest ( Garut), Munjul conifer forest (Ciamis) and Cigorowong conifer forest ( Tasikmalaya). Morphological observation was done on thallus and anatomical observation in medulla, axis and ratio of cortex : medulla : axis. While chemical analysis was conducting by colour test and crystal test. The identification result founded the eleven species, i.e. Usnea baileyi, U.ceratina, U.cornuta, U.filipendula, U. flexilis, U. flexuosa, U.florida, U.glabrata, U.hirta, U. longissima and U. trichodea. Morphological characters that can be used for distinguished of eleven species of Usnea are medulla shape, axisshape, radius of cortex, radius of medulla and diameter of axis. Chemical characters distinguished are reagent K,C, KC and IKI. Based on that characters the key identification have made for Usnea species founded at Priangan and de3scription were arranged for genus and species level. Phenetic analysis done by using NTSY Spc versi 2.0, resulted a Dendrogram which the eleven species of Beard moss can be divided into three branches. The first branch consist of U.baileyi and U.ceratina, the second are U.cornuta, U.flexilis, U.florida, U. flexuosa and U.glabrata and the third branch branch consist of U.filipendula, U.hirta, U.trichodea and U.longissima. Key word : Characterization, relationship, Beard moss, Usnea , Priangan
KADAR INTERLEUKIN-18 PADA KULTUR LIMFOSIT PENDERITA DERMATITIS ATOPIK YANG DISTIMULASI STAPHYLOCOCCAL ENTEROTOXIN B (SEB) Suwarsa, Oki; Sudigdoadi, -; Sutedja, Endang; Idjradinata, Ponpon
Majalah Kedokteran Bandung Vol 47, No 4 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Staphylococcus aureus (S. aureus) mempunyai peranan penting pada patogenesis dermatitis atopik (DA). Peran S. aureus tersebut tidak hanya sebagai pencetus DA, tetapi juga menyebabkan inflamasi kronik. Peran tersebut berhubungan dengan dihasilkannya protein antara lain toksin poten oleh S. aureus, yaitu Staphylococcal enterotoxin B (SEB). Interleukin-18 (IL-18) merupakan regulator penting dari produksi sitokin Th-1 yaitu interferon-? (IFN-?).  Tujuan penelitian ini adalah mengetahui kadar IL-18 pada kultur limfosit pasien DA yang distimulus dengan SEB. Penelitian ini dilakukan pada 20 orang penderita DA (7 laki-laki dan 13 perempuan) dan 20 orang sehat (9 laki-laki dan 11 perempuan) di Rumah Sakit Dr. Hasan Sadikin Bandung, merupakan penelitian eksperimental secara in vitro pada kultur ilmfosit yang distimulus dengan SEB di Laboratorium Penelitian dan Pengujian Terpadu Universitas Gadjah Mada. Terjadi peningkatan kadar IL-18 rata-rata pada kultur limfosit antara sebelum dipapar dan setelah dipapar SEB, baik pada kelompok DA maupun kelompok kontrol. Setelah dilakukan uji statistik perbandingan antara kadar IL-18 rata-rata sebelum dan sesudah dipapar SEB antara kelompok DA dan kontrol, didapatkan hasil kadar IL-18 kelompok DA lebih tinggi bermakna dibanding  dengan kelompok kontrol (p<0,05) sehingga dapat disimpulkan kadar IL-18 meningkat tinggi pada kelompok DA yang dipapar SEB. [MKB. 2015;47(4):249?54]Kata kunci: Dermatitis atopik, interleukin-18 (IL-18), Staphylococcus enterotoxin BInterleukin-18 Levels in Lymphocytes Cultures from Atopic Dermatitis Patients Stimulated by Staphylococcal Enterotoxin BAbstractStaphylococcus aureus (S. aureus) has an important role in the pathogenesis of atopic dermatitis (AD). S. aureus acts as a triggering factor for AD and also causes chronic inflammation. These roles of S. aureus are related to various proteins such as Staphylococcal enterotoxin B (SEB) as a potent toxin. Interleukin-18 (IL-18) is an important regulator of cytokine production of Th-1, which is interferon-? (IFN-?). The aim of this study was to reveal the levels of IL-18 in cultured lymphocytes from AD patients exposed by SEB. This study was conducted on 20 people with DA (7 men and 13 women) and 20 healthy volunteers (9 men and 11 women) in dr. Hasan Sadikin General Hospital. The in vitro experimental study on cultured lympocytes exposed with SEB was performed at the Integrated Research and Testing Laboratory of Gadjah Mada University. The average levels of IL-18 in cultured lymphocytes before and after being exposed to SEB increased both in AD group and control group. After the statistical tests was performed on the ratio of the average levels of IL-18 before and after being exposed to SEB between AD and control groups, it was shown that the levels of IL-18 AD group was significantly higher than the control group (p <0.05). Therefore, it can be concluded that the levels of IL-18 increased higher in AD group exposed by SEB. [MKB. 2015;47(4):249?54]Key words: Atopic dermatitis , interleukin-18, Staphylococcal enterotoxin BDOI: 10.15395/mkb.v47n4.620
Etiology of Allergic Contact Dermatitis based on Patch Test Anggraini, Dita Maulida; Sutedja, Endang; Achadiyani, Achadiyani
Althea Medical Journal Vol 4, No 4 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.12 KB) | DOI: 10.15850/amj.v49n4.1265

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Background: Allergic contact dermatitis is a type of contact dermatitis, whose  prevalence tends to increase every year. Patch test is an important diagnostic test to confirm the disease. The result of patch test can help doctors to perform appropriate treatment.  The aim of the study was to identify  the most frequent allergen causing allergic contact dermatitis based on patch test results.Methods: This was a descriptive retrospective study among patients who underwent patch test at the Dermatology and Venereology Clinic in Dr.Hasan Sadikin General Hospital Bandung, Indonesia from August 1st, 2014 to August 31st, 2015. The patch test result was obtained from the patient’s medical record and recapitulation data. The patient’s medical record would be collected based on inclusion and exclusion criteria. This study also collected demographic data of the patients, including age, sex, and occupation.The collected data were presented using tables.Results: Out of 45 patient’s medical records, 19 patients were male (42.2%) and 26 patients were female (57.8%). Nickel sulphate was the most frequent allergen with 17 sensitization. Thirteen out of 17 patients who were sensitized by nickel sulphate were females. A great majority of the patients were in the age group of 15–44 years. Most of the patients were students (42.2%). Allergic contact dermatitis (64.4%) was the main clinical diagnosis among the patients.Conclusions: The most frequent allergen causes allergic contact dermatitis is nickel sulphate.
A NOSOCOMIAL INFECTION MANIFESTED AS ERYSIPELAS IN PEMPHIGUS FOLIACEUS PATIENT UNDER INTRAVENOUS DEXAMETHASONE TREATMENT Pranata, Achmad Yudha; Gunawan, Hendra; Sutedja, Endang; Suwarsa, Oki; Dharmaji, Hartati Purbo
Indonesian Journal of Tropical and Infectious Disease Vol 6, No 2 (2016)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.292 KB) | DOI: 10.20473/ijtid.v6i2.1992

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Introduction: Puncture wound in diagnostic interventions permits the entry of bacteria into the skin or soft tissue, thus precipitating nosocomial infection, such as erysipelas. There are other risk factors of nosocomial infections including old age, immunosuppressive drugs, and underlying diseases. Pemphigus foliaceus (PF) is an autoimmune disease with corticosteroid treatment as the mainstay therapy, which could cause immunosuppression and predispose patients to infection. The objective of this paper was to report erysipelas as one of the manifestations of nosocomial infection in patients under immunosuppressive therapy. Case: A case of erysipelas acquired on the 9th day of hospitalization in a PF patient underwent intravenous dexamethasone injection, with history of puncture wounds on the previous day on the site of erysipelas was reported. The clinical findings of erysipelas were well defined, painful erythema and edema that felt firm and warm on palpation, with blisters and pustules on top. Gram staining from the pustules and blisters fluid revealed Gram (+) cocci. Patient was given 2 grams intravenous ceftriaxone for 7 days and saline wet compress. Improvement on the erysipelas was seen the day after ceftriaxone injection. The patient was discharged after 12 days of hospitalization with improvement both on the PF and the erysipelas. On the next visit 7 days later, the erysipelas lesion disappeared. Conclusion: Puncture wound and immunosuppresive treatment are the factors that could cause erysipelas as a nosocomial infection, and an appropriate treatment of the infection would decrease the functional disability of the patient.
The Positive Skin Prick Test not Correlate with Disease Severity and Quality of Life in Atopic Dermatitis Patients Suwarsa, Oki; Sormin, Erfina Rohana; Sutedja, Endang; Dharmaji, Hartati Purbo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 29, No 3 (2017): DESEMBER
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.549 KB) | DOI: 10.20473/bikkk.V29.3.2017.229-233

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Background: Atopic dermatitis (AD) is a skin disease which cause stress to the patients. The chronic process of AD can cause physical, social, and psychological impairments. The severity of AD can also be affected by allergen exposures, which in turn will affect the quality of life of the patient. Skin prick test (SPT) can be used to evaluate allergen sensitization. Purpose: To evaluate correlation between SPT positivity to severity and quality of life of AD patients. Methods: The study was an observational cross-sectional study. Twenty five AD patients were recruited based on inclusion and exclusion criteria. Questionnaire was used to measure the quality of life of patients, and Scoring of Atopic Dermatitis (SCORAD) to measure the disease severity. Most of participants were women (80%), with median of age 26.84±13.71. Results: Positive SPT was obtained in 68% of patients, most of them were caused by house dust mites (55.2%). Seventy six percent of patients experienced mild AD, 12% moderate AD, and also 12% patients experienced severe AD. Significant correlation was observed between the severity and quality of life (p=0.001;r=0.617), while the SPT positivity has no correlation with the severity (p=0.912;r=-0.023) and quality of life (p=0.959;r=0.011). Conclusion: This study revealed that the severity of the disease has a correlation with quality of life, but SPT positivity has no significant correlation with severity and quality of life.
KEBERHASILAN TERAPI KOMBINASI MENGGUNAKAN METOTREKSAT INJEKSI DAN SIKLOSPORIN PADA PSORIASIS PUSTULOSA GENERALISATA Suwarsa, Oki; Devi Nursjamsi, Nadilla Carissa; Pangastuti, Miranti; Sutedja, Endang; Dharmadji, Hartati Purbo
Majalah Kedokteran Bandung Vol 49, No 3 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v49n3.1123

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Psoriasis pustulosa generalisata (PPG) adalah bentuk khusus dari psoriasis yang bersifat akut dan berat. Etiologi yang belum diketahui secara pasti menyebabkan pengobatan PPG masih menjadi suatu tantangan. Terapi kombinasi dapat diberikan pada PPG yang berat maupun yang tidak memberikan respons terhadap terapi sistemik tunggal, selain itu terapi kombinasi juga dapat meningkatkan efektivitas dari obat tunggal. Dilaporkan satu kasus PPG pada seorang wanita yang diterapi dengan menggunakan kombinasi metotreksat (MTX)  injeksi dan siklosporin. Dari anamnesis dan pemeriksaan fisis didapatkan pustula berkelompok pada dasar makula eritem yang bergabung membentuk lake of pus, disertai gejala sistemik demam dan leukositosis. Keluhan tersebut sudah berulang sejak 13 tahun yang lalu. Pasien diberikan terapi kombinasi injeksi MTX dan siklosporin. Pustula pada pasien menghilang setelah tujuh hari pemberian obat. Terapi kombinasi dengan MTX injeksi dan siklosporin ini baru pertama kali dilakukan 19 Mei?26 Mei 2017 di Departemen Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung dan memberikan hasil yang baik. [MKB. 2017;49(3):208?12]Kata kunci: Metotreksat, metotreksat injeksi, psoriasis pustulosa generalisata, siklosporin Succesful Treatment of Generalized Pustular Psoriasis with a Combination of Methotrexate Injection and CyclosporineGeneralized pustular psoriasis (GPP) is a special form of acute and severe psoriasis. The definite etiology of GPP remains a challenge. Combination therapy may be given to severe GPP or GPP that does not respond to a single systemic therapy sincecombination therapy may also improve the effectiveness of a monotherapy drug. A GPP case was reported in a woman treated with a combination of methotrexate (MTX) and cyclosporine. From anamnesis and physical examination it was revealed that there were clustered  pustules on the base of erythematous macules that form a lake of pus accompanied by systemic symptoms of fever and leukocytosis. This was a recurrent complaint since 13 years ago. Patients were given combination therapy of MTX injection and cyclosporine. Pustules disappeared after seven days of drug administration. This case was the first combination therapy with MTX injection and cyclosporine used during the period of 19 May to 26 May 2017 at the Department of Dermatology and Venereology Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, resulting in good results. [MKB. 2017;49(3):208?12]Key words: Cyclosporine, generalized pustular psoriasis, methotrexate, methotrexate injection
Efek Penggunaan Probiotik Topikal Terhadap Ekspresi MMP-13 dan Kolagen III pada Lapisan Dermis Tikus yang Dipapar Sinar Ultraviolet-B Tarawan, Vita M.; Anissa, Anissa; Sutedja, Endang; Lesmana, Ronny
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (952.26 KB) | DOI: 10.15416/ijcp.2016.5.2.138

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Proses penuaan kulit terjadi karena kombinasi penurunan kapasitas proliferasi sel-sel kulit, berkurangnya sintesis matriks dermis, dan peningkatan ekspresi enzim yang mendegradasi matriks kolagen. Penelitian ini merupakan eksperimental laboratorik, menggunakan 24 ekor tikus jantan galur Sprague-Dawley sebagai objek penelitian. Pada kelompok perakuan, kulit dorsal kedua kelompok dicukur, kemudian diberikan paparan sinar UVB seminggu tiga kali selama 4 minggu dengan dosis total penyinaran 840 mJ/ cm2. Kulit kelompok perlakuan diolesi krim Lactobacillus plantarum FNCC 0020 yang tidak bereplikasi, sehari 2 kali dengan komposisi aplikasi topikal koloni 247,27x107, sedangkan kelompok kontrol tidak diolesi apapun. Hasil penelitian diperoleh, baik intensitas, distribusi, maupun histoskor MMP-13 antara kelompok perlakuan dan kelompok kontrol tidak menunjukkan ada perbedaan yang bermakna (p>0,05). Intensitas kolagen III baik pada kelompok perlakuan maupun kontrol semua mempunyai derajat kuat, sedangkan distribusi kepadatan kolagennya paling rendah 20–50% dan tertingginya di atas 80%. Perbandingan distribusi kepadatan kolagen III secara statistik sangat bermakna (p<0,01). Pemberian krim topikal L. plantarum FNCC 0020 meningkatkan ekspresi distribusi kepadatan kolagen III namun tidak menurunkan ekspresi MMP-13. Kata kunci: Lactobacillus plantarum, kolagen, (matrix metalloproteinases) MMP13 Effect of Topical Probiotic on MMP-13 and Collagen III Expression in The Dermis Layer of Male Rats Irradiated with Ultraviolet-B Abstract Nowadays, there is a big interest in the use of topical probiotic preparations for skin health. One of the probiotics therurapeutic benefits is used as anti-aging. During aging, there is stimulation of activator protein-1 (AP-1) which is a transcription factor that inhibits the production of collagen and AP-1 supports the breakdown of collagen by enzymes called matrix metalloproteinases (MMPs). As administration of oral Lactobacillus plantarum could inhibit skin aging by lowering the activity of MMP, so the collagen degradation can be derived so probably topical use of Lactobacillus plantarum may give more prominent effects. We used 24 male rats Sprague-Dawley strain as research objects. This study was divided into two groups, the treatment and control groups. The shaved dorsal skin of rats were irradiated with UVB three times a week for 4 weeks with total irradiation dose of 840 mJ/cm2. Skin cream, containing 247.27x107 CFU non-replicating Lactobacillus plantarum FNCC 0020, was smeared on the treatment group, two times daily, whereas the control group did not receive any treatment. Skin biopsies were done at the end of the study for examination of MMP-13 and collagen III expressions. Intensity, distribution, and histoscore of MMP-13 between the treatment and the control group showed no significant difference (p>0.05). The treatment group showed a significant different in the intensity of collagen III with the density distribution of 20–50% and the highest density was 80% (p<0.01). Administration of topical cream L. plantarum FNCC 0020 increased the expression of collagen III density distribution, but not the MMP-13 expression.Keywords: Collagen, Lactobacillus plantarum, (matrix metalloproteinases) MMP13
CINICO-EPIDEMIOLOGICAL PROFILE OF VITILIGO PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG Dwiyana, Reiva Farah; Marindani, Vani; Agustina, Rohana; Setiawan, Setiawan; Idjradinata, Ponpon S.; Sutedja, Endang
Majalah Kedokteran Bandung Vol 49, No 2 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v49n2.1056

Abstract

Vitiligo is the most common hypopigmentation disorder; however, until now there iss no comprehensive epidemiological-clinical study of vitiligo in Indonesia. A descriptive study  using a questionnaire among vitiligo patients in Dr. Hasan Sadikin General Hospital Bandung was conducted to determine the clinical findings, socio-demographic factors, coexisting autoimmune disorders, and severity of disease. All vitiligo patients were recruited during the period of February 2012 to April 2014 from the Dermatology Outpatient Clinic of Dr. Hasan Sadikin General Hospital Bandung, as well as from the Endocrinology and Rheumatology Clinic Department of Internal Medicine; Endocrinology and Allergy and Immunology Clinics Department of Child Health; and Department  of Nuclear Medicine the same hospital. We collected data on socio-demographic profiles, clinical profile, and severity of vitiligo based on Vitiligo European Task Force (VETF). Out of 242 patients, female patients made up the majority of the patients (66.12%). In addition, most patients  wereunder 20 years (33.47%) and experienced onset of vitiligo highest in the first decade of life (29.34%). About 19.42% had positive family history of vitiligo and only 6.2% had history of autoimmune diseases. The majority of patients (77.27%) had vulgaris type of vitiligo with  head-neck (35.36%) asthe most frequent initial site of onset. Based on VETF,  the skin affected was mostly below 10% of body surface area (82.23%), i.e. staging score of between 0?5 (57.44%), and spreading score of between >0?(+5) or 68.18%. It is concluded that vitiligo most commonly occurs in females with the highest onset of under 10-years old and strong relationship with genetic predisposition.T he affected area was relatively small, despite the high spreading score. [MKB. 2017;49(2):132?8]   Key words: Clinical profile, epidemiology, vitiligo  Profil Kliniko-Epidemiologi pada Pasien Vitiligo di RSUP Dr. Hasan Sadikin Bandung   Vitiligo merupakan kelainan hipopigmentasi tersering, tetapi hingga kini belum ada penelitian epidemiologi-klinik yang komprehensif di Indonesia. Penelitian deskriptif menggunakan kuesioner dilakukan pada pasien vitiligo di Rumah Sakit Dr. Hasan Sadikin Bandung untuk mengetahui gambaran klinis, faktor sosio-demografik, kelainan autoimun yang menyertai, dan keparahan penyakit. Seluruh pasien vitiligo dari periode Februari 2012 hingga April 2014 yang berkunjung ke poliklinik Kulit dan Kelamin Rumah Sakit Dr. Hasan Sadikin Bandung, serta poliklinik: Endokrinologi dan Rematologi, Ilmu Penyakit Dalam; Endokrinologi dan Alergi-imunologi, Ilmu Kesehatan Anak; serta Kedokteran Nuklir, diikutsertakan dalam penelitian. Data yang dihimpun mencakup keadaan sosiodemografi, klinik, dan keparahan vitiligo berdasar atas Vitiligo European Task Force (VETF). Dari 242 pasien, perempuan merupakan jenis kelamin terbanyak (66,12%), usia di bawah 20 tahun (33,47%), dan awitan vitiligo terjadi pada dekade pertama kehidupan (29,34%). Sekitar 19,42% memiliki riwayat vitiligo pada keluarga dan hanya 6,2% yang memiliki penyakit autoimun. Umumnya tipe vitiligo vulgaris (77,27%) dengan predileksi pertama pada kepala-leher (35,36%). Area kulit yang terkena berdasarkan VETF ialah di bawah 10% dari body surface area (82,23%), staging score 0?5 (57,44%), dan spreading score antara >0?(+5) atau 68,18%. Simpulan penelitian ini ialah vitiligo banyak mengenai perempuan, awitan tersering pada usia di bawah 10 tahun dengan predisposisi genetik yang tinggi, serta daerah yang terkena vitiligo relatif kecil meskipun spreading score-nya tinggi. [MKB. 2017;49(2):132?8]   Kata kunci: Epidemiologi, gambaran klinik, vitiligo
Co-Authors - Setiawan, - - Sudigdoadi, - Abdassah, Marline Abdassah Achadiyani Achadiyani, Achadiyani Achmad Yudha Pranata, Achmad Yudha Agustina, Rohana Anas Subarnas Anggraini, Dita Maulida Anissa, Anissa Aseng Ramlan Bachti Alisjahbana Budi Setiabudiawan Candrianita, Sasfia Dany Hilmanto Dasim Budimansyah Devi Nursjamsi, Nadilla Carissa DEWI HERAWATI Diah Dhianawaty DLH, Dzul?kar Dwi Prasetyo Edhyana Sahiratmadja Effendi, Jusuf Eka, Astuti Emma Surachman, Emma Surachman Eva Susanti Evi Sri Suryani Firman Fuad Wirakusumah Firman Wirakusumah, Firman Gurnida, Dida Ahmad Hadyana Sukandar Handayani, Retty Hartati Purbo Dharmadji, Hartati Purbo Hartati Purbo Dharmaji, Hartati Purbo Hendra Gunawan Herman Susanto Husin, Farid Ida Parwati Idrajinata, Ponpon Iin Supartinah Noer Ika Agus Rini, Ika Agus Ike MP Siregar, Ike MP Judistianti, Tina Julianti, Mastiur Jusuf S Effendi Karlina, Intan Kurniawati Kurniawati Laniyati Hamijoyo, Laniyati Lastri, Lastri Lelly Yuniarti, Lelly Lesmana, Ronny Lilis Sumiati, Lilis Madjid, Tita Madjid, Tita Husnitawati Madjid8, Tita Husnitawati Marindani, Vani Marliza, Lenni Mose, Johanes MUCHTAN SUJATNO Mulyati, Iceu Nafsi, Nurizzatun Nanan Sekarwana Noegroho, Bambang Nugrahini, Evi Nur Hasanah Nurhalim Shahib Nurhasanah Nurhasanah Oki Suwarsa Pangastuti, Miranti Ponpon Idjradinata Ponpon S Idjradinata Ponpon S. Idjradinata Pri Hastuti, Pri Purwana, Hasan Purwara, Benny Reiva Farah Dwiyana, Reiva Farah Reti Hindritiani Rovina Ruslami, Rovina Setiawan Setiawan Setiawati, Elsa P Sianipar, Imelda M.G Sormin, Erfina Rohana Tarawan, Vita M. Tina Dewi Judistiani Winarni, Lastri Yani Triyani, Yani Yoni Syukriani, Yoni Yuni Susanti Pratiwi, Yuni Susanti