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First-line chemotherapy of advanced or metastatic breast cancer (MBC) with docetaxel and doxorubicin in Indonesia: results from A phase II trial Abdulmuthalib, Abdulmuthalib; Darwis, Idral; Prayogo, Nugroho; Sutjipto, Sutjipto
Medical Journal of Indonesia Vol 14, No 1 (2005): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.486 KB) | DOI: 10.13181/mji.v14i1.166

Abstract

Doxorubicin and docetaxel as a single agent are known as active cytotoxic agents for the treatment of metastatic breast cancer (MBC). Their combination has also shown to be highly active as a second-line chemotherapy of MBC. This study was design to evaluate the efficacy and safety of docetaxel-doxorubicin combination as first line chemotherapy of MBC patients in Indonesia. Twenty-six female patients between 31-65 years old with advanced or MBC was enrolled. No prior taxane or cumulative doxorubicin of 250 mg/m2 was allowed and patients should not have a heart disease. Treatment consisted of doxorubicin 50 mg/m2 as intravenous (IV) bolus followed one hour later by docetaxel 60 mg/m2 by IV infusion over 1 hour every 3 weeks for 6 cycles. Premedication with oral corticosteroid was administered a day prior to chemotherapy until the second day of each cycle. Left ventricular ejection fraction was recorded at baseline and after the 6th cycle. At the end of study, a total of 156 cycles of chemotherapy have been delivered.  Five and 11 patients had a complete response (CR) and partial response (PR), respectively, which accounted for a 61.54% best overall response. Three patients with extensive liver metastases showed complete disappearance after 6 cycles. Most frequent grade 3-4 toxicities were leukopenia (80.77%) and febrile neutropenia (5.77%). Leukopenia was usually short in duration, occurred mainly during the first and second cycle and did not require dose reduction. No patient developed heart failure. There was one death due to progressive disease after 6 cycles. Combination of doxorubicin 50 mg/m2 and docetaxel 60 mg/m2 was sufficiently active as first-line chemotherapy of MBC, especially in patients with liver metastases, with a manageable toxicity profile. (Med J Indones 2005; 14: 20-5)Keywords: docetaxel, doxorubicin, advanced or metastatic breast cancer, phase II trial, anthracycline and taxane combination
A Study of The Assessment for Boron Neutron Capture Therapy Agent Triatmoko, Isman Mulyadi; Sutjipto, Sutjipto
Indonesian Journal of Physics and Nuclear Applications Vol 2 No 1 (2017)
Publisher : Fakultas Sains dan Matematika Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.705 KB) | DOI: 10.24246/ijpna.v2i1.9-19

Abstract

A study of the assessment criteria covers the synthesis and characterization of agent and test their biological effectiveness as boron neutron capture therapy (BNCT) agents in cancer treatment. The cellular uptake of this agent into the glioblastoma cells was assessed by boron analysis (ICP-MS) and by fluorescence imaging (confocal microscopy). The agent enters the glioblastoma cells exhibiting a similar profile, i.e., preferential accumulation in the cytoskeleton and membranes and a low cytotoxic activity (IC50 values higher than 200 μM). The cytotoxic activity and cellular morphological alterations after neutron irradiation in the Research Reactor (>107 neutrons cm−2 s−1) were assessed by the MTT assay and by electron microscopy (TEM). Post neutron irradiation revealed that BNCT has a higher cytotoxic effect on the glioblastoma cells. Results provide a strong rationale for considering one of these compounds as a lead candidate for a new BNCT agent.
Assessment of Analytical Instrumentation for Boron Measurement in BNCT System Triatmoko, Isman Mulyadi; Sutjipto, Sutjipto
Indonesian Journal of Physics and Nuclear Applications Vol 2 No 1 (2017)
Publisher : Fakultas Sains dan Matematika Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.12 KB) | DOI: 10.24246/ijpna.v2i1.20-33

Abstract

The methods boron measurement in BNCT system has generally progressed with developments in analytical instrumentation. Spectrophotometric methods remained the methods of choice for most routine applications until the development of ICP-OES. ICP-OES was also not adequately sensitive for nutritional and medical research involving animal tissues that are naturally low in boron (B). The development of plasma-source MS (e.g., ICP-MS) not only has overcome most of these drawbacks, but also its capability of measuring B isotopes. The application of nuclear reaction methods (mainly prompt-γ spectrometry) has remained limited to some specialized fields. The validity and comparability of three different analytical techniques (QNCR, PGAA, and ICP-MS) for boron measurement in biological samples and application of these methods for examination of blood and tissue samples from a clinical study on boron uptake in blood, tissue, and neoplastic tissue, after infusion of BPA. The PET-based approach to TPS has been applied in BDTPS and a preliminary evaluation of the correct operation has been performed using a heterogeneous boron phantom, called HEBOM. The validation has been accompanied by calculations done with SERA, following the standard approach. BDTPS needs further in vivo experimental validations.
Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy Brahmanta, Arya; Sutjipto, Sutjipto; Narmada, Ida Bagus
Dental Journal (Majalah Kedokteran Gigi) Vol 49, No 2 (2016): (June 2016)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.232 KB) | DOI: 10.20473/j.djmkg.v49.i2.p63-66

Abstract

Background: Mechanical force of orthodontics causes changes in periodontal ligament vascularization and blood flow, resulting in biochemical and cellular changes as well as changes in the contour of the alveolar bone and in the thickness of the periodontal ligaments. Hyperbaric oxygen (HBO) therapy is one of many solutions stimulating the growth of new blood vessels and increasing tissue oxygenation. Thus, HBO plays a role in recovery of periodontal ligament and osteoblasts. Purpose: This study aimed to determine the effects of HBO therapy for seven days on periodontal ligament size and osteoblast number in the tension site during bone remodeling in tooth movement. Method: The study was true experimental laboratories with completely randomized control group post test only design. Twenty-four males guinea pigs were randomly divided into three groups. K0 was the control group without any treatment, K1 was the group given a mechanical orthodontic pressure, and K2 was the group treated with the addition of hyperbaric oxygen therapy. The maxillary incisors were moved distally by elastic separator. After HBO therapy on day 7, all of the groups were sacrificed, and then periodontal ligament size and osteoblast number were analyzed by one-way Anova and LSD statistical tests. Result: The results showed significant differences in the size of the periodontal ligament and the number of osteoblasts in the tension site among the groups (p<0.05). Conclusion: HBO therapy at 2.4 ATA for 7 days is effective in recovery of periodontal ligament and increased osteoblast number during bone remodeling in tension area of orthodontic tooth movement.
Penentuan kandungan logam di dalam sedimen waduk Gajah Mungkur dengan metode analisis aktivasi neutron cepat. Sudaryo, Sudaryo; Sutjipto, Sutjipto
Jurnal Forum Nuklir JFN Vol 5 No 1 Mei 2011
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2120.603 KB)

Abstract

Penentuan kandungan logam di dalam sedimen waduk Gajah Mungkur dengan metode analisis aktivasi neutron cepat. Penelitian mengenai kandungan logam pada sedimen waduk Gajah Mungkur kabupaten Wonogiri telah dilakukan. Penelitian ini bertujuan untuk menentukan kandungan unsur logam di dalam waduk Gajah Mungkur kabupaten Wonogiri dengan metode AANC. Pencuplikan sedimen dilakukan di 3 (tiga) lokasi di daerah waduk tersebut. Pencuplikan pada bulan April 2008 dengan waktu pencuplikan pada jam 10.00-14.00 WIB. Kandungan unsur logam di waduk ditentukan dengan menggunakan Generator Neutron SAMES J-25 serta peralatan spektrometer gamma dengan detektor NaI(Tl) serta standar pembanding SRM 2704 (buffalo river sediment, BRS) dari NIST. Hasil penelitian menunjukkan bahwa konsentrasi kandungan unsur logam yang tersebar di dalam waduk pada lokasi 1 hingga 3 untuk Fe:7,4-32% Al: 12-16%; Si: 40% dan Cr total : 3-16 ppm. Adapun akurasi untuk unsur logam Fe, Al, Si dan Cr total mempunyai kisaran: 5,25 -10,75%; presisi : 10,99-14,25% dan batas deteksi untuk Al=1%, Na=0,14%, Mg=0,05%, Si=2%, Fe=1 % dan Cr=0,01 ppm. Didasarkan data penelitian menunjukkan bahwa di dalam sedimen waduk telah mengalami pencemaran unsur logam berat, utamanya unsur Cr total.
PENGEMBANGAN KURIKULUM PENDIDIKAN KESETARAAN Sutjipto, Sutjipto
Jurnal Ilmiah Visi Vol 11 No 2 (2016): VISI PTK PNF
Publisher : Direktorat Pembinaan Guru dan Tenaga Kependidikan, Pendidikan Anak Usia Dini dan Pendidikan Masyarakat bekerjasama dengan Fakultas Ilmu Pendidikan Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.925 KB) | DOI: 10.21009/JIV.1102.8

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The purpose of this research is to reveal how policy-makers and curriculum developers to design educational curriculum equality. This type of research is qualitative descriptive. The main data were collected by questionnaires and group discussions terpumpun. Data were analyzed using descriptive statistics, namely the depiction of the data with the pattern description. The study was conducted in November 2015 until June 2016, with a sample of teachers and education staff of three learning centers. The results showed. First, policy makers and developers are still putting that designing and realizing equality education curriculum has not made a top priority, but are waiting for formal education first. Second, policy makers and developers have not presenting concrete policy markers related complexity and context of the fundamental aspects of reality which represents the common interests of citizens of the nation that terejawantahkan in the curriculum as a tool tread life. Third, the design of educational curricula equality has not equip knowledge and competence as a prerequisite to work and also not strong attitudes toward integrity, hard work, discipline, mutual cooperation, independence, nationalism and specialized skills to solve the problem of life. Fourth, equal education curriculum design not describe the instruments to face the problem of dropouts and solve socio-economic problems oriented towards life skills in order to enter the life.
Kebijakan Penggunaan Batas Wilayah Epidemiologi dalam Pengendalian Penyakit Malaria (Studi Kasus di Puskesmas Kokap II Kabupaten Kulon Progo, DIY) Sutjipto, Sutjipto; Kusnanto, Hari; Trisnantoro, Laksono; Lazuardi, Lutfan; Astuti, Indwiani
Jurnal Kebijakan Kesehatan Indonesia Vol 4, No 2 (2015)
Publisher : Center for Health Policy and Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1586.302 KB) | DOI: 10.22146/jkki.v4i2.36100

Abstract

Background: There are 396 endemic districts from the total of 495 districts in Indonesia, with an estimated 45% of the population live in the areas that are at risk of infected malaria disease. Kulon Progo Regency is one of regencies in Yogyakarta (DIY), which until now has not declared elimination of malaria. PHC Kokap II located in Kokap sub-district, is the largest contributor of positive malaria cases in Kulon Progo regency due to the potential for outbreaks of malaria, during the period 1997-2004, when the number of malaria positive patients in the PHC Kokap II ranged between 26% - 55% of patients of the total positive malaria cases in Kulon Progo. This study aims to produce epidemiological information that is important in the region of PHC Kokap II associated with the distribution and determinants of malaria that affects the possibility of local transmission. Methods: The study design was a descriptive study, to get an overview of the distribution and determinants of malaria. The observation unit is the population in the form of correlation studies population and a time series. To determine the pattern of malaria transmission we use secondary data between 2009- 2012 malaria cases. Malaria incidence patterns were analyzed by person, place and time. To determine the clusters of malaria we use clustering analysis with the data of malaria cases in the region PHC Kokap II year 2012. To determine the spread of malaria in the cross-border area between PHC Kokap II and PHC Kaligesing we use secondary data year 2010-2012. Results: In the area of PHC Kokap II, we found import cases every year. Even more, in the year 2009 the proportion of import cases was 82% compared with all patients that were found malaria positive. Clusters of malaria is in the west region of PHC Kokap II, which is bordering to the Subdistrict Kaligesing, Purworejo, Central Java Province. Region PHC Kokap II is an area of high vulnerability, the potential to get the risk of transmission of imported cases of malaria is due to the entry of patients or infective vectors from high transmission areas to low transmission. Conclusion: The focus of malaria transmission in the area of PHC Kokap II is at the western part bordering the sub-district Kaligesing, Purworejo. PHC Kokap II is the region of high vulnerability. Policies need to be made use of epidemiological boundaries in the malaria control program in the cross-border region. Latar belakang: Di Indonesia masih terdapat 396 Kabupaten endemis dari 495 Kabupaten yang ada, dengan perkiraan seki- tar 45% penduduk berdomisili di daerah yang berisiko tertular malaria. Kabupaten Kulon Progo merupakan salah satu kabupa- ten di Daerah Istimewa Yogyakarta (DIY), yang sampai saat ini belum dinyatakan eliminasi. Wilayah Puskesmas Kokap II yang berada di Kecamatan Kokap, merupakan penyumbang terbesar penderita positip malaria untuk wilayah Kabupaten Kulon Progo diantaranya karena potensi terjadinya KLB malaria, selama periode tahun 1997-2004, range jumlah penderita positip ma- laria di wilayah Puskesmas Kokap II berkisar antara 26% - 55% penderita positip malaria di Kabupaten Kulon Progo. Pe- nelitian ini bertujuan untuk menghasilkan informasi epidemiologi yang penting di wilayah Puskesmas Kokap II terkait dengan distribusi dan determinan penyakit malaria yang sangat berpe- ngaruh terhadap kemungkinan terjadinya penularan setempat. Metode: Rancangan penelitian ini adalah studi deskriptif untuk mendapatkan gambaran distribusi dan determinan penyakit malaria, unit pengamatan adalah populasi dalam bentuk studi korelasi populasi dan rangkaian berkala. Untuk mengetahui pola penularan malaria digunakan data sekunder kasus ma- laria tahun 2009-2012, dianalisis pola kejadian malaria menurut orang, tempat dan waktu. Untuk mengetahui kluster penderita malaria dilakukan analisis klustering menggunakan data kasus malaria di wilayah Puskesmas Kokap II tahun 2012. Untuk mengetahui penyebaran penderita malaria di daerah lintas batas antara Puskesmas Kokap II Kabupaten Kulon Progo dan Pus- kesmas Kaligesing Kabupaten Purworejo digunakan data sekunder tahun 2010-2012. Hasil: Di wilayah Puskesmas Kokap II setiap tahun selalu dike- temukan kasus import, bahkan dalam tahun 2009 kasus import proporsinya adalah 82% dibandingkan dengan seluruh pen- derita positif malaria yang diketemukan. Kluster penderita ma- laria berada di bagian barat wilayah Puskesmas Kokap II, yaitu berbatasan langsung dengan Kecamatan Kaligesing Kabupaten Purworejo, Provinsi Jawa Tengah. Wilayah Puskesmas Kokap II merupakan daerah vulnerebilitas tinggi, potensial untuk menda- patkan risiko penularan kasus import karena masuknya pende- rita malaria atau vektor yang infektif dari daerah penularan tinggi ke penularan rendah. Kesimpulan: Fokus penularan penyakit malaria di wilayah Puskesmas Kokap II berada pada wilayah bagian barat berba- tasan dengan wilayah administratif Kecamatan Kaligesing, Ka- bupaten Purworejo. Puskesmas Kokap II adalah wilayah vulnerabilitas tinggi, perlu dibuat kebijakan penggunaan batas wilayah epidemiologi dalam program penanggulangan malaria di wilayah lintas batas.
Hubungan antara Kepuasan Kerja dengan Perilaku Kewargaorganisasian (PKO) Guru di SMSK Negeri Kecamatan Pasar Minggu Kota Administrasi Jakarta Selatan Nugroho, Dwi Sakti; Sutjipto, Sutjipto; Matin, Matin
IMPROVEMENT: Jurnal Ilmiah untuk peningkatan mutu manajemen pendidikan Vol 3 No 1 (2016): Improvement: Jurnal Ilmiah untuk Peningkatan Mutu Manajemen Pendidikan
Publisher : Program Studi Manajemen Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.835 KB) | DOI: 10.21009/improvement.03106

Abstract

This study aims to know there is a relationship between job satisfaction with teacher OCB at Vocational High School Pasar Minggu, South Jakarta Administration. This research use quantitative with two variables there in, namely: (X) job satisfaction as independent variables and (Y) OCB as the dependent variable. The method used is survey method with the results of the analysis of correlational studies. The population in this study are teacher’s at vocational high school in Pasar Minggu, South Jakarta there is 275 teachers. Samples were taken by using simple random sampling technique. The technique is based on the sample size used in this study as many as 73 teachers. Data collection for the variable (X) job satisfaction and variable (Y) OCB using a questionnaire. Hypothesis testing is done using product moment correlation formula in can correlation coefficient (r) = 0,45283 and based on the results of hypothesis testing using t-test obtained t for 4.280 &gt; 1.994 t-table. From this research, we get there’s positive relation between job satisfaction with OCB at Vocational High School Pasar Minggu, South Jakarta Administration. The contributions made by teachers job satisfaction on OCB, amounted to 20.51%.