Din Syafruddin
Eijkman Institute for Molecular Biology

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DISTRIBUSI RESISTENSI NYAMUK AEDES AEGYPTI TERHADAP INSEKTISIDA SIPERMETRIN DI SEMARANG Sayono, -; Syafruddin, Din; Sumanto, Didik
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2012: SEMINAR NASIONAL HASIL PENELITIAN 2012
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Pengendalian nyamuk Aedes aegypti merupakan tindakan terpenting dalampenanggulanan penyakit demam berdarah dengue (DBD) karena obat dan vaksin antivirus masihdalam penelitian. Penggunaan insektisida menjadi pilihan utama masyarakat dalam pengendalianAedes > 40 tahun, dan terbukti menimbulkan resistensi di berbagai negara.Tujuan penelitian adalah mengetahui distribusi resistensi nyamuk Aedes aegypti terhadapinsektisida sipermetrin, yang telah dipakai di Indonesia lebih dari 10 tahun.Nyamuk Aedes aegypti diperoleh dari survey larva di rumah penderita DBD dan 9 rumah disekitarnya. Uji resistensi dengan kit standar WHO. Data dianalisis secara diskriptif untukmenentukan status resistensi dan indeks densitas populasi Aedes. Wawancara digunakan untukmengetahui riwayat penggunaan insektisida.Diproleh hasil HI berkisar 41,7 ? 76,9%, rerata 58,44%. CI berkisar 21,9 ? 78,3%, rerata50,54%. BI berkisar 43,75 ? 138,46%, rerata 80,56%. Kematian nyamuk berkisar 0,8 ? 13,5%, rerata5,88%, dengan status resisten.Densitas populasi Aedes aegypti di Semarang melebihi batas aman penularan DBD yangditetapkan WHO (?5%). Resistensi nyamuk Aedes aegypti tersebar luas di Semarang.
Malaria in Jayapura District, Papua Province, Indonesia and resistance to sulfadoxine-pyrimethamine Sorontou, Yohanna; Asih, Puji B.S.; Wanandi, Septelia I.; Ramelan, Wahyuning; Syafruddin, Din
Medical Journal of Indonesia Vol 16, No 1 (2007): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.135 KB) | DOI: 10.13181/mji.v16i1.254

Abstract

Malaria poses a major public health problem in Papua. The rapid spread of drug-resistant parasites and deterioration of the malaria control program following the monetary crisis and civil strife in the late 90’es have worsened the malaria situation in many areas of Papua. To re-assess the current magnitude of malaria problem, a malariometric survey was conducted in three sub-districts of Jayapura District, as well as antimalarial drug sensitivity test using sulfadoxine-pyrimethamine (SP) at the outpatient clinics of Abepura General Hospital (RSU), Hamadi Primary Health Center and Panti Asuhan Katolik Clinics, Sentani, Jayapura District, Papua Province. Screening of 543 subjects in three sub-districts revealed 185 malaria positive subjects, either with P. falciparum, P. vivax or mixed of the two species. All of the malaria cases were asymptomatic. In the SP drug sensitivity test, of the 56 subjects involved, 32 were classified as early treatment failure and two subjects were classified as late treatment failure. The remaining 22 subjects were classified as adequate clinical and parasitological response (ACPR). These results indicated that the surveyed area has a high malaria prevalence and treatment failure to SP and therefore alert to the need of deploying new antimalarial regiment that suit the remote setting. (Med J Indones 2007; 16:32-8) Keywords: malaria, sulfadoxine-pyrimethamine (SP) resistance, Jayapura District, Indonesia
Malaria and Anopheles spp in the villages of Salubarana and Kadaila, Mamuju District, South Sulawesi Province, Indonesia Nurdin, Armyn; Syafruddin, Din; Wahid, Isra; Noor, Nur N.; Sunahara, Toshihiko; Mogi, Motoyoshi
Medical Journal of Indonesia Vol 12, No 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.954 KB) | DOI: 10.13181/mji.v12i4.119

Abstract

Malaria epidemiology in Salubarana and Kadaila villages, Mamuju District, South Sulawesi Province, Indonesia was studied from July-December 2002 to obtain baseline data related to the parasite, mosquito vector, human host, and environmental factors. Monthly malariometric surveys conducted during the six- month period revealed a relatively high prevalence of malaria in Kadaila in comparison to Salubarana. Kadaila was mainly inhabited by migrants from Java, Bali, Lombok, and from other districts of South Sulawesi. Salubarana, on the other hand, was inhabited mainly by indigenous Mandarese. Analysis of 1,113 blood smears taken from individuals randomly involved in the survey revealed 59 positive samples, consisting of Plasmodium falciparum or P. vivax. These two species predominated the samples examined and were occasionally found as mixed infection. Anopheles barbirostris was confirmed as a vector for malaria in this area whereas 7 other species An. barbumbrosus, An. parangensis, An. vagus, An. crawfordi, An.pseudobarbirostris, An. Tessellatus, and An. subpictus should be considered as potential vectors. The first mentioned species predominated, using mainly riverbeds and ground pools as breeding places with a habit of indoor or outdoor resting. These findings could be useful for establishing evidence-based malaria control program in the area. (Med J Indones 2003; 12: 252-8) Keywords: malaria epidemiology, parasite, vectors, environmental factors, Indonesia
The Impact of Malaria in Pregnancy on Infant Susceptibility to Malaria Infection Indrawanti, Ratni; Wijayanti, Mahardika; Hakimi, Mochamad; Juffrie, Mohammad; Kenangalem, Enny; Burdam, Faustina Helena; Triyanti, Leily; Noviyanti, Rintis; Syafruddin, Din; Ahmed, Rukhsana; ter Kuile, Feiko; Poespoprojo, Jeanne Rini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Malaria infection during pregnancy is a significant global health problem with substantialrisks for pregnant women, her foetus, and the newborn child. Infant malaria is a majorpublic health concern in Timika, Papua. The aim of the study was to investigate the impactof malaria during pregnancy on infant’s susceptibility to malaria infections, the timing ofits occurrence, the number of malaria infections during pregnancy. This was a cohortprospective study conducted in Timika, Papua from October 2013 to September 2016.Malaria investigation was done by microscopic and PCR methods. Demographic data andmalaria status of mother-infant pairs were collected and analyzed by SPSS 22.0 version.One hundred seventy-eight infants consisting of 95 (53.37%) infants born to motherswith malaria and 83 (46.63%) without malaria 91 (51.12%) boys and 87 (48.88%) girlswere involved in the study. The mean of mothers’ ages were 25.35 ± 6.30 vs. 26.0 ±5.69 years. At the ages of 6 and 12 months, infants born to malaria positive motherswere more susceptible to malaria infections compared to infants born to malaria negativemothers with RR = 3.49; 95%CI: 1.02-11.96; p = 0.03 and RR = 8.74; 95%CI: 1.14-66.81; p = 0.01, respectively. Independent risk factors of infant susceptibility to malariainfection during the first year of life were malaria in pregnancy (MiP) in 2nd trimester (RR= 4.50; 95%CI: 1.5-13.49; p = 0.07), pregnant women who only got malaria infection1 time during pregnancy (RR=2.95; 95%CI: 1.04-8.33; p = 0.04), and Papuan ethnicity(RR=3.58; 95%CI: 1.22-10.59; p = 0.02). In conclusion, infant susceptibility to malariais associated with maternal malaria status during pregnancy. MiP in second trimester,pregnant women who only had malaria once and Papuan ethnicity were independent riskfactors for infant’s increased susceptibility to malaria infection.